Alcohols-buliding-blocks

Synthesis of an oil absorbent polymer particle with core-shell structure was written by Yang, Fajie;Li, Guoping;Zhang, Zhiheng;Cheng, Lei;Liu, Weili;Liu, Shaozhu. And the article was included in Youqitian Huanjing Baohu in 2014.Quality Control of Diethyleneglycoldiacrylate This article mentions the following:

The core structure of absorbent polymer particle was synthesized by suspension polymerization using Bu acrylate and n-laurylacrylate as monomers, diethylene glycol diacrylate as crosslinking agent, 2,2′-Azobis (2-methylpropionitrile) as initiator. Then, the shell structure was synthesized at the outer surface of the polymer particle using divinylbenzene and phenylethylene as monomers. The effects of the ratio of monomer amounts of core to that of shell, the category and amount of crosslinking agent and initiation temperature on the absorbent ability were studied. The oil absorbent polymer particle with core-shell structure was synthesized with the absorption capacity of 29 g/g. Saturation absorption time of the absorbent polymer particle with core-shell was 3 min, and it was markedly faster than that without core-shell structure. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Quality Control of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formal β-C-H Arylation of Aldehydes and Ketones by Cooperative Nickel and Photoredox Catalysis was written by Liu, Kun;Studer, Armido. And the article was included in Angewandte Chemie, International Edition in 2022.Recommanded Product: 68716-49-4 This article mentions the following:

A method that uses cooperative nickel and photoredox catalysis for the formal β-C-H arylation of aldehydes and ketones via their readily prepared enol ethers e.g., [(2-methylprop-1-en-1-yl)oxy]tris(propan-2-yl)silaneas with (hetero)aryl bromides RBr (R = Ph, 1-benzofuran-5-yl, quinolin-3-yl, etc.) were reported. The method features mild conditions, remarkable scope and wide functional group tolerance. Importantly, the introduced synthetic strategy also allows the β-alkenylation, β-alkynation and β-acylation of aldehydes under similar conditions. Mechanistic studies revealed that this transformation proceeds through a single electron oxidation/Ni-mediated coupling/reductive elimination cascade. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Recommanded Product: 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Crosslinking Polymer Brushes with Ethylene Glycol-Containing Segments: Influence on Physicochemical and Antifouling Properties was written by Dehghani, Ella S.;Spencer, Nicholas D.;Ramakrishna, Shivaprakash N.;Benetti, Edmondo M.. And the article was included in Langmuir in 2016.Electric Literature of C16H26O7 This article mentions the following:

The introduction of different types and concentrations of crosslinks within poly(hydroxyethyl methacrylate) (PHEMA) brushes influences their interfacial, physicochem. properties, ultimately governing their adsorption of proteins. PHEMA brushes and brush-hydrogels were synthesized by surface-initiated, atom-transfer radical polymerization (SI-ATRP) from HEMA, with and without the addition of di(ethylene glycol) dimethacrylate (DEGDMA) or tetra(ethylene glycol) dimethacrylate (TEGDMA) as crosslinkers. Linear (pure PHEMA) brushes show high hydration and low modulus and addnl. provide an efficient barrier against nonspecific protein adsorption. In contrast, brush-hydrogels are stiffer and less hydrated, and the presence of crosslinks affects the entropy-driven, conformational barrier that hinders the surface interaction of biomols. with brushes. This leads to the physisorption of proteins at low concentrations of short crosslinks. At higher contents of DEGDMA or in the presence of longer TEGDMA-based crosslinks, brush-hydrogels recover their antifouling properties due to the increase in interfacial water association by the higher concentration of ethylene glycol (EG) units. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Electric Literature of C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Electric Literature of C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sonochemical synthesis and characterization of CuInS₂ nanostructures using new sulfur precursor and their application as photocatalyst for degradation of organic pollutants under simulated sunlight was written by Jafarinejad, Aazam;Bashiri, Hadis;Salavati-Niasari, Masoud. And the article was included in Arabian Journal of Chemistry in 2022.Synthetic Route of C3H8O2 This article mentions the following:

In this research, we investigated the photocatalytic activity of CuInS₂ nanoparticles in visible light during the decomposition of three toxic dyes (Eriochrome Black T, Rhodamine B, and Erythrosine). The CuInS₂ nanostructures were synthesized by a rapid and simple sonochem. method using dithiooxamide as a sulfur reagent and various capping agents, including SDS, CTAB, and PVP, were applied to achieve a pure structure with fine morphol. The flower-like structure was observed through FESEM images, implying different capping agents and fabrication had a considerable influence on the morphol. of samples. The suitable bandgap of CuInS₂ (1.53 eV) was obtained from DRS anal. and resulted in higher photodegradation efficiency. The fabricated CuInS₂ revealed better photodegradation efficiency (74.8%) to the anionic dyes than cationic dye. A possible photodegradation mechanism was suggested based on scavenger tests of active species. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Synthetic Route of C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tris(tetrabutylammonium) hexakis(tert-butanethiolato-κS)hepta-μ₃-chlorido-μ₃-sulfidohexamolybdate dihydrate was written by Petrov, Pavel A.;Naumov, Dmitry Yu.;Konchenko, Sergey N.. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2012.Quality Control of Sodium 2-methyl-2-propanethiolate This article mentions the following:

The octahedral cluster core of the anion in the structure of the title compound, (C₁₆H₃₆N)₃[Mo₆(C₄H₉S)₆(μ₃-Cl)₇(μ₃-S)]·2H₂O, has 3̅ site symmetry. Two μ₃-Cl atoms fully occupy positions in the cluster core, while the remaining six positions are statistically occupied by Cl and S atoms in a 1:5 ratio. The fully occupied Cl-atom positions are located on sites with 3 symmetry, and the N atom of tetrabutylammonium cation is located on a site with 2 symmetry. The structure contains also two disordered solvent H₂O mols., one of which is located on a 3-fold rotation axis and the other in a general position, both with an occupancy of 0.25. The H₂O mols. are localized in cavities formed by the tetrabutylammonium cations and the tert-butanethiolate groups. The metal clusters are stacked in a cubic close packing arrangement along [001]. Crystallog. data and at. coordinates are given. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Quality Control of Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Theoretical and experimental evidence for the action of terpenes as modulators in lung function was written by Zoenker, K. S.;Bluemel, G.;Probst, J.;Reiterer, W.. And the article was included in Progress in Respiration Research (1963-1994) in 1984.Application of 2451-01-6 This article mentions the following:

The terpenes tested (Pinocarveol  [5947-36-4], Terpin hydrate  [2451-01-6], Myrtenol  [515-00-4], Myrtenal  [564-94-3], Verbenone  [80-57-9], and Trans-verbenol  [1820-09-3]) all decreased the surface tension of a dipalmitoyllecithin monolayer and/or natural rat surfactant, indicating that if they could be placed at the air/water/lipid interface within the alveolar lining layer, they may be able to restore pulmonary function. In rabbits with natural tracheobronchial catarrhal effects, terpenes inhibited mucus secretion, decreased mucus deposition and increased the cilia-mediate mucus transport, indicating that terpenes may change the viscoelasticity of the mucus. In patients with chronic obstructive pulmonary disease, terpenes had variable effects. The use of the terpenes in patients with surfactant/lung function impairment is discussed. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Application of 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Biodegradable fibrous scaffolds with diverse properties by electrospinning candidates from a combinatorial macromer library was written by Metter, Robert B.;Ifkovits, Jamie L.;Hou, Kevin;Vincent, Ludovic;Hsu, Benjamin;Wang, Louis;Mauck, Robert L.;Burdick, Jason A.. And the article was included in Acta Biomaterialia in 2010.Category: alcohols-buliding-blocks This article mentions the following:

The properties of electrospun fibrous scaffolds, including degradation, mechanics and cellular interactions, are important for their use in tissue engineering applications. Although some diversity has been obtained previously in fibrous scaffolds, optimization of scaffold properties relies on iterative techniques in both polymer synthesis and processing. Here, we electrospun candidates from a combinatorial library of biodegradable and photopolymerizable poly(β-amino ester)s (PBAEs) to show that the diversity in properties found in this library is retained when processed into fibrous scaffolds. Specifically, three PBAE macromers were electrospun into scaffolds and possessed similar initial mech. properties, but exhibited mass loss ranging from rapid (complete degradation within ∼2 wk) to moderate (complete degradation within ∼3 mo) to slow (only partial degradation after 3 mo). These trends in mechanics and degradation mimicked what was previously observed in the bulk polymers. Although cellular adhesion was dependent on the polymer composition in films, adhesion to scaffolds that were electrospun with gelatin was similar on all formulations and controls. To further illustrate the diverse properties that are attainable in these systems, the fastest and slowest degrading polymers were electrospun together into one scaffold, but as distinct fiber populations. This dual-polymer scaffold exhibited behavior in mass loss and mechanics with time that fell between the single-polymer scaffolds. In general, this work indicates that combinatorial libraries may be an important source of information and specific polymer compositions for the fabrication of electrospun fibrous scaffolds with tunable properties. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Category: alcohols-buliding-blocks).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ni-Catalyzed Reductive Antiarylative Cyclization of Alkynones was written by Zhou, Zhijun;Liu, Wenfeng;Kong, Wangqing. And the article was included in Organic Letters in 2020.Application In Synthesis of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

A new catalyst system for the antiarylative cyclization of alkynones and aryl halides through a reductive cross-coupling strategy is developed. The transformation proceeds smoothly in the absence of organometallic reagents and features high functional group tolerance. This method provides an effective platform to access a wide variety of synthetically useful endocyclic tetrasubstituted allylic alcs. in a stereoselective manner. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Application In Synthesis of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zinc polyoxometalate immobilized on ionic liquid-modified MCM-41: an efficient reusable catalyst for the selective oxidation of alcohols with hydrogen peroxide was written by Hajian, Robabeh;Jafari, Fereshteh. And the article was included in Journal of the Iranian Chemical Society in 2019.Product Details of 1777-82-8 This article mentions the following:

In this study, Keggin-type polyoxometalate [n-C₄H₉)₄N]_x[PW₁₁ZnO₃₉].nH₂O was successfully immobilized on imidazole-functionalized ionic liquid-modified mesoporous MCM-41 by phys. adsorption. The PW₁₁Zn@MCM-41-Im was characterized by FT-IR, ICP, XRD, SEM, nitrogen adsorption and desorption and DRUV-Vis anal. The results indicated that ZnPW₁₁ could be successfully immobilized on mesoporous MCM-41-Im. This heterogeneous catalyst showed high catalytic performance and excellent selectivity in the oxidation of alcs. to the corresponding carbonyl groups with hydrogen peroxide. Furthermore, the supported ionic liquid catalyst was recovered by simple filtration and reused in four reaction runs with the preserve of the catalytic activity. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Product Details of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation was written by Huang, Yifan;Yokoe, Hiromasa;Kaiho-Soma, Ai;Takahashi, Kazunori;Hirasawa, Yusuke;Morita, Hiroshi;Ohtake, Fumiaki;Kanoh, Naoki. And the article was included in Bioconjugate Chemistry in 2022.Related Products of 111-46-6 This article mentions the following:

Trivalent PROTACs having a functionalization site with controlled orientation were designed, synthesized, and evaluated. Based on the X-ray structure of BRD protein degrader MZ1 (1) in complex with human VHL and BRD4^BD2, we expected that the 1,2-disubstituted Et group near the JQ-1 moiety in MZ1 (1) could be replaced by a planar benzene tether as a platform for further functionalization. To test this hypothesis, we first designed six divalent MZ1 derivatives, 2a-c and 3a-c, by combining three variations of substitution patterns on the benzene ring (1,2-, 1,3-, and 1,4-substitution) and two variations in the number of ethylene glycol units (2 or 1). We then tested the synthesized compounds for the BRD4 degradation activity of each. As expected, we found that 1,2D-EG2-MZ1 (2a)(I), an MZ1 derivative with 1,2-disubstituted benzene possessing two ethylene glycol units, had an activity profile similar to that of MZ1 (1). Based on the structure of 2a, we then synthesized and evaluated four isomeric trivalent MZ1 derivatives, 15a-15d, having a tert-Bu ester unit on the benzene ring as a handle for further functionalization. Among the four isomers, 1,2,5T-EG2-MZ1 (15c)(II) retained a level of BRD4 depletion activity similar to that of 2a without inducing a measurable Hook effect, and its BRD4 depletion kinetics was the same as that of MZ1 (1). Other isomers were also shown to retain BRD4 depletion activity. Thus, the trivalent PROTACs we synthesized here may serve as efficient platforms for further applications. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Related Products of 111-46-6).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 111-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts