Category: alcohols-buliding-blocks

Chen, Tsun-Ren published the artcileIridium/graphene nanostructured catalyst for the N-alkylation of amines to synthesize nitrogen-containing derivatives and heterocyclic compounds in a green process, Formula: C5H12O2, the publication is RSC Advances (2022), 12(8), 4760-4770, database is CAplus and MEDLINE.

A facile iridium/graphene-catalyzed methodol. providing an efficient synthetic route for C-N bond formation is reported. This catalyst can directly promote the formation of C-N bonds, without pre-activation steps, and without solvents, alkalis and other additives. This protocol provides a direct N-alkylation of amines using a variety of primary and secondary alcs. with good selectivity and excellent yields. Charmingly, the use of diols resulted in intermol. cyclization of amines, and such products are privileged structures in biol. active compounds Two examples illustrate the advantages of this catalyst in organic synthesis: the tandem catalysis to synthesize hydroxyzine, and the intermol. cyclization to synthesize cyclizine. Water is the only byproduct, which makes this catalytic process sustainable and environmentally friendly.

RSC Advances published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Formula: C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Hanfeng published the artcileApplication of carboprost tromethamine in treatment of hypertension in pregnancy, Application In Synthesis of 58551-69-2, the publication is Fujian Yiyao Zazhi (2013), 35(5), 99-100, database is CAplus.

Objective: To investigate application of carboprost tromethamine in treatment of hypertension in pregnancy. Methods: 200 cases of patients with hypertension in pregnancy were selected as a treatment group, and 200 cases of normal pregnancy at the same period were selected as a control group. Two groups underwent lumbar epidural anesthesia for cesarean section surgery, the control group was instantly given oxytocin 20 IU injection for uterine wall after childbirth of fetus, the treatment group was one-time given carboprost tromethamine injection 250 μg after childbirth of fetus, and both groups were given 20 IU of oxytocin via continuous i.v. infusion for 6 h. The bleeding state, incidence of postpartum hemorrhage, Hb level, and blood pressure after childbirth were observed during surgery and after surgery within 2 h and 24 h. Results: Compared with the control group, the amount of bleeding within 2h, 24 h after surgery of the treatment group was lower, and incidence of postpartum hemorrhage was lower (P < 0.05). Blood pressure difference of the two groups was not statistically significant (P > 0.05) and the two groups had no significant adverse reactions. Conclusions: Carboprost tromethamine is an effective measure to prevent postpartum hemorrhage of hypertension in pregnancy.

Fujian Yiyao Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Application In Synthesis of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Lingyun published the artcileSelective Transformation of Vicinal Glycols to α-Hydroxy Acetates in Water via a Dehydrogenation and Oxidization Relay Process by a Self-Supported Single-Site Iridium Catalyst, HPLC of Formula: 90-64-2, the publication is ACS Catalysis (2021), 11(21), 12833-12839, database is CAplus.

α-Hydroxy acids have attracted broad attention because of their prevalence in bioactive mols. and biodegradable polymers, but their conventional syntheses are usually restricted to aromatic substrates, especially, in a stepwise manner. Herein, the transformation of alkyl and aryl vicinal glycols to α-hydroxy acetates in water under the air atm. with the solid self-supported NHC-Ir single-site catalyst is reported. Both aliphatic and aromatic glycols are compatible with a much higher catalytic efficiency in the presence of this solid single-site catalyst than other viable mol. catalysts (93% vs <35%) because of the “isolation effect”. Remarkably, this catalyst could be reused for 20 runs without an obvious loss in catalytic activity and selectivity. Control experiments and d. functional theory calculations reveal that the reaction firstly undergoes a dehydrogenation facilitated by the catalyst, and then it proceeds through an unexpected oxidization relay step by oxygen in the air, leading to the α-hydroxy acetate formation. This protocol can potentially contribute to the valorization of readily available and inexpensive diols.

ACS Catalysis published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C10H14N2O, HPLC of Formula: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Ge published the artcileCatalytic depolymerization of Kraft lignin towards liquid fuels over bifunctional molybdenum oxide based supported catalyst, Formula: C9H12O, the publication is Fuel (2021), 121599, database is CAplus.

Catalytic depolymerization of Kraft lignin towards valuable liquid fuels and monomeric phenols has been a significant and extremely attractive target, but it remains a great challenge. Herein, we report a catalytic system consisted of bifunctional molybdenum oxide based supported catalyst for catalytic lignin hydroconversion into alkylated benzenes and phenols. In the meantime, the achieved yield of liquid product was 95% and petroleum ether extracted product was 65% at 300°C for 12 h over 20%MoO_x/ZIF-8@ZIF-67 catalyst. The calorific value was increased from 25.66 MJ/ Kg to 34.31 MJ/Kg. The characterization studies show the incorporation of MoOx species leads to the synergy between redox sites and acid sites. The product anal. and catalytic studies demonstrate its synergism to promote catalytic cleavage of C-O linkages via the coupled hydrodeoxygenation and alkylation reaction. The reasonable catalytic mechanism and redox cycle route of catalyst indicate that the cooperative catalytic system paves the way for high-efficiency waste lignin utilization.

Fuel published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Chao-Wu published the artcileEfficient Microwave-Assisted Pd-Catalyzed Hydroxylation of Aryl Chlorides in the Presence of Carbonate, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Organic Letters (2012), 14(14), 3688-3691, database is CAplus and MEDLINE.

An efficient microwave-assisted, palladium-catalyzed hydroxylation of aryl chlorides in the presence of a weak base carbonate was developed, which rapidly converts aryl and heteroaryl chlorides to phenols, and can be used when the aryl chloride is functionalized with a ketone, aldehyde, ester, nitrile, or amide.

Organic Letters published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C12H14O2, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brown, Herbert C. published the artcileMarkovnikov hydroboration of perfluoroalkylethylenes, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Angewandte Chemie, International Edition (1999), 38(13/14), 2052-2054, database is CAplus and MEDLINE.

Hydroboratation of (perfluoroalkyl)ethenes using dichloroborane and dibromoborane gave products with unprecedented Markovnikov regioselectivity. Thus, hydroboration of 3,3,3-trifluoro-1-propene gave 1,1,1-trifluoro-2-propanol.

Angewandte Chemie, International Edition published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Tianzhang published the artcileIntermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis, Formula: C10H13NO2, the publication is Advanced Synthesis & Catalysis (2019), 361(16), 3886-3892, database is CAplus.

An intermol. multiple dehydrogenative coupling between ketones RC(O)CH₂CH₃ (R = Ph, thiophen-2-yl, (E)-2-phenylethenyl, etc.), cyclohexanone and nucleophilic amines NHR¹R² [R¹ = H; R² = Ph, pyridin-2-yl, morpholin-4-yl, etc.; R¹R² = (C₂)₂O(C₂)₂, (C₂)₅] or boronic acids ArB(OH)₂ (Ar = Ph, furan-2-yl, anthracen-9-yl, etc.) using inexpensive copper(I) oxide as a catalyst was reported. This method provides a facile access to highly desirable chem. products such as α,β-unsaturated ketones (E)-RC(O)CH=CHAr, enaminones (E)-RC(O)CH=CHNR¹R², and synthetically relevant meta-substituted phenols R³C₆H₄OH (R³ = phenylaminyl, morpholin-4-yl, Ph, etc.).

Advanced Synthesis & Catalysis published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C9H12BNO4S, Formula: C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jinping published the artcileBase-assisted activation of phenols in TiO₂ surface complex under visible light irradiation, Category: alcohols-buliding-blocks, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2022), 114005, database is CAplus.

Surface charge-transfer complex formed by TiO₂ and phenols has showed a great potential in visible-light photocatalysis. However, back electron transfer limits the charge transfer efficiency and the activation of phenols in surface complex. Herein, we disclosed the efficient activation of phenols in surface complex by introducing the base. Both homocoupling reactions and butylated hydroxytoluene-trapped experiments clearly demonstrated the generation of phenolic radicals from various lignin-derived substrates. The addition of base caused the blue-shifted absorption of surface complex, while increased the visible light-induced electron excitation from substrate to TiO₂. Vibrational spectra suggested that the interaction between phenolate and TiO₂ was stronger than the interaction between neutral phenol and TiO₂. This base-triggered strategy may be conducive to useful transformations or degradation of phenols via surface complex.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H5FO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gao, Peng published the artcileIBX-Promoted Oxidative Cyclization of N-Hydroxyalkyl Enamines: A Metal-Free Approach toward 2,3-Disubstituted Pyrroles and Pyridines, HPLC of Formula: 96-20-8, the publication is Journal of Organic Chemistry (2020), 85(12), 7939-7951, database is CAplus and MEDLINE.

An iodoxybenzoic acid-mediated selected oxidative cyclization of N-hydroxyalkyl enamines was developed. Through this strategy, a variety of 2,3-disubstituted pyrroles and pyridines were produced in good selectivity involving oxidation of alc., followed by condensation of aldehyde and α-C of enamines. Furthermore, this metal-free method has several advantages, including the use of environmentally friendly reagents, broad substrate scope, mild reaction conditions, and high efficiency.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, HPLC of Formula: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Palmer, Ian Arthur published the artcileNovel salicylic acid analogs induce a potent defense response in Arabidopsis, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is International Journal of Molecular Sciences (2019), 20(13), 3356, database is CAplus and MEDLINE.

The master regulator of salicylic acid (SA)-mediated plant defense, NPR1 (NONEXPRESSER OF PR GENES 1) and its paralogs NPR3 and NPR4, act as SA receptors. After the perception of a pathogen, plant cells produce SA in the chloroplast. In the presence of SA, NPR1 protein is reduced from oligomers to monomers, and translocated into the nucleus. Several of these analogs can induce SA-mediated defense and inhibit growth of Pseudomonas syringae in Arabidopsis. These analogs, when sprayed on Arabidopsis, can induce the accumulation of the master regulator of plant defense NPR1. In a yeast two-hybrid system, these analogs can strengthen the interactions among NPR proteins. We demonstrated that these analogs can induce the expression of the defense marker gene PR1. Furthermore, we hypothesized that these SA analogs could be potent tools against the citrus greening pathogen Candidatus liberibacter spp. In fact, our results suggest that the SA analogs we tested using Arabidopsis may also be effective for inducing a defense response in citrus. Several SA analogs consistently strengthened the interactions between citrus NPR1 and NPR3 proteins in a yeast two-hybrid system. In future assays, we plan to test whether these analogs avoid degradation by SA hydroxylases from plant pathogens. In future assays, we plan to test whether these analogs avoid degradation by SA hydroxylases from plant pathogens.

International Journal of Molecular Sciences published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Application of 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts