Category: alcohols-buliding-blocks

Pan, Mingzhang published the artcileImpact of carbon chain length of alcohols on the physicochemical properties and reactivity of exhaust soot, Synthetic Route of 111-87-5, the main research area is impact carbon chain alc physicochem property reactivity exhaust soot; Different alcohols-diesel fuels; Morphology; Nanostructure; Oxygenated functional groups.

Particle is the main pollutant in diesel engine exhaust, which seriously endangers human health and the atm. environment. The use of alc. fuels in diesel engines can effectively reduce particle emissions, but alc. fuels with different carbon chain lengths will affect the generation process of particles, which in turn changes the physicochem. properties and oxidation characteristics of the particles. Therefore, it is particularly important to study the properties of particle emitted by diesel engines fueling alc. fuels with different carbon chain lengths. The physicochem. properties of soot emitted from com. diesel engines were studied by thermogravimetric analyzer, HRTEM (high-resolution TEM), and XPS (XPS) in this paper, resp. The diesel engine used alc.-diesel blends of different carbon chain lengths with the same oxygen content as fuels, such as methanol/diesel blend (M10), n-butanol/diesel blend (NB25), and n-octanol/diesel blend (NO45), and pure diesel fuel was used as a reference The use of alcs. reduced the fractal dimension (Df) of particles, and the NB25 particles had the smallest Df. Moreover, the particles of blended fuels had smaller primary particle diameter (dp) compared to pure diesel. However, with the use of short-chain to long-chain alcs., an increasing tendency of dp was observed In terms of the nanostructure, as the use of short-chain to long-chain alcs., the La (fringe length) increased, both the d (fringe separation distance) and Tf (fringe tortuosity) reduced, which was not favorable for the oxidation of the particles. In addition, in terms of oxygenated surface functional groups (SFGs), the C=O group occupied a higher proportion in most working conditions relative to the groups of C-O and COO. Further anal. showed that the dp and nanostructure had more influence on the oxidation behavior of soot than Df and oxygenated SFGs.

Science of the Total Environment published new progress about Diesel exhaust gases. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Ye published the artcileEnantioselective Desymmetrization of Bisphenol Derivatives via Ir-Catalyzed Allylic Dearomatization, Recommanded Product: 2,2-Dimethoxyethanamine, the main research area is bisphenol iridium allylic dearomatization catalyst; spirocyclic hexadienone stereoselective preparation.

Spirocyclic hexadienones with multiple stereogenic centers are frequently found in natural products but remain challenging targets to synthesize. Herein, we report the enantioselective desymmetrization of bisphenol derivatives via Ir-catalyzed allylic dearomatization reactions, affording spirocyclic hexadienone derivatives with up to three contiguous stereogenic centers in good yields (up to 90%) and excellent enantioselectivity (up to 99% ee). The high efficiency of this reaction is exemplified by the short reaction time (30 min), low catalyst loading (down to 0.2 mol %), and ability to perform the reaction on a gram-scale. The total syntheses of (+)-tatanan B and (+)-tatanan C were also realized using this Ir-catalyzed allylic dearomatization reaction as a key step.

Journal of the American Chemical Society published new progress about Dearomatization (Allylic). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Recommanded Product: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wagner, Karl G. published the artcileFrom hot stage microscopy to hot melt extrusion – approaches to predict product performance, stability and processability, Formula: C12H24O11, the main research area is drug formulation hot melt extrusion stage microscopy computational model.

There are many drug delivery technologies that may enhance the bioavailability of a poorly water soluble drug. The ranking of the solubilization technologies is a balance between performance (both in vitro and in vivo) and efforts/costs necessary to implement the technol. In order to minimize front loading, i.e. resources expenditure prior to the selection of a front runner technol., an effective and predictive selection process needs to be in place. For hot melt extrusion (HME) this selection process can start with a micro scale performance evaluation on a hot stage microscope (HSM). A batch size of 400 mg can provide sufficient materials to assess drug product attributes like solid state properties, solubility enhancement and phys. stability as well as process related attributes such as processing temperature in a twin screw extruder (TSE). Prototype formulations will then be fed into a 5 mm TSE (apparatus 1-2 g) to confirm performance from the h SM under addnl. shear stress. Small stress stability testing might be performed with these samples or a larger batch (20-40 g) made by the 9 or 12 mm TSE. Simultaneously, numeric process simulations are performed using process data and rheol. and thermal properties of the formulations. Further scale up work to 16 mm and 18 mm TSE confirmed and refined the simulation model. Thus at the end of lab scale development, not only the clin. trial supply is manufactured but also one can form a sound risk assessment to support further scale up even without decades of process experience.

Bulletin Technique Gattefosse published new progress about Dissolution. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khvalbota, Liudmyla published the artcileSimultaneous distillation-solvent extraction gas chromatography-mass spectrometry analysis of Tokaj Muscat Yellow wines, SDS of cas: 505-10-2, the main research area is tokaj muscat yellow wine distillation solvent extraction GC MS.

In the present study, simultaneous distillation-solvent extraction conditions were optimized for the extraction of organic compounds from naturally sweet Tokaj wines. Solvent selection, optimization of phase ratio, time of extraction, and addition of modifier were studied. The volatile organic compounds profile of Slovak Tokaj Muscat Yellow wine was characterized using simultaneous distillation-solvent extraction gas chromatog.-mass spectrometry. Identified volatile organic compounds belonged to terpenes, esters, higher alcs., volatile acids, lactones, and furanoids. At optimized simultaneous distillation-solvent extraction conditions, anal. parameters such as linearity (R2 > 0.98), repeatability (from 3.33% to 10.39%), quantitation, and detection limits for selected compounds (Et hexanoate, geraniol, linalool oxide, α-terpineol, 1-octanol, geranyl acetate, nerol, benzyl alc., benzaldehyde, 1,2-dihydrolinalool, 4-terpineol, and di-Et succinate) were estimated

Separation Science plus published new progress about Botrytis. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, SDS of cas: 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sahoo, Manas Ranjan published the artcileDevelopment and evaluation of polyherbal based medicated candy from Ayurveda herbs reported for cough and cold and evaluation of their anti-viral and anti-bacterial properties, Product Details of C12H24O11, the main research area is Ayurveda polyherbal cough cold antiviral antibacterial property evaluation.

Emergence and spread of new viral and bacterial originated infectious diseases along with mutated new strains posing enormous global challenges. Respiratory infection is one of the major concerns in the current and past situation. With the lack of a safe and effective vaccine and small mols. drugs for effective treatments there is a need of efficacious herbal medicine to tackle infectious diseases. The herbal treatments mentioned in the Ayurveda can be excellent source for an effective treatment. In the present study a hard-boiled candy formulation was from promising herbs recommended herbs from Ayurveda for respiratory health and immunmodulatory actions. The herbs selected were Ocimum sanctum-OS (leafs), Terminalia chebula-TC (fruit), Glycyrrhiza glabra-GG (roots), Curcuma longa-CL (rhizomes), Zingiber officinale-ZO (rhizomes), Piper longum-PL (fruits). The herbs were evaluated for antiviral and antibacterial activity. The results indicated that most of the extracts exhibited antimicrobial activity against pathogens B. subtilis, S.aureus, S.pyogens and S.pneumoniae and showed significant antiviral activity against DENV virus in vitro. The formulated hard-boiled candy was found to be having satisfactory quality parameters of hardness, friability, and dissolving time. The HPTLC profile was developed for the candy formulation as an effective quality control tool. This study indicates that the hard-boiled candy (HBC) could be an ideal solid oral dosage form for herbal drug delivery at local region of oropharyngeal region.

International Journal of Research in Pharmaceutical Sciences (Madurai, India) published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Product Details of C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hayasaka, Kiyoshi published the artcileMetabolic basis and treatment of citrin deficiency, Name: (S)-2-hydroxysuccinic acid, the main research area is review citrin deficiency medium chain triglyceride supplement; adult-onset type II citrullinemia (CTLN2); citrin deficiency; failure to thrive and dyslipidemia by citrin deficiency (FTTDCD); medium-chain triglyceride (MCT); neonatal intrahepatic cholestasis by citrin deficiency (NICCD).

Citrin deficiency is a hereditary disorder caused by SLC25A13 mutations and manifests as neonatal intrahepatic cholestasis (NICCD), failure to thrive and dyslipidemia (FTTDCD), and adult-onset type II citrullinemia (CTLN2). Citrin is a component of the malate-aspartate NAD hydrogen (NADH) shuttle, an essential shuttle for hepatic glycolysis. Hepatic glycolysis and the coupled lipogenesis are impaired in citrin deficiency. Hepatic lipogenesis plays a significant role in fat supply during growth spurt periods: the fetal period, infancy, and puberty. Growth impairment in these periods is characteristic of citrin deficiency. Hepatocytes with citrin deficiency cannot use glucose and fatty acids as energy sources due to defects in the NADH shuttle and downregulation of peroxisome proliferator-activated receptor α (PPARα), resp. An energy deficit in hepatocytes is considered a fundamental pathogenesis of citrin deficiency. Medium-chain triglyceride (MCT) supplementation with a lactose-restricted formula and MCT supplementation under a low-carbohydrate diet are recommended for NICCD and CTLN2, resp. MCT supplementation therapy can provide energy to hepatocytes, promote lipogenesis, correct the cytosolic NAD+/NADH ratio via the malate-citrate shuttle and improve ammonia detoxification, and it is a reasonable therapy for citrin deficiency. It is very important to administer MCT at a dose equivalent to the liver’s energy requirements in divided doses with meals. MCT supplementation therapy is certainly promising for promoting growth spurts during infancy and adolescence and for preventing CTLN2 onset. I.v. administration of solutions containing fructose is contraindicated, and persistent hyperglycemia should be avoided due to glucose intoxication for patients receiving hyperalimentation or with complicating diabetes.

Journal of Inherited Metabolic Disease published new progress about Diabetes mellitus. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Name: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

He, Jun published the artcileA new type of triptycene-based stationary phases with alkylated benzimidazolium cations for gas chromatographic separations, Computed Properties of 111-87-5, the main research area is triptycene benzimidazolium cation gas chromatog stationary phase separation.

Favorable physicochem. properties and unique mol. recognition capability endow triptycene-based materials with good potential as stationary phases for gas chromatog. (GC). This work reports a new type of triptycene-based materials functionalized by three benzimidazolium cations with different peripheral alkyl lengths (denoted as TP-3Bim-5C and TP-3Bim-12C) and their GC separation performance. As a result, they shared high resolving performance for the naphthalene isomers but differed for the benzene derivatives with varying polarity. Moreover, their capillary columns exhibited good repeatability and thermal stability. This work presents a facile strategy for tailoring the selectivity of the TP-based stationary phases and demonstrates their promising future for chromatog. anal.

Chinese Chemical Letters published new progress about Gas chromatographic capillary columns. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

He, Fei published the artcileExploration of key aroma active compounds in strong flavor Baijiu during the distillation by modern instrument detection technology combined with multivariate statistical analysis methods, COA of Formula: C4H10OS, the main research area is hexyl hexanoate phenylacetaldehyde pentanoic acid ethyl linolenate.

Liquid-liquid microextraction (LLME) combined with gas chromatog.-mass spectrometry (GC-MS) and headspace-gas chromatog.-ion mobility spectrometry (HS-GC-IMS) were used to detect the variations in volatile compounds during the distillation process of strong flavor raw Baijiu. The 3D fingerprint spectrum clearly showed a variation in volatile compounds from different distillation stages, and most alc.-soluble and low mol. weight compounds showed a downward trend with the extension of distillation time, but water-soluble, high mol. weight and high boiling compounds showed the opposite result. Then, 50 aroma compounds were sniffed and identified by gas chromatog.-olfactometry-mass spectrometry (GC-O-MS) and multivariate statistical anal. including principal component anal. (PCA) and partial least squares discriminant anal. (PLS-DA) confirmed four aroma active markers related to classification. Finally, the receiver operating characteristic (ROC) curve was further used to verify that Et butanoate and Et hexanoate were the most effective difference marker to distinguish the head Baijiu samples and butanoic acid was the most effective difference marker for distinguishing the heart Baijiu samples from the tail Baijiu samples.

Journal of Food Composition and Analysis published new progress about Acids Role: ANT (Analyte), FFD (Food or Feed Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, COA of Formula: C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Benmansour, Nassima published the artcileEssential oil and hydrosol extract chemical composition, phytochemicals of algerian Rhus pentaphylla Desf. and its antioxidant activity, SDS of cas: 124-76-5, the main research area is Rhus pentaphylla phytochem essential oil hydrosol extract antioxidant activity.

Rhus pentaphylla Desf. (Anacardiaceae) widely grown in Algeria, is an underutilized plant and remains poorly studied. To investigate for the first time, the chem. composition profile of essential oil and hydrosol extract; besides Total Phenolic (TPC), Flavonoid (TFC) and Condensed Tannins Contents (CTC) of fruits, leaves and roots, the fatty acid composition was assessed. The radical scavenging activity of R. pentaphylla extracts was then evaluated. Essential oil and hydrosol extract were isolated resp. by hydrodistillation and liquidliquid-extraction from the aerial parts of R. pentaphylla. The antioxidant activity was evaluated using 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) radical and ferric reducing antioxidant power (FRAP). Chem. compositions of various extracts were investigated using Gas Chromatog. (GC) and GC-Mass Spectrometry (GC-MS). The results of GC and GC-MS anal. revealed 83 components in essential oil and 75 components in hydrosol extract representing resp. 96.9% and 92.5% of the total extract composition The main constituents were hexadecanoic acid (31.5%) followed by spathulenol (14.9%) in the oil while the higher amount present in the hydrosol extract was of spathulenol (14.2%). Otherwise, 13 and 18 fatty acids were identified in roots and fruits resp. The highest levels of TPC and CTC were found in roots extracts while the highest quantity of TFC has been recorded in the leaves extract Besides, hydrosol extract was able to scavenge DPPH and FRAP free radicals more efficiently than essential oil. R. pentaphylla contains bioactive substances that could be used as a new promising source of antioxidant compounds in different applications.

Current Bioactive Compounds published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, SDS of cas: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lopez, Jhon J. published the artcileNew convergent one pot synthesis of amino benzyl ethers bearing a nitrogen-containing bicycle, Recommanded Product: (4-Butoxyphenyl)methanol, the main research area is benzyl alc azabicyclooctanyl alc one pot etherification; benzyloxy azabicyclooctane preparation.

A new convergent one pot method for the synthesis of amino benzyl ethers containing a bicyclic amines, derived from different substituted benzyl alcs. and bicyclic amino alcs. such as tropine, pseudotropine and 3-quinuclidinol using chlorotrimethylsilane and sodium iodide was reported. In order to avoid the competitive reaction with the nitrogen atom, a solution of the sep. prepared alkoxide of tropine, pseudotropine and 3-quinuclidinol was added to the preformed substituted benzyl iodides and allowed to reflux at 90° for 15 h under nitrogen atm. This method provided an efficient alternative of the preparation of amino benzyl ethers in organic synthesis with good yields in comparison with existed methods.

Synthetic Communications published new progress about Benzaldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Recommanded Product: (4-Butoxyphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts