Category: alcohols-buliding-blocks

Lin, Ximeng published the artcileAn alkali-extracted polysaccharide from Zizyphus jujuba cv. Muzao: Structural characterizations and antioxidant activities, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Zizyphus fruit acidic polysaccharide antioxidant; Acidic polysaccharide; Alkaline extraction; Antioxidant activities; Structural characterization; Ziziphus jujuba cv, Muzao.

An acidic polysaccharide (SAZMP3) was isolated from jujube fruit residues by alk. extraction and purified with DEAE-Sepharose Fast Flow and Sephacryl S-300 column chromatog. The structural characterizations of SAZMP3 were determined by high-performance gelpermeation chromatog., gas chromatog., Fourier transform IR spectroscopy, methylation anal., NMR spectroscopy, SEM, and at. force microscopy. The results determined SAZMP3 was an acidic polysaccharide mainly contained rhamnose, galactose, and galacturonic acid with a mol. weight of 9.37 kDa and its backbone might mainly be composed of 1,4-α-D-GalAp with side chains of 1,3-β-D-Galp, 1,3,5-linked Araf, 1,2,4-α-L-Rhap and terminals of 1-linked Araf, 1-linked Rhap, 1-linked Galp by methylation and NMR anal. Besides, SAZMP3 has shown potential antioxidant activity in scavenging free radicals suggesting that it is an antioxidant agent, which might contribute to the functional food qualities of jujube fruit.

International Journal of Biological Macromolecules published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fan, Ruiyi published the artcileStructural elucidation of an acidic polysaccharide from Citrus grandis ‘Tomentosa’ and its anti-proliferative effects on LOVO and SW620 cells, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Citrus colon cancer cell acidic polysaccharide antiproliferative; Anticancer activity; Chemical structure; NMR.

Citrus grandis ‘Tomentosa’ (CGT) which is a region-famous medicinal and edible plant contains plentiful bioactive polysaccharides, however, its chem. structures and specific bioactivities still need to be further explored. In the present study, an acidic polysaccharide (CGTP-AP) was extracted and purified from the pulps of CGT. The structure elucidation and anti-cancer activity of CGTP-AP were investigated. Structure characterization indicated that CGTP-AP was a homogeneous heteropolysaccharide composed of arabinose, galactose and galacturonic acid in a molar ratio of 2.45:1:2.77, with an average mol. weight of 2721.68 kDa. Partial acid hydrolysis, methylation and NMR spectrometry revealed that the backbone of CGTP-AP mainly composed of (1 → 4)-α-D-galacturonan, while the branch principally consisted of (1 → 5)-α-L-Araf. In addition, CGTP-AP exhibited effective anti-proliferation against colon cancer cells LOVO and SW620 cells in dose- and time-dependent manners, with IC50 values of 5.55, 4.35 and 3.52 mg mL-1 after 24, 48 and 72 h, and 5.33, 3.63 and 2.97 mg mL-1 after 24, 48 and 72 h, resp. This study indicated that CGTP-AP might be utilized as a promising food supplement for the patients of colon disorders.

International Journal of Biological Macromolecules published new progress about Cell proliferation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Manzocchi, E. published the artcileFeeding cows with hay, silage, or fresh herbage on pasture or indoors affects sensory properties and chemical composition of milk and cheese, Related Products of alcohols-buliding-blocks, the main research area is milk cheese feeding cow silage herbage indoor sensory property; cheese sensory profile; dairy cow; herbage utilization method; milk sensory profile.

In European countries, silage-free feeding is an ancient tradition and has a particularly pos. reputation among consumers. In the present study, we compared grass-based forages from the same plot conserved as hay or silage or fed fresh either on pasture or indoors, and we evaluated the differences in sensory properties of milk and uncooked pressed cheese. All herbage from the first cut of a grassland dominated by perennial ryegrass was harvested on the same day and preserved either as hay or silage. The first regrowth of the same plot was used for strip grazing or green feeding indoors. Balanced by breed, 24 Montbeliarde and 24 Holstein cows were allocated to the 4 treatments. Apart from the forages, the late-lactation cows received 3 kg/d of dry matter from concentrate After 2 wk of dietary adaptation, the bulk milk of 3 subgroups, each with 4 cows, was collected. Part of the milk was pasteurized, and part was left raw and partly transformed to small-sized Cantal-type cheese ripened for 9 wk. Milk and cheese underwent descriptive sensory anal. by a trained sensory panel, as well as analyses of physicochem. traits. Volatile organic compounds of the cheeses were also analyzed. Raw and pasteurized milk from hay-fed cows had less intense odors of cooked milk, cream, and barnyard than milk from grazing cows, whereby the effect of pasteurization did not differ between herbage utilization methods. Cheeses obtained from cows fed fresh herbage (grazing and indoors) were clearly yellower than cheeses from silage- and hay-fed cows, which coincided with the color intensity perceived by the panelists. Moreover, cheeses from cows fed fresh herbage had more intense barnyard and dry fruit flavors, were perceived as creamier and having less lactic odor, and exhibited more fat exudation than those from cows fed conserved herbage. Only a few differences were observed in milk and cheeses from hay-fed compared with silage-fed cows, and those differences were far less pronounced than those of milk and cheeses from cows fed fresh herbage. In conclusion, the present study did not substantiate assumptions of clear sensory differences of milk and uncooked pressed cheese from hay-fed compared with silage-fed cows. For the first time, this study reports that the global flavor intensity of cheeses from indoor green-fed cows is similar to that of cheeses derived from cows fed conserved forages, whereas cheeses from grazing cows have the greatest global flavor intensity.

Journal of Dairy Science published new progress about Agrostis idahoensis. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Xiao-Tong published the artcileEffects of xingnaojing injection on adenosinergic transmission and orexin signaling in lateral hypothalamus of ethanol-induced coma rats, Synthetic Route of 124-76-5, the main research area is coma xingnaojing injection adenosinergic transmission orexin lateral hypothalamus.

Acute alc. exposure induces unconscious condition such as coma whose main phys. manifestation is the loss of righting reflex (LORR). Xingnaojing Injection (XNJI), which came from Chinese classic formula An Gong Niu Huang Pill, is widely used for consciousness disorders in China, such as coma. Although XNJI efficiently shortened the duration of LORR induced by acute ethanol, it remains unknown how XNJI acts on ethanol-induced coma (EIC). We performed experiments to examine the effects of XNJI on orexin and adenosine (AD) signaling in the lateral hypothalamic area (LHA) in EIC rats. Results showed that XNJI reduced the duration of LORR, which implied that XNJI promotes recovery form coma. Microdialysis data indicated that acute ethanol significantly increased AD release in the LHA but had no effect on orexin A levels. The qPCR results displayed a significant reduction in the Orexin-1 receptors (OX1R) expression with a concomitant increase in the A1 receptor (A1R) and equilibrative nucleoside transporter type 1 (ENT1) expression in EIC rats. In contrast, XNJI reduced the extracellular AD levels but orexin A levels remained unaffected. XNJI also counteracted the downregulation of the OX1R expression and upregulation of A1R and ENT1 expression caused by EIC. Based on these results, we suggest that XNJI promotes arousal by inhibiting adenosine neurotransmission via reducing AD level and the expression of A1R and ENT1.

BioMed Research International published new progress about Blumea balsamifera. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Synthetic Route of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Al-Wahaibi, Lamya H. Naser published the artcileComparative study on the essential oils of Artemisia judaica and A. herba-alba from Saudi Arabia, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Artemisia Aspergillus Syncephalastrum Bacillis Pseudomonas essential oils Saudi Arabia.

The volatile chem. constituents derived from two Asteraceae species (Artemisia judaica and A. herba-alba) were analyzed and compared for the first time using gas chromatog. techniques (GC-MS, GC-FID, Co-GC, LRI determination, database and literature searches) on two different stationary phase columns (polar and nonpolar). This anal. led to the identification of a total of 110 and 81 components from whole plant (stems, leaves and flowers) oils of A. judaica and A. herba-alba resp. The major classes of compounds in both plants included oxygenated monoterpenes, sesquiterpenes and hydrocarbons. The prominent components in the oil of A. judaica were β-eudesmol, hexadecanoic acid, spathulenol, eudesma-4 (15),7-dien-1-β-ol, carvacrol and thymol which account for 67.3% of the total essential oils composition (96.7%). While the main oil constituents from A. herba-alba were piperitone, (E)-ethylcinnamate, (Z)-ethylcinnamate, thymol, isophrone which account for 78.0% of the total oil composition (99.6%). Comparison showed similar composition in thymol and spathulenol while in others major constituents, have opposite values. To the best of our knowledge, both plant species (A. judaica and A. herba-alba) from Saudi Arabia were considered for the first time in this study. In addition, the oils of these plants were screened for their bio-activities and were found to possess significant anti-microbial activities.

Arabian Journal of Chemistry published new progress about Antimicrobial agents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yasukata, Tatsuro published the artcilePractical Synthetic Method for the Preparation of Pyrone Diesters: An Efficient Synthetic Route for the Synthesis of Dolutegravir Sodium, Name: 2,2-Dimethoxyethanamine, the main research area is pyrone diester dolutegravir sodium synthesis.

A highly efficient and practical synthetic method for the preparation of pyrone diesters was established. The pyrone diester 3c (I) can be prepared from readily available starting materials on a multihundred gram scale. The pyrone diester 3c can easily be converted to dolutegravir sodium (II.Na). The synthetic route demonstrated herein provides an efficient and atom-economical synthetic method for preparing this potent anti-HIV agent.

Organic Process Research & Development published new progress about Atom economy. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Name: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Rui published the artcileTreatment of azole-containing industrial wastewater by the Fenton process, Synthetic Route of 110-99-6, the main research area is treatment azole containing industrial wastewater Fenton process.

Some semiconductor fabrication processes generate high-strength wastewater that may contain high concentrations of azoles, amines, hydrogen peroxide, organic, and inorganic co-contaminants, making the treatment of this wastewater challenging. In this study, the Fenton process was utilized for the treatment of 53 mM pyrazole and 34 mM 2-(2-aminoethoxy) ethanol (known as diglycolamine, DGA) in a lab-prepared aqueous mixture containing 3.5 M hydrogen peroxide and 16 mM inorganic fluoride. The effects of operational variables for the Fenton process, such as temperature (10, 18, or 25°C), iron dosing (32.3, 37.3, or 74.5 mM), and pH (2.5, 3.0, or 3.5), on the degradation rates were investigated. The chosen variables were then used to treat wastewater from a semiconductor fabrication facility. The Fenton process was effective in treating both the lab-prepared mixture and semiconductor industrial wastewater. The degradation of pyrazole and DGA yielded a range of byproducts including inorganic ions and organic acids.

Industrial & Engineering Chemistry Research published new progress about Catalytic wastewater decomposition. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Synthetic Route of 110-99-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nguyen, Thuy published the artcileDiarylureas Containing 5-Membered Heterocycles as CB1 Receptor Allosteric Modulators: Design, Synthesis, and Pharmacological Evaluation, COA of Formula: C4H11NO2, the main research area is diarylurea heterocycle synthesis SAR cannabinoid CB1 receptor; CB1 receptor; PSNCBAM-1; allosteric modulators; diarylurea; five-membered heterocycles; structure−activity relationship.

Allosteric modulators have attracted significant interest as an alternate strategy to modulate CB1 receptor signaling for therapeutic benefits that may avoid the adverse effects associated with orthosteric ligands. Here we extended our previous structure-activity relationship studies on the diarylurea-based CB1 neg. allosteric modulators (NAMs) by introducing five-membered heterocycles to replace the 5-pyrrolidinylpyridinyl group in PSNCBAM-1 (1), one of the first generation CB1 allosteric modulators. Many of these compounds had comparable potency to 1 in blocking the CB1 agonist CP55,940 stimulated calcium mobilization and [35S]GTP-γ-S binding. Similar to 1, most compounds showed pos. cooperativity by increasing [3H]CP55,940 binding, consistent with the pos. allosteric modulator (PAM)-antagonist mechanism. Interestingly, these compounds exhibited differences in ability to increase specific binding of [3H]CP55,940 and decrease binding of the antagonist [3H]SR141716. In saturation binding studies, only increases in [3H]CP55,940 Bmax, but not Kd, were observed, suggesting that these compounds stabilize low affinity receptors into a high affinity state. Among the series, the 2-pyrrolyl analog (I) exhibited greater potency than 1 in the [35S]GTP-γ-S binding assay and significantly enhanced the maximum binding level in the [3H]CP5,5940 binding assay, indicating greater CB1 receptor affinity and/or cooperativity.

ACS Chemical Neuroscience published new progress about Central nervous system disease. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, COA of Formula: C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Mengdi published the artcileCyanobacteria blooms potentially enhance volatile organic compound (VOC) emissions from a eutrophic lake: Field and experimental evidence, Category: alcohols-buliding-blocks, the main research area is cyanobacteria bloom volatile organic compound emission eutrophic lake; Cyanobacteria blooms (CBBs); Eutrophic lake; Fluxes; Life stages; Volatile organic compounds (VOCs).

Eutrophication promotes massive cyanobacteria blooms (CBBs), leading to the release of volatile organic compounds (VOCs). To investigate the effects of cyanobacteria on VOC emissions, field campaigns were carried out in eutrophic Chaohu Lake at six sites with different microalgae densities during CBBs in summer 2019, and incubation experiments were performed in the laboratory The results showed that the lake water was the primary source of VOCs at six sampling sites in Chaohu Lake during CBBs, with an average total VOC flux of 81.2 ± 20.6 μg m-2 h-1. Alkanes were the most abundantly emitted VOCs, with a share of 23.1-63.7% of total emitted VOCs, followed by aromatics (16.6-46.3%). The fluxes of total VOCs were significantly greater at sites B and/or C than at site A in July, and at site B′ and/or C′ than at site A′ in August in Chaohu Lake. The fluxes of total VOCs from living and decayed cyanobacteria in the exptl. treatments were two orders of magnitude higher than the corresponding values in the control treatments in the laboratory incubation. Taken together, these results suggested that CBBs potentially enhanced VOC emissions from the eutrophic lake, and that cyanobacteria acted as an important source of VOCs. Addnl., non-methane hydrocarbons (i.e., alkanes, alkenes, and aromatics) predominated among the released VOCs during the stabilization and senescence stages, while oxygenated volatile organic compounds (i.e. alcs., aldehydes, ketones, esters, and furans) prevailed during the apoptosis stage and aromatics and volatile organic sulfur compounds predominated during the decomposition stage, suggesting that VOC emissions varied markedly at different life stages.

Environmental Research published new progress about Aldehydes Role: ANT (Analyte), POL (Pollutant), ANST (Analytical Study), OCCU (Occurrence). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Di Nottia, Michela published the artcileA homozygous MRPL24 mutation causes a complex movement disorder and affects the mitoribosome assembly, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is movement disorder MRPL24 mutation mitoribosome; MRPL24; Mitochondrial disorders; Mitochondrial protein synthesis; Mitoribosomes; Molecular modeling; Movement disorder; Protein interactions; Zebrafish.

Mitochondrial ribosomal protein large 24 (MRPL24) is 1 of the 82 protein components of mitochondrial ribosomes, playing an essential role in the mitochondrial translation process. We report here on a baby girl with cerebellar atrophy, choreoathetosis of limbs and face, intellectual disability and a combined defect of complexes I and IV in muscle biopsy, caused by a homozygous missense mutation identified in MRPL24. The variant predicts a Leu91Pro substitution at an evolutionarily conserved site. Using human mutant cells and the zebrafish model, we demonstrated the pathol. role of the identified variant. In fact, in fibroblasts we observed a significant reduction of MRPL24 protein and of mitochondrial respiratory chain complex I and IV subunits, as well a markedly reduced synthesis of the mtDNA-encoded peptides. In zebrafish we demonstrated that the orthologue gene is expressed in metabolically active tissues, and that gene knockdown induced locomotion impairment, structural defects and low ATP production The motor phenotype was complemented by human WT but not mutant cRNA. Moreover, sucrose d. gradient fractionation showed perturbed assembly of large subunit mitoribosomal proteins, suggesting that the mutation leads to a conformational change in MRPL24, which is expected to cause an aberrant interaction of the protein with other components of the 39S mitoribosomal subunit.

Neurobiology of Disease published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (COXIV). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts