Category: alcohols-buliding-blocks

Deng, Wenwen published the artcileStructural characterization and hypolipidemic activities of purified stigma maydis polysaccharides, Application In Synthesis of 59-23-4, the main research area is stigma maydis polysaccharide hypolipidemic activity; bile acid‐binding; hyperlipidemia; poloxamer 407; stigma maydis polysaccharide.

This study aimed to investigate structural features and antihyperlipidemic effects of the stigma maydis polysaccharide, termed SMP-1. This polysaccharide was composed of D-mannose, L-rhamnose, D-glucose, D-galactose, L-arabinose, D-xylose, and D-galacturonic acid, with a molar ratio of 1.00:0.21:1.41:1.44:0.70:0.44:0.56. The SMP-1 was mainly bonded by (1 → 6) and (1 → 3) linkages, with various monosaccharides being evenly distributed in the main and side chains. Moreover, SMP-1 had neither triple-helical structure nor mol. aggregation. Importantly, the SMP-1 could effectively bind the bile acids in vitro and significantly lower the total cholesterol, triglyceride, low-d. lipoprotein cholesterol levels, and moderately increase the high-d. lipoprotein cholesterol level in poloxamer 407-induced hyperlipidemic mice. Moreover, pretreatment with SMP-1 (≥300 mg/kg) could remarkably reduce fat accumulation and restore hepatocyte morphol. in the liver of hyperlipidemic mice. Altogether, these findings indicated that SMP-1 could be developed as a safe and effective food supplement for preventing and treating hyperlipidemic disorders.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Bile acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fu, Yuan published the artcilePhysicochemical characteristics and biological activities of polysaccharides from the leaves of different loquat (Eriobotrya japonica) cultivars, Synthetic Route of 59-23-4, the main research area is Eriobotrya leaf physicochem polysaccharide; Binding properties; Enzyme inhibition; Eriobotrya japonica; Loquat; Polysaccharides; Weight-average molecular weights.

In order to explore polysaccharides from loquat leaves (LLPs) as functional food ingredients for prevention and treatment of obesity and type 2 diabetes, the physicochem. characteristics, in vitro binding properties, and inhibitory effects on α-amylase and α-glucosidase of polysaccharides from the leaves of different loquat cultivars, including ‘Baiyu’, ‘Chuannong8’, ‘Yuanbao’, and ‘Dawuxing’, were investigated and compared. Results showed that the contents of total uronic acids and degree of esterification in LLPs ranged from (27.04 ± 1.76)% to (41.46 ± 1.91)%, and from (20.54 ± 0.11)% to (26.90 ± 0.10)%, resp. The weight-average mol. weights of LLPs ranged from 4.307 × 106 Da to 5.101 × 106 Da, and the major constituent monosaccharides of LLPs were rhamnose, galacturonic acid, arabinose, and galactose. Furthermore, LLPs exerted strong in vitro fat binding, cholesterol binding, and bile acid binding capacities, as well as remarkable inhibitory effects on α-amylase and α-glucosidase, which might be attributed to their mol. weights, mol. weight distributions, and degree of esterification. Results are helpful for better understanding of chem. structures and bioactivities of polysaccharides from loquat leaves, and LLPs had good potential to be explored as functional food ingredients for prevention and treatment of obesity and type 2 diabetes.

International Journal of Biological Macromolecules published new progress about Bile acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zheng, Beibei published the artcileAssessment of organic acid accumulation and its related genes in peach, HPLC of Formula: 97-67-6, the main research area is Prunus fruits organic acids malate citrate; Citrate; Fruit Quality; GABA; Malate; Peach.

Fruit acidity is an important determinant of peach organoleptic quality, but its regulatory mechanism remains elusive. Measurement of organic acids in ripe fruits of seventy-five peach cultivars revealed the predominant components malate and citrate, accompanied by quinate. Organic acid accumulation increased at early stages of fruit growth, but exhibited a more dramatic reduction in low-acid cultivar during later stages of fruit development compared to high-acid cultivars. Low-acid cultivars showed citrate degradation and less transport of malate into the vacuole due to up- and down-regulation of a GABA pathway gene GAD and a malate transporter gene ALMT9, resp. The NAD-MDH1 gene might control the rate-limiting step in malate synthesis, while three genes, PDK, PK, and ADH, could affect citrate synthesis through the pyruvate-to-acetyl-CoA-to-citrate pathway. Altogether, these results suggested that malate accumulation is controlled at the level of metabolism and vacuolar storage, while metabolism is crucial for citrate accumulation in peach.

Food Chemistry published new progress about Calbindins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, HPLC of Formula: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Xiaoyong published the artcileEfficient recovery of phenol from coal tar processing wastewater with tributylphosphane/diethyl carbonate/cyclohexane: Extraction cycle and mechanism study, Synthetic Route of 111-87-5, the main research area is phenol tributylphosphane diethyl carbonate cyclohexane coal tar processing wastewater.

Sodium sulfate wastewater is a kind of coal tar processing effluent containing highly concentrated phenol. Owing to its high toxicity, phenol pose a serious threat to the natural environment and human health. In this paper, a novel ternary extractant, tributylphosphane (TBP)/diethyl carbonate (DEC)/cyclohexane, was utilized to extract phenol from the wastewater. The combination of 20% TBP, 20% DEC, and 60% cyclohexane yielded a high extraction efficiency of 99.79% under the suggested conditions (time of 6 min, organic-aqueous volume ratio of 1, pH of 5.05 and temperature of 298.15 K). Fourier-transform IR spectroscopy anal. illustrates that the extraction of phenol was enabled by intermol. hydrogen bonding with both TBP and DEC. The stripping of phenol from the phenol-loaded extractant was carried out using an alkali solution, realizing the recovery of phenol resource and the regeneration of extractant. The stripping efficiency reached 96.29% when using 1 mol/L NaOH solution under certain conditions (contact time of 4 min, aqueous-organic volume ratio of 1, and temperature of 313.15 K). Addnl., the pH response anal. shows that the stripping process could be divided into four stages and more than 8 min of contact time leaded to the hydrolysis of the DEC. The ultra-high phenol recovery, up to 99.78%, was achieved from the actual wastewater via a two-stage extraction and back-extraction

Chemical Engineering Research and Design published new progress about Coal tar Role: PEP (Physical, Engineering or Chemical Process), PROC (Process). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mamadalieva, N. Z. published the artcileChemical Composition and Biological Activity of Constituents of Otostegia bucharica, Name: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Otostegia essential oil camphene hexanal ethylbenzene verbenene limonene.

The genus Otostegia (Lamiaceae) comprises 15 species distributed mainly in Central Asia and eastern Africa. Volatile compounds, flavonoids, diterpenes, steroids, tanning agents, and triterpenoids were isolated from plants of this genus . Therefore, the phenol and flavonoid contents, the chem. composition of essential oil of O. bucharica, and the antioxidant and enzyme-inhibiting potential of the plant constituents were studied by us. The qual. and quant. chem. compositions of essential oil of O. bucharica wereanalyzed by GC-MS. A total of 62 compounds were identified and made up 95.7%of the mass (Table 1). Terpinen-4-ol (29.7%), pulegone (18.8%), verbenol (6.9%), α-terpineol (6.1%), and geranyl acetone(5.1%) were the major chem. constituents of the studied essential oil.

Chemistry of Natural Compounds published new progress about Diterpenes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Name: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iglesias, Dario E. published the artcile(+)-Catechin inhibits heart mitochondrial complex I and nitric oxide synthase: functional consequences on membrane potential and hydrogen peroxide production, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is catechin antioxidant NOS hydrogen peroxide mitochondrial membrane potential complex.

In order to study the in vitro effect of flavan-3-ol (+)-catechin on the enzymic activities of mitochondrial complex I and nitric oxide synthase (mtNOS), as well as the consequences on the membrane potential and H2O2 production rate, isolated mitochondria from rat heart were exposed to 3 nM to 100 muM (+)-catechin. NADH-Q1 reductase (complex I) and mtNOS activities were inhibited 25% and 50%, resp., by the addition of 10 nM (+)-catechin to the reaction medium. Moreover, in the nM range, (+)-catechin decreased state 4 mitochondrial membrane potential by about 10 mV, but failed to change the membrane potential measured in the presence of ADP. (+)-Catechin (10 nM) inhibited not only complex I activity, but also the H2O2 production rate (35%) sustained by malate-glutamate, in accordance with the decrease observed in mitochondrial membrane potential. Altogether, the results indicate that (+)-catechin, at nM concentrations, inhibits mitochondrial complex I activity, leading to membrane potential decline and consequently to reduction in H2O2 and NO production rates. The decrease in mtNOS activity could also be a consequence of the direct action of (+)-catechin on the NOS structure, this effect being in accordance with the functional interaction between complex I and mtNOS, as previously reported.

Food & Function published new progress about Flavonoids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zheng, Zhiwei published the artcileKinetic and Thermodynamic Requirements To Extend Solvent Compatibility in Thermal-Assisted Extraction of Inert Platinum Group Metals, Synthetic Route of 111-87-5, the main research area is platinum group metal solvent extraction.

The extraction behavior of inert Pt group metals (PGMs) like Ru(III) and Rh(III) was studied in a HNO3(aqueous)/1-octanol system with a pyridinediamide. As a result, low efficiency of Ru(III) extraction arose from its slow kinetics at 298 K, while the situation was not improved very much even at 356 K. Addition of a hydrophobic anion like Tf2N- increased Ru(III) extraction up to 95% within 3 h at 356 K, where a synergistic effect would be present. Extraction of a more inert PGM like Rh(III) was also enhanced up to 90% within 2 h at 356 K in the presence of Tf2N-. The authors have successfully demonstrated the rapid and efficient extraction of inert PGMs from HNO3(aqueous) to 1-octanol, which is one of the ordinary organic solvents.

ACS Sustainable Chemistry & Engineering published new progress about Platinum-group metals Role: PUR (Purification or Recovery), PREP (Preparation). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Mandy Man-Hsi published the artcileEvaluation of indigenous non-Saccharomyces yeasts isolated from a South Australian vineyard for their potential as wine starter cultures, Formula: C4H10OS, the main research area is non saccharomyces yeast vineyard wine starter culture; Aroma; Fermentation; Flavour; Lipase; Non-Saccharomyces; Protease; Un-inoculated; Wine; β-Glucosidase.

The use of non-Saccharomyces yeast in conjunction with Saccharomyces cerevisiae in wine fermentation is a growing trend in the wine industry. Non-Saccharomyces, through their distinctive production of secondary metabolites, have the potential to pos. contribute to wine sensory profile. To discover new candidate strains for development as starter cultures, indigenous non-Saccharomyces were isolated from un-inoculated fermenting Shiraz musts from a South Australian vineyard (McLaren Vale wine region) and characterized. Among the 77 isolates, 7 species belonging to 5 genera (Kazachstania, Aureobasidium, Meyerozyma, Wickerhamomyces and Torulaspora) were identified by sequencing the internal transcribed spacer regions of the 5.8S rRNA gene (ITS1-5.8S-ITS2 region). The indigenous isolates were evaluated for oenol. properties, namely, ethanol tolerance, enzyme activity, and H2S production To determine their potential industrial use as starter cultures, representative isolates of each species were assessed in a sterile chem. defined grape juice and Viognier grape juice to evaluate their contribution to fermentation kinetics and production of key metabolites, including volatile compounds

International Journal of Food Microbiology published new progress about 5.8S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Formula: C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Izumi, Soutarou published the artcileControl of glucose metabolism is important in tenogenic differentiation of progenitors derived from human injured tendons, Application of (S)-2-hydroxysuccinic acid, the main research area is glucose metabolism progenitor cell differentiation chondrogenesis tendon injury.

Glucose metabolism is altered in injured and healing tendons. However, the mechanism by which the glucose metabolism is involved in the pathogenesis of tendon healing process remains unclear. Injured tendons do not completely heal, and often induce fibrous scar and chondroid lesion. Because previous studies have shown that tendon progenitors play roles in tendon repair, we asked whether connective tissue progenitors appearing in injured tendons alter glucose metabolism during tendon healing process. We isolated connective tissue progenitors from the human injured tendons, obtained at the time of primary surgical repair of rupture or laceration. We first characterized the change in glucose metabolism by metabolomics anal. using [1,2-13C]-glucose using the cells isolated from the lacerated flexor tendon. The flux of glucose to the glycolysis pathway was increased in the connective tissue progenitors when they proceeded toward tenogenic and chondrogenic differentiation. The influx of glucose to the tricarboxylic acid (TCA) cycle and biosynthesis of amino acids from the intermediates of the TCA cycle were strongly stimulated toward chondrogenic differentiation. When we treated the cultures with 2-deoxy-D-glucose (2DG), an inhibitor of glycolysis, 2DG inhibited chondrogenesis as characterized by accumulation of mucopolysaccharides and expression of AGGRECAN. Interestingly, 2DG strongly stimulated expression of tenogenic transcription factor genes, SCLERAXIS and MOHAWK under both chondrogenic and tenogenic differentiation conditions. The findings suggest that control of glucose metabolism is beneficial for tenogenic differentiation of connective tissue progenitors.

PLoS One published new progress about Aggrecans Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Application of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kujundzic, Toni published the artcileEffects of Defoliation Treatments of Babica Grape Variety(Vitis vinifera L.) on Volatile Compounds Content in Wine, Quality Control of 584-02-1, the main research area is Vitis wine volatile compound defoliation; defoliation; gas chromatography; volatile compounds; wine.

The aim of this study was to determine the effects of defoliation performed in the Babica red grape variety on the volatile compounds in produced wine. Three treatments were performed during 2017 and 2018: the removal of six leaves before flowering (FL) and at the end of veraison (VER), as well as control (C). Volatile compounds were analyzed using a gas chromatograph coupled to a mass spectrophotometric detector. Statistically evaluated by anal. of variance (ANOVA at the p = 0.05 level) and principal component anal. (PCA). Defoliation treatments were affected by the concentration of several compounds, but only in one year. The VER2017 treatment significantly increased the concentration of three aliphatic esters up to 8 C atoms and octanoic acid Et ester. The FL2017 treatment increased the concentration of three aliphatic alcs. The FL2018 treatment has significantly enhanced the concentration Et cinnamate but decreased the concentrations of eugenol and dihydro-2-methyl-3(2H)-thiophenone. Both defoliation treatments reduced the concentration of γ-decanolactone in 2017. Aldehydes, monoterpenoles, and monoterpenes remained unaffected by the defoliation treatments. Vintage was found to be the largest source of variability for most volatile compounds under investigation, which was confirmed by PCA. The effect of defoliation in the mild-Mediterranean climate was found to mostly depend on seasonal weather conditions.

Molecules published new progress about Aldehydes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Quality Control of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts