Category: alcohols-buliding-blocks

Kaur, Nirmaljeet published the artcileSynthesis and Application of (S)-Nicotine-Based Chiral Ionic Liquids in Enantiomeric Recognition by Using Fluorescence Spectroscopy, Related Products of alcohols-buliding-blocks, the main research area is nicotine enantiomeric recognition fluorescence spectroscopy synthesis.

The present report discusses the synthesis, characterization and application of novel chiral ionic liquids (CILs) derived from an enantiopure alkaloid (S)-nicotine. The synthesis of the CILs was initiated by the preparation of (-)-bornyl chloroacetate from (-)-borneol and monochloroacetic acid and then used for the quaternization of (S)-nicotine. The derivatives of the parent CIL were obtained via anion-metathesis reactions with sodium salts of dicyanamide and dioctyl sulfosuccinate. The synthesis of the resp. compounds was confirmed through NMR (1H,13C) spectroscopy, mass spectrometry, and FTIR. The thermal stability and optical activity of the CILs were analyzed through TGA, DTG and polarimetry. All the CILs obtained were liquid at room temperature and exhibited thermal stability up to 150 °C. The potential of chiral ionic liquids as enantiomeric recognizing agents for six amino acids (phenylalanine, proline, valine, alanine, leucine, histidine) was determined through fluorescence spectroscopy. CILs performed well against enantiomers of all amino-acid with maximum selectivity 1.22 (phenylalanine) and fluorescence enhancement 24.90 : 23.79 (ID/Io : IL/Io) for enantiomers of leucine.

ChemistrySelect published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Shan-Shui published the artcileAerobic oxidation of alcohols with air catalyzed by decacarbonyldimanganese, Application of 1-(4-Bromophenyl)ethane-1,2-diol, the main research area is manganese catalyzed aerobic oxidation functionalized alc.

The oxidation of alcs. to carbonyl compounds using air as the terminal oxidant is highly desirable. As described in previous reports, the abstraction of α-H of the alc. is the most important step, and it typically requires not only a metal catalyst but also complex ligands, co-catalysts and bases. Herein, we report a practical and efficient method for the oxidation of primary alcs., secondary alcs., 1,2-diols, 1,2-amino alcs., and other α-functionalized alcs. using a com. available catalyst, Mn2(CO)10, and no additives. Preliminary mechanistic studies indicated that an alkoxyl radical intermediate existed in our system, and a plausible mechanism consistent with the exptl. results and literature was proposed.

Green Chemistry published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 92093-23-7 belongs to class alcohols-buliding-blocks, name is 1-(4-Bromophenyl)ethane-1,2-diol, and the molecular formula is C8H9BrO2, Application of 1-(4-Bromophenyl)ethane-1,2-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Srinivasachary, K. published the artcilePractical and Efficient Route to Dolutegravir Sodium via One-Pot Synthesis of Key Intermediate with Controlled Formation of Impurities, COA of Formula: C4H11NO2, the main research area is dolutegravir sodium preparation green chem.

An efficient, cost effective and com. viable synthesis of dolutegravir sodium has been developed from com. available I as the key intermediate. The key features of the synthesis are lower number of synthetic steps and the use of eco-friendly and inexpensive reagents. The process has been demonstrated to meet ICH requirements on scaling up.

Russian Journal of Organic Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, COA of Formula: C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Shengdong published the artcileSilver-Catalyzed Hydrogenation of Ketones under Mild Conditions, Computed Properties of 124-76-5, the main research area is silver catalyst hydrogenation ketone aliphatic aromatic; alc preparation.

The silver-catalyzed hydrogenation of ketones using H2 as hydrogen source is reported. Silver nanoparticles are generated from simple silver (I) salts and operate at 25 °C under 20 bar of hydrogen pressure. Various aliphatic and aromatic ketones, including natural products were reduced into the corresponding alcs. in high yields. This silver catalyst allows for the selective hydrogenation of ketones in the presence of other functional groups.

Advanced Synthesis & Catalysis published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Yiwei published the artcilePrognostic effects of glycometabolism changes in lung adenocarcinoma: a prospective observational study, Quality Control of 97-67-6, the main research area is human lung adenocarcinoma glycometabolism prognostic effect; Lung adenocarcinoma; Warburg effect; clinicopathological characteristics; glycometabolism changes; prognosis.

Changes in glycometabolism of cancer cells provides cancer cells with growth advantages, which are also of great value in the prognosis prediction of the patients with lung adenocarcinoma. However, currently available studies are controversial. We successively collected 100 paired surgical specimens from patients with lung adenocarcinoma. The content of glycometabolic intermediates in tissues was tested by liquid chromatog.-mass spectrometry. Follow-up was conducted every 6 mo for patients enrolled in this study. There were significant differences in the contents of six intermediates, including glucose (P<0.0001), pyruvate (P = 0.0009), lactate (P<0.0001), citrate (P = 0.0001), α-ketoglutarate (P = 0.0002), and fumarate (P = 0.0096). For different TNM stages, the pyruvate content (P<0.001) and lactate content (P<0.001) in the II/III/IV stage cancer tissues were significantly higher than those in the stage I cancer tissues. The overall survival (OS) of patients with high levels of glucose (P = 0.0034), pyruvate (P<0.0001), lactate (P = 0.049), and citrate (P = 0.024) in cancer tissues was significantly worse than that of patients with low levels. N stage (P<0.001) and the contents of pyruvate (P = 0.033) were independent prognostic factors for the OS. The contents of glucose, pyruvate, lactate, and citrate in cancer tissues are higher than that in para-carcinoma tissues, and the long-term survival decrease in patients with higher glucose, pyruvate, lactate, and citrate. Translational Lung Cancer Research published new progress about Carbohydrate metabolism disorders Role: BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Quality Control of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Panda, Surajit published the artcileEfficient α-Alkylation of Arylacetonitriles with Secondary Alcohols Catalyzed by a Phosphine-Free Air-Stable Iridium(III) Complex, Category: alcohols-buliding-blocks, the main research area is iridium complex catalyzed alkylation arylacetonitrile secondary alc.

A well-defined and readily available air-stable dimeric iridium(III) complex catalyzed α-alkylation of arylacetonitriles using secondary alcs. with the liberation of water as the only byproduct is reported. The α-alkylations were efficiently performed at 120°C under solvent-free conditions with very low (0.1-0.01 mol %) catalyst loading. Various secondary alcs. including cyclic and acyclic alcs. and a wide variety of arylacetonitriles bearing different functional groups were converted into the corresponding α-alkylated products in good yields. Mechanistic study revealed that the reaction proceeds via alc. activation by metal-ligand cooperation with the formation of reactive iridium-hydride species.

Journal of Organic Chemistry published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bettoni, Leo published the artcileIron-Catalyzed α-Alkylation of Ketones with Secondary Alcohols: Access to β-Disubstituted Carbonyl Compounds, Recommanded Product: 3-Pentanol, the main research area is iron catalyzed alkylation ketone secondary alc borrowing hydrogen.

An iron-catalyzed borrowing hydrogen strategy has been applied in the synthesis of β-branched carbonyl compounds Various secondary benzylic and aliphatic alcs. have been used as alkylating reagents under mild reaction conditions. The ketones have been isolated in good to excellent yield. Deuterium labeling experiments provide evidence that the alc. is the hydride source in this reaction and that no reversible step or hydrogen/deuterium scrambling takes place during the process.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghosh, Rahul published the artcileTransfer Hydrogenation of Aldehydes and Ketones in Air with Methanol and Ethanol by an Air-Stable Ruthenium-Triazole Complex, Name: 3-Pentanol, the main research area is alc preparation chemoselective green chem; aldehyde ketone methanol ethanol transfer hydrogenation ruthenium triazole catalyst; ruthenium triazole catalyst preparation.

Coordination of 1,4-disubstituted 1,2,3-triazoles with [(p-cymene)RuCl2]2 followed by dehydrochlorination in the presence of a base resulted in the formation of ruthenium complexes, resp. Both were tested for the transfer hydrogenation of aldehydes and ketones in air using ecol. benign and cheap ethanol as the hydrogen source in the presence of a catalytic amount of a base. Air-stable ruthenium complex was proved to be an active catalyst for the transfer hydrogenation of a wide variety of aromatic and aliphatic aldehydes and ketones bearing various functionalities. Catalyst ruthenium complex was also effective for the transfer hydrogenation of carbonyls using the simplest primary alc., methanol, under aerobic conditions. Under the present catalytic protocol, labile or reducible functionalities such as nitro, cyano, and ester groups were tolerated. Good selectivity was also observed for acyclic α,β-unsaturated carbonyls. However, this catalytic protocol was not selective for 2-cyclohexen-1-one as both alkene and keto moieties were reduced. The transfer hydrogenations are believed to proceed via a ruthenium-hydride intermediate. Finally, transfer hydrogenation of acetophenone using isopropanol as a commonly used hydrogen source was also performed and the sustainable and green credentials of these catalytic protocols utilizing methanol, ethanol, and isopropanol were compared with the help of the CHEM21 green metrics toolkit.

ACS Sustainable Chemistry & Engineering published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Name: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Wenjun published the artcileBasic Promotors Impact Thermodynamics and Catalyst Speciation in Homogeneous Carbonyl Hydrogenation, Recommanded Product: n-Octanol, the main research area is promotor thermodn homogeneous catalyst carbonyl hydrogenation.

Homogeneously catalyzed reactions often make use of additives and promotors that affect reactivity patterns and improve catalytic performance. While the role of reaction promotors is often discussed in view of their chem. reactivity, we demonstrate that they can be involved in catalysis indirectly. In particular, we demonstrate that promotors can adjust the thermodn. of key transformations in homogeneous hydrogenation catalysis and enable reactions that would be unfavorable otherwise. We identified this phenomenon in a set of well-established and new Mn pincer catalysts that suffer from persistent product inhibition in ester hydrogenation. Although alkoxide base additives do not directly participate in inhibitory transformations, they can affect the equilibrium constants of these processes. Exptl., we confirm that by varying the base promotor concentration one can control catalyst speciation and inflict substantial changes to the standard free energies of the key steps in the catalytic cycle. Despite the fact that the latter are universally assumed to be constant, we demonstrate that reaction thermodn. and catalyst state are subject to external control. These results suggest that reaction promotors can be viewed as an integral component of the reaction medium, on its own capable of improving the catalytic performance and reshaping the seemingly rigid thermodn. landscape of the catalytic transformation.

Journal of the American Chemical Society published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Onisuru, Oluwatayo Racheal published the artcileTransfer hydrogenation of ketone; an in situ approach toward an eco-friendly reduction, SDS of cas: 584-02-1, the main research area is silica supported palladium particle preparation; ketone transfer hydrogenation green chem.

The use of water as a solvent in chem. reactions has recently been brought to public attention, especially in the exploration of eco-friendly procedures. It is readily available, abundantly accessible, non-toxic, non-flammable, and at a low cost. As opposed to the previous limitation of reactant solubilities associated with aqueous media, a hydrogel such as a hydroxypropyl methylcellulose (HPMC) solution can significantly improve the reactant solubility This investigation employed water and HPMC as the reaction solvent, and the reaction medium viscosity was impressively enhanced. Silica-supported Pd particles (Pd@SiO2) were synthesized and effectively catalyzed the reduction of acetophenone in the presence of sodium borohydride (NaBH4) as the hydrogen source. The conversion of acetophenone to 1-Ph ethanol remained at a very high value of >99.34% with 100% selectivity towards 1-Ph ethanol.

RSC Advances published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, SDS of cas: 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts