Category: alcohols-buliding-blocks

Ye, Xiang-Yu published the artcileDesign of oxa-spirocyclic PHOX ligands for the asymmetric synthesis of lorcaserin via iridium-catalyzed asymmetric hydrogenation, Synthetic Route of 22483-09-6, the main research area is oxa spirocyclic phosphine oxazoline PHOX ligand iridium cyclooctadiene preparation; asym hydrogenation catalyst oxa spirocyclic phosphine oxazoline cyclooctadieneiridium preparation; lorcaserin preparation; crystal mol structure bromomethyltetrahydrobenzoazepinone.

Phosphine-oxazoline (PHOX) ligands are a very important class of privileged ligands in asym. catalysis. A series of highly rigid oxa-spiro phosphine-oxazoline (O-SIPHOX) ligands based on O-SPINOL was synthesized efficiently, and their iridium complexes were synthesized by coordination of the O-SIPHOX ligands to [Ir(cod)Cl]2 in the presence of sodium tetrakis-3,5-bis(trifluoromethyl)phenylborate (NaBArF). The cationic iridium complexes showed high reactivity and excellent enantioselectivity in the asym. hydrogenation of 1-methylene-tetrahydro-benzo[d]azepin-2-ones (up to 99% yield and up to 99% ee). A key intermediate of the anti-obesity drug lorcaserin could be efficiently synthesized using this protocol.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Synthetic Route of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hubert-Pfalzgraf, Liliane G. published the artcileCerium(IV) alkoxides with functional alcohols: synthesis and molecular structure of Ce2(O-iso-Pr)6(μ-OC2H4NMeC2H4NMe2)2, Computed Properties of 2212-32-0, the main research area is crystal structure cerium aminoethylaminoethanolato propoxo polynuclear; cerium aminoethylaminoethanolato propoxo polynuclear; ethanolato aminoethylamino cerium propoxo complex.

Reaction between [Ce(OCHMe2)4]m and the functional aminoalc. HOCH2CH2NMeCH2CH2NMe2 (HL) in different stoichiometries gave high yields of Ce2(OCHMe2)6L2 (1) and Ce3O4(OCHMe2)2L2 (2). 1 Which was characterized by x-ray diffraction is a centrosym. dimer in which all isopropoxo groups are terminal (Ce-O 2.130 Å average, < Ce-O-C 161.3°), while the functional alc. acts as a bridging chelating tridentate ligand, leading to heptacoordination of the metal. Polyhedron published new progress about Crystal structure. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, Computed Properties of 2212-32-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Uzzan, Bernard published the artcileEfficacy of four insect repellents against mosquito bites: a double-blind randomized placebo-controlled field study in Senegal, Synthetic Route of 42822-86-6, the main research area is icaridine DEET paramenthanediol insecticide repellent topical skin mosquito bite.

Insect-borne diseases represent a worldwide threat. In addition to fight against vectors (insecticides) and disease prevention (vaccination against yellow fever, chemoprophylaxis against malaria), insect repellents applied on the skin could help reduce the heavy burden related to these diseases. In a field study performed in Senegal, we compared the efficacy of one skin application between 3 and 4 p.m. of four spray repellents [icaridine 20%, para-menthane-diol (PMD) 20% and 50% and DEET 50%] against placebo, among 100 healthy male and female volunteers experienced with mosquito capture. Double-blind randomized cross-over placebo-controlled study (Latin-square design) during five consecutive nights (7 p.m. to midnight) in two villages was conducted. To avoid residual effect, right or left leg was alternately exposed during consecutive nights and the exposed leg was washed before next night. The statistical model was random and mixed effects ANOVA. All four active repellents provided a significant and similar protection compared with placebo, lasting 8 h. However, there was a non-significant trend for a higher protection by DEET 50% than by PMD 20% (P = 0.07). Duration of protection was similar for all repellents. Their effects were similar among men and women, and against Anopheles or other species. No serious adverse drug reaction was noticed. Using a rigorous methodol. and a large number of volunteers, our well-controlled study demonstrated an important and similar protective effect of all four repellents compared with placebo. Such field studies should be required before approval of any newly developed repellent.

Fundamental & Clinical Pharmacology published new progress about Culicidae (bites). 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Synthetic Route of 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shi, Yajuan published the artcileNorm index for predicting the rate constants of organic contaminants oxygenated with sulfate radical, Name: 3-Pentanol, the main research area is surface water sulfate radical organic contaminant oxygenation rate modeling; Norm index; Organic contaminants; QSPR; Second-order rate constants; Sulfate radical.

The degradation of organic contaminants in aquatic systems has raised immense attention worldwide, and the second-order rate constant (kSO.-4) of water pollutants oxidized by sulfate radical anion is an important index for assessing the degradation efficiency of organics Herein, a new norm math. formula is defined. Based on this, four new descriptors are proposed and a QSPR model is developed for predicting kSO.-4 using 30 families of emerging organic pollutants in water. The statistical results fully prove that this model has good fitting effect and stability with R2 of 0.8862, Q2LOO of 0.8466, and Q25-fold of 0.8329, resp. The validation results including cross validation, applicability domain anal., and model comparison show that this model has good robustness, predictive performance, and reliability. These decent results indicate that the new norm math. formula is effective in calculating descriptors and the norm indexes have a great application for evaluating the transformation fate of organic pollutants by sulfate radical in aquatic systems.

Environmental Science and Pollution Research published new progress about Electronegativity. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Name: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Scettri, Anna published the artcileQuantification of polyols in sugar-free foodstuffs by qNMR, Computed Properties of 64519-82-0, the main research area is polyol quantification sugar free foodstuff NMR; Polyols; Sugar alcohols; Sugar-free foodstuff; qNMR.

We present a qNMR method for the determination of low calories sweeteners (erythritol, mannitol, maltitol, sorbitol, isomalt and xylitol) in sugar-free foodstuff. The structural similarities of these compounds determine often a severe spectral overlap that hampers their quantification via conventional 1D and 2D NMR spectra. This problem is here overcome by exploiting the resolving capabilities of the CSSF-TOCSY experiment, allowing the quantification of all six polyols, with satisfactory results in terms of LoQ (2.8-7.4 mg/L for xylitol, mannitol, sorbitol, 15 mg/L for erythritol, 38 mg/L for maltitol and 91 mg/L for isomalt), precision (RSD% 0.40-4.03), trueness (bias% 0.15-4.81), and recovery (98-104%). Polyols quantification in different sugar-free confectionary products was performed after a simple water extraction without any addnl. sample treatment. While these results demonstrate the robustness of the proposed method for polyols quantification in low calories foods, its applicability can be further extended to other food matrixes or biofluids.

Food Chemistry published new progress about Food (sugar free). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Computed Properties of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Seong, Yeong-Je published the artcilePhysiological and Metabolomic Analysis of Issatchenkia orientalis MTY1 With Multiple Tolerance for Cellulosic Bioethanol Production, Related Products of alcohols-buliding-blocks, the main research area is Issatchenkia orientalis Cellulosic Bioethanol fermentation; Issatchenkia orientalis; bioethanol; fermentation; metabolomics; multiple tolerance.

Yeast with multiple tolerance onto harsh conditions has a number of advantages for bioethanol production In this study, an alc. yeast of Issatchenkia orientalis MTY1 is isolated in a Korean winery and its multiple tolerance against high temperature and acidic conditions is characterized in microaerobic batch cultures and by metabolomic anal. In a series of batch cultures using 100 g L-1 glucose, I. orientalis MTY1 possesses wider growth ranges at pH 2-8 and 30-45°C than a conventional yeast of Saccharomyces cerevisiae D452-2. Moreover, I. orientalis MTY1 showes higher cell growth and ethanol productivity in the presence of acetic acid or furfural than S. cerevisiae D452-2. I. orientalis MTY1 produces 41.4 g L-1 ethanol with 1.5 g L-1 h-1 productivity at 42°C and pH 4.2 in the presence of 4 g L-1 acetic acid, whereas a thermo-tolerant yeast of Kluyvermyces marxianus ATCC36907 does not grow. By metabolomics by GC-TOF MS and statistical anal. of 125 metabolite peaks, it is revealed that the thermo-tolerance of I. orientalis MTY1 might be ascribed to higher contents of unsaturated fatty acids, purines and pyrimidines than S. cerevisiae D452-2. Conclusively, I. orientalis MTY1 could be a potent workhorse with multiple tolerance against harsh conditions considered in cellulosic bioethanol production

Biotechnology Journal published new progress about Growth, microbial. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Di Martino, Catello published the artcileEffect of exogenous proline on the ethanolic tolerance and malolactic performance of Oenococcus oeni, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is Oenococcus proline ethanolic tolerance malolactic performance; Ethanol tolerance; Lactic acid bacteria; Malolactic fermentation; l-proline.

Abstract: The use of malolactic starter cultures, often offer no guarantee of microbiol. success due to the chem. and phys. factors (pH, ethanol, SO2, nutrient availability) that occur during the winemaking process. This study was born with the aim of improving the performance of the lactic acid bacteria used as a starter culture in the de-acidification of wines. Two com. strains of Oenococcus oeni, were used. Was evaluated the effect of exogenous L-proline added during the bacterial growth, on the improvement of their survival in the presence of different ethanol concentrations and their ability to degrade L-malic acid in synthetic wine with the presence of 12% (volume/volume) and 13% (volume/volume) of ethanol. The results showed that L-proline improve ethanol tolerance and so the malolactic performances of O. oeni. This work represents an important strategy to ensure good vitality and improve the performance of the malolactic starter.

Journal of Food Science and Technology (New Delhi, India) published new progress about Growth, microbial. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bober, Josef R. published the artcileGalactose to tagatose isomerization at moderate temperatures with high conversion and productivity, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Lactobacillus sakei arabinose isomerase galactose tagatose.

There are many industrially-relevant enzymes that while active, are severely limited by thermodn., kinetic, or stability issues (isomerases, lyases, transglycosidases). In this work, we study Lactobacillus sakei L-arabinose isomerase (LsLAI) for D-galactose to D-tagatose isomerization-that is limited by all three reaction parameters. The enzyme demonstrates low catalytic efficiency, low thermostability at temperatures > 40°C, and equilibrium conversion < 50%. After exploring several strategies to overcome these limitations, we show that encapsulating LsLAI in gram-pos. Lactobacillus plantarum that is chem. permeabilized enables reactions at high rates, high conversions, and elevated temperatures In a batch process, this system enables ∼ 50% conversion in 4 h starting with 300 mM galactose (an average productivity of 37 mM h-1), and 85% conversion in 48 h. We suggest that such an approach may be invaluable for other enzymic processes that are similarly kinetically-, thermodynamically-, and/or stability-limited. Nature Communications published new progress about Growth, microbial. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ge, Xinyan published the artcileProduction, structure, and bioactivity of polysaccharide isolated from Tremella fuciformis XY, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is polysaccharide Tremella fuciformis; Antioxidant activity; Fermentation optimization; Structure characterization; Tremella fuciformis polysaccharide.

Tremella fuciformis polysaccharide (TFP) is an important bioactive substance in Tremella, that contributes to its use as medicine and food. In this study, a novel fungus Tremella fuciformis XY was isolated and introduced to produce macromol. polysaccharides (TFPB). The fermentation conditions were optimized and results demonstrates that the initial pH, optimal temperature and liquid volume were 6.0, 26°C and 80 mL in a 500 mL flask, resp. The maximum yield of TFPB was 9.05 ± 0.05 g/L, which is 59.05% higher than the basic yield (5.69 ± 0.02 g/L). The TFPB, purified by DEAE column, had a mol. weight (Mw) of 1.14 × 103 kDa and consisted mainly of mannose, glucuronic acid, glucose, galactose, xylose, and rhamnose at a molar ratio of 3.5:1.2:2:1.6:1.4:3. The structure of TFPB was preliminarily investigated by methylation anal., IR spectroscopy, and NMR anal. The main linkage types were identified as 1,4-xylp, 1,4-manp, 1-xylp, 1-manp, 1,4-glcp, and 1,3,4-galp. Moreover, the antioxidant assays showed that TFPB could scavenge reactive oxygen species and hydroxyl radicals.

International Journal of Biological Macromolecules published new progress about Growth, microbial. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kong, Jiahui published the artcilePreparation of the key dolutegravir intermediate via MgBr2-promoted cyclization, Synthetic Route of 22483-09-6, the main research area is dolutegravir intermediate preparation; MgBr2-promoted cyclization; chemoselectivity; dolutegravir.

A novel approach for synthesizing the key dolutegravir intermediate is described via MgBr2-promoted intramol. cyclization. Condensation of com. available Me oxalyl chloride and Et 3-(N,N-dimethylamino)acrylate afforded the vinylogous amide in an excellent yield. Subsequent substitution by aminoacetaldehyde di-Me acetal and Me bromoacetate gave rise to the expected precursor for cyclization, which was promoted by MgBr2 to highly selectively convert into pyridinone diester. The key dolutegravir intermediate was finally prepared by the selective hydrolysis of the corresponding diester via LiOH.

Molecules published new progress about Heterocyclization. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Synthetic Route of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts