Category: alcohols-buliding-blocks

Khebri, Souad published the artcilePhytochemical Profile, Antimicrobial and Antioxidant Activities of Cistus clusii Essential oil From Algeria, Quality Control of 124-76-5, the main research area is Pseudomonas Staphylococcus essential oil phytochem antimicrobial antioxidant property Algeria.

Cistus clusii essential oil has been extracted using hydrodistillation method and characterized by GC/MS. The antioxidant activity was evaluated by two different methods DPPH free radical scavenging, and β-carotene bleaching test. The antimicrobial activity was carried out using disk diffusion method against reference strains; Pseudomonas aeruginosa (ATCC 27865), Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), clin. bacterial (Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus) and fungal (Candida albicans) isolates. The chem. profile of the oil showed 31 compounds This profile was dominated by the presence of monoterpene hydrocarbons (78.4%), oxygenated derivatives (18.8%) and sesquiterpene hydrocarbons as minor constituents of this essential oil (1.9%). The major constituents were Camphene (20.6%), γ-Terpinene (16.5%), Sabinene (12.8%), and Terpineol-4 (13.5%). Other compounds were found in moderately good amounts like α-Terpinene (8.9%), α-Thujene (5.9%), α-Pinene (4.2%), and α- Terpinolene (3.1%). The results of the antimicrobial activity showed that the highest activity was observed against C. albicans and it was higher than pos. control Fluconazole. Conclusion: This study indicates that Cistus clusii essential oil showed potent antioxidant and moderate antimicrobial activities which could be used to explain the use of this species in traditional medicine.

Current Bioactive Compounds published new progress about Candida albicans. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Quality Control of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Garcia, Margarita published the artcileSequential Non-Saccharomyces and Saccharomyces cerevisiae fermentations to reduce the alcoholcontent in wine, Related Products of alcohols-buliding-blocks, the main research area is Saccharomyces Wickerhamomyces Meyerozyma Metschnikowia fermentation alc reduction wine.

Over the last decades, the average alc. content of wine has increased due to climate change and consumer preferences for particular wine styles that resulted in increased grape sugar levels at harvest. Therefore, alc. reduction is a current challenge in the winemaking industry. Among several strategies under study, the use of non-conventional yeasts in combination with Saccharomyces cerevisiae plays an important role for lowering ethanol production in wines nowadays. In the present work, 33 native non-Saccharomyces strains were assayed in sequential culture with a S. cerevisiae wine strain to determine their potential for reducing the alc. content in Malvar white wines. Four of the non-Saccharomyces strains (Wickerhamomyces anomalus 21A-5C, Meyerozyma guilliermondii CLI 1217, and two Metschnikowia pulcherrima (CLI 68 and CLI 460)) studied in sequential combination with S. cerevisiae CLI 889 were best able to produce dry wines with decreased alc. proportion in comparison with one that was inoculated only with S. cerevisiae. These sequential fermentations produced wines with between 0.8% (volume/volume) and 1.3% (volume/volume) lower ethanol concentrations in Malvar wines, showing significant differences compared with the control. In addition, these combinations provided favorable oenol. characteristics to wines such as high glycerol proportion, volatile higher alcs., and esters with fruity and sweet character.

Fermentation published new progress about Candida stellata. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Racolta, E. published the artcileComparatives technologies for dietetic candies production, Synthetic Route of 64519-82-0, the main research area is dietetic candy extrusion color adhesion isomalt.

The production of dietetic candies using isomalt as sugar substitute and some natural ingredients was carried out on a classical technol. line with small batch of 25 kg. The caramel mass obtained by replacing sugar with isomalt, was characterized from rheol., sensorial, phys. – chem. point of view. The improvement of nutritional value was made by adding natural ingredients on the classical technol. line of sugar and glucose syrup candies production by stamping the candy mass. Based on the comparative study of the mentioned parameters, it can be state that the free sugar, but with natural ingredients candies are difficult to produced using the classical technol. due to the differences between the rheol. and phys. – chem. properties of those candies compared with sugar candies. In our study, we produced the caramel mass on the same under vacuum boiling system, but the candy formation was made by casting or extrusion.

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Agriculture published new progress about Candy (dietetic). 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Synthetic Route of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tonga, Murat published the artcileA facile strategy for the development of n-type carbon nanotube composites with tunable thermoelectric properties via thiol-ene chemistry, HPLC of Formula: 7575-23-7, the main research area is thiolene n type carbon nanotube composite thermoelec property.

This work exploits thiol-ene chem. for the development of carbon nanotubes (CNTs) -based, solution-processed, and flexible thermoelec. (TE) composites. A systematic study was implemented by optimizing many aspects: (i) use of π-conjugated vs non-conjugated linkers, (ii) amount and type of CNTs (SWNT vs MWNT) in the composite, and (iii) doping. The resulting samples revealed that the materials exhibited n-type semiconducting behavior without requiring a doping process and attained power factors (PF) up to 1.1 μW m-1 K-2. It was also found that the composites made with non-conjugated linkers showed better TE performance than that of π-conjugated linkers. Besides n-type materials, this methodol. is also capable of producing p-type materials, and n-type materials can also convert to p-type upon doping exposure. A variety of distinct surface morphologies with segregated structures were observed on SEM (SEM). The methodol. which has been benefited here relies on the factors beyond just the blend composition or type of CNTs used, including the specific structure of the linkers, doping process, and the morphol. resulting from the crosslinking composites.

Polymer published new progress about Carbon nanotubes. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, HPLC of Formula: 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tang, Longhao published the artcileEffects of modified carbon nanotubes with different sizes on properties of epoxy shape memory polymers, SDS of cas: 7575-23-7, the main research area is carbon nanotube epoxy shape memory polymer property.

Shape memory polymers (SMPs) have occupied an important role in material application, in which the contribution of various fillers on the enhancement of their low mech. and thermal properties is indispensable. Lots of excellent researches on carbon nanotubes improving comprehensive performance have been accomplished, while few comparative studies about carbon nanotubes with different sizes. In the present study, epoxy shape memory composites of multi-walled carbon nanotubes/epoxy matrix (MWCNTs/epoxy) were prepared, in which MWCNTs with different sizes modified through epoxidation act as enhancement filler. The results indicated that MWCNTs with smaller size possess an efficient effect on improving mech. properties, and MWCNTs with larger size achieve higher enhancement on increasing heat resistance as the filler content is low (0.1%, 0.2%). Furthermore, the effect of MWCNTs on shape recovery ratio and shape recovery speed of composites has also been systematically investigated.

Polymer Composites published new progress about Carbon nanotubes. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, SDS of cas: 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Deed, Rebecca C. published the artcileThe role of yeast ARO8, ARO9 and ARO10 genes in the biosynthesis of 3-(methylthio)-1-propanol from L-methionine during fermentation in synthetic grape medium, Product Details of C4H10OS, the main research area is Saccharomyces fermentation synthetic grape medium methionol L methionine.

3-(Methylthio)-1-propanol (methionol), produced by yeast as an end-product of L-methionine (L-Met) catabolism, imparts off-odours reminiscent of cauliflower and potato to wine. Saccharomyces cerevisiae ARO genes, including transaminases Aro8p and Aro9p, and decarboxylase Aro10p, catalyze two key steps forming methionol via the Ehrlich pathway. We compared methionol concentrations in wines fermented by single Δaro8, Δaro9 and Δaro10 deletants in lab strain BY4743 vs. wine strain Zymaflore F15, and F15 double- and triple-aro deletants vs. single-aro deletants, using headspace-solid phase microextraction coupled with gas chromatog.-mass spectrometry. Deletion of two or more aro genes increased growth lag phase, with the greatest delay exhibited by F15 Δaro8 Δaro9. The single Δaro8 deletion decreased methionol by 44% in BY4743 and 92% in F15, while the Δaro9 deletion increased methionol by 46% in F15 but not BY4743. Single deletion of Δaro10 had no effect on methionol. Unexpectedly, F15 Δaro8 Δaro9 and F15 Δaro8 Δaro9 Δaro10 produced more methionol than F15 Δaro8. In the absence of Aro8p and Aro9p, other transaminases may compensate or an alternative pathway may convert methanethiol to methionol. Our results confirm that Ehrlich pathway genes differ greatly between lab and wine yeast strains, impacting downstream products such as methionol.

FEMS Yeast Research published new progress about Cell enlargement. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Product Details of C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Chihae published the artcileDo Similar Structures Have Similar No Observed Adverse Effect Level (NOAEL) Values? Exploring Chemoinformatics Approaches for Estimating NOAEL Bounds and Uncertainties, Related Products of alcohols-buliding-blocks, the main research area is adverse NOAEL chemoinformatic uncertainty.

Determination of the no observed adverse effect level (NOAEL) of a substance is an important step in safety and regulatory assessments. Application of conventional in silico strategies, for example, quant. structure-activity relationship (QSAR) models, to predict NOAEL values is inherently problematic. Whereas QSAR models for well-defined toxicity endpoints such as Ames mutagenicity or skin sensitization can be developed from mechanistic knowledge of mol. initiating events and adverse outcome pathways, QSAR is not appropriate for predicting a NOAEL value, a concentration at which “”no effect”” is observed This paper presents a chemoinformatics approach and explores how it can be further refined through the incorporation of toxicity endpoint-specific information to estimate confidence bounds for the NOAEL of a target substance, given exptl. determined NOAEL values for one or more suitable analogs. With a sufficiently large NOAEL database, we analyze how a difference in NOAEL values for pairs of structures depends on their pairwise similarity, where similarity takes both structural features and physicochem. properties into account. The width of the estimate NOAEL confidence interval is proportional to the uncertainty. Using the new threshold of toxicol. concern (TTC) database enriched with antimicrobials, examples are presented to illustrate how uncertainty decreases with increasing analog quality and also how NOAEL bounds estimation can be significantly improved by filtering the full database to include only substances that are in structure categories relevant to the target and analog.

Chemical Research in Toxicology published new progress about Chemoinformatics. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Ting published the artcileCharacterization of polysaccharide structure in Citrus reticulate ′Chach′ peel during storage and their bioactivity, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Citrus polysaccharide arabinogalacturonan pectin storage; Glycosidic linkage; Immunomodulatory activity; Molecular weight; NMR; Pectin.

The peel of Citrus reticulate ′Chachiennsis′ (Chachi) is widely accepted as a functional food. It is generally recognized that its health benefits are dependent on storage time. However, the chems. responsible for this phenomonon remain unclear. As bioactive polysaccharides are dominant in Chachi, Chachi polysaccharides with various storage times (5-20 years) were prepared The monosaccharide composition was analyzed by GC-MS. NMR data revealed that Chachi polysaccharides were mainly consisted of arabinogalacturonan and another pectin with side chain of →4)-β-D-Galp-(1 → . α-L-Araf-(1→, →5)-α-L-Araf-(1→, →4)-α-D-GalpA-(1→, →4)-α-D-GalpAMe-(1→, →4)-β-D-Galp-(1→ and →4)-β-D-Glcp-(1→ were detected. The mol. weight of Chachi polysaccharides decreased along with the extension of storage time. However, the basic structure characteristics remained stable. The immumomodulatory activities of Chachi polysaccharides were improved as the storage time extended. The change of mol. weight was responsible for the improved immunomodulatory activity. The results explained how polysaccharides contributed to the enhanced health benefits of Chachi during storage.

Carbohydrate Research published new progress about Chinese medicine. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Feng, Li published the artcileA novel strategy based on targeted cellular metabolomics for quantitatively evaluating anti-aging effect and screening effective extracts of Erzhi Wan, Category: alcohols-buliding-blocks, the main research area is Erzhi wan antiaging targeted cellular metabolomics quant efficacy evaluation; Analytic hierarchy process; Quantitative effect evaluation; Receiver operating characteristic curve; Targeted cellular metabolomics; Traditional Chinese medicine.

The complexity of ingredients in traditional Chinese medicine (TCM) makes it challenging to clarify its efficacy in an acceptable and scientific approach. The present study was aimed to use quantification results from targeted cellular metabolomics to evaluate anti-aging efficacy of a famous Chinese medicine formula, Erzhi Wan (EZW), and screen possible effective extracts, depending on the developed strategy integrating multivariate receiver operating characteristic (ROC) curve and analytic hierarchy process (AHP). In this study, senescent NRK cells induced by D-galactose were treated with drug-containing serum of EZW and four kinds of extracts (petroleum ether, Et acetate, butanol and water). Intermediates of two major metabolic pathways for energy synthesis, tricarboxylic acid (TCA) cycle and glycolysis, were accurately quantified by GC-MS/MS to identify discriminate metabolites for clarifying therapeutic mechanism of EZW based on multivariate statistical anal. Senescent and non-senescent cells were successfully distinguished using these metabolites by ROC curve anal. Next, these metabolites were used as evaluation indexes to quant. reflect different effect of EZW and its extracts, according to the role of them in distinguishing groups and in conjunction with AHP. In vitro detection of senescence-associated β-galactosidase (SA-β-gal) activity was used to verify the reliability of evaluation results. The reversal after treatment of drug-containing serum of EZW and extracts was observed, and the petroleum ether extract might be the potential active extract responsible for the major anti-aging effect of EZW, which was in agreement with in vitro experiments Altogether, metabolomics was a powerful approach for evaluation efficacy and elucidation action mechanisms of TCM. The integrated evaluation strategy in this paper with properties of high practicality, feasibility and effectivity was expected to provide a new insight into comprehensive and quant. efficacy evaluation.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about Chinese medicine. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Wen-Juan published the artcileAntagonistic storage potential of Tagetes minuta, Eupatorium fortunei and Ocimum basilicum oils with volatile secondary metabolites against Tribolium castaneum and Lasioderma serricorne, Computed Properties of 124-76-5, the main research area is Tagetes Eupatorium Ocimum Tribolium Lasioderma volatile secondary metabolite.

Antagonistic storage potential of Tagetes minuta Linnaeus, Eupatorium fortunei Turcz. and Ocimum basilicum L. volatile oils hydrodistillated with main secondary metabolites against two storage pests, Tribolium castaneum and Lasioderma serricorne adults were evaluated. More than 95% volatile secondary metabolites obtained at different hydrodistillation time were identified by gas chromatog.-mass spectrometry (GC-MS), and analyzed with principal component anal. (PCA) and orthogonal partial least squares discriminant anal. (OPLS-DA). Further insecticidal assay exhibited interesting results that T. minuta oil showed the strongest fumigant toxicity against both T. castaneum (LC50 = 6.68 mg/L air) and L. serricorne (LC50 = 3.13 mg/L air) among the three essential oils. As one of the main volatile secondary metabolites, methylthymol was found to possess more powerful fumigant (LC50 = 2.42 mg/L air) and contact toxicity (LD50 = 5.43 μg/adult) against T. castaneum. While, precocene I exhibited the strongest insecticidal toxicity on L. serricorne with the LC50 value of 0.88 mg/L air and LD50 of 3.46 μg/adult, resp. During the repellent assay, T. minuta oil showed the same repellent rate against both T. castaneum and L. serricorne at the highest concentration of 78.63 nL/cm2. The results proved that the essential oils as well as the main volatile secondary metabolites have potential to be developed into novel natural botanical resources on antagonistic storage with traditional Chinese medicine (TCM).

Industrial Crops and Products published new progress about Chinese medicine. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts