Category: alcohols-buliding-blocks

Sagandira, Cloudius R. published the artcileContinuous-Flow Synthesis of (-)-Oseltamivir Phosphate (Tamiflu), SDS of cas: 584-02-1, the main research area is mesylation oseltamivir phosphate Tamiflu synthesis shikimate azide.

Herein the anti-influenza drug (-)-oseltamivir phosphate is prepared in continuous flow from Et shikimate with 54% overall yield over nine steps and total residence time of 3.5 min from the individual steps. Although the procedure involved intermediate isolation, the dangerous azide chem. and intermediates involved were elegantly handled in situ. It is the first continuous-flow process for (-)-oseltamivir phosphate involving azide chem. and (-)-shikimic acid as precursor.

Synlett published new progress about Sulfonylation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, SDS of cas: 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Parpinello, Giuseppina Paola published the artcileComparison of Sangiovese wines obtained from stabilized organic and biodynamic vineyard management systems, Synthetic Route of 505-10-2, the main research area is Sangiovese wine organic biodynamic vineyard management; Bioactive compounds; Biodynamic; Organic; Sensory evaluation; Volatiles compounds; Wine sustainability.

Sangiovese red wines produced from organic (ORG) and biodynamic (BDN) vineyards over two consecutive vintages (2011 and 2012) were compared for chem. and sensory parameters to investigate a sustainable approach to grape production The effects of management practice, vintage, and their interaction were investigated. The ORG wines showed higher total acidity and lower volatile acidity and pH. Although trained panelists highlighted some differences in astringency and odor complexity between ORG and BDN wines, consumers had no preference. The concentrations of anthocyanins, phenolic and cinnamic acids, and flavonols, as well as color components, did not differ-contrary to results from the conversion period from ORG to BDN (2009 and 2010) in the same vineyard (Parpinello, Rombola,́ Simoni, & Versari, 2015). Together, these two studies demonstrate that ORG and BDN wine characteristics tend to be similar after the first year of conversion, indicating that the BDN method can produce high-quality Sangiovese wine.

Food Chemistry published new progress about Wine analysis. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Synthetic Route of 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lan, Yi-Bin published the artcileCharacterization and differentiation of key odor-active compounds of ‘Beibinghong’ icewine and dry wine by gas chromatography-olfactometry and aroma reconstitution, Application In Synthesis of 505-10-2, the main research area is icewine aroma gas chromatog olfactometry; Aroma reconstitution; GC-O; Icewine; PLSR; Quantitative descriptive analysis; ‘Beibinghong’.

Freezing-thawing events contribute to the unique aroma profile of icewines. Differences in key odor-active volatile compounds between ‘Beibinghong’ (Vitis amurensis × V. vinifera) icewines and dry wines were investigated by gas chromatog.-olfactometry and gas chromatog.-mass spectrometry. Acceptable agreement between the olfactometric and quant. results was obtained. ‘Beibinghong’ icewine was characterized by high concentrations of volatile phenols, lactones, (E)-β-damascenone, and phenylacetaldehyde, which were associated with on-vine freezing-thawing events in grape. Low concentrations of higher alc. acetates and Et esters of fatty acids were attributed to hyperosmotic stress during fermentation The overall aroma of icewine could be mimicked by reconstitution containing 44 identified volatiles. Partial least squares regression anal. demonstrated that the concentrations of these volatile compounds determined the distinct sensory profiles of icewines, which have higher intensities of honey/sweet, smoky, caramel, dried fruit, apricot/peach, and floral aromas, and lower intensities of fresh fruity and herbaceous notes in comparison with dry wines.

Food Chemistry published new progress about Wine analysis. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Application In Synthesis of 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kong, Qiuhong published the artcileIn vitro fermentation characteristics of polysaccharide from Sargassum fusiforme and its modulation effects on gut microbiota, Synthetic Route of 59-23-4, the main research area is polysaccharide Sargassum fusiforme fermentation gut microbiota; Fermentation; Gut microbiota; Sargassum fusiforme polysaccharide (SFP); Short chain fatty acids (SCFAs); Structural characteristics.

In this study, polysaccharides from Sargassum fusiforme (SFP) were obtained by cellulase assisted hot water extraction The chem. composition, structural characteristics, and in vitro fermentation properties of SFP were investigated. Results showed that the contents of total carbohydrate, protein, uronic acid and sulfate in SFP were 83.25%, 1.42%, 12.80% and 7.81%, resp. It mainly consisted of fucose glucose and galactose, with mol. weight of 255.83 kDa. UV spectrum, FTIR, SEM and AFM results showed that SFP was a typical sulfate polysaccharide with relative smooth surface and regular shape. After in vitro fermentation for 24 h, the pH value of fermentation medium declined significantly (p < 0.05), utilization of carbohydrate was 53.17%. The contents of total SCFAs increased by 10.77 times. Moreover, SFP fermentation could change obviously the microbiota composition It significantly increased the abundance of Faecalibacterium (increased by 49.07% compared with the Blank24 group), Phascolarctobacterium (increased by 88.06%), Bifidobacterium (increased by 139.13%), Ruminococcaceae_UCG-014 (increased by 177.78%), and Lactobacillus (increased by 400.00%), decreased the abundance of Prevotella_9 (decreased by 34.54%) and Blautia (decreased by 40.79%) at genus level. These results showed that SFP could be utilized by microbiota in human feces, and may have the potential to improve intestinal health. Food and Chemical Toxicology published new progress about Agathobacter. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ranarivelo, Lalasoa R. published the artcileChemical Composition and Antimicrobial Activity of Leaf Essential Oil of Tetradenia nervosa Codd from Madagascar, Collected at Different Stages of Vegetative Growth and Age, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Tetradenia nervosa leaf essential oil chem composition antimicrobial activity.

The chem. composition and antimicrobial activities of the essential oil isolated from the leaves of Tetradenia nervosa, a medicinal shrub from Madagascar have been investigated. The essential oil from the fresh leaves was obtained using hydrodistillation in a Clevenger-type apparatus, and characterized by gas chromatog./mass spectrometry (GC/MS) and gas chromatog./flame ionization detection (GC/FID). Eighty-one components that are 93.68-98.61% of the total composition were quantified and identified. The essential oil composition was dominated by sesquiterpenes (68.69-79.87%) represented by β-Caryophyllene, Bicycloelemene, Bicyclogermacrene, (-)-Spathulenol, and Caryophyllene oxide. Monoterpenes (15.51-24.99%) were characterized by α-Pinene, β-Pinene, 1,8-Cineole, and (+)-Fenchone. β-Caryophyllene remains the major component according to vegetative growth and plant age. The essential oils of T. nervosa tested were active against 16 Gram-pos. and 2 Gram-neg. bacteria strains. The vegetative growth and the plant age did not have any influence on the antimicrobial activity.

ACS Symposium Series published new progress about Aging, plant. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Davidov, Tzila published the artcilePorcine arterial ECM hydrogel: Designing an in vitro angiogenesis model for long-term high-throughput research, Synthetic Route of 97-67-6, the main research area is angiogenesis porcine arterial ECM hydrogel; ECM hydrogel; angiogenesis; arterial ECM; in vitro model.

The field of angiogenesis research provides deep understanding regarding this important process, which plays fundamental roles in tissue development and different abnormalities. In vitro models offer the advantages of low-cost high-throughput research of angiogenesis while sparing animal lives, and enabling the use of human cells. Nevertheless, prevailing in vitro models lack stability and are limited to a few days’ assays. This study, therefore, examines the hypothesis that closely mimicking the vascular microenvironment can more reliably support longer angiogenesis processes in vitro. To this end, porcine arterial extracellular matrix (paECM)- a key component of blood vessels-was isolated and processed into a thermally induced hydrogel and characterized in terms of composition, structure, and mech. properties, thus confirming the preservation of important characteristics of arterial extracellular matrix. This unique hydrogel was further tailored into a three-dimensional model of angiogenesis using endothelial cells and supporting cells, in a configuration that allows high-throughput quant. anal. of cell viability and proliferation, cell migration, and apoptosis, thus revealing the advantages of paECM over frequently used biomaterials. Markedly, when applied with well-known effectors of angiogenesis, the model measures reflected the expected response, hence validating its efficacy and establishing its potential as a promising tool for the research of angiogenesis.

FASEB Journal published new progress about Angiogenesis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Ning published the artcileDesign and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs, Product Details of C4H11NO2, the main research area is semisynthesis oleanolic acid derivative VEGF inhibitor VEGFR2 angiogenesis; Angiogenesis; Oleanolic acid; Structural modification; VEGF inhibitor; VEGFR2.

Angiogenesis inhibitors targeting the VEGF signaling pathway are developed into drugs for the treatment of vaious diseases, such as cancer, rheumatoid arthritis, and age-related macular degeneration. Recent studies have revealed that oleanolic acid (OA), a natural pentacyclic triterpenoid, inhibited the VEGF/VEGFR2 signaling pathway and angiogenesis in HUVECs, which may represent an attractive VEGF inhibitor. In this paper, rational structural modification towards OA was performed in order to improve its inhibitory effects aganist VEGF and anti-angiogenesis potential. As a result, a series of novel OA derivatives, possessing α,β-unsaturated ketone system in ring A and amide functional group at C-28, were prepared and evaluated for cytotoxicity and their ability to inhibit VEGF-induced abnormal proliferation of HUVECs. The results showed that two promising derivatives, OA-1 and OA-16, exhibited no in vitro cytotoxicity against HUVECs but showed more potent inhibitory activity against VEGF-induced proliferation and angiogenesis in HUVECs, compared with OA. The results of Western blot indicated that OA-1 and OA-16 inhibited VEGF-induced VEGFR2 activation. Furthermore, small interfering RNA experiments were performed to confirm that both compounds inhibited VEGF-induced angiogenesis via VEGFR2. Thus, the present study resulted in the discovery of new promising OA-inspired VEGF inhibitors, which can serve as potential lead compounds for the treatment of angiogenesis-related diseases.

Chinese Journal of Natural Medicines (Amsterdam, Netherlands) published new progress about Angiogenesis. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Product Details of C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schiffmann, L. M. published the artcileMitochondrial respiration controls neoangiogenesis during wound healing and tumour growth, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is mitochondrial respiration neoangiogenesis wound healing lung carcinoma melanoma.

Abstract: The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here we assess the impact of mitochondrial bioenergetics on neovascularisation, by deleting cox10 gene encoding an assembly factor of cytochrome c oxidase (COX) specifically in mouse ECs, providing a model for vasculature-restricted respiratory deficiency. We show that EC-specific cox10 ablation results in deficient vascular development causing embryonic lethality. In adult mice induction of EC-specific cox10 gene deletion produces no overt phenotype. However, the angiogenic capacity of COX-deficient ECs is severely compromised under energetically demanding conditions, as revealed by significantly delayed wound-healing and impaired tumor growth. We provide genetic evidence for a requirement of mitochondrial respiration in vascular endothelial cells for neoangiogenesis during development, tissue repair and cancer.

Nature Communications published new progress about Angiogenesis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Yaping published the artcileCharacterization of a polysaccharide with antioxidant and anti-cervical cancer potentials from the corn silk cultivated in Jilin province, Quality Control of 59-23-4, the main research area is corn silk polysaccharide anticervical cancer antioxidant activity; Anti-cervical cancer; Antioxidant; Characterization; Corn silk; Polysaccharides.

Corn silk polysaccharides (CSPs) were extracted from the corn silk cultivated in Jilin province, China, where is one of the golden corn belts worldwide. Three fractions (CSP-1, CSP-2 and CSP-3) were obtained by DEAE-52 cellulose and the former two fractions were further purified by Sephadex G-150 column chromatog. to obtain CSP-S-1 and CSP-S-2. The mol. weights of CSP-S-1 and CSP-S-2 were calculated to be 586 kDa and 813 kDa, resp. CSP-S-1 was composed of galactose, arabinose, xylose and rhamnose at a molar ratio of 4.16:1.00:1.01:6.32 and CSP-S-2 was composed of galactose, arabinose, glucose and rhamnose at a molar ratio of 8.71:3.58:0.169:1.00. CSP-S-2 outperformed CSP-S-1 in scavenging DPPH, ABTS and hydroxyl radicals, and significantly inhibited the proliferation of HeLa cells. IR and NMR anal. indicated that CSP-S-2 was pyranose. CSP-S-2 consisted of 1 → 4 and 1 → 6 linkages and exhibited a triple helix configuration. In summary, CSP-S-2 possesses high potential to be developed as a novel antioxidant and anti-cervical cancer agent.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Quality Control of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Chen published the artcileOptimation for preparation of oligosaccharides from flaxseed gum and evaluation of antioxidant and antitumor activities in vitro, Application In Synthesis of 59-23-4, the main research area is flaxseed gum oligosaccharide antioxidant antitumor activity; Antioxidant activity; Antitumor activity; Flaxseed polysaccharides; Oligosaccharides preparation.

Flaxseed oligosaccharides (FGOS) were prepared by degradation of flaxseed gum (FG) using enzymic method. Factors affecting the enzymic hydrolysis of FG were investigated by single factor and orthogonal tests. In the optimum hydrolysis conditions (reaction time 12 h, temperature 50°C, pH 4.5, cellulase concentration 100 U/mL), the reducing sugar ratio and extraction yield of FGOS were 33.6 ± 0.35% and 56.8 ± 0.41%, resp. The average mol. weight of FGOS was about 1.6 kDa, which consists of mannose, galactose, glucose, arabinose, glucuronic acid, xylose, rhamnose, ribose, galacturonic acid. Fourier-transform IR spectra and NMR indicated that FG was successfully degraded to FGOS. FGOS exhibited better antioxidant activities than FG on scavenging hydroxyl, ABTS and DPPH radicals. In vitro cytotoxicities experiments reveal FGOS acquire the ability of antiproliferation against HepG2 and Hela cells in a dose-dependent manner.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts