Category: alcohols-buliding-blocks

Sahin Yaglioglu, Ayse published the artcileThe antiproliferative and antioxidant activities of the essential oils ofJuniperus species from Turkey, Product Details of C10H18O, the main research area is Juniperus antiproliferative antioxidant essential oil carcinoma population.

The present study aimed to determine the essential oil compositions of four different types of Juniperus species including Juniperus oxycedrus ssp oxycedrus L., Juniperus foetidissima Willd., Juniperus excelsa M. Bieb, and Juniperus communis L. with their antioxidant and antiproliferative activities. The antiproliferative activity of the essential oils was determined against HeLa (human cervix carcinoma) and C6 (rat brain tumor cell) cell lines by BrdU cell proliferation assay. The essential oils were tested for their total reducing power activity, DPPH (2,2′-diphenyl-1-picrylhydrazyl) free radical scavenging activities, and hydrogen peroxide scavenging activities. The overall results of the study showed that the needles of Juniperus species have strong antiproliferative activities as cell selective against C6 cells.

Flavour and Fragrance Journal published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hassine, Dorsaf Ben published the artcileEucalyptus brevifolia F. Muell and Eucalyptus stricklandii Maiden leaves extracts: HPLC-DAD, GC-MS analysis and in vitro biological activities, combined with the principal component analysis, Application In Synthesis of 124-76-5, the main research area is Eucalyptus brevifolia stricklandii leaf extract HPLC MS biol activitiy.

Natural products always have been relevant for the advancement of new pharmacol. products intended to prevent oxidative stress and many diseases since ancient times. Herein, the chem. composition was investigated via chromatog. anal. of varying polarity solvents (petroleum ether, Et acetate, methanol and distilled water) from Tunisian Eucalyptus brevifolia F.M and Eucalyptus stricklandii M. leaves. In vitro provision of biol. activities through their antioxidant power (ABTS.+), ability to inhibit 15-lipoxygenase (15-LOX), acetylcholinesterase (AChE), xanthine oxidase (XOD), as well as, cytotoxic potency were undertaken. Chem. profiling showed that the methanolic extracts of both species were the richest in total phenolic compounds GC-MS anal. of the two Eucalyptus species revealed that spathulenol, globulol, epiglobulol, and trans-Z-alpha-bisabolene-epoxide were the main volatile compounds detected in the different extracts In addition, the derivatization procedure allowed the identification of ethylene glycol, and D-fructofuranose as very abundant mols. The HPLC-DAD has enabled the identification of eight new mols. among them icariin (1.1 mg/g dr), and 5-hydroxy-3prime-methoxyflavone (7.5 mg/g dr) in the E. stricklandii MeOH and EtOAc extracts Aqueous E. brevifolia extract possessed the highest anti-AChE with an IC50 (10 mug/mL). Whereas, the MeOH E. stricklandii extract possessed the highest anti 15-LOX with an IC50 (9.7 mug/mL), as well as, the most important percentage of XOD inhibition 51.1%. All extracts revealed an antiproliferative potency against human cancer cell lines HCT-116, MCF-7 and OVCAR, with an inhibition percentage up to 96%. Taken together, both Eucalyptus species have a broad range of potential applications in several fields, such pharmaceutical, medical and food industries as nutraceutical supplements.

South African Journal of Botany published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xia, Yong-Gang published the artcileA high methyl ester pectin polysaccharide from the root bark of Aralia elata: Structural identification and biological activity, Synthetic Route of 59-23-4, the main research area is Aralia hepatocellular lung cancer root methyl ester pectin polysaccharide; Anti-tumor activity; Antioxidant activity; Aralia elata; Polysaccharides; Structural characteristics.

In this study, a high Me ester pectin polysaccharide, AER-A3 (Mw, 1.12 x 105 g/mol; O-Me ester groups (wt%), 3.81%), was isolated and purified from the root bark of Aralia elata by ion exchange and gel-filtration chromatog. Its planar structure was investigated in combination with UPLC-ESI+-MS, FT-IR, HILIC-UPLC-ESI–HCD-MS/MS, GC-MS and NMR techniques. The main chain of AER-A3 was unambiguously determined to be smooth region and hairy region with a chain length ratio of 1:1, characterized by occurrence of (1 → 2)-α-Rhap, (1 → 2,3)-α-Rhap, (1 → 2,4)-α-Rhap, (1 → 2,3,4)-α-Rhap, and (1 → 4)-α-GalpA, whereas the branched chain included T-α-Rhap, T-α-Araf, (1 → 5)-α-Araf, (1 → 3,5)-α-Araf, T-β-Galp, (1 → 3)-β-Galp, (1 → 3,4,6)-β-Galp, (1 → 4)-Glcp, (1 → 3)-Glcp, and (1 → 3)-Manp. Meanwhile, SEC-MALLS-RID, CD and Congo red assays showed that AER-A3 had no helical conformations but existed as a globular shape with branching. In addition, AER-A3 had good scavenging activities against DPPH, hydroxyl, and superoxide radicals. Anti-tumor assay investigated the effects of AER-A3 on human A549 and HepG2 cancer cell lines in vitro. These results provided a scientific basis for the use of the polysaccharides in A. elata root barks in pharmaceuticals.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Hongyan published the artcileComparison of different extraction methods of polysaccharides from cup plant (Silphium perfoliatum L.), Related Products of alcohols-buliding-blocks, the main research area is Silphium polysaccharide enzyme assisted hot water extraction method.

The purpose of the present research was to compare the effects of four extraction methods on the extraction yields, physicochem. characteristics, and antioxidant activities of polysaccharides from the cup plant (Silphium perfoliatum L.) (CPPs). The extraction methods included the hot water extraction method (HEM), ultrasonic-assisted extraction method (UEM), enzyme-assisted extraction method (EEM), and the ultrasonic-enzyme-assisted extraction method (UEEM). Four corresponding CPP extracts, HEM-CPPs, UEM-CPPs, EEM-CPPs, and UEEM-CPPs, were obtained. The results indicated that there were notable differences between the extraction methods regarding the yield, average mol. weight, uronic acid content, monosaccharide proportions, and the antioxidant activities of the CPPs. HEM-CPPs were extracted with the lowest yield (6.44%). EEM-CPPs had the largest extraction yield (9.87%) and the most notable antioxidant abilities of ferric reducing power and free radical scavenging activity. According to correlation anal., the higher antioxidant abilities of EEM-CPPs might be due to their smaller average mol. weight and a higher content of uronic acid than those of the other extracted CPPs. Therefore, EEM could serve as a promising technique for extracting CPPs.

Process Biochemistry (Oxford, United Kingdom) published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Jianzhi published the artcileProduction and characterization of exopolysaccharides from Chlorella zofingiensis and Chlorella vulgaris with anti-colorectal cancer activity, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Chlorella exopolysaccharide colon cancer antioxidant anticancer agent; Antitumor; Chlorella vulgaris; Chlorella zofingiensis; Exopolysaccharide; Physicochemical property.

The production, physicochem. characteristics, antioxidant and antitumor activities of partial purified exopolysaccharides from Chlorella zofingiensis, Chlorella vulgaris were investigated. The final exopolysaccharides productions were 208.4, 364.3 mg/L and the average mol. weights were 2.66×104, 1.88×104 Da, resp. Monosaccharide anal. indicating that these exopolysaccharides consisted of 10 or 11 different kinds of sugars and derivatives, resp. Addnl., they exhibited obvious radical scavenging activities on DPPH and hydroxyl radicals, which reached to 59.6-71.5% and 44.5-70.4%, resp. Moreover, the antitumor effects were studied using human colon cancer cell lines HCT8. The results showed that they had significant antitumor effects considering the inhibitory effects on cell viabilities (28.3-18.0% on HCT8, resp.). Thus, these exopolysaccharides from microalgae species are worth further investigating as alternative potential antitumor agents.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Jianzhi published the artcileCharacterization of exopolysaccharides produced by microalgae with antitumor activity on human colon cancer cells, Formula: C6H12O6, the main research area is Chlorella colon cancer cell exopolysaccharide antitumor; Antioxidant; Antitumor; Exopolysaccharides; Microalgae; Physicochemical characterization.

The physicochem. characteristics, antioxidant and antitumor activities of partial purified exopolysaccharides from microalgae Chlorella pyrenoidosa FACHB-9, Scenedesmus sp. and Chlorococcum sp. were investigated. The mol. weights were 1.94 × 105, 7.39 × 103 and 3.24 × 104 g/mol, resp. Monosaccharide anal. indicating that these exopolysaccharides consisted of ten different kinds of sugars and derivatives, resp. Furthermore, they exhibited obvious free radicals scavenging abilities, which reached to 55.2-71.4% and 63.1-77.5% on DPPH and hydroxyl radicals, resp. Moreover, the antitumor effects were investigated using human colon cancer cell lines HCT116 and HCT8. The results showed that they had significant antitumor effects considering the inhibitory effects on cell viabilities (17.2-19.2% on HCT116, and 22.9-38.6 on HCT8, resp.), and could decrease the colony amounts (21-42.8% on HCT116, and 11.5-35.2% on HCT8, resp.) at the tested dosage. Thus, these exopolysaccharides may be worth further investigating as effective potential antitumor agents.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fahmi, Abdelgawad published the artcilePhytochemicals, antioxidant activity and hepatoprotective effect of ginger (Zingiber officinale) on diethylnitrosamine toxicity in rats, Synthetic Route of 124-76-5, the main research area is ginger diethylnitrosamine toxicity phytochem antioxidant activity hepatoprotective effect; Diethylnitrosamine toxicity; essential oil; ginger; hepatoprotective effect.

Chronic liver damage has serious medical consequences. To investigate the hepatoprotective effect of dry Zingiber officinale (ginger) and its essential (volatile) oil against diethylnitrosamine (DEN) toxicity in rats. Phenols and flavonoids components were characterized in dry ginger using HPLC-UV instrument while ginger essential oil (E.O.) was investigated via GC-MS technique. Antioxidant activity was determined in-vitro. In rat model, ginger was administrated for 2 mo. Lipid profile, antioxidant biomarkers, liver functions and histopathol. were assessed. Chlorogenic acid (63.85ppm) and hesperidin (156.91ppm) are among the major phenolic and flavonoid constituents in dry ginger. Curcumene (15.21%) and linalool (13.47%) represent the main E.O. constituents. In rats treated with ginger E.O., a significant elevation in serum HDL (31.14%) was accompanied by a decrease in LDL (55.14%). A significant decrease in serum ALT and ALP was reported (56.85% and 53.84%, resp.). Serum GSH-Px activity has significantly increased 75.06%. Meanwhile, E.O. showed anticancer potential against HepG2 cell line (IC50 = 40μg/mL). Liver histopathol. examinations confirmed the protective effect against abnormalities. Ginger was able to reduce the severity of DEN-cytotoxicity in rats, which suggests a novel antioxidant role originating from this medicinal plant.

Biomarkers published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Synthetic Route of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cai, Bingna published the artcileComposition characterization of oyster polysaccharides from Crassostrea hongkongensis and their protective effect against H2O2-induced oxidative damage in IEC-6 cells, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Crassostrea small intestine epithelial cell polysaccharide oxidative damage; IEC-6; Oxidative stress; Oyster polysaccharide.

In this study, we aimed to measure the ability of oyster polysaccharides to promote IEC-6 cell migration and antioxidant activity and further describe their cytoprotective effect on H2O2-challenged IEC-6 cells. The C30-60% fraction of polysaccharides (CHP2) showed rapid stimulation of IEC-6 cell migration after wounding. Then, CHP2 was fractionated into four fractions, namely, CHP2-1, CHP2-2, CHP2-3 and CHP2-4. The CHP2-3 fraction possessed high scavenging activities against 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and oxygen radical absorbance capacity (ORAC), in comparison with other fractions. And CHP2-3 was heteropolysaccharide with sulfuric esters, and it was mainly composed of glucose, galactose and arabinose and had an average mol. weight of 41.81 kDa. Pretreatment with CHP2 and CHP2-3 significantly improved the survival rate of H2O2-treated IEC-6 cells, and reduced intracellular reactive oxygen species (ROS) levels. Moreover, CHP2-3 also significantly decreased H2O2-mediated increases in the secretion of IL-1β and interleukin-6 (IL-6), and attenuated NF-kB p65 activation. These results indicate that CHP2-3 may play a vital role in reducing oxidative damage in IEC-6 cells via radical scavenging, decreasing proinflammatory factors secretion, inhibiting the NF-kB pathway, and thus, reducing cell apoptosis.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vasantharaja, Raguraman published the artcileAttenuation of oxidative stress induced mitochondrial dysfunction and cytotoxicity in fibroblast cells by sulfated polysaccharide from Padina gymnospora, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Padina mitochondrial dysfunction cytotoxicity fibroblast sulfated polysaccharide oxidative stress; Antioxidants; Oxidative stress; Padina gymnospora; Reactive oxygen species; Sulfated polysaccharide.

In this present study, isolation, characterization and protective effect of sulfated polysaccharide (SP) isolated from the brown algae Padina gymnospora was investigated. SP was isolated and characterized through FT-IR, 1H NMR, TGA, GC-MS and CHN anal. The mol. weight of SP was found to be 16 kDa. The isolated SP contains 29.4 ± 0.35% of sulfate, 27 ± 0.11% of fucose, 0.05 ± 0.12% of protein, resp. Furthermore, SP exhibits its excellent radical scavenging effects were evaluated by DPPH, ABTS radical scavenging and reducing power assays. Moreover, pretreatment with SP significantly mitigates H2O2 induced cytotoxicity in L-929 cells in a dose dependent manner. Furthermore, SP pretreatment ameliorates oxidative stress induced apoptosis and DNA damage, alleviates the generation of intracellular reactive oxygen species (ROS) and restores mitochondrial membrane potential (MMP) in L-929 cells through its antioxidant potential. Together, these results suggest that SP can be exploited as a natural antioxidant in the food and pharmaceutical industries.

International Journal of Biological Macromolecules published new progress about Antioxidants. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zebeljan, Aleksandra published the artcileDynamic changes in common metabolites and antioxidants during Penicillium expansum-apple fruit interactions, Safety of (S)-2-hydroxysuccinic acid, the main research area is Penicillium Malus fruit decay metabolites antioxidants dynamics.

Penicillium expansum-infected apple fruit resulted in a disrupted balance of primary metabolites and impacted the ascorbate-glutathione cycle. The initial decline in fructose, malic acid, shikimic acid and total ascorbate content (6 hpi) was followed by a significant increase in malic acid (24 hpi) and total glutathione (3 dpi). Significant increase in sucrose was accompanied by a decline in glucose and ascorbate content (5 dpi). Total glutathione and shikimic acid gradually deteriorated with symptom development. A neg. correlation was found between sucrose and ascorbate-glutathione pool. Other correlations were strong amongst other metabolites and lesion size indicating that they may be involved or important for apple fruit decay.

Physiological and Molecular Plant Pathology published new progress about Antioxidants. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Safety of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts