Category: alcohols-buliding-blocks

Ali, Abbas published the artcileToxicity and Repellency of Magnolia grandiflora Seed Essential Oil and Selected Pure Compounds Against the Workers of Hybrid Imported Fire Ants (Hymenoptera: Formicidae)., HPLC of Formula: 111-87-5, the main research area is Magnolia seed essential oil; fire ant worker; repellency; toxicity.

We tested Magnolia grandiflora L. (Magnoliales: Magnoliaceae) seed essential oil and its pure compounds for their repellency and toxicity against workers of hybrid imported fire ants. Series of dosages were tested starting from 156 µg/g to the dose where the treatment failed. Workers removed significantly less sand from the vials with M. grandiflora seed essential oil and 1-octanol treated sand at serial dosages of 156-4.9 µg/g than the solvent control whereas the amount removed at 2.4-0.6 µg/g was similar to the solvent control. In 1-decanol treatments, workers removed significantly less sand at serial dosages of 156-0.15 µg/g than the solvent control whereas the removal of sand at the dose of 0.08 µg/g was similar to the solvent control. In DEET (N, N-diethyl-meta-toluamide) treatments, workers removed significantly less sand at serial dosages of 156-78 µg/g than the solvent control whereas the quantity of removed sand at 39 µg/g was similar to the solvent control. Based on the mean amount of sand removed, M. grandiflora essential oil, 1-decanol, and 1-octanol showed significantly higher repellency than DEET. 1-Decanol and 1-octanol, present in seed essential oil showed toxicity against fire ant workers. 1-Decanol with LC50 of 140.6 µg/g was the most toxic natural compound followed by 1-octanol (LC50 = 486.8 µg/g). Bifenthrin with LC50 value of 0.018 µg/g showed much higher toxicity than these natural compounds. High repellency and toxicity of 1-decanol makes it a natural compound of interest for further studies under field conditions.

Journal of economic entomology published new progress about Magnolia seed essential oil; fire ant worker; repellency; toxicity. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, HPLC of Formula: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kiris, Baris published the artcileSeparation of Mandelic Acid by a Reactive Extraction Method Using Tertiary Amine in Different Organic Diluents, Safety of n-Octanol, the main research area is mandelic acid; reactive extraction; separation; tri-n-octylamine.

Mandelic acid is a valuable chem. that is commonly used in the synthesis of various drugs, in antibacterial products, and as a skin care agent in cosmetics. As it is an important chem., various methods are used to synthesize and extract this compound However, the yields of the used processes is not significant. A dilute aqueous solution is obtained when using several production methods, such as a fermentation, etc. In this study, the reactive extraction of mandelic acid from aqueous solutions using tri-n-octylamine extractant at 298.15 K was investigated. Di-Me phthalate (DMP), Me iso-Bu ketone (MIBK), 2-octanone, 1-octanol, n-pentane, octyl acetate, and toluene were used as diluents. The batch extraction results of the mandelic acid experiments were obtained for the development of a process design. Calculations of the loading factor (Z), distribution coefficient (D), and extraction efficiency (E%) were based on the exptl. data. The highest separation yield was obtained as 98.13% for 0.458 mol.L-1 of tri-n-octylamine concentration in DMP. The overall extraction constants were analyzed for the complex of acid-amine by the Bizek approach, including K11, K12, and K23.

Molecules published new progress about mandelic acid; reactive extraction; separation; tri-n-octylamine. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Farag, Michael M published the artcileHyaluronic Acid Conjugated Metformin-Phospholipid Sonocomplex: A Biphasic Complexation Approach to Correct Hypoxic Tumour Microenvironment., Category: alcohols-buliding-blocks, the main research area is MiaPaCa-2; hyaluronic acid; hypoxia-inducible factor; metformin; pancreatic ductal adenocarcinoma.

PURPOSE: Development of hyaluronic acid conjugated metformin-phospholipid sonocomplexes (HA-MPS), a biphasic complexation product compiled for enhancing both the lipophilicity and targeting potential of Metformin (MET) to CD44 receptors on pancreatic cancer. METHODS: MET was chemically conjugated to hyaluronic acid (HA) via amide coupling reaction. Then, the HA conjugated MET was physically conjugated to Lipoid™S100 via ultrasound irradiation. A combined D-optimal design was implemented to statistically optimize formulation variables. The HA-MPS were characterized through solubility studies, partition coefficient, drug content uniformity, particle size and zeta potential. The optimized HA-MPS was tested via proton nuclear magnetic resonance, infrared spectroscopy to elucidate the nature of physicochemical interactions in the complex which was further scrutinized on molecular level via molecular docking and dynamic simulation. RESULTS: The solubility and partition studies showed a lipophilicity enhancement up to 67 folds as they adopted inverted micelles configuration based on the packing parameter hypothesis. The optimized HA-MPS showed 11.5 folds lower IC50, extra 25% reduction in oxygen consumption rate, better reduction in hypoxia-inducible factor and reactive oxygen species in MiaPaCa-2 cells. CONCLUSION: These results proved better internalization of MET which was reflected by abolishing hypoxic tumour microenvironment, a mainstay toward a normoxic and less resistant pancreatic cancer.

International journal of nanomedicine published new progress about MiaPaCa-2; hyaluronic acid; hypoxia-inducible factor; metformin; pancreatic ductal adenocarcinoma. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abramovitch, Rudolph A. published the artcileSolution and flash vacuum pyrolyses of β-(3,5-disubstituted-phenyl)ethanesulfonyl azides. Sultam, pyrindine, and azepine formation, SDS of cas: 93427-13-5, the main research area is pyridine cyclopropyldimethyl; pyrolysis arylethanesulfonyl azide mechanism; pyrindine derivative; sultam; sulfonylazepine.

The solution and flash-vacuum pyrolyzes of azides I (R = Me, Cl, MeO, CF3) are reported. When R = Me, FVP results suggest that the substituents stabilize the intermediate leading to the sultam (II, R = R1 = Me). A new product, pyridine III, is observed, and a modification is proposed in the mechanism proposed earlier to account for the FVP of β-arylethanesulfonyl azides. No dihydropyrindine, which would have required a Me migration, is observed When R = Cl, migration of Cl does occur and a mixture of 5H- and 7H-1-pyrindines is obtained, together with other products. When R = MeO, some MeO migration occurs on FVP to give 6,7-dihydro-3,5-dimethoxy-5H-1-pyrindine. Monodemethoxylation to give II (R = MeO, R1 = H) also takes place, and a possible mechanism is proposed. When R = CF3 the main product on FVP at 300° is the fused azepine IV in respectable yield. This is the first example of the isolation of an N-sulfonylazepine from the intramol. reaction of a sulfonylnitrene and from a FVP.

Journal of Organic Chemistry published new progress about pyridine cyclopropyldimethyl; pyrolysis arylethanesulfonyl azide mechanism; pyrindine derivative; sultam; sulfonylazepine. 93427-13-5 belongs to class alcohols-buliding-blocks, name is 2-(3,5-Dichlorophenyl)ethanol, and the molecular formula is C8H8Cl2O, SDS of cas: 93427-13-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carpio, Humberto published the artcileSynthesis of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and homologous pyridine and azepine analogs thereof, Synthetic Route of 50966-69-3, the main research area is pyrrolopyrrolecarboxylic acid; pyrrolopyridinecarboxylic acid; pyrroloazepinecarboxylic acid; pyrroleacetate; pyridinecarboxylic acid pyrrolo; azepinecarboxylic acid pyrrolo.

Several syntheses of the previously unknown 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid (I) and various 5- and 6-substituted derivatives were devised. Some of these processes were extended to the heretofore unreported 5,6,7,8-tetrahydropyrrolo[1,2-a]pyridine-8-carboxylic acid (II) and 5,6,7,8-tetrahydro-9H-pyrrolo[1,2-a]azepine-9-carboxylic acid derivatives (e.g., III). Two new processes were developed for the conversion of pyrroles into the corresponding pyrrole-2-acetic acid esters. Both processes were based on the use of the readily available ethoxalylpyrrole derivatives as the starting material. One sequence involved saponification of the α-keto ester, followed by Wolff-Kishner reduction of the crude α-keto acid salt and subsequent esterification of the acetic acid derivative thus produced. The 2nd synthesis commenced with reduction of the 2-ethoxalpyrrole with NaBH4 to the α-hydroxy ester, which was further reduced to the acetic acid ester with an equimolar mixture of PPh3 and PPh3I2.

Canadian Journal of Chemistry published new progress about pyrrolopyrrolecarboxylic acid; pyrrolopyridinecarboxylic acid; pyrroloazepinecarboxylic acid; pyrroleacetate; pyridinecarboxylic acid pyrrolo; azepinecarboxylic acid pyrrolo. 50966-69-3 belongs to class alcohols-buliding-blocks, name is 3-(1H-Pyrrol-1-yl)propan-1-ol, and the molecular formula is C7H11NO, Synthetic Route of 50966-69-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hofmann, Natalie published the artcileSynthesis of tetrahydroquinolines via borrowing hydrogen methodology using a manganese PN3 pincer catalyst, Formula: C5H12O, the main research area is tetrahydroquinoline preparation.

A straightforward and selective synthesis of 1,2,3,4-tetrahydroquinolines starting from 2-aminobenzyl alcs. and simple secondary alcs. is reported. This one-pot cascade reaction is based on the borrowing hydrogen methodol. promoted by a manganese (I) PN3 pincer complex. The reaction selectively leads to 1,2,3,4-tetrahydroquinolines thanks to a targeted choice of base. This strategy provides an atom-efficient pathway with water as the only byproduct. In addition, no further reducing agents are required.

Organic Letters published new progress about tetrahydroquinoline preparation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Formula: C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khan, Hina published the artcileA prospective randomized trial to compare the effectiveness of zero calorie carbonated drink and water as a solvent in sodium phosphate for colonoscopy., HPLC of Formula: 124-76-5, the main research area is Zero calorie coke, Sodium phosphate..

Objectives: To compare the effectiveness of zero-calorie soft drink and plain water as a solvent for sodium phosphate in terms of good palatability and better patient tolerance. METHODS: The randomised controlled trial was conducted from May to December 2019 at the Dowites Operation Theatre Endoscopy Suite, Surgical Unit 3, Civil Hospital Karachi, and comprised patients aged >18 years of either gender undergoing colonoscopy for screening and non-emergency/non-urgent colorectal diseases. The patients were randomised into group A, which was assigned to take sodium phosphate in water, and group B, which was assigned to take sodium phosphate in zero-calorie soft drink. Bowel preparation was assessed by the consultant during endoscopy. Outcome variables, such as bowel cleanliness, palatability, tolerance of solution, adverse effects, and willingness to repeat the preparation, were evaluated in both groups. Data was analysed using SPSS 21. RESULTS: Of the 162 patients, there were 81(50%) in each of the two groups. There were 124(76.5%) males and the overall mean age was 43±8.66 years. The palatability score was significant (p=0.01) for group B compared to group A. Due to better palatability and tolerance, 64(79%) patients in group B took the preparation in <6 hours. CONCLUSIONS: Use of zero-calorie soft drink was found to be a better option for colonoscopic preparation compared to plain water. RCT Registration: Clinical trial unit (www.clinicaltrials.gov), NCT04316858. JPMA. The Journal of the Pakistan Medical Association published new progress in MEDLINE. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Weiglein, Alice published the artcileOne-trial learning in larval Drosophila, Formula: C8H18O, the main research area is .

Animals of many species are capable of “”small data”” learning, i.e., of learning without repetition. Here we introduce larval Drosophila melanogaster as a relatively simple study case for such one-trial learning. Using odor-food associative conditioning, we first show that a sugar that is both sweet and nutritious (fructose) and sugars that are only sweet (arabinose) or only nutritious (sorbitol) all support appetitive one-trial learning. The same is the case for the optogenetic activation of a subset of dopaminergic neurons innervating the mushroom body, the memory center of the insects. In contrast, no onetrial learning is observed for an amino acid reward (aspartic acid). As regards the aversive domain, one-trial learning is demonstrated for high-concentration sodium chloride, but is not observed for a bitter tastant (quinine). Second, we provide follow-up, parametric analyses of odor-fructose learning. Specifically, we ascertain its dependency on the number and duration of training trials, the requirements for the behavioral expression of one-trial odor-fructose memory, its temporal stability, and the feasibility of one-trial differential conditioning. Our results set the stage for a neurogenetic anal. of one-trial learning and define the requirements for modeling mnemonic processes in the larva.

Learning & Memory published new progress in CAplus and MEDLINE about 111-87-5, 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kempraj, Vivek published the artcile1-Octanol emitted by Oecophylla smaragdina weaver ants repels and deters oviposition in Queensland fruit fly, Product Details of C8H18O, the main research area is .

Abstract: Humans have used weaver ants, Oecophylla smaragdina, as biol. control agents to control insect pests in orchards for many centuries. Over recent decades, the effectiveness of weaver ants as biol. control agents has been attributed in part to deterrent and oviposition inhibiting effects of kairomones produced by the ants, but the chem. identity of these kairomones has remained unknown. We have identified the kairomone responsible for deterrence and oviposition inhibition by O. smaragdina, providing a significant advance in understanding the chem. basis of their predator/prey interactions. Olfactometer assays with extracts from weaver ants demonstrated headspace volatiles to be highly repellent to Queensland fruit fly, Bactrocera tryoni. Using electrophysiol. and bioassays, we demonstrate that this repellence is induced by a single compound, 1-octanol. Of 16 compounds identified in O. smaragdina headspace, only 1-octanol evoked an electrophysiol. response from B. tryoni antennae. Flies had greatly reduced oviposition and spent significantly less time in an olfactometer arm in the presence of 1-octanol or a synthetic blend of headspace volatiles containing 1-octanol than in the presence of a synthetic blend of headspace volatiles without 1-octanol, or clean air. Taken together, our results demonstrate that 1-octanol is the functional kairomone component of O. smaragdina headspace that explains repellence and oviposition deterrence, and is hence an important contributor to the effectiveness of these ants as biol. control agents.

Scientific Reports published new progress in CAplus and MEDLINE about 111-87-5, 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Taghizadeh, Mohsen published the artcileEffects of synbiotic food consumption on glycemic status and serum hs-CRP in pregnant women: a randomized controlled clinical trial., Formula: C12H24O11, the main research area is .

OBJECTIVE: The aim of this study was to determine the effects of synbiotic food consumption on glycemic status and serum high sensitivity C-reactive protein (hs-CRP) levels of Iranian pregnant women. DESIGN: This randomized placebo-controlled clinical trial was performed among 52 pregnant women, primigravida, aged 18-35 year old, in their third trimester. After a 2-wk run-in period, subjects were randomly assigned to consume either a synbiotic (n=26) or control food (n=26) for 9 weeks. The synbiotic food consisted of a probiotic Lactobacillus sporogenes (1×107 CFU), 0.04 g inulin as prebiotic with 0.38 g isomalt, 0.36 g sorbitol and 0.05 g stevia as sweetener per 1 g. Control food (the same substance without probiotic bacteria and inulin) was packed in identical 9-gram packages. Patients were asked to consume the synbiotic and control foods two times a day. Fasting blood samples were taken at baseline and after a 9-wk intervention for quantification of related factors. RESULTS: Consumption of a synbiotic food did not show any significant change regarding the impact of insulin actions in the synbiotic group; nonetheless, compared to the control food, it resulted in a significant decrease in serum insulin levels (-0.26 vs. 6.34 µIU/mL, P=0.014) and HOMA-IR (-0.13 vs. 1.13, P=0.033), a significant difference in HOMA-B (5.30 vs. 34.22, P=0.040) and a significant rise in QUICKI score (0.002 vs. -0.02, P=0.022). CONCLUSIONS: Consumption of a synbiotic food for 9 weeks by pregnant women had beneficial effects on insulin actions compared to the control food, but did not affect FPG and serum hs-CRP concentrations.

Hormones (Athens, Greece) published new progress in MEDLINE about 64519-82-0, 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Formula: C12H24O11.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts