Category: alcohols-buliding-blocks

Qian, Ya-fang published the artcileDetermination of triflusal and its active metabolite 2-hydroxy-4-(trifluoromethyl)benzoic acid in human plasma by LC-MS, Category: alcohols-buliding-blocks, the publication is Yaowu Fenxi Zazhi (2014), 34(9), 1541-1548, database is CAplus.

A reliable liquid chromatog.-mass spectrometry (LC-MS) method for the determination of triflusal and its active metabolite 2-hydroxy-4-(trifluoromethyl)benzoic acid (HTB) in human plasma was developed. The stability of triflusal in human plasma was evaluated when formic acid of different concentrations was used as the esterase inhibitor. The plasma concentrations of triflusal and HTB were determined by LC-MS, resp. Separation of the analytes was achieved on a Hedera ODS-2 column, and MS determination was carried out in electrospray ionization mode. The stability of triflusal in human plasma was kept by adding 20 μL of 4% formic acid to an aliquot of 400 μL of plasma, and then triflusal was extracted with acetyl acetate. Triflusal was eluted with a mobile phase of acetonitrile (A)-5 mmol·L^-1 ammonium acetate solution containing 0.1 % acetic acid (B) using gradient elution (0-0.1 min, 20%A; 0.1-0.15 min, 20%A→30%A; 0.15-6 min, 30%A; 6-6.5 min, 30% A→100% A; 6.5-9.5 min, 100% A; 9.5-10 min, 100% A→20% A; 10-13.7 min, 20% A) at a flow rate of 0.4 mL·min^-1. The deprotonated ions were at m/z 247.0 and 150.0 for monitoring for triflusal and the internal standard (IS) paracetamol, resp. The protein precipitation method was used for HTB sample treatment. HTB in the treated samples was separated with a mobile phase of methanol-5 mmol·L^-1 ammonium acetate solution containing 3% formic acid (75:25) at a flow rate of 0.25 mL·min^-1. The deprotonated ions were at m/z 205.0 and 137.0 for monitoring for HTB and salicylic acid (IS) resp. The calibration ranges were 0.01-20.37 μg·mL^-1 and 0.7-159.9 μg·mL^-1 for triflusal and HTB, resp. As the lower limit of quantitation for triflusal (0.01 μg·mL^-1) was lower than that by the previous reported methods (0.03 μg·mL^-1), the elimination half-life of triflusal in human could be determined more accurately. The current method was successfully applied to determine the concentration levels of triflusal and HTB in human plasma. The methods can be used for determination of triflusal and HTB in human plasma in pharmacokinetics and bioequivalence studies.

Yaowu Fenxi Zazhi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ge, Jie published the artcileEffect of food on the pharmacokinetics of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in healthy subjects, SDS of cas: 328-90-5, the publication is International Journal of Clinical Pharmacology and Therapeutics (2015), 53(3), 272-276, database is CAplus and MEDLINE.

Objective: The objective of this study was to evaluate the pharmacokinetic parameters of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), following a single oral dose of 900 mg in healthy subjects under fed and fasting conditions. Methods: The study participants (n = 12) were randomized to receive one 900 mg triflusal capsule in a fasting condition (no food for 12 h) or a fed condition (after a high-fat meal); after a 2-wk washout period, participants received the same dose of triflusal capsule under the converse condition. Pharmacokinetic parameters were calculated using WinNonlin 6.2 software. Safety was evaluated through assessment of adverse events, standard laboratory evaluations, vital signs, and 12-lead electrocardiog. Results: The mean Cmax of triflusal and HTB were 13.96, 110.2 ug/mL for the fasting state and 9.546, 97.15 ug/mL for the fed state, resp. The AUC0-144 of triflusal and HTB were 19.66, 5,572 h × μg/mL for the fasting state and 22.20, 5,038 h × μg/mL for the fed state, the AUC0-∞ of triflusal and HTB were 19.79, 6,333 h × μg/mL for the fasting state and 22.44, 5,632 h × μg/mL for the fed state, resp. The results showed that Cmax and AUCs for triflusal were outside the bioequivalency (BE) interval after food intake, but there was no statistically significant change for HTB. Conclusion: High-fat food intake may affect the pharmacokinetics of triflusal capsule in healthy subjects.

International Journal of Clinical Pharmacology and Therapeutics published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, En-Xu published the artcileReorganization of a synthetic microbial consortium for one-step vitamin C fermentation, Product Details of C6H10O7, the publication is Microbial Cell Factories (2016), 21/1-21/11, database is CAplus and MEDLINE.

Background: In the industry, the conventional two-step fermentation method was used to produce 2-keto-L-gulonic acid (2-KGA), the precursor of vitamin C, by three strains, namely, Gluconobacter oxydans, Bacillus spp. and Ketogulonicigenium vulgare. Despite its high production efficiency, the long incubation period and an addnl. second sterilization process inhibit the further development. Therefore, we aimed to reorganize a synthetic consortium of G. oxydans and K. vulgare for one-step fermentation of 2-KGA and enhance the symbiotic interaction between microorganisms to perform better. Results: During the fermentation, competition for sorbose of G. oxydans arose when co-cultured with K. vulgare. In this study, the competition between the two microbes was alleviated and their mutualism was enhanced by deleting genes involved in sorbose metabolism of G. oxydans. In the engineered synthetic consortium (H₆ + Kv), the yield of 2-KGA (mol/mol) against d-sorbitol reached 89.7 % within 36 h, increased by 29.6 %. Furthermore, metabolomic anal. was used to verify the enhancement of the symbiotic relationship and to provide us potential strategies for improving the synthetic consortium. Addnl., a significant redistribution of metabolism occurred by co-culturing the K. vulgare with the engineered G. oxydans, mainly reflected in the increased TCA cycle, purine, and fatty acid metabolism Conclusions: We reorganized and optimized a synthetic consortium of G. oxydans and K. vulgare to produce 2-KGA directly from d-sorbitol. The yield of 2-KGA was comparable to that of the conventional two-step fermentation The metabolic interaction between the strains was further investigated by metabolomics, which verified the enhancement of the mutualism between the microbes and gave us a better understanding of the synthetic consortium.

Microbial Cell Factories published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C10H2F12NiO4, Product Details of C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tomer, K. B. published the artcileMass spectrometry in structural and stereochemical problems. CCXXXI. Differentiation between tautomeric ion structures (phenol versus cyclohexadienone), Synthetic Route of 20117-47-9, the publication is Tetrahedron (1973), 29(22), 3491-6, database is CAplus.

Ion cyclotron resonance and pulsed double resonance spectra of ion-mol. reactions of bicyclo[2.2.2]oct-2-en-5,7-dione, PhOD, and C6D5OH with Pr2CO and 1-methylcyclobutanol were determined and the results applied to the structure determination of the C6H6O+ ion generated by electron impact induced expulsion of CH2:CO from PhOAc. The ion was PhO+, not cyclohexadienone+.

Tetrahedron published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C4H8F3NO, Synthetic Route of 20117-47-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fredo Naciuk, Fabricio published the artcileDevelopment of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from Trypanosoma cruzi, Category: alcohols-buliding-blocks, the publication is ACS Medicinal Chemistry Letters (2020), 11(6), 1250-1256, database is CAplus and MEDLINE.

Chagas disease is a parasitic infection affecting millions of people across Latin America, imposing a dramatic socioeconomic burden. Despite the availability of drugs nifurtimox and benznidazole, lack of efficacy and incidence of side-effects prompt the identification of novel, efficient, and affordable drug candidates. To address this issue, one strategy could be probing the susceptibility of Trypanosoma parasites toward NADP-dependent enzyme inhibitors. Recently, steroids of the androstane group have been described as highly potent but nonselective inhibitors of parasitic glucose-6-phosphate dehydrogenase (G6PDH). In order to promote selectivity, we have synthesized and evaluated 26 steroid derivatives of epiandrosterone, e.g., I, in enzymic assays, whereby 17 compounds were shown to display moderate to high selectivity for T. cruzi over the human G6PDH. In addition, three compounds were effective in killing intracellular T. cruzi forms infecting rat cardiomyocytes. Altogether, this study provides new SAR data around G6PDH and further supports this target for treating Chagas disease.

ACS Medicinal Chemistry Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Weber, Edwin published the artcileVersatile and convenient lattice hosts derived from singly bridged triarylmethane frameworks. X-ray crystal structures of three inclusion compounds, Computed Properties of 596-38-3, the publication is Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) (1990), 2167-77, database is CAplus.

A new family of host mols., based on the singly bridged triarylmethanol and triarylacetic acid frameworks, is described. These hosts form crystalline inclusions with a variety of uncharged organic mols. ranging from protic dipolar to apolar compounds (130 different species). The formation and stoichiometry depend in a systematic manner on structural parameters of the host, such as the nature of the functional group and the substituents, and on the substituent positions. The crystal structures of three inclusion compounds [I (R = OH)·benzene (8:3), I (R = OH)·dioxane (4:3), and I (R = CO₂H)·EtOH (1:1)] have been studied by x-ray diffraction. They reveal the building principles of the new inclusion family. In the crystals of I (R = OH)·benzene (8:3), the benzene is interstitially entrapped by H-bonded tetramer clusters of I (R = OH). Crystals of I (R = OH)·dioxane (4:3) are built of H-bonded 2:1 host-guest complexes including interstitial mols. of dioxane. In the case of I (R = CO₂H)·EtOH (1:1), the building principle is formation of 2:2 host-guest clusters via a twelve-membered H-bonded ring.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C17H18N2O6, Computed Properties of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lewinska, Agnieszka published the artcileTargeted hybrid nanocarriers as a system enhancing the skin structure, Safety of 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Molecules (2021), 26(4), 1063, database is CAplus and MEDLINE.

The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in the model formulations-cream, tonic, and gel, and confirmed by TEM. The anal. showed that nanoemulsion has a spherical morphol. and size 220- 300 nm, while levan nanoparticles had irregular shapes independently of the use of matrix and with particle size (130-260 nm). Addnl., we examined the antiradical effect of levan nanoparticles and nanoemulsion in the prototype of formulations by scavenging DPPH (2,2-diphenyl-1-picrylhydrazyl; EPR spectroscopy). The model cream with both nanosystems and the whole range of products with nanosystems were evaluated in vivo for hydration, elasticity, smoothness, wrinkles and vascular lesions, discoloration, resp. The cream improved skin condition in all tested parameters in at least 50% of volunteers. The use of more comprehensive care, addnl. consisting of a tonic and gel, reduced the previously existing skin discoloration to 10.42 ± 0.58%. The presented prototype formulations are promising in improving skin conditions.

Molecules published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Safety of 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Draelos, Zoe Diana published the artcileThe effect of an anti-inflammatory botanical cleanser/night mask combination on facial redness reduction, SDS of cas: 70445-33-9, the publication is Journal of Drugs in Dermatology (2018), 17(6), 671-676, database is CAplus and MEDLINE.

Facial redness is a common difficult to control cosmetic problem representing various phases of rosacea. Using anti-inflammatory/antioxidant botanicals in moisturizer formulations is a possible approach to minimizing the erythema.This research utilized a common facial cleanser, but only applied the botanically based moisturizer to one half face to properly assess efficacy. 30 female subjects Filzpatrick skin types l-IV 30-55 years of age with mild to moderate chronic facial redness, defined as a redness score of 3-6 on a 10-point scale, were enrolled. By the end of week 4, statistically significant improvement was seen on the cleanser/mask treated side in scaling (P<0.001), flaking (P<0.001), tactile smoothness (P<0.001), textural smoothness (P<0.001), firmness (P<0.001), radiance (Pc0.001), luminosity (P<0.001), and overall appearance (P<0.001).Thus, cosmetic moisturizers may be useful in reducing facial redness.

Journal of Drugs in Dermatology published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, SDS of cas: 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Reed, John H. published the artcileA 1,3,2-Diazaphospholene-Catalyzed Reductive Claisen Rearrangement, Synthetic Route of 83706-94-9, the publication is Angewandte Chemie, International Edition (2019), 58(26), 8893-8897, database is CAplus and MEDLINE.

1,3,2-Diazaphospholenes (DAPs) are an emerging class of organic hydrides. In this work, we exploited them as efficient catalysts for very mild reductive Claisen rearrangements. The method is tolerant towards a wide variety of functional groups and operates at ambient temperature Besides being enantiospecific for substrates with existing stereogenic centers, the diastereoselectivity can be switched by varying solvents and DAP catalysts. The reaction kinetics show direct rearrangements of O-bound phospholene enolates and provide a proof-of-principle for catalytic enantioselective reactions.

Angewandte Chemie, International Edition published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Synthetic Route of 83706-94-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Han, Yunfei published the artcileAn Efficiency of 16.46% and a T₈₀ Lifetime of Over 4000 h for the PM6:Y6 Inverted Organic Solar Cells Enabled by Surface Acid Treatment of the Zinc Oxide Electron Transporting Layer, Application of 2-Phenylethanethiol, the publication is ACS Applied Materials & Interfaces (2021), 13(15), 17869-17881, database is CAplus and MEDLINE.

For the inverted organic solar cells (OSCs), the interface contacts between the ZnO electron transporting layer and the organic active layer play an important role in the device performance and stability. Since the solution-processed ZnO surface always contains some base or zinc salt contaminants, we explored how the surface pH conditions influence the performance and stability of the nonfullerene acceptor (NFA) cells. A tight relationship between the surface pH condition and the device performance and stability was established. Specifically, device performance and stability were improved by treating the ZnO films with acid solutions but worsened after base treatment. The large number of hydroxyl groups on the surface of the solution-processed ZnO films was proved to be the main reason for the surface pH condition-related performance, which caused oxygen-deficient defects and unfavorable vertical phase separation in the blend films, hindered the photogenerated charge transfer and collection, and consequently resulted in low short-circuit c.d. and power conversion efficiency (PCE). The surface -OH groups also boosted the photocatalytic activity and led to fast degradation of the nonfullerene acceptor. Removal of the surface -OH groups can alleviate such problems. Different acid solutions, ZrAcac, 2-phenylethylmercaptan (PET), and glutamic acid (GC), were used to treat the ZnO films, and PET treatment was the most effective treatment for performance improvement. An efficiency of 16.46% was achieved for the PM6:Y6 cells and the long-term stability under continuous illumination conditions was significantly improved with a T₈₀ lifetime of over 4000 h (4410 h), showing the excellent long-term stability of this heterojunction solar cell. Our understanding of the surface pH condition-related device performance and stability would guide the development of a feasible method for solving the interface problems in OSCs. We also provide a practical strategy to modify ZnO with acid solutions for high-performance and stable NFA OSCs.

ACS Applied Materials & Interfaces published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts