Category: alcohols-buliding-blocks

Cheng, Yun-Xing published the artcileSynthesis and binding of 6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepine and related ring-opened analogs at central nicotinic receptors, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is European Journal of Medicinal Chemistry (1999), 34(2), 177-190, database is CAplus.

6,7,8,9-Tetrahydro-5H-pyrido[3,4-d]azepine (I) and its N₇-Me derivative were synthesized and evaluated as potential nicotinic acetylcholinergic receptor (nAChR) ligands. On the basis that 6,7,8,9-tetrahydro-5H-pyrido[3,4-c]azepine, which binds to nAChR with low affinity (K_i = 1100 nM), possesses an inter-nitrogen distance (4.6 Å) that may be less than optimal, I was designed due to its similar shape but longer inter-nitrogen distance (5.5 Å). Compound I (K_i = 46 nM) was found to bind with enhanced affinity. However, unlike what is seen with nornicotine/nicotine, N-methylation of I reduced affinity (K_i = 268 nM) rather than enhancing it. The results suggest that the title compounds may interact at nicotine receptors in a manner that is somewhat different from that of nicotine. Ring-opening of the pyrido[3,4-d]azepine ring led to a series of 3-(2-aminoethyl)pyridines that retained the affinity of the cyclic compound Subsequent modification, including further chain lengthening (e.g. (aminopropyl)pyridine derivatives) and introduction of unsaturation, ultimately led to the development of a series of 3-(2-aminoethoxy)pyridine derivatives Simple N-substituted derivatives of 3-(2-aminoethoxy)pyridine were found to bind with K_i values of 20 to 35 nM. Because parallel structural changes in several series of related compounds did not result in parallel shifts in nAChR affinity, it is unlikely that all the investigated compounds bind in a similar fashion at these receptors. Nevertheless, some of these compounds represent novel classes of nAChR ligands.

European Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ji, Na published the artcileToward Alkylphenols Production: Lignin Depolymerization Coupling with Methoxy Removal over Supported MoS₂ Catalyst, Recommanded Product: 4-Propylphenol, the publication is Industrial & Engineering Chemistry Research (2020), 59(39), 17287-17299, database is CAplus.

Alkylphenols are indispensable chems. that are currently derived from fossil resources. Conversion of lignin into alkylphenols in a selective manner is highly desirable, while it represents one of the biggest challenges in biorefinery. Herein, lignin depolymerization coupling with methoxy removal over supported MoS₂ catalyst for the direct production of alkylphenols has been studied. The catalysts were prepared by incipient wetness impregnation and characterized by N₂ physisorption, XRD, NH₃-TPD, CO chemisorption, ICP, TEM, and XPS. The catalytic performance and the reaction mechanism were initially assessed by the hydrodeoxygenation (HDO) of eugenol. Among the catalysts with MoS₂ supported on different supports (HZSM-5, SAPO-34, SiO₂, Al₂O₃, and activated carbon (AC)), the acid-rich MoS₂/AC with high sp. surface areas and more exposed MoS₂ edge sites owed a complete conversion of eugenol and 64.8% yield of 4-propylphenol under 3 MPa H₂ at 300°C for 3 h. In the conversion of lignin-oil, MoS₂/AC catalyst also exhibited excellent activity in the removal of all the methoxy groups in various aromatic monomers, achieving alkylphenols with selectivity up to 76.2%. Notably, this catalytic system also showed potential in simultaneous hydrocracking coupling with methoxy removal of realistic lignin to afford alkylphenols, thus providing a direct strategy for the selective valorization of lignin.

Industrial & Engineering Chemistry Research published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Waugh, Stephen M. published the artcileIsolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/binding, Category: alcohols-buliding-blocks, the publication is Biochemistry (1989), 28(8), 3448-55, database is CAplus and MEDLINE.

Radiolabeled insulin was affinity crosslinked to purified insulin receptor with 6 sep. bifunctional N-hydroxysuccinimde esters of different lengths. Results were qual. identical for each crosslinker in that insulin was predominantly crosslinked through its B chain to the receptor’s α subunit. The maximum efficiencies of crosslinking were 10-15% for the most effective reagents, and this value was dependent upon the concentration and length of the crosslinker. In an effort to locate the crosslinking site, monoiodoinsulin was crosslinked to affinity-purified insulin receptor with disuccinimidyl suberate. Limited proteolysis of the hormone/receptor adduct with Staphylococcus aureus V8 protease, chymotrypsin, or thermolysin in an SDS-containing buffer rapidly generated a 55-kDa, insulin-labeled fragment as shown by SDS-PAGE. It was reported earlier that the 55-kDa chymotryptic fragment contained multiple internal SS bonds as evidenced by its shifting mobility on an SDS gel after dithiothreitol treatment. The 55-kDa fragment is also formed by proteolysis of the receptor in the absence of prior insulin crosslinking. This fragment was prepared in amounts sufficient for sequence anal. and was purified by passage successively over gel-permeation and reverse-phase HPLC columns. The sequence of the fragment’s N terminus corresponds to that of the N terminus of the receptor’s α subunit. This fragment also reacts with an antibody raised against a synthetic peptide corresponding to residues 242-253 of the receptor’s α subunit. On the basis of the fragment’s size, N-terminal sequence, and immunoreactivity, the results indicate that the fragment extends from the α subunit’s N terminus through the SS-rich region of this subunit, i.e., residues 155-312. These results are consistent with this region containing the insulin-binding site.

Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C19H21N3O3S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Manker, Lorenz P. published the artcileSustainable polyesters via direct functionalization of lignocellulosic sugars, Recommanded Product: Pentane-1,5-diol, the publication is Nature Chemistry, database is CAplus and MEDLINE.

The development of sustainable plastics from abundant renewable feedstocks was limited by the complexity and efficiency of their production, as well as their lack of competitive material properties. Here the authors demonstrate the direct transformation of the hemicellulosic fraction of nonedible biomass into a tricyclic diester plastic precursor at 83% yield (95% from com. xylose) during integrated plant fractionation with glyoxylic acid. Melt polycondensation of the resulting diester with a range of aliphatic diols led to amorphous polyesters (M_n = 30-60 kDa) with high glass transition temperatures (72-100°), tough mech. properties (ultimate tensile strengths of 63-77 MPa, tensile moduli of 2,000-2,500 MPa and elongations at break of 50-80%) and strong gas barriers (oxygen transmission rates (100 μm) of 11-24 cc m^-2 day^-1 bar^-1 and H₂O vapor transmission rates (100 μm) of 25-36 g m^-2 day^-1) that could be processed by injection molding, thermoforming, twin-screw extrusion and 3-dimensional printing. Although standardized biodegradation studies still need to be performed, the inherently degradable nature of facilitated their chem. recycling via methanolysis at 64°, and eventual depolymerization in room-temperature H₂O. [graphic not available: see fulltext].

Nature Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Recommanded Product: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Woelke, Christian published the artcileUnderstanding the Effectiveness of Phospholane Electrolyte Additives in Lithium-Ion Batteries under High-Voltage Conditions, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is ChemElectroChem (2021), 8(5), 972-982, database is CAplus.

Six phospholane functional electrolyte additives that enable the formation of an effective cathode electrolyte interphase (CEI) via a polymerization reaction on the electrode surface were designed, synthesized, and comparatively analyzed by means of complementary exptl. and computational methods in order to understand their mode of action in NMC111||graphite battery cells under high voltage conditions. Two reaction mechanisms, namely a phosphate-based and a phosphonate-based mechanism, were postulated and, based on systematic anal., the phosphate mechanism was identified as the more likely. Direct correlation of the phospholane’s structural features and relevant properties impacting the direct correlation of the phospholane’s structural features and relevant properties impacting the overall cycling performance of NMC111||graphite cells, as depicted by capacity retention, stands for a vital example approach towards identifying promising electrolyte components for advanced, targeted applications.

ChemElectroChem published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C9H7NO4, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Giroud, Maude published the artcileRepurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors, Synthetic Route of 328-90-5, the publication is Journal of Medicinal Chemistry (2018), 61(8), 3350-3369, database is CAplus and MEDLINE.

Rhodesain (RD) is a parasitic, human cathepsin L (hCatL) like cysteine protease produced by Trypanosoma brucei (T. b.) species and a potential drug target for the treatment of human African trypanosomiasis (HAT). A library of hCatL inhibitors was screened, and macrocyclic lactams were identified as potent RD inhibitors (K_i < 10 nM), preventing the cell-growth of Trypanosoma brucei rhodesiense (IC₅₀ < 400 nM). SARs addressing the S2 and S3 pockets of RD were established. Three cocrystal structures with RD revealed a noncovalent binding mode of this ligand class due to oxidation of the catalytic Cys 25 to a sulfenic acid (Cys-SOH) during crystallization The P-glycoprotein efflux ratio was measured and the in vivo brain penetration in rats determined When tested in vivo in acute HAT model, the compounds permitted up to 16.25 (vs. 13.0 for untreated controls) mean days of survival.

Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Synthetic Route of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blaser, Hans-Ulrich published the artcileNo Stirring Necessary: Parallel Carbonylation of Aryl Halides with CO and Various Alcohols under Pressure, HPLC of Formula: 27292-49-5, the publication is Journal of Organic Chemistry (2003), 68(9), 3725-3728, database is CAplus and MEDLINE.

The parallel carbonylation of aryl and heteroaryl halides R¹X (R¹ = 4-MeCOC₆H₄, X = Br; R¹ = 2-pyridyl, X = Cl) with 6-25 bar of CO in 1-mL vials in a standard autoclave in the presence of an O-nucleophile R²OH (R² = Bu, PhCH₂, cyclopentyl, etc.) to give the corresponding esters R¹CO₂R² was investigated. With 2-chloropyridine as a model substrate, 102 different O-nucleophiles (primary and secondary alcs., phenols) were studied. No inertization during the loading was necessary. Fifty esters (43 new, yield up to 60%) were isolated and characterized. Ether, ester, ketone, and sometimes even olefin functionalities were usually tolerated. The new method is suitable for screening and small scale synthesis.

Journal of Organic Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, HPLC of Formula: 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Panferova, Liubov I. published the artcileLight-Mediated Sulfur-Boron Exchange, Category: alcohols-buliding-blocks, the publication is Organic Letters (2021), 23(10), 3919-3922, database is CAplus and MEDLINE.

Photochem. organocatalytic substitution of pyridylthio group in alkyl tetrafluoropyridinyl thioethers RS-4-C₅F₄N with bis(catecholato)diboron followed by treatment with pinacol and triethylamine affording pinacol boronic esters RBpin is described. The reaction is promoted by an organic photocatalyst, 2,4,6-tris(diphenylamino)-3,5-difluorobenzonitrile (3DPA2FBN) under irradiation with 400 nm light, and works with primary, secondary, and tertiary sulfides. The electron depleting character of the fluorinated pyridine fragment plays an important role in generating alkyl radicals.

Organic Letters published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yuandi published the artcileCharacteristics of the microbiota and metabolic profile of high-temperature Daqu with different grades, Application of 2-Hydroxy-2-phenylacetic acid, the publication is World Journal of Microbiology & Biotechnology (2022), 38(8), 137, database is CAplus and MEDLINE.

The superior grade Daqu (S_Daqu) and normal grade Daqu (N_Daqu) have obvious differences in flavor, fracture surface, appearance, etc., which can be accurately grouped by well-trained panel based on their sensory properties. However, the differences in microbial community diversity and metabolites between the S_Daqu and N_Daqu were still unclear. The culture-dependent method, the third generation Pacific Biosciences (PacBio) single-mol., real-time (SMRT) sequencing technol., and NMR (NMR) were combined to show the characteristics in microorganisms and metabolites. This showed that the fungal counts were higher in N_Daqu while the richness of bacterial communities was higher in S_Daqu (P < 0.05). Lentibacillus, Burkholderia, Saccharopolyspora, Thermoascus, and Rasamsonia were the dominant genera of S_Daqu while Staphylococcus, Scopulibacillus, and Chromocleista were the dominant genera in N_Daqu. The content of differential acids, amino acids, and alcs. including fumarate, glucuronate, glycine, 4-carboxyglutamate, and myo-inositol in S_Daqu was higher than that in N_Daqu by 1H NMR coupled with multivariate statistical anal. The network anal. regarding microbes and metabolites suggested that Saccharopolyspora showed a strong pos. correlation with 4-carboxyglutamate while Thermoascus and Chromocleista were highly neg. correlated with alanine and isobutyrate, resp. Linear Discriminant Anal. (LDA) Effect Size (LEfSe) revealed that Macrococcus and Caulobacter were regarded as bacterial biomarkers in the S_Daqu while Chromocleista was the key fungal genera in N_Daqu. Functionality prediction indicated that the bacteria in S_Daqu were largely involved in more metabolic activities including biosynthesis, degradation, detoxification, and generation of precursor metabolite and energy.

World Journal of Microbiology & Biotechnology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C9H9F5Si, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gao, Qingwei published the artcileExploring the synergism of sunlight and electrooxidation on persulfate activation for efficient degradation of bisphenol S: Performance, Pathway, and mechanism, SDS of cas: 80-09-1, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2022), 437(Part_1), 135318, database is CAplus.

Sulfate radical-based advanced oxidation processes had been widely applied in the water treatment. In this study, a novel solar-assisted electrooxidation process (SEOP) to activate peroxymonosulfate (PMS) or peroxydisulfate (PDS) was conducted for the degradation of bisphenol S (BPS). The SEOP with persulfate (PS) demonstrated its synergistic effect for BPS degradation, compared with the electrooxidation/PS and the solar process. The hydroxyl radical, sulfate radical (SO·-4), and singlet oxygen were regarded as primary active species in BPS degradation in SEOP with PS. The transition structure complex (persulfate*) on the anode promoted the efficiency of BPS degradation via the non-radical mechanism. The activation of PMS and PDS in SEOP was dominated through radical and non-radical mechanism, resp. To effectively supplement exptl. work with quantum chem. calculation, d. function theory (DFT) showed that the active sites mainly focused on the phenol ring of BPS. The energy barrier calculation indicated that BPS was more susceptible to be attacked by SO·-4 through electron transfer. BPS was mainly degraded by ring-opening, substitution, addition, C-C bond breaking, and decarboxylation reactions. Furthermore, the effective decrease in bio-toxicity of BPS intermediates in SEOP with PS was predicted. Experiments under various current densities, initial concentration of PS, electrolyte, and humic acid suggested the feasibility of SEOP with PS. BPS was degraded with lower energy consumption (0.18 kWh·m^-3·order^-1) in SEOP with PMS than that in SEOP with PDS (0.30 kWh·m^-3·order^-1) and without PS (0.38 kWh·m^-3 order^-1), resp. The SEOP with PS poses the feasible, convenient, and economic potential for the degradation of refractory pollutants.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, SDS of cas: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts