Category: alcohols-buliding-blocks

Lu, Shu-xia published the artcileOptimization of medium composition for two-step fermentation of vitamin C using response surface methodology, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Shipin Kexue (Beijing, China) (2013), 34(3), 202-206, database is CAplus.

2-Keto-L-gulonic acid production during the conversion process from L-sorbose to 2-keto-L-gulonic acid in the two-step fermentation of vitamin C was improved. An efficient companion strain of Bacillus subtilis A9 that facilitates the growth of Gluconobacter oxydans and the production of acids was screened from fresh milk. Based on single factor tests, the compositions of fermentation medium were optimized by response surface methodol. The results showed that three factors including L-sorbose, corn liquor and urea revealed significant impact on the production of 2-KGA. The optimal compositions included 90 g/L L-sorbose, 14.2 g/L corn liquor, 12.2 g/L urea, 4.1 g/L CaCO₃ and 0.2 g/L MgSO₄. Under the optimal medium, the yield of 2-keto-L-gulonic acid was up to 69.74 g/L, which was close to the theor. value of 70.33 g/L with the relative error of-0.59 g/L. The established regression equation for 2-KGA revealed excellent fitting. Therefore, it is credible and can be used for practical prediction.

Shipin Kexue (Beijing, China) published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Tingting published the artcileResponse surface methodology to optimize medium for 2-keto-L-gulonic acid production by new strains system in two-step vitamin C fermentation, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Weishengwuxue Zazhi (2012), 32(2), 47-53, database is CAplus.

The ability of Bacillus pumilus HJ-04 to promote the production of vitamin C (VC) precursor, 2-keto-L-gulonic acid (2-KGA), by 2-KGA-producing strain is stronger than industrial Bacillus megaterium B2980 as associated bacteria in second step of two-step VC fermentation Six factors that affected the 2-KGA production by new strains system were analyzed and optimized adopting single factor test, Plackett-Burman (PB) design, and Box-Behnken design. The results indicated that L-sorbose, urea, and corn syrup were the noticeably influencing factors. The optimum acid-producing condition was 94.95 g/L of L-sorbose, 11.99 g/L of urea, 14.13 g/L of corn syrup. The acid production increased by 12.31 mg/mL, and the production period shortened by 6 h after the optimization.

Weishengwuxue Zazhi published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C20H23N3O2S, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Yu published the artcileOptimization of medium composition for two-step fermentation of vitamin C based on artificial neural network-genetic algorithm techniques, Computed Properties of 526-98-7, the publication is Biotechnology & Biotechnological Equipment (2015), 29(6), 1128-1134, database is CAplus.

The production of 2-keto-L-gulonic acid (2-KGA) during the conversion from L-sorbose to 2-KGA in the two-step fermentation of vitamin C can be improved by using an efficient companion strain Bacillus subtilis A9 to facilitate the growth of Ketogulonicigenium vulgare and the production of 2-KGA. Two optimization models, namely response surface methodol. (RSM) and artificial neural network (ANN), were built to optimize the medium components for mixed-culture fermentation of 2-KGA. The root mean square error, R2 and the standard error of prediction given by the ANN model were 0.13%, 0.99% and 0.21%, resp., while the RSM model gave 1.89%, 0.84% and 2.9%, resp. This indicated that the fitness and the prediction accuracy of the ANN model were higher than those of the RSM model. Furthermore, using genetic algorithm (GA), the input space of the ANN model was optimized, predicting that the maximum 2-KGA production of 72.54 g·L-1 would be obtained at the GA-optimized concentrations of the medium components (L-sorbose, 92.5 g·L-1; urea, 10.2 g·L-1; corn steep liquor, 16 g·L-1; CaCO3, 3.96 g·L-1; MgSO4, 0.28 g·L-1). The 2-KGA production exptl. obtained using the ANN-GA-designed medium was 71.21 ± 1.53 g·L-1, which was in good agreement with the predicted value. The same optimization process may be used to improve the production during bacterial mixed-cultures fermentation by changing the fermentation parameters.

Biotechnology & Biotechnological Equipment published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H8N2, Computed Properties of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Yuan-Yuan published the artcileProtective efficacy of phenoxyacetyl oxazolidine derivatives as safeners against nicosulfuron toxicity in maize, Application In Synthesis of 96-20-8, the publication is Pest Management Science (2021), 77(1), 177-183, database is CAplus and MEDLINE.

Herbicide safeners mitigate crop damage without reducing herbicide efficacy. Here, the protective effects of phenoxyacetyl oxazolidine derivatives as potential safeners were evaluated with a view toward reducing injury caused by sulfonylurea herbicide nicosulfuron to sensitive maize varieties. Growth indexes demonstrated that the bioactivity of compound 9 (N-phenoxyacety-2-methyl-2,4-diethyl-1,3-oxazolidine) was superior to that of R-28725 and all other compounds tested. Compound 9 induced endogenous glutathione and upregulated glutathione-S-transferase (GST) in maize. Thus, it could enhance maize tolerance to nicosulfuron. Compared with the untreated water control group, the maximum reaction rate of GST was increased by 37.62%, while the maximum velocity of GST was decreased by 61.93% after treatment with compound 9. Acetolactate synthase relative activity was significantly enhanced in the case of treatment with compound 9, indicating the excellent protective effects of compound 9 against nicosulfuron in maize. The present work demonstrates that phenoxyacetyl oxazolidine derivatives are potentially efficacious as herbicide safeners and merit further investigation.

Pest Management Science published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is CBF6K, Application In Synthesis of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Sai published the artcileInterfacial Effects of the CuO/GO Composite to Mediate the Side Reactions of N,N-Dimethylformamide Fragments, HPLC of Formula: 23351-09-9, the publication is ACS Applied Materials & Interfaces (2014), 6(24), 22174-22182, database is CAplus and MEDLINE.

The interface between nanocatalysts and graphene oxide (GO) has been found to play a crucial role in enhancing the catalytic activity and improving the selectivity of amination reactions in N,N-dimethylformamide (DMF). The composite catalysts of CuO/GO used for the catalytic coupling of aryl halides with amines in DMF can completely inhibit the side reaction between the aryl halides and fragments of DMF. With identical amounts of Cu-catalysts, the conversion of iodobenzene and the selectivity for the target product reached 100% when CuO/GO composite catalysts were employed, while these results were 70.3 and 42.8%, resp., when CuO catalysts were used alone. Exptl. evidence confirms that the interfacial effect of CuO/GO is the origination of the improved performance of composite catalysts, which has been found to efficiently transfer fragments of DMF to GO and avoid unexpected side reactions during the catalytic process.

ACS Applied Materials & Interfaces published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C7H16Cl2Si, HPLC of Formula: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xuerong published the artcileTransition Metal-Free Aerobic Oxidation of Aryl Secondary and Primary Alcohols to Carbonyl Compounds in Open Air, Synthetic Route of 90-64-2, the publication is ChemistrySelect (2022), 7(3), e202103502, database is CAplus.

Here, an efficient and practical oxidation of aryl secondary and primary alcs. R¹CH(OH)R² (R¹ = Ph, biphenyl-4-yl, 2-naphthyl, etc., R² = H, ME, Et, CO₂H, 4-ClC₆H₄, etc.) to the corresponding carbonyl compounds using NaOtBu in open air at room temperature has been developed. By utilizing NaOtBu/air/toluene, a series of ketones R¹C(O)R² or benzoic acids were obtained in high yields, resp. More importantly, most of the substrates with electron-withdrawing or electron-donating groups could be converted to the corresponding products in high to excellent yields. Furthermore, the practicality of the reaction was demonstrated through a 1.0 g-scale reaction with excellent yield.

ChemistrySelect published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C24H29N5O3, Synthetic Route of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Tongfei published the artcileCopper-catalyzed thioketalization of enones featuring trifluoromethyl groups, Computed Properties of 4410-99-5, the publication is RSC Advances (2021), 11(32), 19832-19835, database is CAplus and MEDLINE.

Here, a copper-catalyzed thioketalization of enones bearing CF₃ groups and various mercaptans was developed, thioketal mols. I [R = Et, i-Pr, allyl, etc.; RR = (CH₂)₂; R² = Me, Ph] had been obtained with moderate to excellent yield. Meanwhile, a preparative scale experiment had been performed giving over 95% yield. This work allowed the straightforward formation of thioketals I containing CF₃ groups and unsaturated double bonds.

RSC Advances published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C7H15NO, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Perales, Eduardo published the artcileEcotoxicity and QSAR studies of glycerol ethers in Daphnia magna, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Chemosphere (2017), 277-285, database is CAplus and MEDLINE.

Glycerol is currently considered a raw, renewable material, which can be used to synthesize new glycerol derivatives that may be used as green solvents. However, these compounds must be environmentally evaluated before their use. The acute ecotoxicity of a series of mono-, di-, and trialkyl ethers synthesized from glycerol for the crustacean Daphnia magna has been studied. The EC₅₀ values of these ethers after 24 h of exposure were determined according to the OECD 202 protocol. Their possible structural-toxicity relationships according to different alkyl substituents have been discussed after applying different QSAR models (with the DARC-PELCO approach and topol. parameters). The results of the immobilization test show that most of the glycerol derivatives studied exhibit relatively low ecotoxicity. There is a correlation between the lipophilicity and the increase of the toxic effect in the crustacean biomodel. Furthermore, the length and the number of the alkyl substituents and ecotoxicity are highly related.

Chemosphere published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonzalez, Tania published the artcileCatalytic CO₂ hydrosilylation with [Mn(CO)₅Br] under mild reaction conditions, Name: Triethylsilanol, the publication is Polyhedron (2021), 115242, database is CAplus.

Carbon dioxide hydrosilylation with earth-abundant transition-metal catalysts is an attractive alternative for the design of greener and cost-effective synthetic strategies. Herein, simple [Mn(CO)₅Br] is an efficient precatalyst in the hydrosilylation of carbon dioxide with Et₃SiH under mild reaction conditions. Using THF as a solvent, triethylsilylformate Et₃SiCH(O)O was obtained in 67% yield after 1 h at 50°C and 4 bar of CO₂ pressure. The selectivity of the reaction was tuned by changing the solvent to a mixture of THF and toluene producing bis(triethylsilyl)acetal (Et₃SiO)₂CH₂ in 86% yield. The CO₂ hydrosilylation was also effective at room temperature and atm. pressure using either THF or the mixture THF/toluene as the solvent resulting in high Et₃SiH conversion (92%-99%) but with a decrease in the selectivity. Radical trapping experiments indicated the participation of radical species in the catalytic mechanism. To the best of our knowledge, this is the first report on CO₂ hydrosilylation catalyzed by transition-metal radical intermediates.

Polyhedron published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Name: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Berger, Bryan W. published the artcileRelating surfactant properties to activity and solubilization of the human adenosine A₃ receptor, Synthetic Route of 85618-21-9, the publication is Biophysical Journal (2005), 89(1), 452-464, database is CAplus and MEDLINE.

The effects of various surfactants on the activity and stability of the human adenosine A₃ receptor (A₃) were investigated. The receptor was expressed using stably transfected HEK293 cells at a concentration of 44 pmol functional receptor per mg membrane protein and purified using over 50 different nonionic surfactants. A strong correlation was observed between a surfactant’s ability to remove A₃ from the membrane and the ability of the surfactant to remove A₃ selectively relative to other membrane proteins. The activity of A₃ once purified also correlates well with the selectivity of the surfactant used. The effects of varying the surfactant were much stronger than those achieved by including A₃ ligands in the purification scheme. Notably, all surfactants that gave high efficiency, selectivity and activity fall within a narrow range of hydrophile-lipophile balance values. This effect may reflect the ability of the surfactant to pack effectively at the hydrophobic transmembrane interface. These findings emphasize the importance of identifying appropriate surfactants for a particular membrane protein, and offer promise for the development of rapid, efficient, and systematic methods to facilitate membrane protein purification

Biophysical Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts