Category: alcohols-buliding-blocks

Pearl, Irwin A. published the artcileLignin and related products. XVI. Synthesis of lignin model compounds of the phenylglycerol β-ether and related series, SDS of cas: 70110-65-5, the publication is Journal of Organic Chemistry (1962), 2111-14, database is CAplus.

Substituted ethyl benzoylacetates have been employed for the preparation of lignin model compounds in the phenylpropane-1,3-diol and phenylpropane-1,2,3-triol series. Direct reduction of these esters with LiAlH₄ yields the corresponding phenylpropane-1,3-diol. Bromination followed by condensation with a phenol and reduction with LiAlH₄ of the resulting ether yields the phenylglycerol β-aryl ether. Bromination followed by acetylation and reduction yields the phenylpropane-1,2,3-triol. Models in the veratryl, 3,4,5-trimethoxyphenyl, 4-hydroxy-3,5-dimethoxyphenyl, 4-benzyloxy-3,5-dimethoxyphenyl, and 4-acetoxy-3,5-dimethoxyphenyl series were prepared Cf. Forest Prod. J. 11, 442(1961); CA 54, 385f.

Journal of Organic Chemistry published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, SDS of cas: 70110-65-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salama, Paul published the artcileWhy Are Wet Wipes So Difficult to Preserve Understanding the Intrinsic Causes, Category: alcohols-buliding-blocks, the publication is Cosmetics (2021), 8(3), 73, database is CAplus.

Over the last two decades, significant advances have been made in developing disposable baby wet wipes. Wet wipes consist of two main components: nonwoven fabric and liquid Being more than 90% water, wet wipes are more susceptible to microbial growth than typical personal care products; hence, high concentrations of preservative compounds are often used to ensure extended protection against contamination. However, there is an obvious tendency to minimize the concentration of irritating actives. Baby wet wipes should contain particularly mild surfactants, well-tolerated preservatives, and a buffer system maintaining the formulation pH at a suitable level for the infant’s skin. Efforts have been centered on removing ingredients with irritation potential, such as phenoxyethanol. In addition, a move towards more natural fabrics is occurring. However, these modifications provoke new challenges in preserving the final products. The nature and composition of the fiber can influence the interactions between the preservative and the wipe, subsequently affecting the performance of the preservative system. In this study, we analyzed the causes of the challenge in preserving wet wipes. We found that fabrics containing natural fibers are the main source of contamination, promoting the generation of biofilms on their surfaces. Moreover, the hydrophilic-lipophilic balance (HLB) was utilized to rationalize the physicochem. interactions between the fabric and the preservatives.

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salama, Paul published the artcileThe use of catalytic amounts of selected cationic surfactants in the design of new synergistic preservative solutions, Recommanded Product: 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Cosmetics (2021), 8(2), 54, database is CAplus.

Preservation using combinations of antibacterial mols. has several advantages, such as reducing the level of usage and broadening their antimicrobial spectrum. More specifically, the use of quaternary ammonium surfactants (QAS)-which are profusely used in hair care products and some are known as efficient antimicrobial agents-is limited due to some potential cytotoxicity concerns. This study shows that the concentration of some widely used cosmetic preservatives can be decreased when combined with very small quantities of QAS, i.e., Polyquaternium-80 (P-80) and/or Didecyldimethylammonium chloride (DDAC). The antimicrobial activity of their mixtures was first evaluated by determining the min. inhibitory concentration (MIC) before and after the addition of QAS. Following up on this finding and targeting an ultimate consumer friendly antimicrobial blend, yet with optimal safety, we chose to utilize the food-grade preservative Maltol as the main natural origin antimicrobial agent mixed with min. concentrations of QAS to improve its moderate antimicrobial properties. The preservatives were tested for MIC values, challenge tests and synergy using the fractional inhibitory concentration index (FICI). The antimicrobial efficacy of Maltol was found to be synergistically improved by introducing catalytic amounts of P-80 and/or DDAC.

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Recommanded Product: 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diaw, A. K. D. published the artcileAn experimental study of the electronic absorption and fluorescence spectral properties of new p-substituted-N-phenylpyrroles and their electrosynthesized polymers, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2015), 1107-1114, database is CAplus and MEDLINE.

Electronic absorption and fluorescence spectral properties of new p-substituted-N-phenylpyrroles (N-PhPys), including HOPhPy, MeOPhPy, ThPhPy, PhDPy, DPhDPy, PyPhThThPhPy, and their available, electrosynthesized polymers were investigated. Electronic absorption spectra, fluorescence excitation and emission spectra, fluorescence quantum yields (Φ_F) and lifetimes (τ_F), and other photophys. parameters of these N-PhPy derivatives and their polymers were measured in DMF, DMSO diluted solutions and/or solid state at room temperature The electronic absorption spectra of N-PhPy derivatives and their polymers included one to several bands, located in the 270-395 nm region, according to the p-Ph substituent electron-donating effect and conjugated heteroaromatic system length. The fluorescence excitation spectra were characterized by one broad main peak, with, in most cases, one (or more) poorly resolved shoulder (s), appearing in the 270-405 nm region, and their emission spectra were generally constituted of several bands located in the 330-480 nm region. No significant shift of the absorption, fluorescence excitation and emission spectra wavelengths was found upon going from the monomers to the corresponding polymers. Φ_F Values were high, varying between 0.11 and 0.63, according to the nature of substituents(s) and to the conjugated system extension. Fluorescence decays were mono-exponential for the monomers and poly-exponential for PyPhThThPhPy and for polymers. τ_F Values were relatively short (0.35-5.17 ns), and markedly decreased with the electron-donor character of the Ph group p-substituent and the conjugated system extension.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diaw, A. K. D. published the artcileNew poly(p-substituted-N-phenylpyrrole)s. Electrosynthesis, electrochemical properties and characterization, Safety of 4-(1H-Pyrrol-1-yl)phenol, the publication is Synthetic Metals (2013), 74-85, database is CAplus.

Poly(N-p-hydroxyphenylpyrrole) [poly(HOPhPy)], poly(N-p-methoxyphenylpyrrole) [poly(MeOPhPy)], poly(N-p-thiophene-phenylpyrrole) [poly(ThPhPy)], poly(1,1′-phenylene dipyrridyl) [poly(PhDPy)] and poly(1,1′-diphenylene dipyrridyl) [poly(DPhDPy)] were electrosynthesized from the corresponding monomers on Pt electrode in 0.1 M tetrabutylammonium hexafluorophosphate (TBAPF₆) acetonitrile solutions, using cyclic voltammetry (CV), galvanostatic and potentiostatic modes. The electrodeposited films were characterized by CV, FT-IR spectrometry, X-ray photoelectron spectra (XPS), and SEM. Electron-donating substituent effects on the polymer electrochem. properties were investigated by CV. The CV of the films indicated a good redox behavior and a peak position depending on the nature of substituent. FT-IR spectral studies allowed one to predict a linear and regular structure of the polymer chains, the coupling taking place in the 2 and 5 positions of the pyrrole rings. XPS anal. showed a variation of the film doping levels (26-42% for oxidized films and 6-12% for reduced films) with the electron-donor character of the Ph p-substituents. The conjugated π-electronic system was extended by strong electron-donating substituents which led to a higher doping level of the polypyrrolic chains and a polymer structure with high-energy and polar bonds like CN⁺ and CN⁺. SEM anal. revealed changes in the polymer film morphol. and thickness with the nature of substituents.

Synthetic Metals published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Safety of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yildirim, Ayhan published the artcileD-Fructose-Derived Acetonide as a Green Neutral Organocatalyst for Proficient One-Pot and Three-Component Preparation of 1,3-Benzoxazine Monomers, Product Details of C12H20O6, the publication is ChemistrySelect (2020), 5(23), 6971-6977, database is CAplus.

A series of 1,3-benzoxazine monomers were successfully synthesized by simple one-pot and three-component condensation of phenol, paraformaldehyde and varying types of primary aliphatic and aromatic amines in a molar ratio of 1 : 2 : 1 and in the presence of non-acidic 2,3;4,5-di-O-isopropylidene-β-D-fructopyranose as an effective green carbohydrate based organocatalyst obtained from renewable feedstock. This multicomponent method provided a convenient fast approach for the construction of valuable 1,3-benzoxazine monomers (8 examples) with moderate to excellent yields. The chem. structures of the synthesized benzoxazines were confirmed by FTIR, ¹H NMR, ¹³C NMR spectra and elemental anal.

ChemistrySelect published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C23H20BN, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gogoi, Nibedita published the artcileGrafting of Ru(III) complex onto nanosilica and its implication as heterogeneous catalyst for aerobic oxidative hydroxylation of arylboronic acids, Application In Synthesis of 17236-59-8, the publication is Tetrahedron Letters (2016), 57(36), 4050-4052, database is CAplus.

An ecofriendly and highly efficient protocol for aerobic oxidative hydroxylation of aryl and heteroaryl boronic acids catalyzed by Ru(III) amidine complex immobilized on nanosilica, derived from rice husk, has been developed. The main significance of this protocol is the base free and aerobic reaction condition at room temperature, short reaction time, aqueous reaction medium, and excellent yield of the product. This heterogeneous catalyst is reusable up to sixth cycle without loss in activity.

Tetrahedron Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Application In Synthesis of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ginzburg, O. F. published the artcileProducts of condensation of arylcarbinols with 1-phenyl-3-methyl-5-pyrazolone. III, Product Details of C19H14O2, the publication is Zhurnal Obshchei Khimii (1957), 993-7, database is CAplus.

cf. C.A. 49, 1049a. Refluxing 0.3 g. 1-phenyl-3-methyl-5-pyrazolone and 0.4 g. 9-phenylxanthhydrol in dry MeOH 2 hrs. gave 95.8% 9-phenyl-9-(1-phenyl-3-methyl-4,5-dihydro-5-oxo-4-pyrazolyl)xanthene (I), m. 220-1°; also formed in AcOH solution The product can be dissolved in aqueous alc. NaOH, refluxed, and regenerated on acidification; it is also recovered readily after being refluxed in AcOH containing a little HCl. I (0.43 g.) in 10 ml. 60% EtOH containing 1 g. NaOH was treated with 0.001 mole diazosulfanilic acid and the resulting precipitate separated; the filtrate contained the azo dye from sulfanilic acid and the pyrazolone as shown by the absorption spectrum, while the precipitate was 9-phenylxanthhydrol, m. 159°. 1-Phenyl-3-methyl-4-triphenylmethyl-5-pyrazolone treated similarly gave the same azo compound in solution and a precipitate of Ph₃COH. Similar results were obtained with 1-phenyl-3-methyl-4-(9-phenyl-10-methyl-9,10-dihydro-9-acridyl)-5-pyrazolone (II), diphenyl-p-dimethylaminophenyl(1-phenyl-3-methyl-4,5-dihydro-5-oxo-4-pyrazolyl)methane, and bis(p-dimethylaminophenyl)phenyl(1-phenyl-3-methyl-4,5-dihydro-5-oxo-4-pyrazolyl)methane (III), all of which yielded the same azo compound in the solution Conductivity of II and III was determined in PhNO₂ over a period of time; a constant value is established only after 24 hrs. The results indicate that the increasing conductivity of such solutions is caused by cleavage between the 4-position of the pyrazolone and the arylcarbinyl group with formation of expected ionic charges. The process is unusually slow.

Zhurnal Obshchei Khimii published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Product Details of C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blandamer, Michael J. published the artcileMechanism and solvent reorganization accompanying hydrolyses of anchimerically assisted alkyl halides in water, SDS of cas: 2588-77-4, the publication is Journal of the American Chemical Society (1969), 91(10), 2678-83, database is CAplus.

This paper deals with the problem of solvent reorganization, anchimeric assistance, and mechanism for hydrolysis of 9 alkyl halides where the neighboring group is -OH, -OMe, or -SMe. By using the temperature coefficient of the enthalpy as a gauge of relative solvent reorganization, we show that the transition state in the hydrolysis of those alkyl halides giving evidence of anchimeric assistance resembles that for an SN1 mechanism. This conclusion was supported in one case by 13C labeling experiments in spite of product analysis seemingly favoring SN2 nucleophilic displacement by the solvent.

Journal of the American Chemical Society published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C5H11BrO, SDS of cas: 2588-77-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jeminejs, Andris published the artcileApplication of Azide-Tetrazole Tautomerism and Arylsulfanyl Group Dance in the Synthesis of Thiosubstituted Tetrazoloquinazolines, Synthetic Route of 4410-99-5, the publication is Synthesis (2021), 53(8), 1443-1456, database is CAplus.

Nucleophilic aromatic substitution reaction between 4-arylthio-2-chloroquinazolines I (Ar = C₆H₅, 4-BrC₆H₄, 4-FC₆H₄, 4-ClC₆H₄, 4-CH₃C₆H₄) and NaN₃ takes place with an unusual sulfanyl group dance and leads to the formation of 5-(arylthio)tetrazolo[1,5-c]-quinazolines II, which do not form the azide tautomer and do not undergo CuAAC reactions with alkynes. On the other hand, 5-azidotetrazolo[1,5-a]quinazoline (formally described as 2,4-diazidoquinazoline) undergoes regioselective nucleophilic aromatic substitution with thiols at C5 and forms 5-(alkyl/arylthio)tetrazolo[1,5-a]quinazolines III (R¹ = cyclopentyl, C₆H₅, CH₂C₆H₅, etc.), the structure of which has been proved by X-ray crystallog. The latter exist in tautomeric equilibrium with their 2-azidoquinazoline form, which provides possibility for copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction, leading to the 4-alkyl/arylthio-2-(1H-1,2,3-triazol-1-yl)quinazolines IV (R² = C₆H₅, cyclopropyl, Bu, etc.).

Synthesis published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Synthetic Route of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts