Category: alcohols-buliding-blocks

Maji, Ankur published the artcileWell-Defined Phosphine-Free Manganese(II)-Complex-Catalyzed Synthesis of Quinolines, Pyrroles, and Pyridines, Recommanded Product: 2-Aminobutan-1-ol, the publication is Journal of Organic Chemistry (2022), 87(13), 8351-8367, database is CAplus and MEDLINE.

Herein, authors report a simple, phosphine-free, and inexpensive catalytic system based on a manganese(II) complex for synthesizing different important N-heterocycles such as quinolines, pyrroles and pyridines from amino alcs. and ketones. Several control experiments, kinetic studies, and DFT calculations were carried out to support the plausible reaction mechanism. Authors also detected two potential intermediates in the catalytic cycle using ESI-MS anal. Based on these studies, a metal-ligand cooperative mechanism was proposed.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qiao, Chunhua published the artcile5′-O-[(N-Acyl)sulfamoyl]adenosines as Antitubercular Agents that Inhibit MbtA: An Adenylation Enzyme Required for Siderophore Biosynthesis of the Mycobactins, SDS of cas: 328-90-5, the publication is Journal of Medicinal Chemistry (2007), 50(24), 6080-6094, database is CAplus and MEDLINE.

A study of the structure-activity relationships of 5′-O-[N-(salicyl)sulfamoyl]adenosine (6), a potent inhibitor of the bifunctional enzyme salicyl-AMP ligase (MbtA, encoded by the gene Rv2384) in Mycobacterium tuberculosis, is described, targeting the salicyl moiety. A systematic series of analogs was prepared exploring the importance of substitution at the C-2 position revealing that a hydroxy group is required for optimal activity. Examination of a series of substituted salicyl derivatives indicated that substitution at C-4 was tolerated. Consequently, a series of analogs at this position provided 4-fluoro derivative, which displayed an impressive MIC₉₉ of 0.098 μM against whole-cell M. tuberculosis under iron-limiting conditions. Examination of other heterocyclic, cycloalkyl, alkyl, and aminoacyl replacements of the salicyl moiety demonstrated that these nonconservative modifications were poorly tolerated, a result consistent with the fairly strict substrate specificities of related nonribosomal peptide synthetase adenylation enzymes.

Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shivarkar, Anandkumar B. published the artcileTandem Synthesis of β-Amino Alcohols from Aniline, Dialkyl Carbonate, and Ethylene Glycol, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Industrial & Engineering Chemistry Research (2008), 47(8), 2484-2494, database is CAplus.

An efficient tandem route for selective synthesis of β-amino alcs. from anilines, dialkyl carbonate and ethylene glycol in the presence of recyclable Na-Y zeolite was demonstrated. Transesterification of dialkyl carbonate by ethylene glycol produce ethylene carbonate which further reacts with aniline to give β-amino alcs. in a single step. This reaction system was studied under high-pressure and pot reaction condition. Various process parametric effects were studied for the reaction of aniline, dialkyl carbonate, and ethylene glycol. A maximum 51% yield of mono-β-amino alc., i.e., N-phenylethanolamine (NPEA). Is obtained under pressure conditions. The yield of NPEA was improved drastically (>91%) by carrying out the reaction under pot conditions using di-Et carbonate as transesterification agent. Finally activity and selectivity of solid catalyst was explained on the basis of nature of active sites and pore structure of the catalyst.

Industrial & Engineering Chemistry Research published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C8H9BFNO3, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Reitti, Marcus published the artcileSynthesis of Phenols and Aryl Silyl Ethers via Arylation of Complementary Hydroxide Surrogates, Synthetic Route of 17877-23-5, the publication is Organic Letters (2018), 20(7), 1785-1788, database is CAplus and MEDLINE.

Two transition-metal-free methods to access substituted phenols via the arylation of silanols or hydrogen peroxide with diaryliodonium salts are presented. The complementary reactivity of the two nucleophiles allows synthesis of a broad range of phenols without competing aryne formation, as illustrated by the synthesis of the anesthetic Propofol. Furthermore, silyl-protected phenols can easily be obtained, which are suitable for further transformations.

Organic Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Synthetic Route of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Cheng published the artcileKinetics of nitrogen-, oxygen- and sulfur-containing compounds hydrotreating during co-processing of bio-crude with petroleum stream, Recommanded Product: 4-Propylphenol, the publication is Applied Catalysis, B: Environmental (2022), 121197, database is CAplus.

The rational selection of catalysts and process parameters for co-processing biomass- and waste-derived bio-crudes with petroleum streams requires detailed reaction networks and kinetics of the conversion of heteroatom-containing compounds existed in both kinds of feedstocks. We provide the kinetics and reaction networks for the hydrotreating of N,N-diethyldodecanamide and N-methyldodecanamide, model compounds of major components in bio-crudes from hydrothermal liquefaction of wet waste. Their conversion undergoes via two pathways over sulfided NiMo/Al₂O₃ catalyst: deoxygenation followed by denitrogenation of the amine intermediate (DO pathway), and denitrogenation followed by deoxygenation of the alkanol intermediate (DN pathway)-with the DO pathway dominant over the DN pathway. H2S inhibits the deoxygenation step and promotes the denitrogenation step in the DO pathway. The amine intermediate inhibits the amide conversion, with weaker effects on the conversion of secondary amide than on the tertiary amide. The kinetics of hydrotreating of several model compounds representing the main species during co-processing indicate that the removal of nitrogenous species, which are in large quantities and of varying structures, remains the main challenge (compared with S- and O-removal) for co-processing.

Applied Catalysis, B: Environmental published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C14H31NO2, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ding, Feiqing published the artcileSquaryl group modified phosphoglycolipid analogs as potential modulators of GPR55, Safety of (R)-Oxiran-2-ylmethanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2018), 54(61), 8470-8473, database is CAplus and MEDLINE.

Lysophosphatidyl glucoside (LPGlc) is a structurally unique glycolipid that acts as a guidance cue for extending axons during central nervous system development by activating the class A G protein coupled receptor (GPR) 55 of spinal cord sensory axons. GPR55 not only plays an important role during development, but is also implicated in many disease states, rendering mols. that target GPR55 of widespread interest. In this study, we developed synthetic access to a novel class of LPGlc analogs featuring a squaryl diamide group as surrogate for the phosphodiester. We report the facile synthesis of a series of LPGlc analogs, their GPR dependent biol. activity and a systematic anal. of the structure-activity relationship in regards to GPR55 modulation. The lead compound featuring identical configuration at all stereo-centers compared to natural LPGlc exhibits an activity to repel axons of dorsal root ganglion (DGR) nociceptive neurons.

Chemical Communications (Cambridge, United Kingdom) published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Safety of (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gormemis, Ahmet E. published the artcileBenzofuroindole analogues as potent BK_Ca channel openers, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is ChemBioChem (2005), 6(10), 1745-1748, database is CAplus and MEDLINE.

New, potent, large-conductance, calcium-activated potassium-channel (BK_Ca) openers that show calcium-independent activation in electrophysiol. evaluations have been designed through optimizing the structure of the benzofuroindole skeleton by comparison with a known BK_Ca-channel opener (BMS-204352). A series of substituted benzofuroindoles I (R¹ = H, Br; R² = H, CF₃, OCH₃, Cl; R³ = H, COOH, COOCH₃, Cl, OCH₃, CF₃; R⁴ = H, Cl, F; R⁵ = H, Cl, CF₃; R⁶ = H, Cl, F, CF₃) were prepared via sequence of reactions including as a key step either classical Fischer indole or microwave assisted cyclization of phenylhydrazones of benzofuranones. The BK_Ca-channel-opening activities of synthesized benzofuroindoles were studied. In particular, compound I (R¹ = R⁴ = R⁵ = H; R² = CF₃; R³ = COOH, R⁶ = Cl) showed the most potent and effective activity in an intracellular calcium-independent manner. These new potassium channel openers might find therapeutic use to treat neuronal damage and be applied to therapeutic intervention in stroke, asthma, hypertension, convulsion, and traumatic brain injury.

ChemBioChem published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Habek, Jasna Čerkez published the artcileREFRACTORY BRADYCARDIA–A RARE COMPLICATION OF CARBOPROST TROMETHAMINE FOR INDUCTION OF ABORTION, COA of Formula: C25H47NO8, the publication is Acta clinica Croatica (2016), 55(2), 323-5, database is MEDLINE.

We report a first case of refractory several-hour sinus bradycardia, a rare but already described side effect of intramuscular administration of carboprost tromethamine to induce abortion for medical indication in a patient without cardiovascular and other diseases. After administration of atropine sulfate 3×0.5 mg intravenously without effect, the patient‘s sinus rhythm spontaneously normalized as carboprost was eliminated from the body (it has a 3-hour half-life). It is reasonable to believe that the specific prostaglandin underlay the etiology of bradycardia.

Acta clinica Croatica published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, COA of Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Semleit, Nina published the artcileControlling the Gold(I)-Catalyzed 1,5-Allenene Reaction: Construction of Fused Rings with Excellent Diastereoselectivity, Category: alcohols-buliding-blocks, the publication is Organic Letters (2021), 23(24), 9635-9639, database is CAplus and MEDLINE.

In the present study, the gold(I)-catalyzed reaction of 1,5-allenenes was controlled in such a way that instead of a [2+3] cycloaddition, a 5-exo-cyclization with the formation of a carbocation occurred. The latter could be trapped with both oxygen and carbon nucleophiles. In the investigated system, fused tricyclic frameworks I (R = Me; R¹ = Me, Cl, Br, etc.; Nu = OMe, OEt, 2-furyl, etc.) with three contiguous stereocenters with excellent chemo- and diastereoselectivity in up to 95% yield were obtained.

Organic Letters published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C14H19NO8, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cavez, Damien published the artcileMaize black Mexican sweet suspension cultured cells are a convenient tool for studying aquaporin activity and regulation, Synthetic Route of 85618-21-9, the publication is Plant Signaling & Behavior (2009), 4(9), 890-892, database is CAplus and MEDLINE.

Aquaporins (AQPs) are channel proteins that facilitate and regulate the permeation of water across biol. membranes. Black Mexican sweet suspension cultured cells are a convenient model for studying the regulation of maize AQP expression and activity. Among other advantages, a single cell system allows the contribution of plasma membrane AQPs (PIPs, plasma membrane intrinsic proteins) to the membrane water permeability coefficient (P_f) to be determined using biophys. measurement methods, such as the cell pressure probe or protoplast swelling assay. We generated a transgenic cell culture line expressing a tagged version of ZmPIP2;6 and used this material to demonstrate that the ZmPIP2;6 and ZmPIP2;1 isoforms phys. interact. This kind of interaction could be an addnl. mechanism for regulating membrane water permeability by acting on the activity and/or trafficking of PIP hetero-oligomers.

Plant Signaling & Behavior published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts