Category: alcohols-buliding-blocks

Wu, Xia published the artcileApplication of urapidil in prevention and treatment of adverse reactions caused by carboprost tromethamine in cesarean section, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Nanjing Yike Daxue Xuebao, Ziran Kexueban (2015), 35(9), 1305-1307, database is CAplus.

The application effect of urapidil on prevention and treatment of adverse reactions caused by carboprost tromethamine in cesarean section was observed A total of 60 full-term pregnant patients who needed cesarean section of lower uterine segment were randomly divided into urapidil group (U group) and normal saline group (N group), 30 cases in each group. After fetal childbirth, based on injection of carboprost tromethamine 250 μg, urapidil of 12.5 mg was i.v. injected in U group, and 20 mL normal saline was injected in N group. The mean arterial blood pressure (MAP), heart rate (HR) and pulse oxygen saturation (SPO₂) were recorded in both groups before anesthesia (T₀), at fetal childbirth (T₁), 10 min after injection of carboprost tromethamine (T₂) and 30 min after injection of carboprost tromethamine (T₃). And the adverse reactions in both groups were observed There were no statistically significant differences in MAP, HR and SPO₂ at T₀ between both two groups (P>0.05). Compared with T₀, MAP and HR in N group were increased at T₂ (P<0.05), while SPO₂ was decreased (P<0.05). Compared with N group, MAP and HR in U group were decreased at T₂ (P<0.05), while SPO₂ was increased (P<0.05). The incidences of headache and chest tightness were higher in N group than in U group (P<0.05). Urapidil can be effectively used in the prevention and treatment of adverse reactions caused by carboprost tromethamine in cesarean section, which is conducive to the stability of circular breathing.

Nanjing Yike Daxue Xuebao, Ziran Kexueban published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C11H8O3, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Byun, Jaewon published the artcileImpact of uncertainty in technological cycle on circular economy: Bio-based jet fuel range alkenes and pentanediols production, HPLC of Formula: 111-29-5, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2021), 356-361, database is CAplus.

In terms of circular economy (CE), the coprodn. of biofuels and bio-based chems. could be a feasible strategy to improve the biorefinery economics. However, this approach is significantly affected by the variation of the techno-economic parameters. Thus, we evaluated the techno-economic feasibility of an integrated strategy through deterministic and stochastic models for the coprodn. of biofuels (jet fuel range alkenes (JFA)) and bio-based chems. (pentanediols and pentane) to identify the impact of uncertainty in technol. cycle on the CE action plan. The deterministic anal. estimated the min. JFA selling price (MJSP) expressed per gasoline gal equivalent (GGE) and led to the identification of six major techno-economic parameters having a significant impact on the economics. Stochastic anal. was performed based on the Monte Carlo simulation, leading to probabilistic results on the economic feasibility of the integrated strategy, taking into account the uncertainty in the six identified parameters. In five of the six scenarios developed considering each uncertainty, the chances of MJSP being lower than the maximum biofuel price (USD 3.10 GGE^-1) in the last three years (2017-2019) were higher than 50% (53.2-88.1%), implying that, despite the uncertainties reflected in the major techno-economic parameters, the integrated strategy could be a risk-averse investment.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, HPLC of Formula: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Wangzhi published the artcilePalladium-Catalyzed Linear Hydrothiocarbonylation of Unactivated Terminal Alkenes: Synthesis of Aliphatic Thioesters, Name: 2-Phenylethanethiol, the publication is Organic Letters, database is CAplus and MEDLINE.

A Pd-catalyzed hydrothiocarbonylation of unactivated terminal alkenes is presented. According to this protocol, aliphatic thioesters were synthesized with exclusive linear selectivity under mild reaction conditions. Good to excellent yields (up to 91% yield), broad substrate scope, broad functional group tolerance, and utility of the method demonstrated the advantages of this protocol.

Organic Letters published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C29H24FN7O, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Caiping published the artcileDiscovery of Salidroside Glycoside Analogs as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia, Name: 3-Hydroxyphenylacetic acid, the publication is Journal of Medicinal Chemistry (2022), 65(1), 135-162, database is CAplus and MEDLINE.

Therapeutic angiogenesis is a potential therapeutic strategy for hind limb ischemia (HLI); however, currently, there are no small-mol. drugs capable of inducing it at the clin. level. Activating the hypoxia-inducible factor-1 (HIF-1) pathway in skeletal muscle induces the secretion of angiogenic factors and thus is an attractive therapeutic angiogenesis strategy. Using salidroside, a natural glycosidic compound as a lead, we performed a structure-activity relationship (SAR) study for developing a more effective and drug angiogenesis agent. We found a novel glycoside scaffold compound (C-30) with better efficacy than salidroside in enhancing the accumulation of the HIF-1α protein and stimulating the paracrine functions of skeletal muscle cells. This in turn significantly increased the angiogenic potential of vascular endothelial and smooth muscle cells and, subsequently, induced the formation of mature, functional blood vessels in diabetic and non-diabetic HLI mice. Together, this study offers a novel, promising small-mol.-based therapeutic strategy for treating HLI.

Journal of Medicinal Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Name: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jeon, Mina published the artcileTransformation of Silanes into Silanols using Water and Recyclable Metal Nanoparticle Catalysts, Category: alcohols-buliding-blocks, the publication is ChemCatChem (2012), 4(4), 521-524, database is CAplus.

The highly selective and efficient transformation of organosilanes into silanols was achieved using readily available heterogeneous metal nanoparticle catalysts on an Al oxyhydroxide support [M/AlO(OH), M = Pd, Au, Rh, Ru, and Cu]. The transformation was performed under ambient conditions with H₂O. Among the catalysts studied, the Pd catalyst showed the highest activity; it was highly recyclable and applicable for large-scale reactions. The Pd catalyst was effective for a wide range of silanes, although small amounts of hydrogenated side products were formed in some cases for alkynyl silanes. The hydrogenation reaction was suppressed by using an O atm. or by using a gold catalyst. The Au catalyst could be reused at least ten times without any loss in activity.

ChemCatChem published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jeon, Mina published the artcileTransformation of Silanes into Silanols using Water and Recyclable Metal Nanoparticle Catalysts, Name: Triethylsilanol, the publication is ChemCatChem (2012), 4(4), 521-524, database is CAplus.

The highly selective and efficient transformation of organosilanes into silanols was achieved using readily available heterogeneous metal nanoparticle catalysts on an Al oxyhydroxide support [M/AlO(OH), M = Pd, Au, Rh, Ru, and Cu]. The transformation was performed under ambient conditions with H₂O. Among the catalysts studied, the Pd catalyst showed the highest activity; it was highly recyclable and applicable for large-scale reactions. The Pd catalyst was effective for a wide range of silanes, although small amounts of hydrogenated side products were formed in some cases for alkynyl silanes. The hydrogenation reaction was suppressed by using an O atm. or by using a gold catalyst. The Au catalyst could be reused at least ten times without any loss in activity.

ChemCatChem published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Name: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, W. published the artcileSpaceflight-induced enhancement of 2-keto-L-gulonic acid production by a mixed culture of Ketogulonigenium vulgare and Bacillus thuringiensis, Formula: C6H10O7, the publication is Letters in Applied Microbiology (2013), 57(1), 54-62, database is CAplus and MEDLINE.

Two bacterial strains used for industrial production of 2-keto-L-gulonic acid (2-KLG), Ketogulonigenium vulgare 2 and Bacillus thuringiensis 1514, were loaded onto the spacecraft Shenzhou VII and exposed to space conditions for 68 h in an attempt to increase their fermentation productivities of 2-KLG. An optimal combination of mutants B. thuringiensis 320 and K. vulgare 2194 (KB2194-320) was identified by systematically screening the pH and 2-KLG production of 16 000 colonies. Compared with the coculture of parent strains, the conversion rate of L-sorbose to 2-KLG by KB2194-320 in shake flask fermentation was increased significantly from 82·7% to 95·0%. Furthermore, a conversion rate of 94·5% and 2-KLG productivity of 1·88 g l^-1 h^-1 were achieved with KB2194-320 in industrial-scale fermentation (260 m³ fermentor). An observed increase in cell number of K2194 (increased by 47·8%) during the exponential phase and decrease in 2-KLG reductase activity (decreased by 46·0%) were assumed to explain the enhanced 2-KLG production The results suggested that the mutants KB2194-320 could be ideal substitutes for the currently employed strains in the 2-KLG fermentation process and demonstrated the feasibility of using spaceflight to breed high-yielding 2-KLG-producing strains for vitamin C production Significance and Impact of the Study : KB2194-320, a combination of two bacterial strains bred by spaceflight mutation, exhibited significantly improved 2-KLG productivity and hence could potentially increase the efficiency and reduce the cost of vitamin C production by the two-step fermentation process. In addition, a new pH indicator method was applied for rational screening of K2, which dramatically improved the efficiency of screening.

Letters in Applied Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C18H23N3O4S, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Weichao published the artcileA plate method for rapid screening of Ketogulonicigenium vulgare mutants for enhanced 2-keto-L-gulonic acid production, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Brazilian Journal of Microbiology (2017), 48(3), 397-402, database is CAplus and MEDLINE.

A new plate method was developed for rapid screening of Ketogulonicigenium vulgare mutants overproducing 2-keto-L-gulonic acid (2-KLG). The screening methodol. took the advantage of the acidity caused by 2-KLG, which changes the color of bromothymol blue (pH indicator) from blue to yellow. Using the proposed method, a mutant, K. vulgare 65, was selected from 20,000 colonies produced by a strain subjected to spaceflight mutagenesis. When co-cultured with Bacillus megaterium 2980 in 20-L fermenters, K. vulgare 65 showed a high conversion rate (94.45%) of l-sorbose to 2-KLG. In contrast to the traditional screening method, this one significantly improved the frequency of obtaining pos. mutants. Theproposed plate screening method is cost-effective and easy to run and is thus useful for the isolation and screening of K. vulgare mutants overproducing 2-KLG.

Brazilian Journal of Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C8H5F3N4, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Rui-jiao published the artcileStudy on effect of oxytocin combined with carboprost tromethamine in preventing postpartum hemorrhage in high-risk women, Category: alcohols-buliding-blocks, the publication is Zhongguo Fuyou Baojian (2016), 31(15), 3033-3035, database is CAplus.

Objective: To analyze the preventive effect of the combination of carboprost tromethamine and oxytocin on postpartum hemorrhage in cesarean section of high-risk women, and observe the occurrence of adverse reactions after maternal medication. Methods: A total of 120 high-risk pregnant women who were scheduled for cesarean delivery at the Obstetrics Department of Liaobu Hospital in Dongguan City were collected, and randomly divided into 3 groups. 40 cases in group A, who were given oxytocin alone. 40 patients in group B were treated with oxytocin combined with carboprost methylate suppository. 40 patients in group C were given oxytocin combined with carboprost tromethamine. The intraoperative and postoperative bleeding volume, postpartum hemorrhage, treatment and adverse reactions of the three groups were compared. Results: The intraoperative and postoperative 2 h bleeding volume of group B and group C were significantly lower than that of group A (P < 0.05), among which the difference of group C was more significant. The bleeding volume in group C was significantly lower than that in group A and group B at 2-24 h after operation (P < 0.05). The incidence of postpartum hemorrhage, blood transfusion rate, and treatment rate of other hemostatic measures in group B and group C were significantly lower than those in group A (P < 0.05). Conclusion: The combination of carboprost tromethamine and oxytocin can effectively reduce the amount of postpartum hemorrhage and the incidence of postpartum hemorrhage in high-risk women, and it is safe and worthy of further promotion.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C11H19N, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xianxian published the artcileExtraction of honokiol from Artemisia argyi and in vitro and in vivo investigation of its antifungal activity, SDS of cas: 90-64-2, the publication is Natural Product Research, database is CAplus and MEDLINE.

Extracts from plants used in Chinese medicine can be good sources of fungicides for agricultural applications. In this study, we separated and identified antifungal compounds from four traditional Chinese medicine extracts and evaluated their antifungal activities in vitro and in vivo. In vitro, honokiol extracted from Artemisia argyi showed broad-spectrum antimicrobial and mycelial inhibitory activity with EC50 in the range 3.56 – 33.85 μg/mL against eight plant pathogens. q-PCR indicated that honokiol might induce cell cancerisation and inhibit cellular respiration, which provided significant insights into honokiol function in tobacco resistance to mol. mechanisms of the phytopathogenic fungus Phytophthora nicotianae. In vivo, honokiol significantly decreased the rate of fungal infection in eggplants, potatoes, grapes, cherry tomatoes, and cucumbers, and enhanced disease resistance in tobacco. Overall, our results indicate that honokiol has the potential to control a variety of fungal and oomycete diseases, and A. argyi could be a source of honokiol.

Natural Product Research published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C20H21ClN4O4, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts