Category: alcohols-buliding-blocks

Jaya, Gladys Tiffany published the artcileOne-pot conversion of lignocellulosic biomass to ketones and aromatics over a multifunctional Cu-Ru/ZSM-5 catalyst, Quality Control of 645-56-7, the publication is Applied Catalysis, B: Environmental (2022), 121368, database is CAplus.

The complete conversion of lignocellulosic biomass to selective and highly valuable chems. is challenging because of its inertness and complexity. Herein, we report a direct chemocatalytic route for the complete one-pot conversion of raw woody biomass to cyclic ketones and aromatic monomers over a multifunctional bi-metallic Cu-Ru catalyst on HZSM-5 (Cu-Ru/Z). The Si/Al ratio of HZSM-5 plays an effective role in the product distribution. High-yield ketones (60.9% based on carbon in holocellulose) and aromatics (28.4% based on carbon in lignin) were produced in an aqueous medium. Three strategies, metal domain encapsulation inside the zeolitic framework, SiO₂ layer coating, and carbon layer coating, were employed to overcome the weak hydrothermal stability associated with HZSM-5. The carbon-coated Cu-Ru/Z catalyst exhibited high stability up to three reaction cycles. Optimization of the reaction conditions, reaction mechanisms for the selective ketone synthesis, and catalyst deactivation mechanisms are discussed.

Applied Catalysis, B: Environmental published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Quality Control of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Hui-xia published the artcileClinic efficacy of carboprost tromethamine in preventing vaginal delivery postpartum hemorrhage in subsequent pregnancy after cesarean parturition, Formula: C25H47NO8, the publication is Zhongguo Linchuang Yanjiu (2013), 26(6), 565-566, database is CAplus.

Objective To evaluate efficacy and safety of carboprost tromethamine (Hemabate) in preventing vaginal delivery postpartum hemorrhage in subsequent pregnancy after cesarean parturition. Methods: 96 cases of vaginal delivery subsequently pregnant women after cesarean parturition were randomly divided into observation group of 46 cases and control group of 50 cases, and the observation group was given oxytocin 20U by i.v. infusion after delivery and Hemabate 250μg by deep i.m. injection in hip, while the control group was given oxytocin 20U by i.v. infusion after delivery. Postpartum hemorrhage between the groups and postpartum hemorrhage amount in 2h were compared. Results: Observation group had one case of postpartum hemorrhage (2.17%), and control group had 6 cases of postpartum hemorrhage in (12.00%), and the two groups showed no significant difference (P > 0.05 ). Observation group had decrease in average 2h postpartum hemorrhage amount than the control group (207.34 ± 78.88) vs (263.64 ± 87.49) ml, and the difference was statistically significant P < 0.05. Conclusions: Hemabate can be used for preventing vaginal delivery postpartum hemorrhage in subsequent pregnancy after cesarean parturition with high safety, to some extent, can reduce the incidence of postpartum hemorrhage.

Zhongguo Linchuang Yanjiu published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lou, Sunqi published the artcileIn Situ Growth of CsPbBr₃ Perovskite Nanocrystals in Lead-Based Matrix toward Significantly Enhanced Water/Photo Stabilities, Name: 2-Hydroxy-2-phenylacetic acid, the publication is Advanced Optical Materials (2022), 10(1), 2101448, database is CAplus.

Perovskite nanocrystals (NCs) are considered as the next-generation platforms for optoelectronic applications, but their poor stability greatly restricts their development. Here, we present a facile composite strategy to synthesize highly stable CsPbBr₃/Pb-MA composite by in situ embedding the CsPbBr₃ NCs in a C₁₆H₁₄Br₂O₆Pb₂ (Pb-MA) organometallic compound (MOC). The CsPbBr₃/Pb-MA composite powders show intense green emission at 519 nm, with a photoluminescence quantum yield of about 48.5% and a full width at half-maximum of about 17 nm. More interestingly, benefitted from the protection of MOC, the CsPbBr₃/Pb-MA composites can maintain 43% and 83% of initial intensity after being illuminated under blue light for 36 h and being immersed in water for 192 h, resp. Compared to the original CsPbBr₃ NCs, the light/water stability of CsPbBr₃/Pb-MA composites is enhanced by about 40 and 700 times (the PL intensities maintain at about 60% of the initial one), resp. As a proof-of-concept, the as-fabricated devices exhibit a wide color gamut, 97.7% and 98.2% of Rec. 2020 for white light-emitting diodes and laser diodes, resp. These findings demonstrate that the combination of MOC and perovskite NCs is an optimized strategy for the exploitation of high-performance perovskite composites for their future optoelectronic applications.

Advanced Optical Materials published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Name: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dong, Chunwei published the artcile[Cu₃₆H₁₀(PET)₂₄(PPh₃)₆Cl₂] Reveals Surface Vacancy Defects in Ligand-Stabilized Metal Nanoclusters, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2021), 143(29), 11026-11035, database is CAplus and MEDLINE.

Precise identification and in-depth understanding of defects in nanomaterials can aid in rationally modulating defect-induced functionalities. However, few studies have explored vacancy defects in ligand-stabilized metal nanoclusters with well-defined structures, owing to the substantial challenge of synthesizing and isolating such defective metal nanoclusters. Herein, a novel defective copper hydride nanocluster, [Cu₃₆H₁₀(PET)₂₄(PPh₃)₆Cl₂] (Cu36; PET: phenylethanethiolate; PPh₃: triphenylphosphine), is successfully synthesized at the gram scale via a simple one-pot reduction method. Structural anal. reveals that Cu36 is a distorted half cubic nanocluster, evolved from the perfect Nichol’s half cube. The two surface copper vacancies in Cu36 are found to be the principal imperfections, which result in some structural adjustments, including copper atom reconstruction near the vacancies as well as ligand modifications (e.g., substitution, migration, and exfoliation). D. functional theory calculations imply that the above-mentioned defects have a considerable influence on the electronic structure and properties. The modeling suggests that the formation of defective Cu36 rather than the perfect half cube is driven by the enlargement of the energy gap between the HOMO and the LUMO of the nanocluster. The structural evolution induced by the surface copper atom vacancies provides atomically precise insights into the defect-induced readjustment of the local structure and introduces new avenues for understanding the chem. of defects in nanomaterials.

Journal of the American Chemical Society published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nematulloev, Saidkhodzha published the artcile[Cu₁₅(PPh₃)₆(PET)₁₃]²⁺: a Copper Nanocluster with Crystallization Enhanced Photoluminescence, Name: 2-Phenylethanethiol, the publication is Small (2021), 17(27), 2006839, database is CAplus and MEDLINE.

Due to their atomically precise structure, photoluminescent copper nanoclusters (Cu NCs) have emerged as promising materials in both fundamental studies and technol. applications, such as bio-imaging, cell labeling, phototherapy, and photo-activated catalysis. In this work, a facile strategy is reported for the synthesis of a novel Cu NCs coprotected by thiolate and phosphine ligands, formulated as [Cu₁₅(PPh₃)₆(PET)₁₃]²⁺, which exhibits bright emission in the near-IR (NIR) region (≈720 nm) and crystallization-induced emission enhancement (CIEE) phenomenon. Single crystal x-ray crystallog. shows that the NC possesses an extraordinary distorted trigonal antiprismatic Cu₆ core and a, unique among metal clusters, “tri-blade fan”-like structure. An in-depth structural investigation of the ligand shell combined with d. functional theory calculations reveal that the extended C-H···π and π-π intermol. ligand interactions significantly restrict the intramol. rotations and vibrations and, thus, are a major reason for the CIEE phenomena. This study provides a strategy for the controllable synthesis of structurally defined Cu NCs with NIR luminescence, which enables essential insights into the origins of their optical properties.

Small published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gong, Jun published the artcileIodization-enhanced fluorescence and circularly polarized luminescence for dual-readout probe design, Recommanded Product: 2-Phenylethanethiol, the publication is Sensors and Actuators, B: Chemical (2021), 130610, database is CAplus.

Circularly polarized luminescence (CPL) is a preferential emission from chiral systems. Introducing CPL to traditional small fluorescence probes will greatly enhance selectivity and sensitivity due to avoiding the background fluorescence. Small-mol. probes are practically useful for bioimaging and sensing but always suffer from weak CPL properties. To optimize chiral perturbation, the study of structure-CPL correlation is an urgent necessity. Here, we investigated the influence of 3, 3′-substituent of BINOL on optical properties and found that iodization could significantly enhance the fluorescence quantum yield (Φ_F) and dissymmetry factor (|g_lum|). Based on this finding, we presented a strategy to design dual-readout probes emiting both robust total fluorescence and CPL upon activation. As an application example, we first designed a pair of thiols probes, R/S-P1, with the fluorescence readout showing good linear response to cysteine, and CPL signal displaying significant enhancement with |g_lum| from undetectable value to 0.7 x 10^-3.

Sensors and Actuators, B: Chemical published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rajendran, Ranjith kumar published the artcileBiodegradation of the endocrine disrupter 4-tert-octylphenol by the yeast strain Candida rugopelliculosa RRKY5 via phenolic ring hydroxylation and alkyl chain oxidation pathways, Related Products of alcohols-buliding-blocks, the publication is Bioresource Technology (2017), 55-64, database is CAplus and MEDLINE.

4-(1,1,3,3-Tetramethylbutane)-phenol (4-tert-OP) is one of the most prevalent endocrine disrupting pollutants. Information about bioremediation of 4-tert-OP remains limited, and no study has been reported on the mechanism of 4-tert-OP degradation by yeasts. The yeast Candida rugopelliculosa RRKY5 was proved to be able to utilize 4-methylphenol, bisphenol A, 4-ethylphenol, 4-tert-butylphenol, 4-tert-OP, 4-tert-nonylphenol, isooctane, and phenol under aerobic conditions. The optimum conditions for 4-tert-OP degradation were 30°C, pH 5.0, and an initial 4-tert-OP concentration of 30 mg L^-1; the maximum biodegradation rate constant was 0.107 d^-1, equivalent to a min. half-life of 9.6 d. SEM revealed formation of arthroconidia when cells were grown in the presence of 4-tert-OP, whereas the cells remained in the budding form without 4-tert-OP. Identification of the 4-tert-OP degradation metabolites using liquid chromatog.-hybrid mass spectrometry revealed three different mechanisms via both branched alkyl side chain and aromatic ring cleavage pathways.

Bioresource Technology published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Xing-De published the artcileDesign, synthesis and structural-activity relationship studies of phanginin A derivatives for regulating SIK1-cAMP/CREB signaling to suppress hepatic gluconeogenesis, Name: Pentane-1,5-diol, the publication is European Journal of Medicinal Chemistry (2022), 114171, database is CAplus and MEDLINE.

Persistent activation of hepatic gluconeogenesis is a main cause of fasting hyperglycemia in patients with type 2 diabetes (T2D), and the salt-induced kinase 1 (SIK1) acts as a key modulator in regulating hepatic gluconeogenesis. Recently, we first reported phanginin A (PA, 1), a natural cassane diterpenoid isolated from the seeds of Caesalpinia sappan, exhibited potent anti-diabetic effect through activation of SIK1 and increasing PDE4 activity to inhibit hepatic gluconeogenesis pathway by suppressing the cAMP/PKA/CREB pathway in the liver. In present study, we designed and prepared 25 PA derivatives and their structure-activity relationship (SAR) for gluconeogenesis inhibitory activity were established. Among them, compound I exhibited remarkable inhibitory activity on hepatic gluconeogenesis by enhancing the SIK1 phosphorylation and ameliorated the hyperglycemia of type 2 diabetic mice. Our results supported that compound I could be served as a potential candidate for the treatment of T2D.

European Journal of Medicinal Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C16H24BF4Ir, Name: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Liqin published the artcileFK506-Binding Protein Ligands: Structure-Based Design, Synthesis, and Neurotrophic/Neuroprotective Properties of Substituted 5,5-Dimethyl-2-(4-thiazolidine)carboxylates, Computed Properties of 101-98-4, the publication is Journal of Medicinal Chemistry (2006), 49(14), 4059-4071, database is CAplus and MEDLINE.

Structure-based design and discovery of novel neuroimmunophilin FK506-binding protein (FKBP) ligands were pursued in the present study. The binding mode of the known FKBP ligand, 3-(3-pyridyl)-1-propyl- (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate, in a complex with FKBP12 was investigated using LUDI simulation and upon which a novel scaffold structure predicted to possess improved binding affinity was designed. A virtual combinatorial library composed of diverse combinations of two substituted groups was constructed using Project Library, followed by an automated screening of the library against the ligand binding site on FKBP52 using DOCK. Forty-three candidate compounds I [R¹ = Me₃C, EtCMe₂, cyclopentyl, cyclohexyl, n-hexyl, n-octyl, Ph, 4-ClC₆H₄, 2,4,6-Me₃C₆H₂, PhCMe₂CH₂; R² = 3-(3-pyridyl)-1-Pr, Ph(CH₂)₃, H₂C:CH(CH₂)₈, etc.] that displayed favorable binding with the receptor were identified and synthesized. The neurotrophic activity of the candidate compounds was evaluated on chick dorsal root ganglion cultures in vitro. As a result, 15 compounds exhibited pos. effects on ganglion neurite outgrowth in the presence of 0.15 ng/mL NGF, among which 7 compounds at testing concentrations of 1 pM and 100 pM showed greater efficacy than 1 at 100 pM. I [R¹ = Me₃C; R² = 3-(3-pyridyl)-1-propyl; (II)] afforded the most potent effect in promoting the processes of neurite outgrowth and which was in a concentration-dependent manner from 1 pM to 100 pM. Half-maximal effect occurred at about 10 pM. Moreover, II at a dosage of 10 mg/kg was found to be significantly neuroprotective in a mouse peripheral sympathetic nerve injury model induced by 8 mg/kg 6-hydroxydopamine. This study further suggests the clin. potential of novel FKBP ligands as a new therapeutic approach in the treatment of neurodegenerative disorders, such as Parkinson’s disease.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C9H11BO4, Computed Properties of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chung, Shu-Ting published the artcileSynthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives, SDS of cas: 27292-49-5, the publication is Research on Chemical Intermediates (2016), 42(2), 1195-1215, database is CAplus.

Several derivatives of 4H-chromene and chromeno[2,3-b]pyridine were efficiently prepared under microwave irradiation in a one-pot reaction, and their anti-inflammatory activities were evaluated. Six synthetic products (1b, 1c, 1h, 2d, 2j, and 2l) exhibited more powerfully inhibited the production of tumor necrosis factor-α-induced nitric oxide (NO) than quercetin and exhibited comparable cell viability in both human and porcine chondrocytes. In particular, 2d at dosages of 10 and 20 mg/kg had a very potent anti-inflammatory effect by suppressing the formation of carrageenan-induced rat paw edema and prostaglandin E₂. The results herein suggest that these compounds may have potential as structural templates in the design and development of new anti-inflammatory drugs.

Research on Chemical Intermediates published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, SDS of cas: 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts