Category: alcohols-buliding-blocks

Blaauwendraad, Sophia M. published the artcileAssociations of maternal urinary bisphenol and phthalate concentrations with offspring reproductive development, Synthetic Route of 80-09-1, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 119745, database is CAplus and MEDLINE.

Fetal exposure to bisphenols and phthalates may influence development of the reproductive system. In a population-based, prospective cohort study of 1059 mother-child pairs, we examined the associations of maternal gestational urinary bisphenols and phthalates concentrations with offspring reproductive development from infancy until 13 years. We measured urinary bisphenol and phthalate concentrations in each trimester. We obtained information on cryptorchidism or hypospadias after birth from medical records. At 9.7 years, we measured testicular and ovarian volume by MRI. At 13.5 years, we measured child Tanner stages and menstruation through questionnaire. We performed linear or logistic regression models for boys and girls to assess the associations of maternal urinary average and trimester-specific bisphenols and phthalates with child reproductive outcomes. Next, to further explore potential synergistic or additive effects of exposures together, we performed mixed exposure models using a quantile g computation approach. Models were adjusted for maternal age, ethnicity, body-mass index, education, parity, energy intake, smoking and alc. use, and childs gestational age at birth, birthweight and body-mass index. In boys, no associations of maternal gestational phthalate or bisphenol with offspring cryptorchidism and hypospadias were found. Higher maternal high-mol.-weight phthalate and total bisphenol, but not phthalic acid or low-mol.-weight phthalate, were associated with larger child testicular volume at 10 years. Higher maternal phthalic acid and total bisphenol were associated with earlier genital and pubic hair development at 13 years, resp. (p-values<0.05). In girls, we found no associations of maternal urinary bisphenol and phthalate with ovarian volume or menstrual age. Only higher maternal urinary high-mol.-weight phthalate was associated with earlier pubic hair development at 13 years (p-values <0.05). Higher mixture exposure was associated with earlier pubic hair development in both sexes. In conclusion, higher maternal gestational urinary bisphenol and phthalate concentrations were associated with alterations in offspring reproductive development, mainly in boys.

Environmental Pollution (Oxford, United Kingdom) published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Synthetic Route of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Black, Kvar C. L. published the artcileIn vivo fate tracking of degradable nanoparticles for lung gene transfer using PET and Ĉerenkov imaging, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Biomaterials (2016), 53-63, database is CAplus and MEDLINE.

Nanoparticles (NPs) play expanding roles in biomedical applications including imaging and therapy, however, their long-term fate and clearance profiles have yet to be fully characterized in vivo. NP delivery via the airway is particularly challenging, as the clearance may be inefficient and lung immune responses complex. Thus, specific material design is required for cargo delivery and quant., noninvasive methods are needed to characterize NP pharmacokinetics. Here, biocompatible poly(acrylamidoethylamine)-b-poly(DL-lactide) block copolymer-based degradable, cationic, shell-cross-linked knedel-like NPs (Dg-cSCKs) were employed to transfect plasmid DNA. Radioactive and optical beacons were attached to monitor biodistribution and imaging. The preferential release of cargo in acidic conditions provided enhanced transfection efficiency compared to non-degradable counterparts. In vivo gene transfer to the lung was correlated with NP pharmacokinetics by radiolabeling Dg-cSCKs and performing quant. biodistribution with parallel positron emission tomog. and Cerenkov imaging. Quantitation of imaging over 14 days corresponded with the pharmacokinetics of NP movement from the lung to gastrointestinal and renal routes, consistent with predicted degradation and excretion. This ability to noninvasively and accurately track NP fate highlights the advantage of incorporating multifunctionality into particle design.

Biomaterials published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Recommanded Product: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Samarajeewa, Sandani published the artcileDegradable Cationic Shell Cross-Linked Knedel-like Nanoparticles: Synthesis, Degradation, Nucleic Acid Binding, and in Vitro Evaluation, Product Details of C18H20N2O12, the publication is Biomacromolecules (2013), 14(4), 1018-1027, database is CAplus and MEDLINE.

In this work, degradable cationic shell crosslinked knedel-like (deg-cSCK) nanoparticles were developed as an alternative platform to replace similar nondegradable cSCK nanoparticles that have been utilized for nucleic acids delivery. An amphiphilic diblock copolymer poly(acrylamidoethylamine)₉₀-block-poly(DL-lactide)₄₀ (PAEA₉₀-b-PDLLA₄₀) was synthesized, self-assembled in aqueous solution, and shell crosslinked using a hydrolyzable crosslinker to afford deg-cSCKs with an average core diameter of 45 ± 7 nm. These nanoparticles were fluorescently labeled for in vitro tracking. The enzymic- and hydrolytic-degradability, siRNA binding affinity, cell uptake and cytotoxicity of the deg-cSCKs were evaluated. Esterase-catalyzed hydrolysis of the nanoparticles resulted in the degradation of ca. 24% of the PDLLA core into lactic acid within 5 d, as opposed to only ca. 9% degradation from aqueous solutions of the deg-cSCK nanoparticles in the absence of enzyme. Cellular uptake of deg-cSCKs was efficient, while exhibiting low cytotoxicity with LD50 values of ca. 90 and 30 μg/mL in RAW 264.7 mouse macrophages and MLE 12 cell lines, resp., ca. 5- to 6-fold lower than the cytotoxicity observed for nondegradable cSCK analogs. Addnl., deg-cSCKs were able to complex siRNA at an N/P ratio as low as 2, and were efficiently able to facilitate cellular uptake of the complexed nucleic acids.

Biomacromolecules published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Product Details of C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Watanabe, Bunta published the artcileSynthesis and inhibitory activity of substrate-analog fructosyl peptide oxidase inhibitors, SDS of cas: 20880-92-6, the publication is Bioorganic & Medicinal Chemistry Letters (2015), 25(18), 3910-3913, database is CAplus and MEDLINE.

Fructosyl peptide oxidases (FPOXs) play a crucial role in the diagnosis of diabetes. Their main function is to cleave fructosyl amino acids or fructosyl peptides into glucosone and the corresponding amino acids/dipeptides. In this study, the substrate-analog FPOX inhibitors were successfully designed and synthesized. These glycosyl-amino acid inhibitors mimic N^α-fructosyl-L-valine (Fru-Val), [N^α-fructosyl-L-valyl]-L-histidine (Fru-ValHis), and N^ε-fructosyl-L-lysine (εFru-Lys), resp. The secondary nitrogen atom in the natural substrates, linking fructose and amino acid or dipeptide moieties, was substituted in glycosyl-amino acids with a sulfur atom to avoid enzymic cleavage. Kinetic studies revealed that prepared glycosyl-amino acids act as competitive inhibitors against an FPOX obtained from Coniochaeta sp., and K_i values of 11.1, 66.8, and 782 μM were obtained.

Bioorganic & Medicinal Chemistry Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H15BF2O2, SDS of cas: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Satoh, Yasushi published the artcileHighly selective synthesis of hydrosiloxanes by Au-catalyzed dehydrogenative cross-coupling reaction of silanols with hydrosilanes, Computed Properties of 17877-23-5, the publication is ACS Catalysis (2017), 7(3), 1836-1840, database is CAplus.

We report a highly selective synthesis of siloxane building blocks containing SiH₂or SiH functionalities. The system AuCl(PPh₃)/PPh₃ or AuCl(PPh₃)/PBu₃ catalyzed the reaction of trihydrosilanes with silanols giving SiH₂-containing siloxanes exclusively. On the other hand, a highly selective reaction of dihydrosilanes with silanols to afford SiH-containing siloxanes was achieved by simply changing the phosphine ligand to a bidentate one, xantphos. Usefulness of SiH₂-containing siloxanes was demonstrated by the synthesis of a trisiloxane, Et₃SiOSi(Ph)(H)OSi^tBuMe₂, and a pentasiloxane, Ph₂Si(OSiHPhOSiEt₃)₂, bearing SiH functionalities.

ACS Catalysis published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Computed Properties of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Satoh, Yasushi published the artcileHighly selective synthesis of hydrosiloxanes by Au-catalyzed dehydrogenative cross-coupling reaction of silanols with hydrosilanes, Synthetic Route of 597-52-4, the publication is ACS Catalysis (2017), 7(3), 1836-1840, database is CAplus.

We report a highly selective synthesis of siloxane building blocks containing SiH₂or SiH functionalities. The system AuCl(PPh₃)/PPh₃ or AuCl(PPh₃)/PBu₃ catalyzed the reaction of trihydrosilanes with silanols giving SiH₂-containing siloxanes exclusively. On the other hand, a highly selective reaction of dihydrosilanes with silanols to afford SiH-containing siloxanes was achieved by simply changing the phosphine ligand to a bidentate one, xantphos. Usefulness of SiH₂-containing siloxanes was demonstrated by the synthesis of a trisiloxane, Et₃SiOSi(Ph)(H)OSi^tBuMe₂, and a pentasiloxane, Ph₂Si(OSiHPhOSiEt₃)₂, bearing SiH functionalities.

ACS Catalysis published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Synthetic Route of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Aliaga-Lavrijsen, Melanie published the artcileHydrolysis and Methanolysis of Silanes Catalyzed by Iridium(III) Bis-N-Heterocyclic Carbene Complexes: Influence of the Wingtip Groups, Name: Triethylsilanol, the publication is Organometallics (2015), 34(11), 2378-2385, database is CAplus.

New [Ir(CH₃CN)₂(I)₂{κC,C’-bis(NHC)}]BF₄ complexes featuring bis-NHC ligands with a methylene bridge and different N substitution (-CH₂CH₂CH₂CH₃ and -CH₂CH₂OPh) were synthesized. NMR studies and x-ray diffraction structures evidenced that the wingtip group -CH₂CH₂OPh presents a hemilabile behavior in solution, with the oxygen atom coordinating and dissociating at room temperature, which contrasts with the strong coordination of the ether functions in the complex [Ir(I)₂{κC,C’,O,O’-bis(NHC^OMe)}]BF₄ (bis(NHC^OMe) = methylenebis(N,N’-bis(2-methoxyethyl)imidazol-2-ylidene)), previously reported by us. These complexes proved to be efficient catalysts for the hydrolysis and methanolysis of silanes, affording mol. hydrogen and silyl alcs. or silyl ethers as the main reaction products in excellent yields. The hydrogen generation rates were very much dependent on the nature of the hydrosilane and the coordination ability of the wingtip group. The latter also played a key role in the recyclability of the catalytic system.

Organometallics published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Name: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tolmacheva, Irina A. published the artcileSynthesis and evaluation of antiviral activities of triterpenic conjugates with 2-aminobutan-1-ol as potent microbicidal agents, Recommanded Product: 2-Aminobutan-1-ol, the publication is Medicinal Chemistry Research (2019), 28(10), 1648-1660, database is CAplus.

The effect of the synthetic modifications of the triterpenic A ring on the level of antiviral activity of triterpenic C3, C28 amides with a residue of racemic, (S), or (R)-enantiomeric 2-aminobutan-1-ol against herpes simplex viruses type I (HSV-I) and type II (HSV-II), as well as against human immunodeficiency virus type I (HIV-1) was investigated. The 2,3-secolupane racemic amide 5a was selected as a potent microbicidal agent with the highest virus inhibitory (against HSV-I and HSV-II) and virucidal (against HSV-1 and HIV-1) actions, the antiviral activity of which was provided by the (S)-enantiomeric conjugate 5b.

Medicinal Chemistry Research published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C19H21N3O, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheng, Feixiong published the artcileIn Silico Assessment of Chemical Biodegradability, COA of Formula: C22H38O2, the publication is Journal of Chemical Information and Modeling (2012), 52(3), 655-669, database is CAplus and MEDLINE.

Biodegradation is the principal environmental dissipation process. Due to a lack of comprehensive exptl. data, high study cost and time-consuming, in silico approaches for assessing the biodegradable profiles of chems. are encouraged and is an active current research topic. We developed in-silico methods to estimate chem. biodegradability in the environment. At SST, 1440 diverse compounds tested under the Japanese Ministry of International Trade and Industry (MI-TI) protocol were used. Four different methods (support vector machine, k-nearest neighbor, naive B-ayes, and CU.5 decision tree) were used to build the combinatorial classification probability models of ready vs. not ready biodegradability using physicochem. descriptors and fingerprints sep. The overall predictive accuracies of the best models were >80% for the external test set of 164 diverse compounds Some privileged substructures were further identified for ready or not ready biodegradable chems. by combining information gain and substructure fragment anal. Here, 27 new predicted chems. were selected for exptl. assay through the Japanese MI-TI test protocols, which validated that all 27 compounds were predicted correctly. The predictive accuracies of our models outperform the commonly used software of the E-PI Suite. Our study provided critical tools for early assessment of biodegradability of new organic chems. in environmental hazard assessment.

Journal of Chemical Information and Modeling published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, COA of Formula: C22H38O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dimitrova, Maria published the artcileReactivity descriptors for the hydrogen bonding ability of aliphatic alcohols, HPLC of Formula: 2240-88-2, the publication is Journal of Molecular Structure (2003), 657(1-3), 317-324, database is CAplus.

A series of 18 aliphatic alcs. and their hydrogen-bonded complexes with ammonia are studied by applying d. functional theory computations at the B3LYP/631G(d,p) level. Theor. determined electronic parameters-partial at. charges and electrostatic potential at nuclei (EPN)-are employed to characterize the reactivity of the monomer alcs. The variations of binding energy are also interpreted in terms of the well-known exptl. solvatochromic parameters, α. It is shown that both the exptl. α constants and EPN values characterize quant. the reactivity of the studied mols. toward the complexation process. A linear link between α constants and EPN values was also found.

Journal of Molecular Structure published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, HPLC of Formula: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts