Category: alcohols-buliding-blocks

Bachovchin, Daniel A. published the artcileSuperfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening, Quality Control of 23351-09-9, the publication is Proceedings of the National Academy of Sciences of the United States of America (2010), 107(49), 20941-20946, S20941/1-S20941/172, database is CAplus and MEDLINE.

Serine hydrolases (SHs) are-one of the largest and most diverse enzyme classes in mammals. They play fundamental roles in virtually all physiol. processes and are targeted by drugs to treat diseases such as diabetes, obesity, and neurodegenerative disorders. Despite this, we lack biol. understanding for most of the 110+ predicted mammalian metabolic SHs, in large part because of a dearth of assays to assess their biochem. activities and a lack of selective inhibitors to probe their function in living systems. We show here that the vast majority (>80%) of mammalian metabolic SHs can be labeled in proteomes by a single, active site-directed fluorophosphonate probe. We exploit this universal activity-based assay in a library-vs.-library format to screen 70+ SHs against 140+ structurally diverse carbamates. Lead inhibitors were discovered for ∼40% of the screened enzymes, including many poorly characterized SHs: Global profiles identified carbamate inhibitors that discriminate among highly sequence-related SHs and, conversely, enzymes that share inhibitor sensitivity profiles despite lacking sequence homol. These findings indicate that sequence relatedness is not a strong predictor of shared pharmaol. within the SH superfamily. Finally, we show that lead carbamate inhibitors can be optimized into pharmacol. probes that inactivate individual SHs with high specificity in vivo.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yin, L. published the artcileDesign, synthesis and antibacterial activity of novel N-formylhydroxylamine derivatives as PDF inhibitors, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2011), 50B(5), 695-703, database is CAplus.

N-formylhydroxylamines RC(NH₂):COCH₂NHCOCHBuCH₂N(OH)CHO (R = substituted Ph) were synthesized through a multi-step protocol starting from H₂C(CO₂Et)₂. The newly synthesized compounds were screened for antibacterial activity. All the compounds exhibited potent in-vitro inhibitory activity against S. aureus and weak activity against K. pneumoniae.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C14H10O4S2, Recommanded Product: 3-(2-Chlorophenyl)-5-isoxazolemethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Yang published the artcilePorous organic cage for enantiomeric fluorescence recognition of amino acid and hydroxy acid, COA of Formula: C8H8O3, the publication is Luminescence (2021), 36(8), 2022-2027, database is CAplus and MEDLINE.

A new method based on the enantioselective recognition of porous organic cages CC3-R was established for the first time. Porous organic cages are widely used for separation, adsorption and host-guest interaction sensing, but are rarely used for fluorescence sensing. Based on the inherent chiral environment of CC3-R and the inherent fluorescence properties of the organic ligands constituting the cage, when different chiral monomers diffuse into the cage, different effects occur to produce changes in fluorescence. We found for the first time that the fluorescence of CC3-R can be enhanced and quenched by tyrosine and mandelic acid, resp., and that different chiral monomers are enhanced or quenched differently at the same concentration Unlike the chiral recognition of other composite luminescent materials, the chiral porous organic cage not only utilizes its own host-guest effect for chiral recognition, but also utilizes the organic ligands constituting the cage for luminescence recognition. This work provides an alternative method to accomplish chiral recognition other than chromatog., that is using porous organic cages (POC), but it can show the advantages of simplicity, low cost and high sensitivity. We believe this work could provide valuable thoughts in the exploration of POC in chiral recognition as new FL probes for the future.

Luminescence published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, COA of Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xi-Zhao published the artcileConcise synthesis and antimicrobial activities of new substituted 5-isoxazolpenicillins, Computed Properties of 438565-33-4, the publication is Journal of the Chinese Chemical Society (Taipei, Taiwan) (2007), 54(3), 643-652, database is CAplus.

The synthesis of a series of penicillin aryl-isoxazole derivatives, such as I [R = Ph, C₆H₄-4-F, -2-Cl, -4-Cl, -2-Br, -2-OMe, -4-OMe, -3-NO₂, -4-NO₂, -3-CF₃, -4-CF₃, C₆H₃-2,4-Cl₂, -3,4-Cl₂, C₆H₂-2,4,5-Cl₃, -3,4,5-Cl₃, pyridin-2-yl, pyridin-4-yl], were prepared via amidation reactions of the corresponding aryl-substituted isoxazolecarbonyl chlorides with 6-aminopenicillanic acid. Concise large-scale synthesis of the 3,5-disubstituted isoxazoles by 1,3-dipolar cycloaddition reactions of the intermediate aryloximes RCH:NOH with HCCCH₂OH using CuSO₄.5H₂O as catalyst was also investigated. Some of the synthesized compounds were assayed for antimicrobial activities, showing satisfactory antimicrobial activities against Gram-neg. bacteria.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C4H7BrO2, Computed Properties of 438565-33-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Datong published the artcileSynthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings, Category: alcohols-buliding-blocks, the publication is Archives of Pharmacal Research (2010), 33(6), 831-842, database is CAplus and MEDLINE.

Two series of novel 2-Bu succinate-based Hydroxamate derivatives containing isoxazole rings, e.g. I [R = H, i-Bu], were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcusaureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.

Archives of Pharmacal Research published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C8H14O4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xin, Zhuo published the artcileRu-Catalyzed Switchable N-Hydroxyethylation and N-Acetonylation with Crude Glycerol, SDS of cas: 101-98-4, the publication is ChemSusChem (2020), 13(8), 2007-2011, database is CAplus and MEDLINE.

Highly efficient Ru-catalyzed selective C-C or C-O bond cleavage of polyols (e.g., crude glycerol) for N-hydroxyethylation or N-acetonylation of amines to give β-amino alcs. RR¹N(CH₂)₂OH [R = Ph, 2-MeC₆H4, 4-ClC₆H₄, etc.; R¹ = Me, Et, Bn, etc.] and β-amino ketones ArNR₂CH₂C(O)Me [Ar = Ph, 2-MeC₆H₄, 4-BrC₆H₄, etc.; R² = Me, Bn, etc.] in moderate-to-excellent yields was achieved through the hydrogen-borrowing approach. The use of new redox-active catalysts containing bisphosphine/thienylmethylamine ligands allowed this hydrogen-borrowing system to be operated selectively under both basic and acidic conditions.

ChemSusChem published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H4N2O2, SDS of cas: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Si published the artcileFitness analysis between the L-sorbosone dehydrogenase modules and Ketogulonigenium vulgare chassis, Synthetic Route of 526-98-7, the publication is Shengwu Gongcheng Xuebao (2016), 32(9), 1224-1232, database is CAplus and MEDLINE.

Ketogulonigenium vulgare is an acid-producing strain in the process of two-step vitamin C fermentation L-sorbosone dehydrogenase (SNDH) is one of the key enzymes during the biosynthesis of 2-keto-L-gulonic acid (2-KGA), the precursor of vitamin C. However, the catalytic mechanism of SNDH is unclear. According to the whole genome sequencing of K. vulgare, two genes encoding sorbosone dehydrogenases, one derived from the chromosome (named as sndhg) and one from plasmid (named as sndhp), were introduced into an industrial strain K. vulgare. The overexpression of gene sndhg had hardly effect on 2-KGA production, and the overexpression of gene sndhp produced an obvious byproduct in the fermentation broth. Combinational expression of sndhg/sndhp with pqqA (obtaining sndhg-pqqA and sndhp-pqqA modules) in K. vulgare resulted in the similar fermentation phenotype to two previous strains. After serial sub-cultivation of co-cultured Bacillus endophyticus with each engineered K. vulgare for 50 d, the conversion rate of 2-KGA increased by 15.4%, 179%, 0.65% and 125% compared with that of the parental K. vulgare with B. endophyticus. This study shows that adaptive evolution of microbial consortium is an effective strategy to increase the fitness between functional modules and chassis, thus quickly getting better strains for production of 2-KGA.

Shengwu Gongcheng Xuebao published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Synthetic Route of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Si published the artcileComparative analysis of L-sorbose dehydrogenase by docking strategy for 2-keto-L-gulonic acid production in Ketogulonicigenium vulgare and Bacillus endophyticus consortium, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Journal of Industrial Microbiology & Biotechnology (2016), 43(11), 1507-1516, database is CAplus and MEDLINE.

Improving the yield of 2-keto-L-gulonic acid (2-KGA), the direct precursor of vitamin C, draws more and more attention in industrial production In this study, we try to increase the 2-KGA productivity by computer-aided selection of genes encoding L-sorbose dehydrogenases (SDH) of Ketogulonicigenium vulgare. First, six SDHs were modeled by docking strategy to predict the binding mode with co-factor PQQ. The binding energy between SSDA1-H/SSDA1-L and PQQ was the highest, followed by SSDA3/SSDA2. The binding energy between SSDA1-P/SSDB and PQQ was the lowest. Then, these genes were overexpressed, resp., in an industrial strain K. vulgare HKv604. Overexpression of ssda1-l and ssda1-h enhanced the 2-KGA production by 7.89 and 12.56 % in mono-cultured K. vulgare, and by 13.21 and 16.86 % when K. vulgare was co-cultured with Bacillus endophyticus. When the engineered K. vulgare SyBE_Kv000116013 (overexpression of ssda1-p) or SyBE_Kv000116016 (overexpression of ssdb) was co-cultured with B. endophyticus, the 2-KGA production decreased significantly. The docking results were in accordance with the exptl. data, which indicated that computer-aided modeling is an efficient strategy for screening more efficient enzymes.

Journal of Industrial Microbiology & Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Shen published the artcileHighly efficient and selective oxidation of various substrates under mild conditions using a lanthanum-containing polyoxometalate as catalyst, Formula: C6H16OSi, the publication is Applied Catalysis, A: General (2013), 188-194, database is CAplus.

A La-containing polyoxometalate (POM) of DA₁₁[La(PW₁₁O₃₉)₂] (denoted as DA-La(PW₁₁)₂; DA = Decyltrimethylammonium cation) is highly efficient and selective for oxidation of various substrates including alkenes, alkenols, sulfides, silane and alc. with only one equivalent H₂O₂ as oxidant at 25°, and the POM catalyst can be easily recovered and reused for ten times without obvious decrease of catalytic activity and the yields for catalyst recovery are all >95%. The epoxidation of cis-cyclooctene proceeds efficiently in 98% yield with only 0.08 mol% of DA-La(PW₁₁)₂, and the turnover number (TON) can reach ≤1200 at 25°.

Applied Catalysis, A: General published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C15H14N2, Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Yuan published the artcileTheoretical study on the formation mechanisms, dynamics and the effective catalysis of the nitrophenols, Category: alcohols-buliding-blocks, the publication is ChemistrySelect (2018), 3(36), 10188-10197, database is CAplus.

The hydrogen abstraction reactions of mono-substituted phenols and nitrogen dioxide may be the sources of HONO and phenoxy radical. Further addition reaction of NO₂ and phenoxy radical can form 2-nitrophenol (2-NP) and 4-nitrophenol (4-NP). The specific formation mechanisms and dynamics of NPs have drawn significant attention in recent days. The promoted reaction mechanisms by water, phenol and intermediate have also been studied. Compared with the naked reaction, the catalytic pathways can reduce the energy barrier from 48.40 kcal/mol to 18.23, 23.03 and 18.87 kcal/mol to form 2-NP, resp. Water mols. are the most effective catalysts, and the energy barrier could be further reduced to 8.20 kcal/mol when three water mols. are participating in the reaction. Water mols. can not only promote the formation of 4-NP, but also simplify the reaction steps. In general, the water mols. serve as catalysts in the formation of NPs. The rate constants of 2-NP and its hydrates have been predicted. The results are listed as follows: k_2-NP =3.82×10^-13; k_2-NP-1W =2.43×10^-7; k_2-NP-2W =3.39×10^-4 cm³mol.^-1s^-1. The rate constants of mono-substituted phenols (methylamino phenol, aminophenol and hydroquinone) and NO₂ are also predicted by the traditional transitional state theory and variational transition state theory using the B3LYP/6-311++G(3df,3pd)//6-311++G(d). For the most dominant path, the rate constants for o/m/p-methylaminophenol are 1.91×10^-14, 4.28×10^-20 and 8.78×10^-15 cm³mol.^-1s^-1, resp.

ChemistrySelect published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts