Category: alcohols-buliding-blocks

Fan, Weihua published the artcileDegradation of phenanthrene by consortium 5H under hypersaline conditions, Product Details of C11H8O3, the publication is Environmental Pollution (Oxford, United Kingdom) (2022), 119730, database is CAplus and MEDLINE.

PAHs have been widely detected to accumulate in saline and hypersaline environments. Moderately halophilic microbes are considered the most suitable player for the elimination of PAHs in such environments. In this study, consortium 5H was enriched under 5% salinity and completely degraded phenanthrene in 5 days. By high-throughput sequencing, consortium 5H was identified as being mainly composed of Methylophaga, Marinobacter and Thalassospira. Combined with the investigation of intermediates and enzymic activities, the degradation pathway of consortium 5H on phenanthrene was proposed. Consortium 5H was identified as having the ability to tolerate a wide range of salinities (1%-10%) and initial PAH concentrations (50 mg/L to 400 mg/L). It was also able to function under neutral to weak alk. conditions (pH from 6 to 9) and the phytotoxicity of the produced intermediates showed no significant difference with distilled water. Furthermore, the metagenome of consortium 5H was measured and analyzed, which showed a great abundance of catabolic genes contained in consortium 5H. This study expanded the knowledge of PAH-degradation under hypersaline environments and consortium 5H was proposed to have good potential for the elimination of PAH pollution in saline/hypersaline environments.

Environmental Pollution (Oxford, United Kingdom) published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Choi, Jae Yeon published the artcileDevelopment of ⁶⁸Ga-labeled mannosylated human serum albumin (MSA) as a lymph node imaging agent for positron emission tomography, Product Details of C13H15NO6S, the publication is Nuclear Medicine and Biology (2011), 38(3), 371-379, database is CAplus and MEDLINE.

Introduction: Although many sentinel lymph node (SLN) imaging agents labeled with ^99mTc have been developed, no positron-emitting agent has been specifically designed for SLN imaging. Furthermore, the development of the beta probe and the requirement for better image resolution have increased the need for a positron-emitting SLN imaging agent. Here, we describe the development of a novel positron-emitting SLN imaging agent labeled with ⁶⁸Ga. Methods: A mannosylated human serum albumin (MSA) was synthesized by conjugating α-D-mannopyranosylphenyl isothiocyanate to human serum albumin in sodium carbonate buffer (pH 9.5), and then 2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid was conjugated to synthesize NOTA-MSA. Numbers of mannose and NOTA units conjugated in NOTA-MSA were determined by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. NOTA-MSA was labeled with ⁶⁸Ga at room temperature The stability of ⁶⁸Ga-NOTA-MSA was checked in labeling medium at room temperature and in human serum at 37°C. Biodistribution in normal ICR mice was investigated after tail vein injection, and micro-positron emission tomog. (PET) images were obtained after injecting ⁶⁸Ga-NOTA-MSA into a tail vein or a footpad. Results: The numbers of conjugated α-D-mannopyranosylphenyl isothiocyanate and 2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid units in NOTA-MSA were 10.6 and 6.6, resp. The labeling efficiency of ⁶⁸Ga-NOTA-MSA was greater than 99% at room temperature, and its stability was greater than 99% at 4 h. Biodistribution and micro-PET studies of ⁶⁸Ga-NOTA-MSA showed high liver and spleen uptakes after i.v. injection. ⁶⁸Ga-NOTA-MSA injected into a footpad rapidly migrated to the lymph node. Conclusions: ⁶⁸Ga-NOTA-MSA was successfully developed as a novel SLN imaging agent for PET. NOTA-MSA is easily labeled at high efficiency, and s.c. administered ⁶⁸Ga-NOTA-MSA was found to migrate rapidly to the lymph node.

Nuclear Medicine and Biology published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Product Details of C13H15NO6S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cho, Hea-Young published the artcileGastrointestinal and hepatic first-pass effects of triflusal in rats, SDS of cas: 328-90-5, the publication is Yakche Hakhoechi (2001), 31(4), 265-271, database is CAplus.

In order to elucidate the influence of intestinal and hepatic first-pass effect on the pharmacokinetics of triflusal, the biotransformation of triflusal in the gastrointestinal tract and liver was designed. Moreover, we tried to establish an HPLC method applicable for bioassay and available to pharmacokinetics, not only with the simultaneous determination of triflusal and its active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), but also with improving sensitivity. After the administration of triflusal (10 mg/kg) and HTB (10 mg/kg) into femoral vein, portal vein (only triflusal) and oral route (only triflusal), pharmacokinetic parameters were investigated from the plasma concentration-time profiles of triflusal and HTB in rats. An HPLC method was developed for the simultaneous determination of triflusal and HTB in rat plasma, urine and bile. The HPLC anal. was carried out using a C18 column and acetonitrile-methanol-water (25:10:65, volume/volume/v) as the mobile phase and UV detection at 234 nm. Furosemide was used as the internal standard The calibration curves were linear over the concentration range 0.05-5.0 μg/mL for triflusal and 0.2-200.0 μg/mL for HTB with correlation coefficients greater than 0.999 and with intra-day or inter-day coefficients of variation not exceeding 10.0%. This assay procedure was applied to the study of metabolite pharmacokinetics of triflusal and HTB in rats. It was supposed that triflusal was almost metabolized in vivo because urinary and biliary excreted amounts of triflusal could be ignored as it was lower than 1.2 % of the administered dose. According to the gastrointestinal and hepatic biotransformation pathways of triflusal, it was found that triflusal was hydrolyzed by about 5 % in intestine and metabolized by about 53 % in liver, and that the bioavailability of triflusal after oral administration of triflusal was 0.44, and also that the fraction of total elimination rate of triflusal which formed HTB in liver (F_mi, %) was about 98%. These results showed that triflusal was almost metabolized in liver, and the total elimination of triflusal in the body was dependent to the formation rate of HTB from triflusal in liver.

Yakche Hakhoechi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, SDS of cas: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cho, Hea-Young published the artcileSimultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography, HPLC of Formula: 328-90-5, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2003), 798(2), 257-264, database is CAplus and MEDLINE.

A rapid, selective and sensitive HPLC method was developed and validated for the simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl HOBz (HTB), in rat and human plasma. HPLC anal. was carried out using a 5-μm particle size, C₁₈-bonded SiO₂ column and MeCN-MeOH-H₂O (25:10:65, volume/volume/v) as the mobile phase and UV detection at 234 nm. Furosemide was used as the internal standard The method involved extraction with an MeCN-CHCl₃ mixture (60:40, volume/volume) and evaporation to dryness with N stream. The chromatograms showed good resolution and sensitivity and no interferences by plasma constituents. The mean absolute recovery for human plasma was 93.5 ± 4.2% for triflusal and 98.5 ± 3.1% for HTB. The lower limits of quantification of triflusal and HTB in human plasma were 20 and 100 ng/mL, resp. The calibration curves in human plasma were linear over the concentration range 0.02-5.0 μg/mL for triflusal and 0.1-200.0 μg/mL for HTB with correlation coefficients >0.999 and with inter- or intra-day coefficients of variation (CV) not exceeding 10.0%. This assay procedure was applied to the study of metabolite pharmacokinetics of triflusal and HTB in rat and human.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, Jungjoon published the artcileFlexible Tetrahydropyran Synthesis from Homopropargylic Alcohols Using Sequential Pd-Au Catalysis, Application of (R)-Oxiran-2-ylmethanol, the publication is Organic Letters (2017), 19(1), 242-245, database is CAplus and MEDLINE.

A flexible synthetic method toward highly substituted tetrahydropyran is reported. The key transformation involves atom-efficient sequential metal catalysis consisting of Pd-catalyzed addition of homopropargylic alcs. to alkoxyallene and the subsequent gold(I)-catalyzed cycloisomerization. Notably, this method gives access to both 2,6-cis- and 2,6-trans-tetrahydropyrans, e.g., I, possessing diverse substitution patterns.

Organic Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application of (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kopriva, Ivica published the artcileNon-negative Least Squares Approach to Quantification of ¹H Nuclear Magnetic Resonance Spectra of Human Urine, Formula: C8H8O3, the publication is Analytical Chemistry (Washington, DC, United States) (2021), 93(2), 745-751, database is CAplus and MEDLINE.

Because of its quant. character and capability for high-throughput screening, ¹H NMR (NMR) spectroscopy is used extensively in the profiling of biofluids such as urine and blood plasma. However, the narrow frequency bandwidth of ¹H NMR spectroscopy leads to a severe overlap of the spectra of components present in the complex mixtures such as biofluids. Therefore, ¹H NMR-based metabolomics anal. is focused on targeted studies related to concentrations of the small number of metabolites. Here, we propose a library-based approach to quantify proportions of overlapping metabolites from ¹H NMR mixture spectra. The method boils down to the linear non-neg. least squares (NNLS) problem, whereas proportions of the pure components contained in the library stand for the unknowns. The method is validated on an estimation of the proportions of (i) the 78 pure spectra, presumably related to type 2 diabetes mellitus (T2DM), from their synthetic linear mixture; (ii) metabolites present in 62 ¹H NMR spectra of urine of subjects with T2DM and 62 ¹H NMR spectra of urine of control subjects. In both cases, the inhouse library of 210 pure component ¹H NMR spectra represented the design matrix in the related NNLS problem. The proposed method pinpoints 63 metabolites that in a statistically significant way discriminate the T2DM group from the control group and 46 metabolites discriminating control from the T2DM group. For several T2DM-discriminative metabolites, we prove their presence by independent anal. determination or by pointing out the corresponding findings in the published literature.

Analytical Chemistry (Washington, DC, United States) published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bhattacharya, Ushashi published the artcileSurface charge manipulation and electrostatic immobilization of synaptosomes for super-resolution imaging: a study on tau compartmentalization, Category: alcohols-buliding-blocks, the publication is Scientific Reports (2021), 11(1), 18583, database is CAplus and MEDLINE.

Synaptosomes are subcellular fractions prepared from brain tissues that are enriched in synaptic terminals, widely used for the study of neural transmission and synaptic dysfunction. Immunofluorescence imaging is increasingly applied to synaptosomes to investigate protein localization. However, conventional methods for imaging synaptosomes over glass coverslips suffer from formaldehyde-induced aggregation. Here, we developed a facile strategy to capture and image synaptosomes without aggregation artifacts. First, ethylene glycol bis(succinimidyl succinate) (EGS) is chosen as the chem. fixative to replace formaldehyde. EGS/glycine treatment makes the zeta potential of synaptosomes more neg. Second, we modified glass coverslips with 3-aminopropyltriethoxysilane (APTES) to impart pos. charges. EGS-fixed synaptosomes spontaneously attach to modified glasses via electrostatic attraction while maintaining good dispersion. Individual synaptic terminals are imaged by conventional fluorescence microscopy or by super-resolution techniques such as direct stochastic optical reconstruction microscopy (dSTORM). We examined tau protein by two-color and three-color dSTORM to understand its spatial distribution within mouse cortical synapses, observing tau colocalization with synaptic vesicles as well postsynaptic densities.

Scientific Reports published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ding, Shi published the artcileExploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is Archiv der Pharmazie (Weinheim, Germany) (2019), 352(11), 1900129, database is CAplus and MEDLINE.

To gain further knowledge of the structure-activity relationship and druggability of novel oxazolidinone-based UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) inhibitors as Gram-neg. antibacterial agents, compounds containing the hydrophobic tails with different lengths and terminal substitutions were synthesized and their antibacterial activities against standard and clin. isolated Gram-neg. strains were evaluated. We summarized their structure-activity relationships and found that oxazolidinone-based compounds exhibited a narrower antibacterial spectrum compared with threonine-based compounds Furthermore, we parallelly compared the metabolic stabilities of the compounds with the classic threonine scaffold and the novel oxazolidinone scaffold in liver microsomes. The results indicated that the druggability of the oxazolidinone scaffold may be inferior to the classic threonine scaffold in the design of LpxC inhibitors.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diao, Xinyong published the artcileRational design of oligomeric MoO₃ in SnO₂ lattices for selective hydrodeoxygenation of lignin derivatives into monophenols, Name: 4-Propylphenol, the publication is Journal of Catalysis (2021), 234-251, database is CAplus.

Novel Mo-Sn bimetallic oxide catalysts with highly dispersed oligomeric MoO₃ in SnO₂ lattices, which were synthesized by the co-precipitation method and pretreated by anhydrous ethanol, were first employed in the hydrodeoxygenation of various lignin derivatives to produce monophenols with high activity and selectivity. In comparison with the pure α-MoO₃ and the previous reported catalysts, the α-2Mo1Sn exhibited superior activity in the hydrodeoxygenation of guaiacol, with full conversion and 92.5% phenol yield at 300°C under 4 MPa initial H₂ pressure in n-hexane for 4 h. According to comprehensive characterizations and catalytic measurements, the excellent performance of α-2Mo1Sn was ascribed to the formation of abundant Sn-O-Mo-O_V interfacial sites, which possessed strong Mo-Sn interaction with enhanced surface area, electron-donating group binding ability, Lewis acidity, and redox ability. It was demonstrated that over the present α-2Mo1Sn catalyst system, the Sn-O-Mo-O_V interfacial sites could greatly facilitate the adsorption and activation of C_aromatic-OCH₃ and C_aromatic-CH₃ bonds, and thus significantly promote the demethoxylation and demethylation reaction to produce phenol. This work figures out the rational design of MoO₃-based catalyst and displays a clear potential for the selective hydrodeoxygenation of lignin derivatives into monophenols.

Journal of Catalysis published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Name: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diao, Xinyong published the artcileFabricating high temperature stable Mo-Co₉S₈/Al₂O₃ catalyst for selective hydrodeoxygenation of lignin to arenes, COA of Formula: C9H12O, the publication is Applied Catalysis, B: Environmental (2022), 121067, database is CAplus.

Achieving high-temperature stability/duration without compromising the activity remains an arduous task in catalyst design, particularly for MoS₂ materials. Herein, a robust catalyst with Mo doped Co₉S₈ nanoparticles anchored on Al₂O₃ matrix is fabricated, which could selectively convert lignin to arenes with high hydrodeoxygenation activity, selectivity and particularly excellent stability. In the hydrodeoxygenation of di-Ph ether, this catalyst afforded 99.8% conversion and 91.0% yield of benzene at 265°C for at least 10 reaction runs. The resultant Mo-Co₉S₈ structure with chem. connection by covalent bonds of Mo-S-Co type on the Co₉S₈ surface demonstrates strong ability in the adsorption and activation of oxygen-containing substrates, which enables the effective C-O cleavage while avoids undesirable hydrogenation of benzene ring. The superior stability and water-resistance at elevated temperature was attributed to the anchoring effect of Al₂O₃ matrix and “protection” of surface-rich Co₉S₈ species to the active Mo-Co₉S₈ center. This strategy provides new sights for the rational design of efficient and stable sulfide catalysts toward the applications in demanding high-temperature reactions.

Applied Catalysis, B: Environmental published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, COA of Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts