Category: alcohols-buliding-blocks

Zhu, Da-Liang published the artcileNickel-Catalyzed Etherification of Phenols and Aryl Halides through Visible-Light-Induced Energy Transfer, Product Details of C9H12O, the publication is Organic Letters (2021), 23(21), 8327-8332, database is CAplus and MEDLINE.

A visible-light-initiated, nickel-catalyzed O-arylation of phenols with arylhalides using t-BuNH(i-Pr) as the base and thioxanthen-9-one as the photosensitizer under visible light was reported. This photocoupling exhibited a broad substrate scope.

Organic Letters published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H8BNO3, Product Details of C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ganda, Sylvia published the artcileBiodegradable Glycopolymeric Micelles Obtained by RAFT-controlled Radical Ring-Opening Polymerization, COA of Formula: C12H20O6, the publication is Macromolecules (Washington, DC, United States) (2016), 49(11), 4136-4146, database is CAplus.

The design and synthesis of an entirely degradable glycopolymer micelle was presented. This design relies on the utilization of RAFT-controlled radical ring-opening polymerization (rROP) technique to afford multiple insertions of cleavable ester linkages onto the backbone of the corona. RAFT polymerization using a macroRAFT agent based on poly(ε-caprolactone) PCL was employed to control the polymerization of well-defined statistical glycopolymers of 1-O-acryloyl-2,3:4,5-di-O-isopropylidene-β-D-fructopyranose (1-O-AiPrFru) and 5,6-benzo-2-methylene-1,3-dioxepane (BMDO) monomer. Three block copolymers were synthesized to generate poly(ε-caprolactone)-b-poly[(1-O-acryloyl-2,3:4,5-di-O-isopropylidene-β-D-fructopyranose)-co-(5,6-benzo-2-methylene-1,3-dioxepane)] (PCL-b-P[(1-O-AiPrFru)-co-(BMDO)]) with varying block lengths. Self-assembly of the deprotected block copolymers generated nonspherical egg shaped micelles, where the shorter chains PCL₁₀₆-b-P[(1-O-AFru)₆₉-co-(BMDO)₉] underwent self-assembly forming micelles with the hydrodynamic diameter (D_H) of 106 nm. The biodegradation of these micelles were investigated via enzymic degradation by Lipase Pseudomonas sp., indicating entirely degradable architectures, which are no longer visible via dynamic light scattering (DLS). SEC further confirmed the appearance of fragmented glycopolymeric units. In vitro cell proliferation assay of the micelles and their degradation products revealed no toxicity against healthy human fibroblast HS27 and breast cancer MDA-MB-231 cell lines. The polymer concentration range tested was up to 0.20 mg·mL^-1 with the cell viabilities of ≥95%.

Macromolecules (Washington, DC, United States) published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Zhixiang published the artcileOxalic Diamides and tert-Butoxide: Two Types of Ligands Enabling Practical Access to Alkyl Aryl Ethers via Cu-Catalyzed Coupling Reaction, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2019), 141(8), 3541-3549, database is CAplus and MEDLINE.

A robust and practical protocol for preparing alkyl aryl ethers has been developed, which relies on using two types of ligands to promote Cu-catalyzed alkoxylation of (hetero)aryl halides. The reaction scope is very general for a variety of coupling partners, particularly for challenging secondary alcs. and (hetero)aryl chlorides. In case of coupling with aryl chlorides and bromides, two oxalic diamides serve as the powerful ligands. The tert-butoxide is first demonstrated as a ligand for Cu-catalyzed coupling reaction, leading to alkoxylation of aryl iodides complete at room temperature Addnl., a number of carbohydrate derivatives are applicable for this coupling reaction, affording the corresponding carbohydrate-aryl ethers in 29-98% yields.

Journal of the American Chemical Society published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Haolan published the artcilePreparation of highly dispersed Cu catalysts from hydrotalcite precursor for the dehydrogenation of 1,4-butanediol, Quality Control of 111-29-5, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2021), 251-259, database is CAplus.

Copper-based catalysts are widely used in methanol synthesis, selective catalytic reduction of NOx, hydrogenation, dehydrogenation and hydrogenolysis reactions. In this work, a series of Cux/Zn₃–₀.₅xMg₃–₀.₅xAl₂O₉-x catalysts were prepared via the controlled calcination and reduction of hydrotalcite-like structured CuxZn₃–₀.₅xMg₃–₀.₅xAl₂(OH)₁₆CO₃ precursors. The formation process of Cu₂/Zn₂Mg₂Al₂O₇ from Cu₂Zn₂Mg₂Al₂(OH)₁₆CO₃ was characterized via several techniques. Characterizations results indicated that the dispersion of Cu in reduced Cu₂/Zn₂Mg₂Al₂O₇ reached 79.3%, and it exhibited excellent activity for the dehydrogenation of 1,4-butanediol (1,4-BDO) to γ-butyrolactone (GBL). The detected conversion of 1,4-BDO reached 99.2% with a 99.5% selectivity of GBL at 240°C, 0.1 MPa and LHSV-1 = 0.13 h, and the calculated productivity of GBL was 7.07 g-GBL/g-cat/h. And Cu₂/Zn₂Mg₂Al₂O₇ could maintain its activity within 50 h on stream.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Quality Control of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hu, Yiping published the artcileDesign, Synthesis, Molecular Docking Studies of Deferasirox Derivatives of 1,2,4-Triazole as Potential Antimicrobial Agents, Formula: C8H5F3O3, the publication is ChemistrySelect (2021), 6(45), 12914-12920, database is CAplus.

A series of deferasirox derivatives of 1,2,4-triazole I (R¹ = H, CF₃; R² = R³ = H, CF₃, COOH, COOMe, COOEt) were designed and synthesized by the ring-opening rearrangement reaction of Ph hydrazine or its substituents and imines, some compounds are previously unknown. The antibacterial activities of all compounds against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Candida albicans and Aspergillus niger were exptl. evaluated. Most of them exhibited potential antimicrobial activity and promising antifungal activity. Especially, I (R¹ = CF₃; R² = COOEt; R³ = H) and I (R¹ = CF₃; R² = H; R³ = COOEt) showed the best antimicrobial activity (MIC₉₀ = 0.125-2.0μg/mL) against Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli, while compounds I (R¹ = R² = H; R³ = COOMe), I (R¹ = CF₃; R² = COOMe; R³ = H) showed excellent antifungal activity (MIC₉₀ = 0.5-2.0μg/mL). The mol. docking anal. further revealed that all the synthesized derivatives have shown potential binding affinities.

ChemistrySelect published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Formula: C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Antinolo, M. published the artcilePhotochemistry of CF₃(CH₂)₂CHO in air: UV absorption cross sections between 230 and 340 nm and photolysis quantum yields at 308 nm, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2012), 231(1), 33-40, database is CAplus.

This work constitutes the first study on the photochem. degradation process of CF₃(CH₂)₂CHO. First, the wavelength and temperature dependence of the UV absorption cross sections, σ_λ, was determined The n → π^* electronic transition band of C=O chromophore was characterized between 230 and 340 nm in the 269-323 K range. A hyperchromic effect was observed in the structured part of the band when the temperature decreases. The pulsed laser photolysis of a stationary mixture of CF₃(CH₂)₂CHO/cyclohexane (OH-scavenger)/air or N₂ was carried out at 308 nm. Online Fourier transform IR (FTIR) spectroscopy was employed to monitor the decay of CF₃(CH₂)₂CHO and to obtain the photolysis quantum yield as a function of total pressure (20.5-760 Torr). A slight curvature in the Stern-Volmer plot was observed at pressures lower than 75 Torr. At high pressures, the pressure dependence of can be described by a Stern-Volmer relationship. Photodissociation of CF₃(CH₂)₂CHO at 308 nm can produce HCO and CF₃(CH₂)₂ radicals , CF₃CH₂CH₃ and CO and CF₃(CH₂)₂CO radicals and H atoms. HCO radicals are rapidly converted into CO in the presence of O₂. Formation of CF₃CH₂CHO and CF₃CH₂CH₂OH evidences the importance of secondary chem. involving CF₃(CH₂)₂ radicals formed in channel . Further photodegradation of CF₃CH₂CHO yields mainly CF₃CHO. Small quantities of HC(O)OH were also detected. CF₃(CH₂)₂C(O)OH was only observed in the absence of OH-scavenger, implying that formation of CF₃(CH₂)₂CO radicals in channel is not an important photolysis pathway. Consequently, photodissociation of CF₃(CH₂)₂CHO in the actinic region is a source of shorter fluorinated oxygenated compounds, but it is not expected to be a source of fluorinated acids.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Antinolo, Maria published the artcileAtmospheric removal of a series of fluoroalcohols and fluoroaldehydes: photochemistry initiated by OH radicals and sunlight, Category: alcohols-buliding-blocks, the publication is Trends in Photochemistry & Photobiology (2013), 89-103, database is CAplus.

A review. Hydrofluorocarbons (HFCs) are one of the alternatives to ozone-depleting chlorofluorocarbons (CFCs) in refrigeration, air conditioning and foam blowing. But their high global warming potentials (GWPs) have given rise to the concern that increased use and direct emissions of HFCs could have a significant impact on climate change. Some other CFC alternatives such as fluorinated alcs. (FAs) have been proposed in many industrial applications. The tropospheric photooxidation of FAs yields fluorinated aldehydes as secondary pollutants. To evaluate the tropospheric persistence of these species it is necessary to determine the rate coefficients of the main removal pathways in the gas-phase, namely UV photolysis and reaction with hydroxyl (OH) (J and k_OH, resp.). The tropospheric lifetimes (*au) of a species can be calculated from J and k_OH. In this article, the gas-phase kinetics of OH radicals with CF₃CH₂CH₂OH, CF₃(CH₂)₂CH₂OH, CF₃CF₂CH₂OH, CHF₂CF₂CH₂OH, CF₃CH₂CHO, CF₃(CH₂)₂CHO and CF₃CF₂CHO recently reported by our research group, as a function of temperature (263-359 K) and pressure (40-215 Torr of He), is reviewed. The determination of k_OH as a function of temperature was performed by Pulsed Laser Photolysis – Laser Induced Fluorescence (PLP – LIF). Furthermore, a photochem. study of the fluorinated compounds at 308 nm (in the actinic region) is also reviewed here, including the determination of the UV absorption cross sections (σ_λ) between 200 and 370 nm and photodissociation quantum yields by PLP at 308 nm coupled to Fourier transform IR (FTIR) spectroscopy (Φ_λ = 308nm). The formation of the photodegradation products initiated by absorption of UV radiation at 308 nm in a simulated clean atm. is also reviewed. It can be concluded that hydrofluorinated alcs. (HFAs) are suitable for replacing HFCs, since they are short-lived compounds that do not contribute to the Earth’s global warming. The degradation of these fluorocompounds is not expected to significantly contribute to air pollution in free-NO_x atmospheres.

Trends in Photochemistry & Photobiology published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Antinolo, Maria published the artcileTemperature Effects on the Removal of Potential HFC Replacements, CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH, Initiated by OH Radicals, Category: alcohols-buliding-blocks, the publication is Environmental Science & Technology (2011), 45(10), 4323-4330, database is CAplus and MEDLINE.

Gas phase kinetic coefficients of OH^– with 2 primary fluorinated alcs., CF₃CH₂CH₂OH (k₁) and CF₃(CH₂)₂CH₂OH (k₂), potential hydrofluorocarbon (HFC) replacements, are reported as a function of temperature (263-358° K) for the first time. K₁ and k₂ (together referred to as k_i) were measured under pseudo-first-order conditions with respect to the initial OH^– concentration using the pulsed laser photolysis/laser-induced fluorescence technique. The observed k_i temperature dependence (in cm³/mol.-s) is described by the following Arrhenius expressions: k₁(T) = (2.82 ± 1.28) × 10^-12 exp{-(302 ± 139)/T} cm³/mol.-s and k₂(T) = (1.20 ± 0.73) × 10^-11 exp{-(425 ± 188)/T} cm³/mol.-s. Arrhenius parameter uncertainties are at a 95% confidence level (±2σ). K_i(T) uncertainties include statistical and systematic errors. Activation energies were (2.5 ± 1.2) kJ/mol and (3.6 ± 1.6) kJ/mol for the OH^–-reaction with CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH, resp. Global lifetime (τ) at 275° K for CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH due to the OH^–-reaction was estimated to be approx. 2 wk and 5 days, resp. Reported Arrhenius parameters can be used in 3-dimensional models which account for geog. region and season of emissions to estimate a matrix of instantaneous lifetimes. As a consequence of the substitution of the -CH₃ group by a -CH₂OH group in HFC, e.g., CF₃CH₂CH₃ and CF₃(CH₂)₂CH₃, the tropospheric lifetime with respect to the OH^– reaction is significantly shorter, and, since their radiative forcing is similar, global warming potentials for CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH are negligible. Thus, CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH seem to be suitable alternatives for HFC.

Environmental Science & Technology published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brunet, Ernesto published the artcileThe use of lanthanide luminescence as a reporter in the solid state: Desymmetrization of the prochiral layers of γ-zirconium phosphate/phosphonate and circularly polarized luminescence, Application In Synthesis of 57044-25-4, the publication is Microporous and Mesoporous Materials (2013), 222-234, database is CAplus and MEDLINE.

Solid-state CPL measurements were performed for the first time on hybrid, laminar materials based on γ-ZrP pillared with organic diphosphonates. Ad hoc optically pure diphosphonates (I) were synthesized and the luminescence properties of their complexation with Tb(III) were verified in solution CD and CPL measurements showed that the bistriazolylpyridine chromophores bonded to the metal provided an effective chiral environment that produced significant signals. In the case of the γ-ZrP-derived materials, exptl. evidence and simple mol. modeling hinted to the occurrence of supramol. chirality in the particles, induced by the intrinsic dissymmetry of the organic diphosphonates or by the intercalation of chiral species such as 1-phenethylamine. Chirality at the supramol. level was revealed in the solid state by the CPL signals measured from reporter Tb(III) ions intercalated in the hybrid matrix.

Microporous and Mesoporous Materials published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Martinez-Hernandez, Gabriela Belen published the artcileA mixture of quercetin 4′-O-rhamnoside and isoquercitrin from Tilia americana var. mexicana and its biotransformation products with antidepressant activity in mice, Quality Control of 621-37-4, the publication is Journal of Ethnopharmacology (2021), 113619, database is CAplus and MEDLINE.

The present study aims to focus on the evaluation of the antidepressant effect of the mixture of two flavonoids (FMix), and its interaction with serotonergic drugs. One of the fractions contained FMix wich is constituted of the mixture of quercetin 4′-O-rhamnoside y isoquercitrin. The mice were divided into the several following groups: FMix; FMix (1.0 mg/kg) and agonist DOI (2.0 mg/kg); FMix (1.0 mg/kg) and antagonist ketanserin (KET, 0.03 mg/kg) of 5-HT2A receptors; FMix (1.0 mg/kg) and selective agonist 8-OH-DPAT (8-OH, 0.01 mg/kg); FMix (1.0 mg/kg) and antagonist WAY100635 (WAY, 0.5 mg/kg) of 5HT1 receptors; PHL; DOPAC; p-HPAA; and m-HPAA were tested in FST or OFT. FMix induced dependent-dose antidepressant activity and, at the highest dose administered, a sedative effect was also observed The 8-OH-DPAT, or the DOI, or the KET combination with FMix (1.0 mg/kg) induced a higher antidepressant effect than compounds alone; there was no effect exerted with WAY. The activity on OFT increased only with the FMix and KET combination. At the same time, the products of the aglycon metabolism of quercetin, i.e., DOPAC and p-HPAA, decreased the immobility time of the mice in FST at 1.0 mg/kg, and a dose-curve was formed for these. The antidepressant effect of FMix could depend, at least in part, on the degradation products of quercetin and with a possible action mode through interaction with the serotoninergic system.

Journal of Ethnopharmacology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Quality Control of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts