Category: alcohols-buliding-blocks

Leong, Shi Xuan published the artcileNoninvasive and Point-of-Care Surface-Enhanced Raman Scattering (SERS)-Based Breathalyzer for Mass Screening of Coronavirus Disease 2019 (COVID-19) under 5 min, Synthetic Route of 111-29-5, the publication is ACS Nano (2022), 16(2), 2629-2639, database is CAplus and MEDLINE.

Population-wide surveillance of COVID-19 requires tests to be quick and accurate to minimize community transmissions. The detection of breath volatile organic compounds presents a promising option for COVID-19 surveillance but is currently limited by bulky instrumentation and inflexible anal. protocol. Here, we design a hand-held surface-enhanced Raman scattering-based breathalyzer to identify COVID-19 infected individuals in under 5 min, achieving >95% sensitivity and specificity across 501 participants regardless of their displayed symptoms. Our SERS-based breathalyzer harnesses key variations in vibrational fingerprints arising from interactions between breath metabolites and multiple mol. receptors to establish a robust partial least-squares discriminant anal. model for high throughput classifications. Crucially, spectral regions influencing classification show strong corroboration with reported potential COVID-19 breath biomarkers, both through experiment and in silico. Our strategy strives to spur the development of next-generation, noninvasive human breath diagnostic toolkits tailored for mass screening purposes.

ACS Nano published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Synthetic Route of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

de Meijere, Armin published the artcileDe novo synthesis of racemic spirocyclopropane-annelated 2-deoxyhexose derivatives, Quality Control of 50915-29-2, the publication is European Journal of Organic Chemistry (2003), 472-478, database is CAplus.

High-pressure-induced inverse-electron-demand hetero-Diels-Alder reactions of Et trans-4-ethoxy-2-oxo-3-butenoate and Me trans-4-benzyloxy-2-oxo-3-butenoate with benzyl (cyclopropylidenemethyl) ether each yielded mixtures of two separable diastereomeric esters (64% and 80%, resp.) which, in three subsequent steps, led to the 3-ethylated and 3-benzylated α- and β-anomeric benzyl spiro[2-deoxy-(D,L)-arabino-hexopyranoside-2,1′-cyclopropanes] α-10a,b and β-10a,b, resp. The relative configuration of β-10a was proved by an X-ray crystal structure anal. Deprotection of β-10b was achieved by Pd-catalyzed hydrogenation in dimethylacetamide leading to spiro[2-deoxy-α/β-2-(D,L)-arabino-hexopyranoside-2,1′ -cyclopropane].

European Journal of Organic Chemistry published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Quality Control of 50915-29-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Beilfuss, W. published the artcileA new concept to boost the preservative efficacy of phenoxyethanol, SDS of cas: 70445-33-9, the publication is SOFW Journal (2005), 131(11), 30,32-36, database is CAplus.

A new cosmetic preservative for leave-on products based on a combination of the active ingredient phenoxyethanol and the skin care additive and deodorant active ethylhexylglycerin is presented. Ethylhexylglycerin boosts the antimicrobial activity of phenoxyethanol. Properties, antimicrobial activity and a possible mechanism of action are discussed.

SOFW Journal published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, SDS of cas: 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bolli, Martin H. published the artcileNovel S1P₁ receptor agonists – Part 5: From amino-to alkoxy-pyridines, Related Products of alcohols-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2016), 326-341, database is CAplus and MEDLINE.

In a previous communication we reported on the discovery of aminopyridine 1 as a potent, selective and orally active S1P₁ receptor agonist. More detailed studies revealed that this compound is phototoxic in vitro. As a result of efforts aiming at eliminating this undesired property, a series of alkoxy substituted pyridine derivatives was discovered. The photo irritancy factor (PIF) of these alkoxy pyridines was significantly lower than the one of aminopyridine 1 and most compounds were not phototoxic. Focused SAR studies showed, that 2-, 3-, and 4-pyridine derivatives delivered highly potent S1P₁ receptor agonists. While the 2-pyridines were clearly more selective against S1PR₃, the corresponding 3- or 4-pyridine analogs showed significantly longer oral half-lives and as a consequence longer pharmacol. duration of action after oral administration. One of the best compounds, cyclopentoxy-pyridine 45b lacked phototoxicity, showed EC₅₀ values of 0.7 and 140 nM on S1PR₁ and S1PR₃, resp., and maximally reduced the blood lymphocyte count for at least 24 h after oral administration of 10 mg/kg to Wistar rats.

European Journal of Medicinal Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Xiaojia published the artcileReductive Catalytic Depolymerization of Semi-industrial Wood-Based Lignin, SDS of cas: 111-29-5, the publication is Industrial & Engineering Chemistry Research (2021), 60(47), 16827-16838, database is CAplus and MEDLINE.

The current work studies the reductive catalytic depolymerization (RCD) of lignin from a novel semi-industrial process. The aim was to obtain aromatic mono-, di-, tri-, and tetramers for further valorization. The substrate and products were characterized by multiple anal. methods, including high pressure size-exclusion chromatog. (HPSEC), gas chromatog.-mass spectrometry, GC-flame ionization detector (FID), GC-FID/thermal conductivity detector (TCD), and NMR. The RCD was studied by exploring the influence of different parameters, such as lignin solubility, reaction time, hydrogen pressure, reaction temperature, pH, type and loading of the catalyst, as well as type and composition of the organic/aqueous solvent. The results show that an elevated temperature, a redox catalyst, and a hydrogen atm. are essential for the depolymerization and stability of the products, while the reaction medium also plays an important role. The highest obtained mono- to tetramers yield was 98% and mono- to dimers yield over 85% in the liquid phase products. The reaction mechanisms influenced the structure of the aliphatic chain in the monomers, but left the phenolic structure along with the methoxy groups largely unaltered. The current work contributes to the development and debottlenecking of the novel and sustainable overall process, which utilizes efficiently all the fractions of wood, in line with the principles of green engineering and chem.

Industrial & Engineering Chemistry Research published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, SDS of cas: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Qiao published the artcileSynthesis and photoluminescence of organotin-dithiothreitol clusters, Recommanded Product: 2-Aminobutan-1-ol, the publication is Journal of Solid State Chemistry (2021), 122056, database is CAplus.

Three novel organotin oxysulfide hybrid clusters (BuSn)₄(DTT)₄M (M = Sn⁴⁺ (1), Ti⁴⁺ (2), Hf⁴⁺ (3); DTT = 1,4-dithiothreitol) were prepared by hydrothermal methods and their crystal structures were determined by single-crystal X-ray diffraction. These clusters are isostructural, pentanuclear complexes containing four peripheral butyltin fragments, and a central metal site of either tin, titanium or hafnium. Solid state variable temperature fluorescence spectra showed that the position and the intensity of key emission peaks of the three isomorphic compounds are significantly different. Compound 1 gave bimodal emission at 420 and 445 nm upon excitation at 360 nm, and its peak positions remained unchanged. Compounds 2 and 3 were excited by 365 and 460 nm radiation, resp., and their maximum emission peaks were red-shifted in different degrees with decreasing temperature All their peak intensity increased with decreasing temperature Solid-state UV/visible diffuse reflectance spectra displayed that these three isostructural compounds have wide optical band gaps of 3.72, 2.68, and 3.19 eV, resp.

Journal of Solid State Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C26H41N5O7S, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Boyd, Mary K. published the artcileWater quenching behavior of excited 9-xanthylium cations in aqueous sulfuric acid solutions, SDS of cas: 596-38-3, the publication is Journal of the American Chemical Society (1991), 113(19), 7294-300, database is CAplus.

A series of 9-alkyl- and 9-aryl-substituted xanthylium cations (I; R = H, Me, Me₂CHr, cyclo-Pr, tert-Bu; II; R¹ = H, p-CF₃, p– and m-Me, p– and m-OMe) were generated from the corresponding 9-xanthenols in strongly acidic aqueous MeCH (2:1) solutions (39-78% H₂SO₄). Steady-state irradiation at 370 nm produced the excited cations, all of which were fluorescent in the 520-nm region. Fluorescence lifetimes varied considerably with acid concentration, from subnanosecond values at low acidity to 20-35 ns at high acidity. Stern-Volmer plots of Φ_F°/Φ_F vs. the free water concentration in these acid solutions gave linear plots in all cases, yielding k_q values in the 10⁶-10⁹ M^-1 s^-1 range, depending on substituents. For the 9-aryl systems, a plot of log k_q vs. a recently determined σ^hν scale was reasonably linear (r = 0.974) with a ρ value of -1.5, which is opposite in sign to that recently determined for H₂O quenching of the same cations in their ground states. Possible explanations for this surprising result are considered.

Journal of the American Chemical Society published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, SDS of cas: 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Mingyu published the artcileNovel amorphous solid dispersion based on natural deep eutectic solvent for enhancing delivery of anti-tumor RA-XII by oral administration in rats, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is European Journal of Pharmaceutical Sciences (2021), 105931, database is CAplus and MEDLINE.

At present, oral chemotherapy showing the advantages of non-invasiveness, convenience, and high patient compliance, is gradually replacing traditional i.v. chemotherapy to treat patients with cancer. RA-XII, a unique natural cyclopeptide, exhibits various biol. activities, such as anti-tumor, anti-angiogenic, and anti-metastatic activities. Designing an orally available formulation of RA-XII is of great importance in the development of clin. useful anticancer agents. However, RA-XII shows low oral bioavailability in rats due to its poor solubility and low permeability. To overcome these limitations, in this work, a natural deep eutectic solvent (NADES) was designed to efficiently deliver RA-XII by oral administration. A novel NADES composed of betaine and mandelic acid in the molar ratio of 1:1 (Bet-Man NADES) was successfully prepared based on a binary phase diagram of Bet and Man. Acute toxicity studies indicated that Bet-Man NADES was well tolerated with acceptable toxicity. In Bet-Man NADES solutions, the solubility of RA-XII was increased by up to 17.54-fold, and the diffusion and permeability of RA-XII carried out in a Franz cell was also significantly improved 10.35 times. In terms of biopharmaceutical classification this is translated into a change for RA-XII from class IV to class II systems. More importantly, Bet-Man NADES was transferred into the solid formulation by the inclusion of a polymer, and amorphous solid dispersions based on Bet-Man NADES (PVP K30/NADES/RA-XII, ASDs) were successfully prepared to improve uniformity, apparent solubility, dissolution, and cytotoxicity in vitro. Consequently, the oral bioavailability of RA-XII in NADES solutions and ASDs was enhanced by approx. 11.58 and 7.56 times compared with that of pure RA-XII in 0.5% CMC-Na. Thus, it can be seen that a natural deep eutectic solvent and its modified amorphous solid dispersions are appropriate novel strategies for improving dissolution rate and bioavailability of poor soluble natural products such as RA-XII.

European Journal of Pharmaceutical Sciences published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdallah el hadj, A. published the artcileAI-PCSAFT approach: New high predictive method for estimating PC-SAFT pure component properties and phase equilibria parameters, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is Fluid Phase Equilibria (2022), 113297, database is CAplus.

In this work, a new approach based on the association of Artificial intelligence method (AI) and PC-SAFT equation of state is applied to conceive a model for estimating the solubility of solid drugs in supercritical carbon dioxide. Neuro-equation of state approach (NES) is the new technique that takes benefit from the advantages of both ANN and PC-SAFT equation of state. The new method decomposes into three main stages, first the optimization of direct ANN for predicting solids-scCO₂ phase equilibrium (where 15 binary systems are used), then the ANN inverse is performed to be an alternative to group contribution methods (GCMs) for estimating the pure components and phys. properties (reduce the uncertainty committed in estimating these properties) and enhance the PCSAFT equation of state to estimate phase equilibrium parameters and finally, ANN-PCSAFT approach is used to estimate the solubility of 213 solid solutes in supercritical carbon dioxide. The performance strategy has been carried out using a linear regression anal. of the predicted vs. exptl. outputs, as an indication of the predictive ability of the developed method. The new approach is successfully applied to the phase equilibrium modeling for 213 binary systems with high accuracy (the comparison in terms of average absolute relative deviation (AARD %) showed a variation from 2 to 6%) and allowed to enhance the phase equilibrium modeling by reducing the number of optimized parameters and surpass the main drawbacks faced in this area mainly the non-availability of phys. properties and EOS pure component properties and the limitation of the equation of state.

Fluid Phase Equilibria published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tudorascu, Marius published the artcileEnzymes in organic syntheses. I. Olefin transformation to addition products catalyzed by chloroperoxidase, SDS of cas: 55376-31-3, the publication is Progress in Catalysis (1993), 63-70, database is CAplus.

Chloroperoxidase in free or immobilized form catalyzed the addition reactions of olefins with hypohalous acids generated from metal halides and H₂O₂. Thus, the reaction of propylene with LiBr-H₂O₂ afforded 1-bromo-2-propanol (92-3%) and 2-bromo-1-propanol.

Progress in Catalysis published new progress about 55376-31-3. 55376-31-3 belongs to alcohols-buliding-blocks, auxiliary class Polymerization Reagents,ATRP Initiators, name is 2-Bromo-2-methylpropan-1-ol, and the molecular formula is C16H14O6, SDS of cas: 55376-31-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts