Category: alcohols-buliding-blocks

Lai, Yiang published the artcilePotential application of BC₃ nanotube for removal of bisphenol from water; density functional theory study, Formula: C12H10O4S, the publication is Journal of Molecular Liquids (2022), 119147, database is CAplus.

Using d. functional theory, the current study reported stability, structures, inter-mol. forces, and the electronic characteristics in the solution of complexes which was formed between bisphenol S (BPS) and the BC₃ nanotube (BC₃NT). The potential application of BC₃NT in removing BPS was investigated. BPS had an interaction with B atom of BC₃NT with its S atom and the energy of adsorption was approx. -29.31 kcal/mol. The electronic characteristics of BC₃NT were significantly affected by BPS, which facilitated the adsorption process. Moreover, the donor-acceptor interaction mainly controlled the adsorption mechanism of BPS. In addition to promoting the development of sustainable and cheap heteroatom carbon-based materials (HCBMs), the current study systematically investigated the adsorption mechanism of HCBMs for BPS.

Journal of Molecular Liquids published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Formula: C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Ce published the artcileLymphatic-targeted cationic liposomes: A robust vaccine adjuvant for promoting long-term immunological memory, Name: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Vaccine (2014), 32(42), 5475-5483, database is CAplus and MEDLINE.

Although retaining antigens at the injection site (the so-called “depot effect”) is an important strategy for vaccine development, increasing evidence showed that lymphatic-targeted vaccine delivery with liposomes could be a promising approach for improving vaccine efficacy. However, it remains unclear whether antigen depot or lymphatic targeting would benefit long-term immunol. memory, a major determinant of vaccine efficacy. In the present study, OVA antigen was encapsulated with DOTAP cationic liposomes (LP) or DOTAP-PEG-mannose liposomes (LP-Man) to generate depot or lymphatic-targeted liposome vaccines, resp. The result of in vivo imaging showed that LP mostly accumulated near the injection site, whereas LP-Man not only effectively accumulated in draining lymph nodes (LNs) and the spleen, but also enhanced the uptake by resident antigen-presenting cells. Although LP vaccines with depot effect induced anti-OVA IgG more potently than LP-Man vaccines did on day 40 after priming, they failed to mount an effective B-cell memory response upon OVA re-challenge after three months. In contrast, lymphatic-targeted LP-Man vaccines elicited sustained antibody production and robust recall responses three months after priming, suggesting lymphatic targeting rather than antigen depot promoted the establishment of long-term memory responses. The enhanced long-term immunol. memory by LP-Man was attributed to vigorous germinal center responses as well as increased Tfh cells and central memory CD4⁺ T cells in the secondary lymphoid organs. Hence, lymphatic-targeted vaccine delivery with LP-Man could be an effective strategy to promote long-lasting immunol. memory.

Vaccine published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H26N2, Name: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tsai, Charng-Sheng published the artcileDevelopment of trifunctional probes for glycoproteomic analysis, Safety of 3-(Methylamino)phenol, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(30), 5575-5577, database is CAplus and MEDLINE.

Here the authors examine the applications of two trifunctional probes with different linkers for their abilities in both target detection via 3-azido-7-aminocoumarin and enrichment via biotin, when reacting with alkynyl sugars. Probe I carries an azido group for both conjugation and fluorescent triggering. When the 1,2,3-triazole ring was formed by Cu(I)-catalyzed Azide-Alkyne (3 +2) Cycloaddition, it activated the fluorescent property of 3-azido-7-aminocoumarin to provide a high fluorescent signal for rapid and sensitive target detection, while the biotin group in probe I offered the advantage of glycoprotein enrichment. To increase the elution yield of labeled targets that bind to streptavidin matrixes, the authors further introduced a cleavable linker (cystamine) between 3-azido-7-aminocoumarin and biotin in probe II. Thus after binding to streptavidin matrixes, the labeled targets can be recovered by treatment with reducing agents such as dithiothreitol or tris(2-carboxyethyl)phosphine to break the disulfide bond and give fluorescent labeled biomols.

Chemical Communications (Cambridge, United Kingdom) published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C6H12O2, Safety of 3-(Methylamino)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Yi published the artcileEfficient Oxidation of Paracetamol Triggered by Molecular-Oxygen Activation at β-Cyclodextrin-Modified Titanate Nanotubes, Formula: C12H10O4S, the publication is Chemistry – An Asian Journal (2022), 17(13), e202200352, database is CAplus and MEDLINE.

Titanate nanotubes (TNTs) were coated with a cyclic oligosaccharide (carboxymethyl-β-cyclodextrin, CM-β-CD) to obtain a photocatalyst (CM-β-CD-TNT) for efficiently activating mol. oxygen and removing the target contaminant. The hydrophobic cavity and the large sp. surface area of the photocatalyst provide abundant active sites for activating mol. oxygen. The free radical capture experiment and quenching experiment showed that cyclodextrin could facilitate adsorption and activation of mol. oxygen to produce O₂.-. Therefore, compared with the pristine TNT, CM-β-CD-TNT accelerated the oxidation efficiency of paracetamol (APAP) by 3.4 times. Moreover, the ring cleavage reaction induced by CM-β-CD-TNT effectively reduced the acute toxicity of wastewater containing APAP. Furthermore, 100% of bisphenol A (BPA), bisphenol S (BPS), phenol, 2,4-dichlorophen (2,4-DCP), and carbamazepine (CBZ) were degraded by CM-β-CD-TNT after 2.5 h UV light irradiation This strategy provides a new dimension for the advanced treatment of organic wastewater by organic macrocyclic mol.-modified materials.

Chemistry – An Asian Journal published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C4H5NS2, Formula: C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Pengzhi published the artcileSynthesis of AD-Dihydrodipyrrins Equipped with Latent Substituents of Native Chlorophylls and (Bacterio)chlorophylls, Application of Pentane-1,5-diol, the publication is Journal of Organic Chemistry (2021), 86(17), 11794-11811, database is CAplus and MEDLINE.

Native chlorophylls and bacteriochlorophylls share a common trans-substituted pyrroline ring D (17-propionic acid, 18-methyl), whereas diversity occurs in ring A particularly at the 3-position. Two dihydrodipyrrins equipped with native-like D-ring substituents and A-ring substituents have been synthesized. The synthesis relies on a Schreiber-modified Nicholas reaction to construct the stereochem. defined precursor to ring D, a dialkyl-substituted pent-4-ynoic acid. The carboxylic acid group of the intact propionic acid proved unworkable, whereupon protected propionate (-CO₂^tBu) and several latent Pr ethers were examined The tert-butyldiphenylsilyl-protected propanol substituent proved satisfactory for reaction of the chiral N-acylated oxazolidinone, affording (2S,3S)-2-(3-((tert-butyldiphenylsilyl)oxy)propyl)-3-methylpent-4-ynoic acid in ~30% yield over 8 steps. Two variants for ring A, 2-tert-butoxycarbonyl-3-Br/H-5-iodo-4-methylpyrrole, were prepared via the Barton-Zard route. Dihydrodipyrrin formation from the pyrrole and pentynoic acid entailed Jacobi Pd-mediated lactone formation, Petasis methenylation, and Paal-Knorr-type pyrroline formation. The two AD-dihydrodipyrrins bear the D-ring Me and protected propanol groups with a stereochem. configuration identical to that of native (bacterio)chlorophylls, and a bromine or no substitution in ring A corresponding to the 3-position of (bacterio)chlorophylls. The analogous β-position of a lactone-pyrrole intermediate on the path to the dihydrodipyrrin also was successfully brominated, opening opportunities for late-stage diversification in the synthesis of (bacterio)chlorophylls.

Journal of Organic Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C9H8O4, Application of Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khan, Ali published the artcileChange of the microemulsion structure with the hydrophile-lipophile balance of the surfactant and the volume fractions of water and oil, Quality Control of 70445-33-9, the publication is Journal of Physical Chemistry (1986), 90(22), 5799-801, database is CAplus.

In the 4-component system water/C₁₂H₂₅OCH₂CH₂SO₄Ca_1/2/C₄H₉CH(C₂H₅)CH₂O CH₂CH(OH)CH₂OH/C₁₀H₂₂ with 5 weight% total surfactant (surfactant + cosurfactant), 2 different microemulsion phases are formed when water and oil contents are both high, with only small differences in cosurfactant content. The structure of the microemulsions was investigated by the Fourier transform pulsed gradient spin-echo NMR technique and was found to be quite different (closed domains of oil in water, or water in oil, or bicontinuous) for different conditions (water-to-oil ratio, cosurfactant concentration). The microemulsion structure changes dramatically with small changes in cosurfactant concentration

Journal of Physical Chemistry published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Pengfei published the artcileA mild acetolysis procedure for the regioselective removal of isopropylidene in di-O-isopropylidene-protected pyranoside systems, Computed Properties of 20880-92-6, the publication is Carbohydrate Research (2017), 7-13, database is CAplus and MEDLINE.

A mild acetolysis method for the regioselective removal of isopropylidene group from di-O-isopropylidene-protected hexopyranosides is reported. O-Isopropylidene-protected intermediates play an important role in carbohydrate chem., as they are often found in com. available furanosyl and pyranosyl materials, and some of them contain more than one O-isopropylidene groups. Methods that permit regioselective removal of O-isopropylidene groups are extremely valuable, as the number of steps in the total synthesis of complex oligosaccharides could be significantly decreased. Here we report that trifluoroacetic acid (TFA)/acetic anhydride (Ac₂O) can be used to regioselectively convert one of the two O-isopropylidene groups to vicinal di-O-acetates in the di-O-isopropylidene-protected galacto- and fructopyranosyl systems, and the reagent is compatible with some common functionalities such as sulfonate esters, bromide, azide etc.

Carbohydrate Research published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C8H5F3O2S, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bouchet, Samuel published the artcileExtending Cross Metathesis To Identify Selective HDAC Inhibitors: Synthesis, Biological Activities, and Modeling, Related Products of alcohols-buliding-blocks, the publication is ACS Medicinal Chemistry Letters (2019), 10(6), 863-868, database is CAplus and MEDLINE.

Dissym. cross metathesis of alkenes as a convergent and general synthetic strategy allowed for the preparation of a new small series of human histone deacetylases (HDAC) inhibitors. Alkenes bearing Boc-protected hydroxamic acid and benzamide and trityl-protected thiols were used to provide the zinc binding groups and were reacted with alkenes bearing aromatic cap groups. One compound was identified as a selective HDAC6 inhibitor lead. Addnl. biol. evaluation in cancer cell lines demonstrated its ability to stimulate the expression of the epithelial marker E-cadherin and tumor suppressor genes like SEMA3F and p21, suggesting a potential use of this compound for lung cancer treatment. Mol. docking on all 11 HDAC isoforms was used to rationalize the observed biol. results.

ACS Medicinal Chemistry Letters published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Layek, Buddhadev published the artcileAPC targeted micelle for enhanced intradermal delivery of hepatitis B DNA vaccine, HPLC of Formula: 96345-79-8, the publication is Journal of Controlled Release (2015), 143-153, database is CAplus and MEDLINE.

Chronic hepatitis B is a serious liver disease and puts people at high risk of death from cirrhosis and liver cancer. Although DNA vaccination has been emerged as a potential immunotherapeutic strategy for the treatment of chronic hepatitis B, the efficiencies were not adequate in clin. trials. Here we describe the design, synthesis, and evaluation of mannosylated phenylalanine grafted chitosan (Man-CS-Phe) as a DNA delivery vector for direct transfection of antigen presenting cells to improve cellular and humoral immunity to plasmid-coded antigen. The cationic Man-CS-Phe micelles condense plasmid DNA into nanoscale polyplexes and provide efficient protection of complexed DNA from nuclease degradation The mannose receptor-mediated enhanced cell uptake and high in vitro transfection efficiency of the polyplexes were demonstrated in RAW 264.7 and DC 2.4 cells using GFP-expressing plasmid DNA. Furthermore, intradermal immunization of BALB/c mice indicated that hepatitis B DNA vaccine/Man-CS-Phe polyplexes not only induced multi-fold higher serum antibody titer in comparison to all other formulations including FuGENE HD, but also significantly stimulated T-cell proliferation and skewed T helper toward Th1 polarization. These results illustrate that the Man-CS-Phe can serve as a promising DNA delivery vector to harness both cellular and humoral arms of immune system.

Journal of Controlled Release published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, HPLC of Formula: 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pospisil, Jan published the artcileAntioxidants and stabilizers. XXII. Comparison of the antioxidative activities of dihydric phenols and their oxidation products, Formula: C14H22O2, the publication is European Polymer Journal (1970), 6(10), 1347-58, database is CAplus.

The effects of 4-tert-alkyl pyrocatechols (I) and their oxidation produces on the autoxidation of Tetralin (initiated at 60° with azobisisobutyronitrile) were investigated. Whereas I act as oxidation inhibitors, 4-tert-alkyl 1,2-benzoquinones have pronounced retardation effects and 2-hydroxy-5-tert-alkyl 1,4-benzoquinones have only negligible effects. Similar investigations were carried out with 2-tert-alkyl hydroquinones, the inhibition activities of which are 2.5 to 3.5 times lower than those of I. The oxidation products of alkylhydroquinones (2-tertalkyl 1,4-benzoquinones and 2-hydroxy-6-tert-alkyl 1,4-benzoquinones) are much weaker oxidation retarders than quinones derived from alkylpyrocatechols. The antioxidative activity of I and 2-tert-alkyl hydroquinones in the stabilization of Tetralin is influenced by the same substituent factors as in the oxidation of isotactic polypropylene. Conclusions concerning the structural factors influencing the antioxidative activity of these quinoid compounds can be extrapolated to the polymeric substrate.

European Polymer Journal published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Formula: C14H22O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts