Category: alcohols-buliding-blocks

Zhou, Xiaoyuan published the artcileLignol Cleavage by Pd/C Under Mild Conditions and Without Hydrogen: A Role for Benzylic CH Activation?, COA of Formula: C15H16O3, the publication is ChemSusChem (2014), 7(6), 1623-1626, database is CAplus and MEDLINE.

The cleavage of CO bonds in lignin model compounds without hydrogen was developed using the com. available Pd/C. Hydrogen donor solvents are helpful for this reaction through transfer hydrogenation, but not necessary. A redox neutral process that utilizes the internal hydrogen source for the cleavage is also possible. An initial mechanistic study indicates that the β-benzylic-H atom in the substrate plays a critical role and that the present system undergoes a process different from previous reports.

ChemSusChem published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C24H20Ge, COA of Formula: C15H16O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Butkevich, Alexey N. published the artcileFluorescent Rhodamines and Fluorogenic Carbopyronines for Super-Resolution STED Microscopy in Living Cells, Safety of 3-(Methylamino)phenol, the publication is Angewandte Chemie, International Edition (2016), 55(10), 3290-3294, database is CAplus and MEDLINE.

A range of bright and photostable rhodamines and carbopyronines with absorption maxima in the range of λ=500-630 nm were prepared, and enabled the specific labeling of cytoskeletal filaments using HaloTag technol. followed by staining with 1 μM solutions of the dye-ligand conjugates. The synthesis, photophys. parameters, fluorogenic behavior, and structure-property relationships of the new dyes are discussed. Light microscopy with stimulated emission depletion (STED) provided one- and two-color images of living cells with an optical resolution of 40-60 nm.

Angewandte Chemie, International Edition published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Safety of 3-(Methylamino)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kurimoto, Yuji published the artcileEfficient Synthesis and Properties of [1]Benzothieno[3,2-b]thieno[2,3-d]furans and [1]Benzothieno[3,2-b]thieno[2,3-d]thiophenes, Recommanded Product: Thiophen-3-ol, the publication is Asian Journal of Organic Chemistry (2018), 7(8), 1635-1641, database is CAplus.

Efficient synthesis of benzodithienofurans (BDTF) e.g. I and benzodithienothiophenes (BDTT) e.g. II were achieved by the combination of an addition-elimination reaction, reduction and Pd-catalyzed dehydrogenative cyclization. The synthesis of Π-extended BDTF and BDTT derivatives through the use of coupling reactions was also achieved. The detailed phys. properties like DFT, cyclic voltametry, UV visible absorption and fluorescence of these compounds were investigated. The newly synthesized BDTFs exhibited strong fluorescence compared with BDTTs. 2,2′-bis([1]benzothieno[3,2-b]thieno[2,3-d]furan) (BBTTF) exhibited p-type organic field-effect transistor (OFET) properties.

Asian Journal of Organic Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Recommanded Product: Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Urayama, Teppei published the artcileO₂-enhanced catalytic activity of gold nanoparticles in selective oxidation of hydrosilanes to silanols, Recommanded Product: Triisopropylsilanol, the publication is Chemistry Letters (2015), 44(8), 1062-1064, database is CAplus.

O₂ acts as a nonconsumed activator for gold nanoparticles (AuNPs) in the oxidation of hydrosilanes to silanols with water under O₂ atm, providing an acceleration of more than 200 times relative to the reaction rate under Ar atm. The AuNP catalyst under aerobic conditions exhibits high activity in the oxidation with high turnover numbers (1230000). Various hydrosilanes including less-reactive bulky ones can be converted to the corresponding silanols in excellent yields. Moreover, the present AuNP catalyst is reusable while maintaining the high performance.

Chemistry Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C22H18Cl2N2, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tran, Chieu D. published the artcileChiral ionic liquids for enantioseparation of pharmaceutical products by capillary electrophoresis, Category: alcohols-buliding-blocks, the publication is Journal of Chromatography A (2008), 1204(2), 204-209, database is CAplus and MEDLINE.

A chiral ionic liquid (IL), S-[3-(chloro-2-hydroxypropyl)trimethylammonium] [bis((trifluoromethyl)sulfonyl)amide] (S-[CHTA]⁺[Tf₂N]^–), which can be easily and readily synthesized in a one-step process from com. available reagents, can be successfully used both as co-electrolyte and as a chiral selector for CE. A variety of pharmaceutical products including atenolol, propranolol, warfarin, indoprofen, ketoprofen, ibuprofen and flurbiprofen, can be successfully and baseline separated with the use of this IL as electrolyte. Interestingly, while S-[CHTA]⁺[Tf₂N]^– can also serve as a chiral selector, enantioseparation cannot be successfully achieved with S-[CHTA]⁺[Tf₂N]^– as the only chiral selector. In the case of ibuprofen, a second chiral selector, namely a chiral anion (sodium cholate), is needed for the chiral separation For flurbiprofen, in addition to S-[CHTA]⁺[Tf₂N]^– and sodium cholate, a third and neutral chiral selector, 1-S-octyl-β–thioglucopyranoside (OTG), is also needed. Due to the fact that the chirality of this chiral IL resides on the cation (i.e., -[CHTA]⁺), and that needed addnl. chiral selector(s) are either chiral anion (i.e., cholate) or chiral neutral compound (OTG), the results obtained seem to suggest that addnl. chiral selector(s) are needed to provide the three-point interactions needed for chiral separations

Journal of Chromatography A published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C3H5BN2O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghavtadze, Nugzar published the artcileConversion of 1-alkenes into 1,4-diols through an auxiliary-mediated formal homoallylic C-H oxidation, Synthetic Route of 17877-23-5, the publication is Nature Chemistry (2014), 6(2), 122-125, database is CAplus and MEDLINE.

The ubiquitous nature of C-H bonds in organic mols. makes them attractive as a target for rapid complexity generation, but brings with it the problem of achieving selective reactions. In developing new methodologies for C-H functionalization, alkenes are an attractive starting material because of their abundance and low cost. Here we describe the conversion of 1-alkenes into 1,4-diols. The method involves the installation of a new Si,N-type chelating auxiliary group on the alkene followed by iridium-catalyzed C-H silylation of an unactivated δ-C(sp³)-H bond to produce a siloxane intermediate. Oxidation of the C-Si bonds affords a 1,4-diol. The method is demonstrated to have broad scope and good functional group compatibility by application to the selective 1,4-oxygenation of several natural products and derivatives

Nature Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Synthetic Route of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Azzena, Ugo published the artcileReductive cleavage of N-substituted 2-aryl-1,3-oxazolidines: generation of α-amino-substituted carbanions, SDS of cas: 101-98-4, the publication is Journal of Organic Chemistry (1993), 58(24), 6707-11, database is CAplus.

The behavior of N-substituted 2-aryl-1,3-oxazolidines I (R = H, Me, Ph, R¹ = aryl, R² = Me, Et) have been investigated under conditions of electron transfer from alkali metals in aprotic solvents. The reduction led to the regioselective cleavage of the benzylic carbon-oxygen bond, with formation of the corresponding N-substituted benzylamino alcs. RR¹CHNR²CH₂CH₂OH in good yields. Investigation of the mechanism of this reductive cleavage, with the aid of labeling experiments, showed the intermediate formation of α-tertiary amino-substituted carbanions.

Journal of Organic Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, SDS of cas: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Robalo, Joao R. published the artcileInfluence of Methylene Fluorination and Chain Length on the Hydration Shell Structure and Thermodynamics of Linear Diols, Application of Pentane-1,5-diol, the publication is Journal of Physical Chemistry B (2021), 125(49), 13552-13564, database is CAplus and MEDLINE.

The interplay between the local hydration shell structure, the length of hydrophobic solutes, and their identity (perfluorinated or not) remains poorly understood. We address this issue by combining Raman-multivariate curve resolution (Raman-MCR) spectroscopy, simulation, and quantum-mech. calculations to quantify the thermodn. and the first principle interactions behind the formation of defects in the hydration shell of alkyl-diol and perfluoroalkyl-diol chains. The hydration shell of the fluorinated diols contains substantially more defects than that of the nonfluorinated diols; these defects are water hydroxy groups that do not donate hydrogen bonds and which either point to the solute (radial-dangling OH) or not (nonradial-dangling OH). The number of radial-dangling OH defects per carbon decreases for longer chains and toward the interior of the fluorinated diols, mainly due to less favorable electrostatics and exchange interactions; nonradial-dangling OH defects per carbon increase with chain length. In contrast, the hydration shell of the nonfluorinated diols only contains radial-dangling defects, which become more abundant toward the center of the chain and for larger chains, predominantly because of more favorable dispersion interactions. These results have implications for how the folding of macromols., ligand binding to biomacromols., and chem. reactions at water-oil interfaces could be modified through the introduction of fluorinated groups or solvents.

Journal of Physical Chemistry B published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Application of Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bonfils, Edwige published the artcileUptake by macrophages of a biotinylated oligo-α-deoxythymidylate by using mannosylated streptavidin, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Bioconjugate Chemistry (1992), 3(4), 277-84, database is CAplus and MEDLINE.

Streptavidin substituted with mannose residues increased by 20-fold the intracellular concentration of a biotinylated dodecakis(α-deoxythymidylate) in macrophages by comparison with the uptake of free oligodeoxynucleotide. Streptavidin, the bacterial homolog of the very basic avidin, which does not contain any carbohydrate moieties and is a neutral protein, was substituted with 12 mannose residues in order to be recognized and internalized by mannose-specific lectins on the surface of macrophages. A 3′-biotinylated 5′-fluoresceinylated dodecakis(α-deoxythymidylate) was synthesized and bound onto mannosylated streptavidin. The conjugate was isolated, and by using flow cytometry, it was shown that the uptake of fluoresceinylated oligodeoxynucleotides bound to mannosylated streptavidin by macrophages is 20-fold higher than that of free oligodeoxynucleotides and that the uptake was competitively inhibited by mannosylated serum albumin. Glycosylated streptavidin conjugates recognizing specific membrane lectins on different cells provide the possibility to target biotinylated antisense oligodeoxynucleotides and to increase the biol. effect of these chemotherapeutic agents.

Bioconjugate Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Teng, Shuang published the artcileTogni-II Reagent Mediated Selective Hydrotrifluoromethylation and Hydrothiolation of Alkenes, COA of Formula: C8H10S, the publication is Chinese Journal of Chemistry (2021), 39(12), 3429-3434, database is CAplus.

Based on the redox reactions of Togni-II reagent and thiols (such as propane-2-thiol, cyclohexanethiol, dodecan-1-thiol, p-toluenethiol, etc.), a thiol-tuned selective functionalization of unactivated olefins was disclosed. In combination with aryl thiol (p-toluenethiol), stoichiometric amount of Togni-II reagent prompted a hydrotrifluoromethylation of alkenes (such as N-allyl-benzamide, 1-phenyl-but-3-en-1-ol, 4-chloro-benzoic acid pent-4-enyl ester, etc.), in which, aryl thiol played as reductant and hydrogen source; while by utilization of alkyl thiols (such as propane-2-thiol, cyclohexanethiol, dodecan-1-thiol, etc.), catalytic amount of Togni-II reagent initiated thiol-ene and thiol-yne reactions. The reported applications are characterized by their operational simplicity and wide functional group tolerance.

Chinese Journal of Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C14H19NO8, COA of Formula: C8H10S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts