Category: alcohols-buliding-blocks

Gagauzov, I. published the artcileDerivatives of 1,3-dimethylxanthine. I. Direct condensation of 1,3-dimethylxanthine with alkanolamines, Safety of 2-(Benzyl(methyl)amino)ethanol, the publication is Farmatsiya (Sofia, Bulgaria) (1977), 27(2), 1-6, database is CAplus.

Direct condensation of theophylline (I) with 1 equivalent HOCH₂CH2NRR¹ (R = Me, Et, Pr, Bu, CH₂CH₂CHMe₂, CH₂Ph, CH₂CH₂OH, CH₂CH₂OAc, CH₂CH₂OBz; R¹ = CH₂Ph, CH₂CH₂OH, CH₂CH₂OAc, CH₂CH₂OBz, CH₂CH₂O₂CH:CHPh) at 250-320° in a salt bath 50-90 min gave resinous II, which were taken up in EtOH and precipitated as the tartrates or saccharinates in 42-74% yield. The salts were H₂O-soluble and had bronchodilating, antihistaminic and diuretic effects, but were more toxic than I.

Farmatsiya (Sofia, Bulgaria) published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Safety of 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiaozhou published the artcileKlebsiella sp. PD3, a phenanthrene (PHE)-degrading strain with plant growth promoting properties enhances the PHE degradation and stress tolerance in rice plants, SDS of cas: 86-48-6, the publication is Ecotoxicology and Environmental Safety (2020), 110804, database is CAplus and MEDLINE.

Phenanthrene (PHE) is harmful to human health and is difficult to be eliminated from environment. In this study, an aerobic bacterium capable of use PHE as a sole carbon source and energy was isolated and classified as Klebsiella sp. PD3 according to 16S rDNA anal. The degradation efficiency of PHE reached to about 78.6% after 12 days of incubation with strain PD3. Identification of metabolites formed during PHE degradation process by this strain was carried out by GC-MS. The first degradation step of PHE by PD3 was proposed to generate 1-hydroxy-2-naphthoic acid. PD3 significantly improved growth performance, biomass production, seed germination rate, photosynthetic capacity, antioxidant levels, relative water content and chlorophyll accumulation in rice (Oryza sativa L.) plants under PHE stress conditions in comparison with non-inoculation treatment. Moreover, PD3-inoculated rice showed lower ROS accumulation, ethylene production, ACC content, ACC oxidase activity and electrolyte leakage under PHE treatment compared to non-inoculated ones. The combination use of rice plants and strain PD3 was also shown to enhance the removal efficiency of PHE from the soil and decline the PHE accumulation in plants. Synergistic use of plants and bacteria with PHE degradation ability and PGPR attributes to remediate the PHE-contaminated soil will be an important and effective way in the phytoremediation of PHE-contaminated soils.

Ecotoxicology and Environmental Safety published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Straker, R. N. published the artcileComputational ligand design in enantio- and diastereoselective ynamide [5+2] cycloisomerization, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is Nature Communications (2016), 10109, database is CAplus and MEDLINE.

Many diastereoselective (substrate stereocontrol), and enantioselective (catalyst stereocontrol) cycloisomerizations was developed. However, asym. cycloisomerizations where a chiral catalyst specifies the stereochem. outcome of the cyclization of a single enantiomer substrate-regardless of its inherent preference-were unknown. A combined theor. and exptl. approach enables the design of a highly reactive rhodium catalyst for the stereoselective cycloisomerization of ynamide-vinylcyclopropanes to [5.3.0]-azabicycles was showed. Highly diastereoselective cycloisomerizations using an achiral catalyst, and then explored phosphoramidite-complexed rhodium catalysts in the enantioselective variant, where theor. investigations uncovered an unexpected reaction pathway in which the electronic structure of the phosphoramidite dramatically influences reaction rate and enantioselectivity was established. A marked enhancement of both was observed using the optimal theory-designed ligand, which enabled double stereodifferentiating cycloisomerizations in both matched and mismatched catalyst-substrate settings.

Nature Communications published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C20H22ClN3O3, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Qiu-hong published the artcileClinical effect of the combined application of carboprost tromethamine injection and gauze on patients with previa placenta underwent cesarean section, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Linchuang Yixue (2016), 36(2), 24-25, database is CAplus.

The aim of this paper is to investigate the clin. effects of combined application of Carboprost tromethamine injection and gauze on patients with previa placenta underwent cesarean section. From March 2013 to March 2015, forty-two patients with previa placenta underwent cesarean section were selected in the sixth people’s hospital of Nanhai district, all patients were randomly divided into observation group and control group. The patients in observation group were given Carboprost tromethamine injection and gauze to stop bleeding, while the patients in control group were managed with gauze only. The operation situations(bleeding volume, operation time, transfusion rate, and uterus resection rate), the bleeding volume after operation(2 h, 4 h, 8 h, 12 h), and adverse effects after operation of the two groups were observed The bleeding volume in operation of observation group and control group was resp.(361.3±69.9) ml vs. (552.0±59.6) ml, and there was significant difference(P<0.05). No significant difference was observed in operation time, transfusion rate, uterus resection rate or adverse effects after operation between the two groups(P>0.05). The effects of hemostasis of the combined application of carboprost tromethamine injection and gauze are better than gauze only on patients with previa placenta underwent cesarean section.

Linchuang Yixue published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Feng, Qiangqiang published the artcileKey variables prediction based on mechanism models of 2-KGA mixed culture fermentation, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Huagong Xuebao (Chinese Edition) (2013), 64(8), 2913-2917, database is CAplus.

2-Keto-L-gulonic acid (2-KGA), the precursor for vitamin C synthesis, is produced by the mixed culture of Ketogulonicigenium vulgare and Bacillus megaterium. In this paper, the previously established kinetic model for 2-KGA mixed culture was firstly tested with the data of 80 industrial batches. Based on sensitivity anal., it was found that some insensitive parameters might be assigned fixed values to minimize computing time. Then, the model was used to predict the most important state variables, i.e., substrate and product concentrations Moving data window technique and rolling parameter identification approach were used in the prediction process 4 h and 8 h ahead prediction errors for 2-KGA concentration were less than 5%.

Huagong Xuebao (Chinese Edition) published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hoang, Giang T. published the artcileIntramolecular Oxyacylation of Alkenes Using a Hydroxyl Directing Group, Computed Properties of 328-90-5, the publication is Journal of Organic Chemistry (2014), 79(23), 11383-11394, database is CAplus and MEDLINE.

Alkene oxyacylation is a new strategy for the preparation of β-oxygenated ketones. Now, with Ir catalysis and low-cost salicylate esters, alkene oxyacylation can be promoted by simple and versatile hydroxyl directing groups. This paper discusses catalyst optimization, substituent effects, mechanistic experiments, and the challenges associated with asym. catalysis. Crossover experiments point to several key steps of the mechanism being reversible, including the most likely enantiodetermining steps. The oxyacylation products are also prone to racemization without catalyst when heated alone; however, crossover is not observed without catalyst. These observations account for the low levels of enantioinduction in alkene oxyacylation. The versatility of the hydroxyl directing group is highlighted by demonstrating further transformations of the products.

Journal of Organic Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Computed Properties of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Heravi, Majid M. published the artcileNickel-Catalyzed Deoxycyanation of Activated Phenols via Cyanurate Intermediates with Zn(CN)₂: A Route to Aryl Nitriles, Quality Control of 17236-59-8, the publication is Organic Letters (2018), 20(9), 2753-2756, database is CAplus and MEDLINE.

A novel, and efficient nickel-catalyzed deoxycyanation of phenolic compounds using relatively nontoxic Zn(CN)₂ as the cyanide source was developed. The reaction of C-O bond activated phenolic compounds by 2,4,6-trichloro-1,3,5-triazine with Zn(CN)₂ in the presence of a nickel precatalyst afforded the aromatic nitriles in good to excellent yields.

Organic Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Quality Control of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Iranpoor, Nasser published the artcileNickel-Catalyzed One-Pot Deoxygenation and Reductive Homocoupling of Phenols via C-O Activation Using TCT Reagent, Safety of Thiophen-3-ol, the publication is Organic Letters (2015), 17(2), 214-217, database is CAplus and MEDLINE.

A new method for C-O bond activation of phenolic compounds has been achieved using 2,4,6-trichloro-1,3,5-triazine (TCT) to utilize in one-pot Ni-catalyzed deoxygenation and reductive homocoupling reactions. With this simple method, phenolic compounds were converted to their corresponding arenes or biaryl compounds under mild conditions [e.g., treatment of 2-naphthol with TCT followed by NiCl₂(PCy₃)₂ and MeOH/Zn/KI afforded naphthalene (85%), and treatment of p-cresol with TCT followed by NiCl₂(PCy₃)₂ and Zn/Et₄NI afforded 4,4′-dimethylbiphenyl (84%)]. The introduced methodol. has a broad scope and demonstrates good functional group compatibility.

Organic Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Safety of Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khokhar, Vaishali published the artcilePrototropic forms of hydroxy derivatives of naphthoic acid within deep eutectic solvents, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Physical Chemistry Chemical Physics (2021), 23(15), 9096-9108, database is CAplus and MEDLINE.

Deep eutectic solvents (DESs) are not only recognized as benign and inexpensive alternatives to ionic liquids, they offer a unique solvation milieu due to the varying H-bonding capabilities of their constituents. Proton-transfer involving a probe and its prototropic forms strongly depend on the H-bonding nature of the solubilizing media. The presence of prototropic forms of three probes, 1-hydroxy-2-naphthoic acid (1,2-HNA), 3-hydroxy-2-naphthoic acid (3,2-HNA), and 6-hydroxy-2-naphthoic acid (6,2-HNA) is investigated in two DESs, named ChCl:urea and ChCl:glycerol, constituted of H-bond acceptor choline chloride and different H-bond donors, urea and glycerol, resp., in a 1 : 2 mol ratio under ambient conditions. While 1,2-HNA and 3,2-HNA exhibit an intramol. H-bonding ability, 6,2-HNA does not. In contrast to common polar solvents, where the monoanionic emitting form of 1,2-HNA is also supported along with the neutral one, in both the DESs only the neutral emitting form exists. Addition of acid to the two DESs, resp., fail to generate the monocationic form of the probe. Addition of a base to ChCl:urea results in the generation of the monoanionic form; even a very high strength of the base fails to generate the monoanionic emitting form in ChCl:glycerol. Relatively higher H-bond donating acidity of ChCl:glycerol results in added hydroxyl getting involved in H-bonding with alc. functionalities of ChCl:glycerol leading to the absence of proton extraction to create the monoanionic form of the probe. Only the monoanionic emitting form of 3,2-HNA is present in ChCl:urea; in ChCl:glycerol, due to its higher H-bond donor acidity, the neutral emitting form is also detected. Addition of high strength of acid to ChCl:urea does result in formation of the neutral emitting form. Addition of an aqueous base results in the formation of the dianionic form of 3,2-HNA in ChCl:urea; however, in ChCl:glycerol, the added base fails to convert the neutral form of this probe to the monoanionic form as efficiently as that in ChCl:urea. The monoanionic (carboxylate) form of 6,2-HNA exits in ChCl:urea, whereas the neutral form is present in ChCl:glycerol due to its higher H-bond donating acidity. Addition of an acid can induce a shift in prototropic equilibrium towards the neutral form of 6,2-HNA in ChCl:urea; no change is observed in the behavior of this probe in ChCl:glycerol as the acid is added. Both the DESs support the dianionic form of 6,2-HNA in the presence of the base; the added base helps extract both -OH and -COOH protons of this probe. The H-bond donor component of the DES is clearly established to play a critical role in the prototropic behavior of the probe.

Physical Chemistry Chemical Physics published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xinsheng published the artcileCatalytic Conversion of Tetrahydrofurfuryl Alcohol over Stable Pt/MoS₂ Catalysts, Application In Synthesis of 111-29-5, the publication is Catalysis Letters (2021), 151(9), 2734-2747, database is CAplus.

MoS₂ supported noble metal catalysts were used for the catalytic conversion of terahydrofurfuryl alc. (THFA) to 1,5-pentanediol (1,5-PDO) and its derivate tetrahydropyrane (THP). Over the optimal 4%Pt/MoS₂-FR catalyst, 75.8% overall selectivity (35.4% to 1,5-PDO and 40.4% to THP) and 63.7% conversion of 5 wt% THFA solution were obtained after 8 h reaction at 250°C. The catalyst showed stable catalytic performance in five-cycle reactions, demonstrating the robustness of Pt/MoS₂ under the harsh hydrothermal and hydrogenation conditions. A variety of characterizations, including CO-DRIFTS, HRTEM, H₂-TPR, Raman spectroscopy and XPS revealed that typical behavior of strong metal-support interaction (SMSI) existed between Pt and MoS₂, largely caused by the coverage of MoS₂ over Pt and rarely reported previously. The Pt/MoS₂ had intact structure under the harsh conditions thanks to the SMSI and chem. stability of MoS₂. The acidity of Pt/MoS₂ was negligible, and the active sites for the reaction were attributed to Pt and the Mo sites interacting closely on the catalysts. The reaction pathway was proposed according to the product distributions and the results of conditional experiments

Catalysis Letters published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Application In Synthesis of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts