Category: alcohols-buliding-blocks

Nechitailo, N. A. published the artcileDihydric phenols as stabilizers for irradiated polypropylene, COA of Formula: C14H22O2, the publication is Plasticheskie Massy (1966), 37-41, database is CAplus.

Polypropylene (I) of mol. weight 390,000 after addition of 0.1 mmol of stabilizer/g. was irradiated with ⁶⁰Co γ-rays at an intensity of 1.0-1.5 megarads/h. in vacuo with a dose of 160 megarads or in air with a dose of 40 megarads. After irradiation, the fraction insoluble in o-xylene and intrinsic viscosity (in Decalin at 135°) of I were determined As stabilizers hydroquinone (II), 2-methylhydroquinone (III), 2-tert-butylhydroquinone (IV), 2-tert-octylhydroquinone (V), 2,5-di-tert-butylhydroquinone (VI), pyrocatechol (VII), 4-methylpyrocatechol (VIII), 4-tert-butylpyrocatechol (IX), 4-tert-octylcatechol (X), and 3,5-di-tert-butylpyrocatechol (XI) were used. The oxidation of I with air was determined by DTA and ir anal. γ-rays caused fission of chains and a decrease in mol. weight and softening temperature; simultaneously, crosslinking took place and an insoluble gel was formed. In the absence of air, no oxidation took place and only IX, X, and XI decreased the destruction of I; the amount of gel formed in I without stabilizers was 77.5%, and with II 68.0%, III 54.8%, IV 50.3%, V 43.7%, VI 67.0%, VII 40%, VIII 15.0%, IX 14.2%, X 71.0%, and XI 8.7%. Dihydric phenols shifted the temperature of the oxidation initiation to higher temperatures; the effect of alkyl derivatives of VII containing tert-Bu groups was especially strong. Oxidation of I irradiated in the presence of air was weakened by the addition of several phenols (no formation of a gel fraction, strong diminution of absorption by OH groups in the ir spectrum). The intrinsic viscosity of I irradiated in the presence of air was 0.13 for pure I (before irradiation 3.2), for II 0.11, III 0.23, IV 0.13, V 0.22, VI 0.13, VII 0.31, VIII 0.31, IX 0.20, X 0.11, and XI 0.17.

Plasticheskie Massy published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, COA of Formula: C14H22O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Michnova, Hana published the artcileBioactivity of methoxylated and methylated 1-hydroxynaphthalene-2-carboxanilides: comparative molecular surface analysis, Product Details of C11H8O3, the publication is Molecules (2019), 24(16), 2991, database is CAplus and MEDLINE.

A series of twenty-six methoxylated and methylated N-aryl-1-hydroxynaphthalene-2-carboxanilides was prepared and characterized as potential anti-invasive agents. The mol. structure of N-(2,5-dimethylphenyl)-1-hydroxynaphthalene-2-carboxamide as a model compound was determined by single-crystal X-ray diffraction. All the analyzed compounds were tested against the reference strain Staphylococcus aureus and three clin. isolates of methicillin-resistant S. aureus as well as against Mycobacterium tuberculosis and M. kansasii. In addition, the inhibitory profile of photosynthetic electron transport in spinach (Spinacia oleracea L.) chloroplasts was specified. In vitro cytotoxicity of the most effective compounds was tested on the human monocytic leukemia THP-1 cell line. The activities of N-(3,5-dimethylphenyl)-, N-(3-fluoro-5-methoxy-phenyl)- and N-(3,5-dimethoxyphenyl)-1-hydroxynaphthalene-2-carbox-amide were comparable with or even better than the commonly used standards ampicillin and isoniazid. All promising compounds did not show any cytotoxic effect at the concentration >30 μM. Moreover, an in silico evaluation of clogP features was performed for the entire set of the carboxamides using a range of software lipophilicity predictors, and cross-comparison with the exptl. determined lipophilicity (log k), in consensus lipophilicity estimation, was conducted as well. Principal component anal. was employed to illustrate noticeable variations with respect to the mol. lipophilicity (theor./exptl.) and rule-of-five violations. Addnl., ligand-oriented studies for the assessment of the three-dimensional quant. structure-activity relationship profile were carried out with the comparative mol. surface anal. to determine electron and/or steric factors that potentially contribute to the biol. activities of the investigated compounds

Molecules published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ho, Angel published the artcileAcid-Catalyzed Intramolecular Ring-Opening Reactions of Cyclopropanated Oxabenzonorbornadienes with Carboxylic Acid Nucleophiles, Related Products of alcohols-buliding-blocks, the publication is Synthesis (2022), 54(5), 1422-1430, database is CAplus.

The present work demonstrates the ability of carboxylic acid tethered cyclopropanated oxabenzonorbornadienes (CPOBDs) to undergo ring-opening reactions in mild acidic conditions. The optimized reaction conditions involve the use of pTsOH in DCE at 90°C. Two regioisomers are formed but the reactions are highly regioselective towards type 3 ring-opened products. It was observed that substitution at the C5 and aryl positions of CPOBD significantly hinders the ring-opening reactions leading to decreased yields of ring-opened products, although high regioselectivity for the Type 3 ring-opened products is still maintained. Herein, the first examples of acid-catalyzed intramol. ring-opening reactions of CPOBD with carboxylic acid nucleophiles are reported.

Synthesis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dias, Patricia published the artcile3-Hydroxyphenylacetic Acid: A Blood Pressure-Reducing Flavonoid Metabolite, HPLC of Formula: 621-37-4, the publication is Nutrients (2022), 14(2), 328, database is CAplus and MEDLINE.

Regular intake of polyphenol-rich food has been associated with a wide variety of beneficial health effects, including the prevention of cardiovascular diseases. However, the parent flavonoids have mostly low bioavailability and, hence, their metabolites have been hypothesized to be bioactive. One of these metabolites, 3-hydroxyphenylacetic acid (3-HPAA), formed by the gut microbiota, was previously reported to exert vasorelaxant effects ex vivo. The aim of this study was to shed more light on this effect in vivo, and to elucidate the mechanism of action. 3-HPAA gave rise to a dose-dependent decrease in arterial blood pressure when administered i.v. both as a bolus and infusion to spontaneously hypertensive rats. In contrast, no significant changes in heart rate were observed In ex vivo experiments, where porcine hearts from a slaughterhouse were used to decrease the need for laboratory animals, 3-HPAA relaxed precontracted porcine coronary artery segments via a mechanism partially dependent on endothelium integrity. This relaxation was significantly impaired after endothelial nitric oxide synthase inhibition. In contrast, the blockade of SKCa or IKCa channels, or muscarinic receptors, did not affect 3-HPAA relaxation. Similarly, no effects of 3-HPAA on cyclooxygenase nor L-type calcium channels were observed Thus, 3-HPAA decreases blood pressure in vivo via vessel relaxation, and this mechanism might be based on the release of nitric oxide by the endothelial layer.

Nutrients published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, HPLC of Formula: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lowenthal, Mark S. published the artcileDeveloping qualitative LC-MS methods for characterization of Vaccinium berry Standard Reference Materials, HPLC of Formula: 526-98-7, the publication is Analytical and Bioanalytical Chemistry (2013), 405(13), 4451-4465, database is CAplus and MEDLINE.

Standard Reference Materials (SRMs) offer the scientific community a stable and homogeneous source of material that holds countless application possibilities. Traditionally, the National Institute of Standards and Technol. (NIST) has provided SRMs with associated quant. information (certified values) for a select group of targeted analytes as measured in a solution or complex matrix. While the current needs of the SRM community are expanding to include non-quant. data, NIST is attempting to broaden the scope of how and what information is offered to the SRM community by providing qual. information about biomaterials, such as chromatog. fingerprints and profiles of untargeted identifications. In this work, metabolomic and proteomic profiling efforts were employed to characterize a suite of six Vaccinium berry SRMs. In the discovery phase, liquid chromatog.-tandem mass spectrometry (LC-MS/MS) data was matched to mass spectral libraries; a subsequent validation phase based on multiple-reaction monitoring LC-MS/MS relied on both retention time matching of authentic standards along with fragmentation data for a qual. overview of the most prominent organic compounds present. Definitive and putative identifications were determined for over 70 metabolites based on reporting guidelines set forth by the Metabolomics Standards Initiative (Metabolomics 3(3):211-221, 2007), and the capability of electrospray ionization mass spectrometry (ESI-MS) to profile untargeted metabolites within a complex matrix using mass spectral matching is demonstrated. Bottom-up proteomic analyses were possible using peptide databases translated from expressed sequence tags (ESTs). Homol. searches provided identification of novel Vaccinium proteins based on homol. to related genera. Chromatog. fingerprints of these berry materials were acquired for supplemental qual. information to be provided to users of these SRMs. An unbounded set of qual. data about a biomaterial is a valuable complement to quant. information traditionally provided in NIST Certificates of Anal.

Analytical and Bioanalytical Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pan, Haijuan published the artcileObservation on effect of carboprost tromethamine in prevention of postoperative bleeding during cesarean section with placenta previa, Quality Control of 58551-69-2, the publication is Guizhou Yiyao (2021), 45(7), 1064-1065, database is CAplus.

Objective: To investigate the effect of carboprost tromethamine in the prevention of postoperative bleeding during cesarean section with placenta previa. Methods: A controlled study was conducted on 88 puerperae with placenta previa who underwent cesarean section in our hospital from 2017.5 to 2019.5, and they were divided into observation group (carboprost tromethamine) and control group (oxytocin) 44 cases in each group, and the grouping method was random number table method to explore the effect of different treatments on postpartum hemorrhage and adverse reactions of puerperae. Results: The research objects in this paper were compared in terms of intraoperative blood loss, postoperative 12-h blood loss and postoperative 24-h blood loss. The observation group was significantly lower than the control group, and the difference was statistically significant (P < 0.05). Compared with the total effective rate, the observation group (97.73%) was significantly higher than the control group (86.36%), and the difference was statistically significant (P < 0.05). The observation group (2.27%, 9.09%) was significantly lower than the control group (15.91%, 27.27%), and the difference was statistically significant (P < 0.05). CONCLUSION: The application of carboprost tromethamine to pregnant women undergoing cesarean section with placenta previa could significantly reduce intraoperative and postoperative blood loss, with definite curative effect, less adverse reactions and high safety. This method was worthy of application and promotion.

Guizhou Yiyao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Quality Control of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Uroz, Stephane published the artcileDual transcriptomics and proteomics analyses of the early stage of interaction between Caballeronia mineralivorans PML1(12) and mineral, Computed Properties of 526-98-7, the publication is Environmental Microbiology (2020), 22(9), 3838-3862, database is CAplus and MEDLINE.

Summary : Minerals and rocks represent essential reservoirs of nutritive elements for the long-lasting functioning of forest ecosystems developed on nutrient-poor soils. While the presence of effective mineral weathering bacteria was evidenced in the rhizosphere of different plants, the mol. mechanisms involved remain uncharacterized. To fill this gap, we combined transcriptomic, proteomics, geo-chem. and physiol. analyses to decipher the potential mol. mechanisms explaining the mineral weathering effectiveness of strain PML1(12) of Caballeronia mineralivorans. Considering the early-stage of the interaction between mineral and bacteria, we identified the genes and proteins differentially expressed when: (i) the environment is depleted of certain essential nutrients (i.e., Mg and Fe), (ii) a mineral is added and (iii) the carbon source (i.e., glucose vs mannitol) differs. The integration of these data demonstrates that strain PML1(12) is capable of (i) mobilizing iron through the production of a non-ribosomal peptide synthetase-independent siderophore, (ii) inducing chemotaxis and motility in response to nutrient availability and (iii) strongly acidifying its environment in the presence of glucose using a suite of GMC oxidoreductases to weather mineral. These results provide new insights into the mol. mechanisms involved in mineral weathering and their regulation and highlight the complex sequence of events triggered by bacteria to weather minerals.

Environmental Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C3H5BN2O2, Computed Properties of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sokolova, Daria published the artcileEnantioselective Tail-to-Head Terpene Cyclizations by Optically Active Hexameric Resorcin[4]arene Capsule Derivatives, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Angewandte Chemie, International Edition (2022), 61(25), e202203384, database is CAplus and MEDLINE.

Mol. capsules enabled the conversion of substrates inside a closed cavity, mimicking to some extent enzymic catalysis. Chirality transfer from the mol. capsule onto the encapsulated substrate was only studied in a few cases. Here the chirality transfer was possible inside a rather large mol. container of approx. 1400 S3 was demonstrated. Specifically, the first examples of optically active hexameric resorcin[4]arene capsules such as I [R = Et, n-Pr, n-Bu], their ability to enantioselectively catalyze tail-to-head terpene cyclizations, and the surprisingly high sensitivity of enantioselectivity on the structural modifications was presented.

Angewandte Chemie, International Edition published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C7H6O3, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Itoh, Hiroshi published the artcileUV absorption of n-alkyl 1-thio-β-D-glucopyranosides and its utilization in chromatographic separation, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Tetrahedron Letters (2017), 58(37), 3678-3680, database is CAplus.

The UV absorption of n-alkyl β-D-glucopyranosides was not used so far for their detection which is usually performed by the refractive index detector. The authors demonstrate the HPLC separation of several n-alkyl β-D-glucopyranosides with linear gradient by using UV detector and support the authors’ findings with time-dependent d. functional theory calculations

Tetrahedron Letters published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Name: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kelemen, Vanja published the artcileBrown rice proteins as delivery system of phenolic and volatile compounds of raspberry juice, Related Products of alcohols-buliding-blocks, the publication is International Journal of Food Science and Technology (2022), 57(4), 1866-1874, database is CAplus.

Development of novel food ingredients with health benefits as well as desired sensory attributes is of great importance for food industry. For that purpose, complexes (BRP/R) between brown rice proteins (amounts varied; 2%, 6% and 10%) and raspberry juice were prepared Obtained complexes were evaluated for the amount of volatile compounds, phenolic content, anthocyanin content and antioxidant activity. Those parameters depended on proteins amount The highest adsorption of total phenolics and anthocyanins (18.18 mg g^-1 and 4.59 mg g^-1, resp.) was observed on complexes obtained with the lowest amount of proteins (2%). Regarding volatiles, dominant flavor note in raspberry juice was berry (40% of overall flavor), followed by citrus and woody notes (each around 18%), while dominant flavor note on complexes was citrus note (60%) followed by green note (15%). These results suggest an efficient plant-based approach to produce value-added protein-based complexes with possible utility as food colorant and flavoring.

International Journal of Food Science and Technology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts