Category: alcohols-buliding-blocks

Luo, Guanzhou published the artcileFacile fabrication of an F-POSS polymer-based liquid-repellent Cu mesh with excellent durability and self-cleaning performance, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate), the main research area is octavinyl polyhedral oligomeric silsesquioxane copper polymer durability.

A facile method that combines alkali-assisted oxidation and -SH chelation with a click chem. reaction was employed to create an F-POSS polymer surface (fluorinated octavinyl polyhedral oligomeric silsesquioxane polymer)-based Cu mesh (F-POSS-OM). The as-prepared F-POSS-OM surface displayed a cohering hierarchical nano-F-POSS polymer granule/micro-Cu(OH)2 wire structure, which provided a re-entrant geometry needed for liquid-repellency and low liquid sliding angles (<15°). Moreover, the easy-prepared structure endows the F-POSS-OM with remarkable durability for mech. and chem. damages, including wear abrasion, tape-peeling, 100 cm-height hammer impact, severe hand twisting, strong acid/base/salt solutions, and high temperatures Importantly, F-POSS-OM still retained excellent self-cleaning performance even after being subjected to these damages. Soft Matter published new progress about Click chemistry. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Recommanded Product: Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sharma, Sadhana published the artcileThe effects of processing variables on electrospun poly(ethylene glycol) fibrous hydrogels formed from the thiol-norbornene click reaction, Synthetic Route of 7575-23-7, the main research area is PEG norbornene PEO I2959click reaction tissue engineering shear modulus.

Electrospinning has been used to create scaffolds with tunable micro/nano architecture, stiffness, and porosity to mimic native extracellular matrix. This study investigated the effects of electrospinning parameters and hydrogel formulation (solvent and crosslinker type) on the architecture and properties of fibrous poly(ethylene glycol) (PEG) hydrogels formed from a photoclick thiol-norbornene reaction. Fibrous hydrogels were prepared using hydrogel precursors (four-arm PEG norbornene and multi-thiol crosslinker), sacrificial poly(ethylene oxide) (PEO, 400 kDa), and photoinitiator (I2959) in either 2,2-triflouroethanol (TFE) or water. Three thiol crosslinkers- 2,2′-(ethylenedioxy)diethanethiol (EDT), pentaerythritol tetrakis(3mercaptopropionate) (PTMP), and PEG dithiol (PEGDT)- were investigated. Fibrous PEG networks with uniform fibers were produced at applied voltages of 10 or 12 kV for TFE and 16 kV for water. Fiber diameters of electrospun hydrogels were largely affected by the solvent when combined with PEO concentration and ranged from 0.5 to 3.5 mm in dry state. While the effect of crosslinker type on fiber diameter, morphol., and porosity of the fibrous hydrogel was minimal, it did modulate its shear modulus. To this end, this study provides the groundwork for selecting processing parameters to achieve desired properties of fibrous PEG thiol-norbornene hydrogels for intended tissue engineering applications ranging from neural, cardiovascular to musculoskeletal.

Journal of Applied Polymer Science published new progress about Click chemistry. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Synthetic Route of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gablier, Alexandra published the artcileTransesterification in Epoxy-Thiol Exchangeable Liquid Crystalline Elastomers, Safety of Pentaerythritol tetra(3-mercaptopropionate), the main research area is transesterification epoxy thiol exchangeable liquid crystalline elastomer.

The incorporation of vitrimer bond-exchange chem. into liquid crystalline elastomer networks produces “”exchangeable liquid crystal elastomers”” (xLCE). These materials offer a facile method of material reshaping and alignment post-polymerization via the application of a mech. stress above the temperature of activation of bond exchange. We use diepoxy mesogenic monomers with thiol-terminated spacers and crosslinker to investigate a range of resulting xLCE. The “”click”” chem. of thiols results in good control over the network topol. and low glass transition in this family of materials. By combining different spacers, we were able to obtain smectic and nematic phases and adjust the liquid crystal to the isotropic phase transition between 42 and 140°C, while the elastic-plastic transition temperature was maintained close to 200°C. The broad gap between these temperatures ensures that thermally actuating uniformly aligned elastomers are stable and show no residual plastic creep, making epoxy-thiol xLCE promising for a range of engineering applications.

Macromolecules (Washington, DC, United States) published new progress about Click chemistry. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Safety of Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tian, Guangming published the artcilePhotodirected 2D-to-3D morphing structures of shape memory polycaprolactone/W18O49 nanowires composite film, Application of Pentaerythritol tetra(3-mercaptopropionate), the main research area is tungsten oxide polycaprolactone composite film photodirected shape memory effect.

Shape memory materials possess programmable complex and large deformations toward external stimuli, which are particularly essential for their potential applications. For the transformation of planar two-dimensional (2D) structures into complex 3D structures, the design of asym. or bilayer thin sheets is usually required. In this paper, we propose a facile strategy to achieve these complex 3D structures that can be transformed to various pre-determined shapes sequentially by laser-triggered site-specific deformations. The response of shape memory polycaprolactone (PCL) to laser is realized by phys. doping W18O49 nanowires into the cross-linked PCL diacrylate matrix. When irradiated by 98 mW cm-2 laser, the pre-stretched PCL/W18O49 film shows an out-of-plane bending deformation due to the temperature gradient and single-domain orientation on the thickness between the upper layer and lower layer. The bending rates and amplitudes of the film can be tailored by adjusting the parameters of irradiation time, the film thickness as well as the pre-stretch strain. Remarkably, the pre-stretched film can automatically bend in more intricate complex deformations by integration with kirigami cuts in planar. Finally, we demonstrate that by activating the dynamic transesterification reaction within the same film, it can also achieve the 2D-to-3D transformations. With these decent features, this kind of novel PCL//W18O49 film shows great potential in the field of biomedical devices or soft robotics.

Science China Materials published new progress about Click chemistry. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application of Pentaerythritol tetra(3-mercaptopropionate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khedri, Zohrab published the artcileKirkwood-Buff integrals and structure factor for binary mixtures of ionic liquid with 1-alkanol, Safety of n-Octanol, the main research area is alkanol Kirkwood Buff integral binary mixture ionic liquid.

In this paper, we have tried to describe the factors affecting mol. interactions and structure of binary systems including 1-Hexyl-3-methylimidazolium Nitrate ([Hmim][NO3]) and 1-alkanol (1-hexanol, up to 1-decanol) using Kirkwood-Buff (KB) integrals and structure factor. Obtained results indicate that unlike mols. tend to form favorable interactions via forming hydrogen bonds or dipolar interactions and stay alongside, while an increase in the carbon chain of 1-alkanols reduces the strength of bonds and tendency of the unlike mols. to stay together. Moreover, the structure of mixtures was studied using the concentration-concentration structure factor, SCC(0). Results from the application of this parameter show that in all binary mixtures, heterocoordination is predominant, ordering occurs in solutions and fluctuations are less than random orientation. In addition, the chem. short-range order parameter α’, which is an important function to understand the complex formation and phase segregation in the liquid mixtures, was calculated and discussed for mentioned mixtures For current binary mixtures, exptl. data and theor. investigations are novel and reported for the first time.

Journal of Molecular Liquids published new progress about Binary mixtures. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Losada-Perez, Patricia published the artcileAsymmetric liquid-liquid criticality in the ideal volumetric mixing approximation, Product Details of C5H12O, the main research area is nitromethane pentanol liquid criticality volumetric mixing.

We address the question on the validity of the ideal volumetric mixing approximation, a customarily used approach to analyze liquid-liquid phase transitions. Thus, liquid-liquid coexistence curves for the binary mixture composed by nitromethane and 3-pentanol were obtained from direct single-phase mass d. measurements as a function of temperature A reasonable agreement with previously reported data obtained from refractive index measurements has been found, indicating that assuming ideal mixing is rather reasonable. Furthermore, the implications of the ideal volumetric mixing approximation on asym. liquid-liquid criticality are explored in the framework of complete scaling formulation, with emphasis on the coexistence curves in the mole fraction-temperature and volume fraction-temperature planes as well as on the behavior of the isobaric heat capacity per particle and per unit volume and the associated Yang-Yang-type anomalies.

Journal of Chemical Thermodynamics published new progress about Binary mixtures. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Product Details of C5H12O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reifenrath, William G. published the artcilePercutaneous Absorption of an Insect Repellent p-Menthane-3,8-DIOL: A Model for Human Dermal Absorption, Recommanded Product: 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is menthanediol insect repellent skin absorption swine model solvent.

P-Menthane-3,8-diol(38DIOL) was recently introduced as a natural topical insect repellent in the com. product “”OFF! Botanicals”” lotion. The objective of this study was to provide an estimate of the potential for 38DIOL systemic absorption in humans. 14C 38DIOL formulated in the lotion and in an EtOH solution was applied to excised swine skin in an in vitro flow-through test system predictive of skin absorption in humans. Twenty-four hours after application, radiolabel recovered from the dermis and receptor fluid was summed to determine % absorption. At a dose of approx. 80 μg/cm2 of 38DIOL in the lotion, a value of 3.5 ± 0.8% of applied dose was obtained with swine skin. The corresponding value for 38DIOL in EtOH (90 μg/cm2) was not significantly different (3.0 ± 1.2%). Most of the applied dose of 38DIOL was found to evaporate from swine skin (77 ± 8% for the lotion and 87 ± 1% for EtOH solution), thus limiting percutaneous absorption values. For reference purposes, the swine skin absorptions of piperonyl butoxide (PBO) at 100 μg/cm2 in isopropanol, N,N-diethyl-m-toluamide (DEET) at 500 μg/cm2 in EtOH, and neat isododecane at 650 μg/cm2 (in order of increasing volatility) were 15 ± 6%, 23 ± 3%, and 0.09 ± 0.05% of applied dose resp. Isododecane was lost almost exclusively from the skin surface by evaporation For addnl. reference, absorptions of PBO, DEET, and 38DIOL were found to be higher with excised rat skin.

Journal of Toxicology and Environmental Health, Part A: Current Issues published new progress about Bioaccumulation. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Recommanded Product: 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wright, JaLessa N. published the artcileAcute increases in O-GlcNAc indirectly impair mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover, Application of (S)-2-hydroxysuccinic acid, the main research area is OGlcNAc LonP dysregulation mitochondrial protein bioenergetics; LonP1; Thiamet-G; bioenergetics; mitochondria; protein -GlcNAcylation; protein turnover.

The attachment of O-linked β-N-acetylglucosamine (O-GlcNAc) to the serine and threonine residues of proteins in distinct cellular compartments is increasingly recognized as an important mechanism regulating cellular function. Importantly, the O-GlcNAc modification of mitochondrial proteins has been identified as a potential mechanism to modulate metabolism under stress with both potentially beneficial and detrimental effects. This suggests that temporal and dose-dependent changes in O-GlcNAcylation may have different effects on mitochondrial function. In the current study, we found that acutely augmenting O-GlcNAc levels by inhibiting O-GlcNAcase with Thiamet-G for up to 6 h resulted in a time-dependent decrease in cellular bioenergetics and decreased mitochondrial complex I, II, and IV activities. Under these conditions, mitochondrial number was unchanged, whereas an increase in the protein levels of the subunits of several electron transport complex proteins was observed However, the observed bioenergetic changes appeared not to be due to direct increased O-GlcNAc modification of complex subunit proteins. Increases in O-GlcNAc were also associated with an accumulation of mitochondrial ubiquitinated proteins; phosphatase and tensin homolog induced kinase 1 (PINK1) and p62 protein levels were also significantly increased. Interestingly, the increase in O-GlcNAc levels was associated with a decrease in the protein levels of the mitochondrial Lon protease homolog 1 (LonP1), which is known to target complex IV subunits and PINK1, in addition to other mitochondrial proteins. These data suggest that impaired bioenergetics associated with short-term increases in O-GlcNAc levels could be due to impaired, LonP1-dependent, mitochondrial complex protein turnover.

American Journal of Physiology published new progress about Bioaccumulation. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Application of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sudhakar, Sekar published the artcileBiodistribution and pharmacokinetics of thiolated chitosan nanoparticles for oral delivery of insulin in vivo, Application In Synthesis of 7575-23-7, the main research area is thiolated chitosan nanoparticle insulin oral delivery pharmacokinetics; Bioavailability; Chitosan; Insulin; Mucoadhesion; Oral delivery.

To improve the quality of life of diabetic patients, oral delivery of insulin would be better than s.c. injection, and the encapsulation of insulin for its oral delivery is a promising alternative one. In this study, we prepared an oral insulin delivery system using thiolated chitosan nanoparticles (TCNPs) loaded with insulin (Ins) and tested under in vitro and in vivo systems. TCNPs prepared from CS and pentaerythritol tetrakis (3-mercaptopropionate) (PETMP) at 4:1 ratio showed 220 ± 4 nm, 2.3 ± 1 mV, and 119 ± 4μmol g-1 in their size, charge and sulfhydryl content, resp . There was a sustained release of insulin from the TCNPs at pH 5.3. TCNPs treatment did not alter cell viability in vitro and oral administration of TCNPs reached over the tip of the microvilli near the intestinal mucosa in vivo. There were increased and decreased the levels of insulin and glucose in the blood, resp. when Ins-TCNPs were orally administered in the diabetes induced rats. Thus, our results suggested that the insulin stays significantly for a prolonged period to make bio-distribution and bioavailability due to its interaction with the mucus of the intestine, thus offering a better oral insulin delivery system for diabetic patients.

International Journal of Biological Macromolecules published new progress about Bioavailability. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lategahn, Jonas published the artcileInhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S, Name: 3-(Methylthio)propan-1-ol, the main research area is nonsmall cell lung cancer osimertinib EGFR drug resistance.

Precision medicine has revolutionized the treatment of patients in EGFR driven non-small cell lung cancer (NSCLC). Targeted drugs show high response rates in genetically defined subsets of cancer patients and markedly increase their progression-free survival as compared to conventional chemotherapy. However, recurrent acquired drug resistance limits the success of targeted drugs in long-term treatment and requires the constant development of novel efficient inhibitors of drug resistant cancer subtypes. Herein, we present covalent inhibitors of the drug resistant gatekeeper mutant EGFR-L858R/T790M based on the pyrrolopyrimidine scaffold. Biochem. and cellular characterization, as well as kinase selectivity profiling and western blot anal., substantiate our approach. Moreover, the developed compounds possess high activity against multi drug resistant EGFR-L858R/T790M/C797S in biochem. assays due to their highly reversible binding character, that was revealed by characterization of the binding kinetics. In addition, we present the first x-ray crystal structures of covalent inhibitors in complex with C797S-mutated EGFR which provide detailed insight into their binding mode.

Chemical Science published new progress about Bioavailability. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Name: 3-(Methylthio)propan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts