Category: alcohols-buliding-blocks

Arulprakasam, Karthick Raja published the artcileGenome mining of biosynthetic gene clusters intended for secondary metabolites conservation in actinobacteria, Category: alcohols-buliding-blocks, the main research area is genome mining secondary metabolite actinobacteria; Anti-microbial resistance; Biosynthetic gene cluster; Genome mining; Non-ribosomal peptide synthetases; Polyketide synthases; Secondary metabolites.

Evolution of genome sequencing technol., on the one hand, and advancement of computational genome mining tools, on the other hand, paves way for improvement in predicting secondary metabolites. In past, numerous efforts were made concerning genome mining for recognizing secondary metabolites within the genus, but only a negligible quantity of comparative genomic reports had carried out among species of different genera. In this study, we explored potential of 24 actinobacteria species belonging to the genera, including Streptomyces, Nocardia, Micromonospora, and Saccharomonospora, to traverse diversity and distribution of Biosynthetic Gene Clusters (BGCs). Investigating results obtained from antiSMASH (Antibiotics and Secondary Metabolites Anal. Shell), NaPDoS (Natural Product Domain Seeker), and NP.searcher revealed conservation of genus-specific gene clusters among various species. E.g., NAGGN (n-acetyl glutaminyl glutamine amide) is present in Micromonospora, furan in Nocardia, melanin, and lassopeptide occur in Streptomyces. Bioactive compounds like alkyl-O-dihydro geranyl methoxy hydroquinone, SapB, desferrioxamine E, 2-Methylisoborneol, mayamycin, cyclodipeptide synthase, diisonitrile, salinichelin, hopene, ectoine and isorenieratene are highly conserved among diverse genera. Furthermore, pharmacol. activity of actinobacterial derived metabolites against bacterial and fungal pathogens were illustrated. We need to accomplish large-scale anal. of natural products, including various genera of actinobacteria to deliver comprehensive intuition to overcome antibiotic resistance.

Microbial Pathogenesis published new progress about Actinobacteria. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Song, Min published the artcileDietary chenodeoxycholic acid improves growth performance and intestinal health by altering serum metabolic profiles and gut bacteria in weaned piglets, Formula: C4H10OS, the main research area is dietary chenodeoxycholic acid improve growth altering gut bacteria metabolism; Chenodeoxycholic acid; Growth performance; Gut health; Gut microbiota; Serum metabolite; Weaned piglet.

Nutritional diarrhea and subsequent performance degradation in weaned piglets are major challenges for the pig industry. Bile acids (BA) can be added to the diet as emulsifiers. This experiment was conducted to investigate the effects of chenodeoxycholic acid (CDCA), a major primary BA, on growth performance, serum metabolic profiles and gut health in weaned piglets. A total of 72 healthy weaned piglets were randomly assigned to the control (CON) and the CDCA groups, which were feed a basal diet and the basal diet supplemented with 200 mg/kg CDCA for 30 d, resp. Our results demonstrated that CDCA significantly increased final BW and average daily gain (ADG), decreased feed-to-gain (F:G) ratio and tended to reduce diarrhea incidence. In addition, CDCA increased the villus height-to-crypt depth (V:C) ratio, elevated goblet cell numbers and the expression of tight junction proteins, suggesting the enhancement of intestinal barrier function. As an emulsifier, CDCA increased jejunal lipase activity and the mRNA expression of pancreatic lipases. CDCA supplementation also altered the serum metabolic profiles, including increasing the levels of indole 3-acetic acid, N′-formylkynurenine and theobromine that were beneficial for gut health. Moreover, the relative abundance of 2 beneficial gut bacteria, Prevotella9 and PrevotellaceaeTCG-001, were increased, whereas the relative abundance of a harmful bacteria, Dorea, was decreased in the gut of weaned piglets supplemented with CDCA. Importantly, the altered serum metabolic profiles showed a strong correlation with the changed gut bacteria. In conclusion, CDCA improved the growth performance of weaned piglets by improving intestinal morphol. and barrier function, and enhancing lipid digestion, accompanied by alterations of serum metabolic profiles, and changes in relative abundance of certain gut bacteria.

Animal Nutrition published new progress about Actinobacteria. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Formula: C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

El Ouahdani, Khadija published the artcileThymus algeriensis and Artemisia herba-alba Essential Oils: Chemical Analysis, Antioxidant Potential and In Vivo Anti-Inflammatory, Analgesic Activities, and Acute Toxicity, Related Products of alcohols-buliding-blocks, the main research area is Thymus Artemisia essential oil antiinflammatory analgesic agent acute toxicity; Artemisia herba-alba; Thymus algeriensis; analgesic; anti-inflammatory; antioxidant; toxicity.

The study of bioactive mols. of natural origin is a focus of current research. Thymus algeriensis and Artemisia herba-alba are two medicinal plants widely used by the Moroccan population in the traditional treatment of several pathologies linked to inflammation. This study aimed to evaluate the single and combined antioxidant, anti-inflammatory and analgesic effects of the essential oils extracted from these two medicinal plants, and also their potential toxicity. Essential oils were extracted using hydro-distillation in a Clevenger-type apparatus The antioxidant activity was evaluated by two methods: the scavenging of the free radical DPPH, and the reduction in iron. Anti-inflammatory activity was evaluated by evaluating the edema development induced by carrageenan injecting, while the analgesic power was evaluated according to the number of abdominal contortions induced by the i.p. injection of acetic acid (0.7%). The acute oral toxicity was performed to assess the potential toxicity of the studied EOs, followed by an anal. of the blood biochem. parameters. The results of the two antioxidant tests indicated that our extract mixture exhibits good iron reduction capacity and very interesting DPPH free radical scavenging power, with an IC50 of around 4.38 ± 0.98 μg/mL higher than that of the benchmark antioxidant, BHT. The anti-inflammatory test demonstrated that the mixture administered orally at a dose of 150 mg/kg has a better activity, exceeding that of 1% Diclofenac, with a percentage of maximum inhibition of the edema of 89.99 ± 4.08. The number of cramps in the mice treated with the mixture at a dose of 150 mg/kg is significantly lower (29.80 ± 1.92) than those of the group treated with Tramadol (42.00 ± 2.70), resp. The toxicity results show no signs of toxicity with an LD50 greater than 150 mg/Kg. These interesting results show that the two plants′ EOs had an important anti-inflammatory, analgesic, and antioxidant activity, and also a powerful synergistic effect, which encourages further in-depth investigations on their pharmacol. proprieties.

Molecules published new progress about Acute toxicity. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sharma, Mahima published the artcileBacopa monnieri attenuates glutamate-induced nociception and brain mitochondrial toxicity in Zebrafish, COA of Formula: C4H6O5, the main research area is Bacopa Danio glutamate nociception brain mitochondrial toxicity apoptosis; Apoptosis; Bacopa monnieri; Brain; Glutamate; Mitochondria; Zebrafish.

Bacopa monnieri L.(BM; Family: Scrophulariaceae), commonly known as Brahmi, is traditionally used as a nootropic agent. BM also exhibits significant analgesic activity in exptl. models of pain. However, the effect of Bacopa monnieri against glutamate-induced nociception in zebrafish is yet to be explored in exptl. condition. Therefore, the present study was designed to evaluate the effect of BM against glutamate-induced nociception and brain mitochondrial toxicity in adult zebrafish (Danio rerio). BM at 0.625, 1.25 and 2.5 mg/mL was administered to adult zebrafish and after half an hour glutamate was injected through i.m. route of administration. Indomethacin was used as standard drug. After behavioral anal., the fish were euthanized and the brain was isolated and stored for further biochem. anal. BM (1.25 and 2.5 mg/mL) and indomethacin significantly attenuated the glutamate-induced increase in number of line crossing compared to control group animals. Addnl., BM (1.25 and 2.5 mg/mL) and indomethacin significantly reduced the glutamate induced increase in cytosolic calcium level. Further, there was a substantial improvement in mitochondrial function, integrity and bioenergetics in term of respiratory control rate and ADP/O in zebrafish brain. Moreover, BM (1.25 and 2.5 mg/mL) and indomethacin significantly reduced the glutamate-induced mitochondria-dependent apoptosis in zebrafish brain. Therefore, BM could be a potential alternative drug candidate in the management of pain.

Metabolic Brain Disease published new progress about Acute toxicity. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, COA of Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Peng published the artcileSolubility of Isomalt in the Water + Ethanol Solvent System at (288.15, 298.15, 308.15, and 318.15) K, Synthetic Route of 64519-82-0, the main research area is solubility isomalt water ethanol solvent system.

The solubility of isomalt in the water + ethanol solvent system was measured with the mole fraction of water ranging from 0.00 to 1.00 at (288.15, 298.15, 308.15, and 318.15) K by using the laser method that is timesaving and the gravimetric method that is more reliable. The data were fitted using the simplified Jouyban-Acree model. In this study, the solubility data obtained by these two methods were compared. The mean relative deviations for isomalt solubility determined by the laser method and the gravimetric method were less than 25 % and 17 %, resp.

Journal of Chemical & Engineering Data published new progress about Crystallization. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Synthetic Route of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Yiping published the artcileThree-stage microwave extraction of cumin (Cuminum cyminum L.) Seed essential oil with natural deep eutectic solvents, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Cuminum tricyclene seed essential oil natural deep eutectic solvent.

As a class of promising green media, natural deep eutectic solvents (NADESs) have attracted more and more attention in recent years. In this paper, a novel method based on microwave-assisted natural deep eutectic solvents pretreatment coupled with microwave hydrodistillation (MA-NADES-MHD) was used for the extraction of essential oil from Cuminum cyminum L. seed. NADESs were used as pretreatment solvents for adsorbing microwaves and dissolving cellulose. The maximum yield of essential oil obtained with this three-stage microwave extraction technol. was 2.22% (weight/weight) when the natural deep eutectic solvent composed of choline chloride and L-lactic acid (with 1:3 of molar ratio) with 40% (weight/weight) of water. Compared with microwave hydrodistillation (MHD) and ultrasound-assisted natural deep eutectic solvents pretreatment combined with microwave hydrodistillation (UA-NADES-MHD) in which essential oil yield of 1.13% (weight/weight) and 1.57% (weight/weight) were obtained, resp., the MA-NADES-MHD naturally brought more essential oil. Notably, a total of 45, 48, and 58 volatile components were identified by using gas chromatog.-mass spectrometry with MHD, UA-NADES-MHD, and MA-NADES-MHD, resp. Hence, NADESs had a significant impact on the extraction of essential oil with higher yield, premium quality, and more quantity, especially when it was combined with microwave technol. Moreover, the MA-NADES-MHD as an economical and eco-friendly technique had the potential to be applied to other plant materials.

Industrial Crops and Products published new progress about Cuminum cyminum. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Borchers, Philipp S. published the artcileA Viologen Polymer and a Compact Ferrocene: Comparison of Solution Viscosities and Their Performance in a Redox Flow Battery with a Size Exclusion Membrane, Formula: C17H28O8S4, the main research area is bipyridine styrene polymer ferrocene containing pentaerythritol redox flow battery.

In this work, the synthesis and characterization of a compact, ferrocene tetramer and a linear viologen polymer is reported. The latter material is a new, 4,4′-bipyridine containing, organo-soluble polymer. As aimed for solubility in nonpolar solvents, a 2-ethylhexyl-moiety to promote organosoly. and 4-vinylbenzyl serving as a polymerizable group are introduced to a 4,4′-bipyridine. The halide anions of the monomer cation are exchanged to bis(trifluoromethansulfon)imide, which further enhances organosoly. The monomer is subsequently copolymerized with styrene by free radical polymerization In addition, a four-ferrocene-containing compact structure, based on pentaerythritol, is synthesized via the straightforward radical thiol-ene reaction. The polymer solutions are thoroughly characterized hydrodynamically. Subsequently, propylene carbonate-based solutions of both materials are prepared to allow an assessment for future energy storage applications. This is done by testing battery characteristics in a custom-made flow-cell with a simple dialysis membrane for phys. separation of the active materials. The capability of energy storage is verified by leaving the charged materials in solution in an open circuit for 24 h. Here, more than 99% of the stored charges can be recovered. Cycling the battery for 100 times reveals the remarkable stability of the materials of only 0.2% capacity loss per day in the battery setup.

Macromolecular Chemistry and Physics published new progress about Current density. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Formula: C17H28O8S4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sims, Samantha M. published the artcileCorrelating structure with ionic conductivity in bis(phosphonium)-containing [NTf2] thiol-ene networks, Related Products of alcohols-buliding-blocks, the main research area is correlating ionic conductivity phosphonium containing ionic liquid photopolymerization.

Thiol-ene photopolymerization was employed in order to prepare a series of covalently crosslinked bis(phosphonium)-containing poly(ionic liquid) (PIL) networks. While the counteranion was held constant (NTf2), the structure of the bis(phosphonium)-containing ‘ene’ monomer was varied in order to explore the breadth of thermal, mech. and conductive properties available for this system. Towards this end, it was determined that more flexible spacers within the cationic monomer led to PIL networks with lower Tg values and higher conductivities. Most notable was a two- to three-orders-of-magnitude increase in ionic conductivity (from 10-9 to 10-6 S cm-1 at 30 °C, 30% relative humidity) when the R group on phosphonium was changed from Ph to iso-Pr. Changing the functional group ratio to off-stoichiometry also led to a slight increase in conductivity Although the thermal stability (Td5%) of the phosphonium ionic liquid monomers was found to be significantly higher (>400 °C) than that of analogous imidazolium monomers, this improvement was not observed to directly transfer over to the polymer where a two-step decomposition pathway was observed The first step is attributed to the thiol monomer backbone while the second step correlates well with decomposition of the phosphonium portion of the PIL. © 2019 Society of Chem. Industry.

Polymer International published new progress about Dielectric loss. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Yiqiong published the artcileEffect of simulated gastrointestinal digestion in vitro on the antioxidant activity, molecular weight and microstructure of polysaccharides from a tropical sea cucumber (Holothuria leucospilota), Computed Properties of 59-23-4, the main research area is Holothuria simulated gastrointestinal digestion polysaccharide antioxidant microstructure.

The physicochem. properties of Holothuria leucospilota polysaccharides (HLP) were measured, and the changes of mol. weight (Mw), antioxidant activity and microstructure in vitro were studied. The Mw of HLP was approx. 52.80 kDa, and the monosaccharide composition was primarily fucose, rhamnose and glucuronic acid. HLP showed good antioxidant activity at high concentration (≥2 mg/mL), and the DPPH (1,1-Diphenyl-2-picryl-hydrazil) free radical scavenging rate reached approx. 84%. It was observed that saliva did not have an effect on the Mw and antioxidant capability of HLP. Gastric and intestinal digestion significantly reduced the Mw of HLP (from 52.80 kDa to 14.67 kDa and 12.01 kDa) and maintained high antioxidant activity. In addition, the structure and surface morphol. were markedly altered. After simulated gastric digestion, the HLP changed from a smooth, irregular, and angular structure to a layered honeycomb with a large volume This result demonstrated that the decrease of Mw after gastric digestion was caused by the destruction of aggregates. Due to the decomposition of glycosidic bonds after digestion in intestine, HLP showed loose, small and blocky structures. Thus, HLP had antioxidant activity, and this activity was improved after gastric and intestinal digestion.

Food Hydrocolloids published new progress about Digestive juice. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luhn, Oliver published the artcileDissolution profile of novel composite pellet cores based on different ratios of microcrystalline cellulose and isomalt, Category: alcohols-buliding-blocks, the main research area is dissolution composite pellet microcrystalline cellulose isomalt Eudragit.

There is a growing interest towards the application of inert cores as starting materials for pharmaceutical pellet manufacturing They serve as alternatives to develop and adapt a relatively simple manufacturing technol. compared with an extrusion/spheronization process. The major objective of this study was to investigate the effect of the compositions of core materials on the drug release profile. Pure microcrystalline cellulose (MCC), isomalt and different types of novel composite MCC-isomalt cores were layered with model drug (sodium diclofenac) and were coated with acrylic polymer. The effect of the osmolality in the gastrointestinal tract was simulated using glucose as osmotically active agent during in vitro dissolution tests. The results demonstrated the dependence of drug dissolution profile on the ratio of MCC and isomalt in the core and the influence of osmotic properties of the dissolution medium. Isomalt used in the composite core was able to decrease the vulnerability of the dissolution kinetics to the changes in the osmotic environment. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci.

Journal of Pharmaceutical Sciences published new progress about Digestive tract. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts