Category: alcohols-buliding-blocks

Ribeiro, Adriana Santos published the artcileSynthesis of (R)-(-) and (S)-(+)-3-(1-pyrrolyl)propyl N-(3,5-dinitrobenzoyl)-α-phenylglycinate and derivatives. A suitable chiral polymeric phase precursor, Application of 3-(1H-Pyrrol-1-yl)propan-1-ol, the main research area is phenylglycine N dinitrobenzoyl derivative enantiomeric preparation; pyrrolylpropyl dinitrobenzoylphenylglycinate preparation precursor polymeric film.

A synthetic route to obtain 3-(1-pyrrolyl)propyl (R)- and (S)-N-(3,5-dinitrobenzoyl)-α-phenylglycinate (1, 2) and derivatives is described. In a first step, pyrrole derivatives were prepared using the Clauson-Kaas method. The esterification, second step, was performed using basic conditions due to sensitivity of the pyrrole group toward acidic conditions. A tautomeric equilibrium involving the stereogenic center induces the product epimerization. The substitution of DMAP and Et3N by a highly hindered base, proton-sponge, furnished the final products without racemization. The enantiomeric excess of 1, 2 and of the corresponding Me esters (3 and 4) were determined by 1H NMR anal. in the presence of optically active Eu(tfc)3. Epimerization was not observed in the preparation of the amine salts of (R)- and (S)-N-(3,5-dinitrobenzoyl)-α-phenylglycine with triethylamine and 1-[3-(dimethylamino)propyl]pyrrole.

Tetrahedron: Asymmetry published new progress about Esterification. 50966-69-3 belongs to class alcohols-buliding-blocks, name is 3-(1H-Pyrrol-1-yl)propan-1-ol, and the molecular formula is C7H11NO, Application of 3-(1H-Pyrrol-1-yl)propan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nishimura, Mitsugu published the artcileEfficient GC/MS analysis of hydroxy lipid compounds from geochemical samples using tertiary-butyldimethylsilyl etherification, Application In Synthesis of 13099-34-8, the main research area is hydroxy lipid compound analysis geochem sample GC MS; butyldimethylsilyl etherification hydroxy lipid compound analysis GC MS.

To improve GC/MS anal. of hydroxy compounds from various sources, such as alkanols, sterols, diols, keto-ols and hydroxy fatty acids (FAs) with complex compositions, the authors evaluated their column-chromatog. separation after silylation. N-tertiary-butyldimethylsilylimidazole (t-BDMS) was expected to be the most effective silylating reagent to make -OH groups more inert and hence to promote separation according to the chem. and structural differences in their individual alkyl groups. The t-BDMS etherification of hydroxy compounds remarkably improved their purification and separation by strongly constraining or enhancing the chromatog. different behavior possibly caused by chem. and structural differences in the alkyl groups. Thus, the complex mixtures of hydroxy compounds from lacustrine and marine sediments were clearly fractionated into each major compound group, i.e., alkanols, sterols, diols, hydroxy FAs and keto-ols. Also, the individual sterols, diols and hydroxy FAs were separated into four, two and five specific sub-groups, resp. It is worth noting that, by using only one column, this anal. improvement was achieved with excellent reproducibility. Such fine fractionations resulted in a substantial decrease in the complexity of the gas chromatograms of all major hydroxy compounds The improvement enabled the authors to simply and accurately identify and quantify major as well as trace homologs and isomers of various hydroxy compounds with a high level of sensitivity using GC/MS. Consequently, the authors found some series of hitherto unknown compounds to serve as information sources for organisms and environments. The chromatog. fractionation following t-BDMS etherification of lipids from various geochem. samples provides not only a greater understanding of their mol. distributions and stable carbon isotopic ratios, but also substantially upgrades lipid anal. efficiency as a whole.

Organic Geochemistry published new progress about Etherification. 13099-34-8 belongs to class alcohols-buliding-blocks, name is 17-Hydroxyheptadecanoic acid, and the molecular formula is C17H34O3, Application In Synthesis of 13099-34-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anzano, Jesus M. published the artcileChemistry practices for undergraduate students: plastic polymers characterization by gas chromatography, Safety of n-Octanol, the main research area is polymer plastic property gas chromatog.

The present study deals with the chem.-anal. characterization of plastics, specifically anal. determination of phthalates in polyvinyl chloride (PVC) and the quantification of residual styrene (S) monomer in plastic polystyrene (PS); both polymers are commonly used in food packaging. In determining phthalates, the method’s principle used, is the precipitation of the PVC polymer followed by hydrolysis of the plasticizers and the leaching of the alc. obtained in an organic phase. To study the efficiency of the reaction, dioctyl phthalate (DOP) has been used as a standard In determining S, the method used, is based on the total sample-plastic dissolution followed by the precipitation of the PS leaving behind the monomer. It does not include dilution methods. In both tests, the quant. determination is made by gas chromatog. (GC).

Journal of Laboratory Chemical Education published new progress about Food packaging. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Koltun, Stephen J. published the artcileSensory and chemical characteristics of tomato juice from fresh market cultivars with comparison to commercial tomato juice, Recommanded Product: 3-Pentanol, the main research area is tomato juice sensory metabolites.

Florida tomatoes are primarily produced for the fresh market and have not been widely used in processed tomato products. This study tested six Florida fresh market tomato cultivars (FLA 8083, FLA 8297, FLA 8344, FLA 8570, FLA 8924 and Garden Gem) to determine suitability for juice production Genetic and environmental-induced variation was studied, and analyses identified metabolites that influenced the perceptual and hedonic responses of tomato juice. Each cultivar was processed into juice by hot breaking at 86 C for 3.5 min and then pasteurization at 121 C for 42 s for a shelf stable product. Among the six pilot products, FLA 8344 cultivar had significantly higher soluble solids content and titratable acidity in all three experiments The pH of each of the tomato juices made from fresh market tomatoes was within or below the typical range for tomato juice. Garden Gem was consistently rated significantly (P ≤ .05) higher for aroma, overall liking, tomato flavor, texture and overall flavor. In all three experiments, tomato juice from a fresh market cultivar simultaneously had the greatest abundance of green-note volatiles (hexanal, 1-hexanol, (Z)-3-hexen-1-ol, etc) and the lowest abundance of cooked-note volatiles (di-Me sulfide, methional and furfural). Consumer acceptance increased as salt concentration increased and while season had minor effects on the chem. composition of the juice, consumers preferred the Spring processed tomato juice over Fall.

Flavour and Fragrance Journal published new progress about Fruits (juice). 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

El-Seesy, Ahmed I. published the artcileImpacts of octanol and decanol addition on the solubility of methanol/hydrous methanol/diesel/biodiesel/Jet A-1 fuel ternary mixtures, COA of Formula: C8H18O, the main research area is octanol decanol hydrous methanol diesel biodiesel jetA1 fuel solubility.

This study attempts to enhance the mixture instability of methanol/hydrous methanol mixed with diesel fuel, waste cooking oil (WCO) biodiesel, and Jet A-1 fuel using n-octanol and n-decanol as cosolvent at numerous temperatures of 10°C, 20°C, and 30°C. The experiment is divided into two stages: first, blending pure methanol with diesel oil, Jet A-1, and WCO biodiesel individually utilizing n-octanol and n-decanol as cosolvent at various temperatures Second, combining hydrous methanol (90% methanol + 10 wt% water) with diesel oil, Jet A-1, and WCO biodiesel independently and applying n-octanol and n-decanol as cosolvent at different temperatures Pure methanol or hydrous methanol is mixed with the base fuels at different mixing proportions varying from 0 to 100 vol% with 10 vol% increments. The co-solvent, mainly n-octanol and n-decanol (titrant), is progressively and sep. inserted into the tube with continuous shaking by utilizing a high-precision pipet until the ternary mixtures’ phase borders seem. The findings demonstrate phase separation in pure methanol-diesel and pure methanol-Jet A-1 combinations even when the blend temperature increased to 60°C. The pure methanol/biodiesel combination proves complete solubility without adding an external agent. The results also illustrate that the ambient temperature considerably affects the stability of mixture and amount of cosolvent in the blend. n-Octanol and n-decanol showed promising performance in enhancing the phase stability issue of methanol and hydrous methanol with the base fuels. It can be deduced that the min. amount of cosolvent is recorded for biodiesel-hydrous methanol, Jet A-1-hydrous methanol, and diesel-hydrous methanol, resp.

RSC Advances published new progress about Biodiesel fuel. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, COA of Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Jia-Jia published the artcileGC-MS profile of Hua-Feng-Dan and RNA-Seq analysis of induced adaptive responses in the liver, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Hua Feng Dan RNA sequence liver bioinformatic signaling GCMS; GC-MS; GEO database; Hua-Feng-Dan; RNA-seq; adaptation; bioinformatics.

Hua-Feng-Dan is a patent Chinese medicine for stroke recovery and various diseases. This study used GC-MS to profile its ingredients and RNA-Seq to analyze the induced adaptive response in the liver. Hua-Feng-Dan was subjected to steam distillation and solvent extraction, followed by GC-MS anal. Mice were orally administered Hua-Feng-Dan and its “”Guide drug”” Yaomu for 7 days. Liver pathol. was examined, and total RNA isolated for RNASeq, followed by bioinformatic anal. and quant. real-time PCR (qPCR). Forty-four volatile and fifty liposol. components in Hua-Feng-Dan were profiled and analyzed by the NIST library and their concentrations quantified. The major components (>1%) in volatile (5) and liposol. (10) were highlighted. HuaFeng-Dan and Yaomu at hepatoprotective doses did not produce liver toxicity as evidenced by histopathol. and serum enzyme activities. GO Enrichment revealed that Hua-Feng-Dan affected lipid homeostasis, protein folding, and cell adhesion. KEGG showed activated cholesterol metabolism, bile secretion, and PPAR signaling pathways. Differentially expressed genes (DEGs) were identified by DESeq2 with p < 0.05 compared to controls. Hua-Feng-Dan produced more DEGs than Yaomu. qPCR on selected genes largely verified RNA-Seq results. Ingenuity Pathways Anal. of the upstream regulator revealed activation of MAPK and adaptive responses by Hua-FengDan, and Yaomu was less effective. Hua-Feng-Dan-induced DEGs were highly correlated with the Gene Expression Omnibus database of chem.-induced adaptive transcriptome changes in the liver. GC-MS primarily profiled volatile and liposol. components in Hua-FengDan. Hua-Feng-Dan at the hepatoprotective dose did not produce liver pathol. changes but induced metabolic and signaling pathway activations. The effects of Hua Feng-Dan on liver transcriptome changes point toward induced adaptive responses to program the liver to produce hepatoprotective effects. Frontiers in Pharmacology published new progress about Bioinformatics. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Hao published the artcileThe enhanced mechanisms of Hansschlegelia zhihuaiae S113 degrading bensulfuron-methyl in maize rhizosphere by three organic acids in root exudates, Name: (S)-2-hydroxysuccinic acid, the main research area is bensulfuronmethyl degradation organic acid root exudate maize rhizosphere Hansschlegelia; Bensulfuron-methyl; Chemotactic response; Hansschlegelia zhihuaiae S113; Maize rhizosphere; Organic acids.

The residues of bensulfuron-Me (BSM), a sulfonylurea herbicide, in soil have caused serious damage to the rotation of susceptible crops. Many studies have reported that the removal of BSM in soil was achieved by adding degrading bacteria. However, the mechanisms used by bacteria to degrade BSM in the crop rhizosphere remain unclear. In this study, a BSM-degrading bacterium, Hansschlegelia zhihuaiae S113, was applied to investigate the enhancement of effects mediated by organic acids during the bioremediation of BSM-contaminated maize rhizosphere soil. Organic acids, such as -malic acid, tartaric acid, and fumaric acid, identified in maize root exudates, significantly stimulated the expression of cheA, which encoded the histidine kinase in strain S113 and contributed to the chemotactic response. This process accelerated the accumulation of strain S113 around the maize roots and promoted the colonization process on maize roots. The growth of strain S113 was significantly increased by -malic acid but not tartaric acid or fumaric acid. After the S113 suspension was root-irrigated to BSM-contaminated soil, the d. of strain S113 colonizing root surfaces and in rhizosphere soil reached 1.1 x 104 cells/g for roots and 4.9 x 104 cells/g in dry soil at 15 d, leading to 80.9% BSM degradation efficiency. The treatment with the addition of a mixture of S113 and -malic acid completely degraded BSM in rhizosphere soil due to the strong attraction and growth promotion of strain S113 by -malic acid, with a higher efficiency than that with the extra addition of fumaric acid (89.7%) or tartaric acid (87.0%). This paper revealed the enhancement effects of organic acids identified in root exudates for the in situ bioremediation of BSM-contaminated rhizosphere soil.

Ecotoxicology and Environmental Safety published new progress about Bioremediation. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Name: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ganapathy, Birintha published the artcileBioremediation of palm oil mill effluent (POME) using indigenous Meyerozyma guilliermondii, Application In Synthesis of 584-02-1, the main research area is palm oil mill effluent bioremediation Meyerozyma wastewater treatment; Aerobic treatment; Bioremediation; Chemical oxygen demand; Indigenous; Lipase; Oil and grease; Palm oil mill effluent.

Despite being a key Malaysian economic contributor, the oil palm industry generates a large quantity of environmental pollutant known as palm oil mill effluent (POME). Therefore, the need to remediate POME has drawn a mounting interest among environmental scientists. This study has pioneered the application of Meyerozyma guilliermondii with accession number (MH 374161) that was isolated indigenously in accessing its potential to degrade POME. This strain was able to treat POME in shake flask experiments under aerobic condition by utilizing POME as a sole source of carbon. However, it has also been shown that the addition of suitable carbon and nitrogen sources has significantly improved the degradation potential of M. guilliermondii. The remediation of POME using this strain resulted in a substantial reduction of COD (COD) of 72%, total nitrogen of 49.2% removal, ammonical nitrogen of 45.1% removal, total organic carbon of 46.6% removal, phosphate of 60.6% removal, and 92.4% removal of oil and grease after 7 days of treatment period. The strain also exhibited an extracellular lipase activity which promotes better wastewater treatment. Addnl., Fourier transform IR spectroscopy (FTIR) and gas chromatog.-mass spectrometry (GC-MS) analyses have specifically shown that M. guilliermondii strain can degrade hydrocarbons, fatty acids, and phenolic compounds present in the POME. Ultimately, this study has demonstrated that M. guilliermondii which was isolated indigenously exhibits an excellent degrading ability. Therefore, this strain is suitable to be employed in the remediation of POME, contributing to a safe discharge of the effluent into the environment.

Environmental Science and Pollution Research published new progress about Bioremediation. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Application In Synthesis of 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hosseiny Davarani, Saied Saeed published the artcileQuantification of controlled release leuprolide and triptorelin in rabbit plasma using electromembrane extraction coupled with HPLC-UV, Formula: C8H18O, the main research area is HPLC UV plasma determination controlled release leuprolide triptorelin pharmacokinetics; electromembrane extraction HPLC controlled release leuprolide triptorelin; Electromembrane extraction; Leuprolide; Pharmacokinetic; Rabbit plasma; Triptorelin.

An electromembrane extraction followed by HPLC-UV technique was developed and validated for quantification of leuprolide and triptorelin in rabbit plasma. The influencing parameters on the extraction efficiency were optimized using exptl. design methodol. The optimized conditions were found to be; supported liquid membrane: a mixture of 1-octanol and 2-Et hexanol (1:1) containing 10% volume/volume di(2-ethylhexyl) phosphate, applied voltage: 5 V, extraction time: 5 min, pH of the donor phase: 4.5 and pH of the acceptor phase: 1.0. The optimized method was validated for linearity, intraday and interday precision, and accuracy in rabbit plasma. The range of quantification for both peptides was 0.5-1000 ng/mL with regression coefficients higher than 0.994. Relative recoveries of leuprolide and triptorelin were found to be 80.3 and 75.5%, resp. Limits of quantification and detection for both peptides were found to be 0.5 and 0.15 ng/mL, resp. The validated method was successfully applied to pharmacokinetic study of the 1-mo depot formulations of each peptide after s.c. administration to rabbits.

Electrophoresis published new progress about Blood analysis. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fashi, Armin published the artcileAn analytical strategy based on the combination of ultrasound assisted flat membrane liquid phase microextraction and a smartphone reader for trace determination of malondialdehyde, Name: n-Octanol, the main research area is ultrasound assisted flat membrane liquid phase microextraction malondialdehyde; Biological samples; Derivatization; Membrane extraction; Preconcentration; RGB analysis; Sugaring out.

A new cleanup process entitled ultrasonic assisted flat membrane liquid phase microextraction (UA-FM-LPME) was introduced. The UA-FM-LPME procedure in two phase format was applied for the extraction-preconcentration of malondialdehyde (MDA) as an analyte model from the biol. samples after a derivatization reaction. In the designed extraction setup, the simultaneous use of two flat sheet membranes and the application of ultrasonic radiation provided the efficient mass transfer of MDA into the acceptor phase in a short extraction time (2 min). The collected organic phase was then analyzed through Red-Green-Blue (RGB) image anal. and HPLC coupled with UV-visible spectroscopy (HPLC-UV/visible) as detection methods. The key parameters affecting the extraction process were studied and optimized. The effect of the sugaring out on the partition of MDA into the extraction phase was examined for the first time. Under optimal conditions, linearity was observed in the concentration range of 8-1000 ng mL-1 for HPLC, and 10-1000 ng mL-1 for RGB anal., with the coefficient of determination (R2) values >0.9973. The introduced method also offered satisfactory relative standard deviations (RSDs) <4.0%. In order to examine the reliability of the technique in complicated matrixes, three different biol. samples (urine, saliva and blood plasma) were analyzed and the acceptable results in terms of relative recoveries (89.7-102.4%) were obtained. The designed setup in combination with RGB anal. will provide a low-cost alternative technique for rapid determination of MDA in clin. diagnosis or biochem. anal. without the need to complex, time consuming and expensive anal. instruments. Talanta published new progress about Blood analysis. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Name: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts