Category: alcohols-buliding-blocks

Qaisar, Rizwan published the artcileRestoration of sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity prevents age-related muscle atrophy and weakness in mice, Computed Properties of 97-67-6, the main research area is muscle atrophy weakness SERCA gastrocnemius CDN1163 sarcopenia MEF2C; sarcopenia; sarcoplasmic reticulum calcium-transporting ATPase; skeletal muscle.

Sarcopenia has a significant neg. impact on healthspan in the elderly and effective pharmacol. interventions remain elusive. We have previously demonstrated that sarcopenia is associated with reduced activity of the sarcoplasmic reticulum Ca2+ ATPase (SERCA) pump. We asked whether restoring SERCA activity using pharmacol. activation in aging mice could mitigate the sarcopenia phenotype. We treated 16-mo male C57BL/6J mice with vehicle or CDN1163, an allosteric SERCA activator, for 10 mo. At 26 mo, maximal SERCA activity was reduced 41% in gastrocnemius muscle in vehicle-treated mice but maintained in old CDN1163 treated mice. Reductions in gastrocnemius mass (9%) and in vitro specific force generation in extensor digitorum longus muscle (11%) in 26 vs. 16-mo-old wild-type mice were also reversed by CDN1163. CDN1163 administered by intra-peritoneal injection also prevented the increase in mitochondrial ROS production in gastrocnemius muscles of aged mice. Transcriptomic anal. revealed that these effects are at least in part mediated by enhanced cellular energetics by activation of PGC1-α, UCP1, HSF1, and APMK and increased regenerative capacity by suppression of MEF2C and p38 MAPK signaling. Together, these exciting findings are the first to support that pharmacol. targeting of SERCA can be an effective therapy to counter age-related muscle dysfunction.

International Journal of Molecular Sciences published new progress about Aging, animal. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Computed Properties of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yanar, Karolin published the artcileIs -Galactose a Useful Agent for Accelerated Aging Model of Gastrocnemius and Soleus Muscle of Sprague-Dawley Rats?, Category: alcohols-buliding-blocks, the main research area is D galactose gastrocnemius soleus muscle oxidative stress aging; D-galactose; aging; gastrocnemius; musculoskeletal aging; reactive oxygen species; soleus.

Elderly population and age-related diseases are on the rise. On the contrary, aging studies are tech. hard to conduct, because they require elderly animals, the maintenance of which requires ample effort and is expensive. To tackle this problem, -galactose is used to hasten the aging process in various tissues in rodent models and it has been shown to successfully mimic the oxidative alterations that take place in the natural aging process in various tissues both by our group and others. In the present study, the validity of -galactose aging model in skeletal muscles was tested both on predominantly slow-twitch (soleus) and rather fast-twitch (gastrocnemius) muscle in male Sprague-Dawley rats and the results are compared with young littermate controls and naturally aged rats. Redox-related modifications in soleus and gastrocnemius were assessed by measurement of protein carbonyl groups, advanced oxidation protein products, lipid hydroperoxides, total thiol, and Cu, Zn-superoxide dismutase activities. In the present study, we provide biochem. evidence demonstrating that -galactose-induced mimetic aging does result in oxidative stress-related redox alterations that are comparable with the alterations that occur in natural aging in soleus. On the contrary, in the -galactose-induced mimetic aging of gastrocnemius, even though the oxidative stress markers were significantly increased, the endpoint redox homeostasis markers were not statistically comparable with the redox status of naturally aged group.

Rejuvenation Research published new progress about Aging, animal. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wasityastuti, Widya published the artcileEffects of low and moderate treadmill exercise on liver of D-galactose-exposed aging rat model, HPLC of Formula: 59-23-4, the main research area is galactose phys exercise aging hepatic fibrosis; Aging; M1/M2 ratio; d-galactose; exercise; liver fibrosis.

Aging increases liver susceptibility to diseases and it causes inflammation in liver tissue which can lead to fibrosis. Studies suggest that aging is caused by the accumulation of free radicals. Lack of phys. activity can lower hormone levels and increase free radicals that can accelerate the aging process. Hence, phys. activity is very important to maintain functions of organs. This research was aimed to study the effects of low and moderate treadmill exercise on D-Galactose-exposed aging rat model by evaluating the degree of hepatic fibrosis, number of M1 and M2, and M1/M2 ratio. Twenty-four 3-mo-old male Wistar aging model rats were randomly divided into four groups, i.e., three treatment groups with daily 300 mg kgBW-1D-Galactose injection administrated i.p. for 4 wk and 1 control group with normal saline injection. Two of the D-Galactose treated groups were given low and moderate treadmill exercise for 4 wk. It was concluded that low intensity treadmill exercise significantly lowered the degree of D-Galactose-exposed hepatic fibrosis, and moderate treadmill exercise was able to restore the injured liver tissue back to the non-aging state. Administration of D-Galactose causes inflammation marked by the elevated number of M1 and M2 macrophages. Moderate treadmill exercise drove M1/M2 ratio back to the control condition.

Physiological Reports published new progress about Aging, animal. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yawei published the artcileQuantitative structure activity relationship (QSAR) modeling of the degradability rate constant of volatile organic compounds (VOC) by OH radicals in atmosphere, Recommanded Product: 3-Pentanol, the main research area is modeling atm volatile organic degradability hydroxyl radical reaction; volatile organic quant structure activity relationship atm degradation; Hydroxyl radical; Multiple linear regression; QSAR; Reaction rate constant; Volatile organic compounds.

reactions with OH- is an important way to remove most volatile organic compounds (VOC) from the atm.; thus, the reaction rate constant (kOH) is important to assess the VOC persistence and exposure risk, and is greatly significant to evaluate the VOC ecol. risk. Fukui indexes and bond order largely affect VOC degradation, but to date, quant. structure activity relationship (QSAR) models for VOC degradation have rarely considered these two factors. these factors were assessed along with other relevant quant. parameters. a total of 180 substances were divided into training (144 substances) and test (36 substances) sets used to build and validate QSAR models, resp. internal/external verification and y-randomization tests showed the established model had excellent stability and reliability. HOMO energy, possible attack by radicals, and chem. bond cleavage were the main factors affecting VOC removal. the scope of the application domain was determined and model robustness was further verified.

Science of the Total Environment published new progress about Air pollution. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Recommanded Product: 3-Pentanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Lei published the artcileTransition-Metal-Free Photoredox Phosphonation of Aryl C-N and C-X Bonds in Aqueous Solvent Mixtures, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is aryl halide photoredox cross coupling reaction phosphite phenothiazine catalyst; aromatic aryl phosphonate preparation green solvent.

Herein, the authors present an efficient and mild methodol. for the synthesis of aromatic phosphonate esters in good to excellent yields using 10H-phenothiazine, an inexpensive commodity chem., as a photoredox catalyst. The reaction exhibits wide functional group compatibility enabling the transformation in the presence of ketone, amide, ester, amine, and alc. moieties. Importantly, the reaction proceeds using a green solvent mixture primarily composed of H2O, thus lowering the environmental footprint of this transformation compared to current methods. The transformation also proceeds under atm. conditions, which further differentiates it from current methods that require inert atm. Mechanistic work using fluorescence quenching experiments and radical trapping approaches support the proposed mechanism.

ACS Sustainable Chemistry & Engineering published new progress about Green solvents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fu, Huijie published the artcileEffect of cadmium stress on inorganic and organic components in xylem sap of high cadmium accumulating rice line (Oryza sativa L.), SDS of cas: 97-67-6, the main research area is Oryza xylem sap cadmium stress; Cd; Inorganic anion; Organic component; Rice; Xylem sap.

Physiol. properties involved in cadmium (Cd) transport were investigated in the high Cd accumulating rice line (Lu527-8) in comparison with the normal rice line (Lu527-4) through a soil culture experiment The results showed that Cd contents in xylem saps of Lu527-8 were 1.68-2.55 times higher than those of Lu527-4 under Cd stress. A high-pos. correlation between Cd contents in xylem saps and Cd contents in shoots was observed Lu527-8 owned a more rapid and effective transport of Cd to above-ground part. By analyzing the relationship between inorganic anions, organic components and Cd contents in xylem saps, the lower HPO2-4 and oxalate contents were considered to be related to the higher Cd transport in xylem sap of Lu527-8. As for citrate, tartaric and histidine content, significant increases were observed with the increasing Cd contents in xylem saps of two rice lines, and their contents of Lu527-8 were significantly higher than those of Lu527-4. Citrate, tartaric and histidine could take part in root-to-shoot Cd transport in xylem.

Ecotoxicology and Environmental Safety published new progress about Growth (plant). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, SDS of cas: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lewandowska, Aneta published the artcileGel Polymer Electrolytes with Mixture of Triazolium Ionic Liquids and Propylene Carbonate, Application In Synthesis of 7575-23-7, the main research area is triazolium ionic liquid propylene carbonate gel polymer electrolyte; Kamlet–Taft parameters; gel polymer electrolytes; thiol–ene polymerization; triazolium ionic liquids.

This study is focused on the structural influence of 1,2,4-triazolium ionic liquid (IL), i.e., the effect of the length of the substituent and the type of substitution (1-methyl-4-alkyl or 1-alkyl-4-methyl) used in the mixture with propylene carbonate (PC) on the properties of thiol-ene polymer ionogels and on the preparation of an ionogel with satisfactory mech. and conductive properties. PC allows for higher conductivity but also causes electrolyte leakage from the gel. When using triazolium IL (instead of the imidazolium one), because of the stronger interactions between components of the system, the ionogels do not leak. In this study, 1,4-dialkyl-1,2,4-triazolium ILs were successfully synthesized by the alkylation of 1,2,4-triazole. Subsequently, gel polymer electrolytes were obtained by one-pot thiol-ene photopolymerization reactions of tetrafunctional thiols with different chem. structures: pentaerythritol tetra(3-mercaptopropionate) (PETMP) or pentaerythritol tetra(3-mercaptobutyrate) (PETMB) and trifunctional ene (TATT) in the presence of a mixture of 1,4-dialkyl-1,2,4-triazolium IL with PC. Measurements made by electrochem. impedance spectroscopy showed that all ionogels with TATT+PETMB as a polymer matrix presented smaller relative ionic conductivity compared to ionogels containing TATT+PETMP. The puncture resistance and elongation at puncture, measured by the puncture resistance method, were higher for ionogels with poly(TATT+PETMB) than for those with poly(TATT+PETMP). Moreover, ILs containing a Me group in position N1 of the 1,2,4-triazole ring presented lower puncture resistance than ionogels with ILs containing a Me group in position N4, especially for shorter alkyl chains. Addnl., the photo-differential scanning calorimetry method was employed to characterize the course of photopolymerization The compositions and their constituents were characterized by UV and IR spectroscopy.

Gels published new progress about Henry reaction. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kaneko, Kazuyoshi published the artcileDynamic and static properties of mixtures of 1-butyl-3-methylimidazolium tetrafluoroborate and alcohols with various alkyl chain lengths, Recommanded Product: n-Octanol, the main research area is butyl methylimidazolium tetrafluoroborate ionic liquid alc mixture self diffusion.

The dynamic and static properties of mixtures of 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF4]) and alcs. with various alkyl chain lengths were investigated. For alc. concentrations of 20 mol% or less, where the alc./ionic liquid system maintains a nano-heterogeneous structure, the self-diffusion coefficient and the chem. shift of anions and cations in the alc./[BMIM][BF4] system were not dependent on the alkyl chain length of the alc., but were almost coincident with each other when comparing the same solvent concentration This indicates that the solution structure of pure [BMIM][BF4] was almost maintained in the alc./ionic liquid system. Moreover, alc. having short alkyl chain length and water moved clearly faster than the IL, but the movement of alc. having long alkyl chain length moved close to that of the IL suggesting that the alcs. may not be able to move significantly in the IL.

Journal of Molecular Liquids published new progress about Hydrophobicity. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hui, Heping published the artcilePurification, characterization and antioxidant activities of a polysaccharide from the roots of Lilium davidii var. unicolor Cotton, Formula: C6H12O6, the main research area is Lilium root polysaccharide antioxidant; Antioxidant activity; Characterization; Lilium davidii var. unicolor Cotton; O-acetyl glucomannan; Purification.

A polysaccharide (LPR) was separated from the roots of Lilium davidii var. unicolor Cotton with hot water extraction, ethanol precipitation, and purification by anion-exchange and gel-permeation chromatog. LPR was characterized. The weight-average mol. weight (MW) of LPR was 5.12 × 104 g/moL. Glucose and mannose comprised LPR with a molar ratio of 2.9:3.3. IR, NMR and methylation anal. showed that LPR was a natural O-acetyl glucomannan, the backbone mainly contained β-(1 → 4)-linked D-glucopyranosyl and β-(1 → 4)-linked D-mannopyanosyl, and the branches probably linked at O-2 and/or O-3 of the mannosyl and glucosyl residues. The acetyl groups mainly attached at O-2 or O-3 of mannosyl residues. X-ray diffractometric (XRD) anal. and SEM (SEM) anal. revealed that LPR was a semi-crystalline substance with porous lamellar structure. Bioassays in vitro indicated that LPR had distinct scavenging activities on hydroxyl radical and DPPH radical. These findings provided a reference for functional underutilization roots of L. davidii as natural antioxidant in food and pharmaceutical industry.

International Journal of Biological Macromolecules published new progress about Lilium davidii. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schoettl, Sebastian published the artcileSolubilization power of surfactant-free microemulsions, Recommanded Product: n-Octanol, the main research area is solubilization microemulsion propane.

Hydrophobe solubilization concepts rely on the shielding of solutes from water in nonpolar domains comprising traditional surfactants. We show how an octanol/ethanol/water surfactant-free microemulsion solvates hydrophobic propane in small octanol/ethanol aggregates similar to traditional micelles. These aggregates have the comparable solvent quality as bulk octanol/ethanol with the same composition

Physical Chemistry Chemical Physics published new progress about Microemulsions. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts