Category: alcohols-buliding-blocks

Ma, Stephen J. published the artcileSurface Chemical Functionalization of Wrinkled Thiol-Ene Elastomers for Promoting Cellular Alignment, Quality Control of 7575-23-7, the main research area is cell adhesion polymer; Thiol–ene; cell alignment; cell-matrix interactions; controlled cell culture; mesenchymal stem cells; photopatterning; photopolymerization; substrate wrinkling.

Wrinkled polymer surfaces find broad applicability; however, the polymer substrates are often limited to poly(dimethylsiloxane) (PDMS), which limits spatial control over wrinkle features and surface chem. An approach to surface functionalization of wrinkled elastomer substrates is demonstrated through versatile, multistep thiol-ene click chem. The elastomer is formed using a thiol-Michael reaction of tetrathiol with excess diacrylates while wrinkle formation is induced through a second free radical UV polymerization of the acrylates on the surface of the elastomer. Due to oxygen inhibition of the free radical polymerization, pendant acrylates at the surface remain unreacted and are subsequently functionalized with a multifunctional thiol, which can be further reacted through a number of thiol-X “”click”” reactions. As a demonstration, these thiol surfaces are further modified to either promote cell adhesion of human mesenchymal stem cells (hMSCs) through coupling with RGDS-containing peptides or surface passivation through reaction with hydrophilic hydroxyl Et acrylate moieties. Through engineering both surface chem. and surface topog., hMSCs exhibited increased spreading and cell d. on RGDS-functionalized surfaces and a 2-fold increase in cell alignment when cultured on wrinkled substrates. Gradient-functionalized surfaces created by tuning the wrinkle wavelength with UV irradiation enabled rapid screening of the effect of topog. on the hMSCs. Further, this application of click chem. enables simultaneous tuning of wrinkle topol. and surface chem. toward targeted material applications.

ACS Applied Bio Materials published new progress about Cell adhesion. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Quality Control of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mikkelsen, Maria Dalgaard published the artcileAncient origin of fucosylated xyloglucan in charophycean green algae, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Xyloglucan cell wall Charophycean.

The charophycean green algae (CGA or basal streptophytes) are of particular evolutionary significance because their ancestors gave rise to land plants. One outstanding feature of these algae is that their cell walls exhibit remarkable similarities to those of land plants. Xyloglucan (XyG) is a major structural component of the cell walls of most land plants and was originally thought to be absent in CGA. This study presents evidence that XyG evolved in the CGA. This is based on (a) the identification of orthologs of the genetic machinery to produce XyG, (b) the identification of XyG in a range of CGA and, (c) the structural elucidation of XyG, including uronic acid-containing XyG, in selected CGA. Most notably, XyG fucosylation, a feature considered as a late evolutionary elaboration of the basic XyG structure and orthologs to the corresponding biosynthetic enzymes are shown to be present in Mesotaenium caldariorum.

Communications Biology published new progress about Cell division. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Qing published the artcileCircular RNA MAT2B Promotes Glycolysis and Malignancy of Hepatocellular Carcinoma Through the miR-338-3p/PKM2 Axis Under Hypoxic Stress, SDS of cas: 97-67-6, the main research area is RNA MATB glycolysis malignancy hepatocellular carcinoma PKM prognosis stress.

Glucose metabolism reprogramming, which is a well-established characteristic of multiple cancers, demands a higher rate of glycolysis to meet the increasing demands for macromol. synthesis and to maintain rapid proliferation in a hypoxic environment. However, the mechanism underlying this switch remains to be elucidated. In this study, we investigated the function of circular RNA MAT2B (circMAT2B) in hepatocellular carcinoma (HCC) glucose metabolism reprogramming and malignancy. CircMAT2B was identified by bioinformatics anal. of Gene Expression Omnibus data sets. CircMAT2B expression was up-regulated in HCC tissues and cell lines. HCC patients with high circMAT2B expression had shortened overall survival. We analyzed the pos. correlation between glycolysis and circMAT2B expression in HCC using a maximum standardized uptake value determined by preoperative positron emission tomog./computed tomog. scanning combined with high-performance liquid chromatog. assessment of the metabolites of glycolysis and the citric acid cycle. The effect of circMAT2B on glycolysis was validated in vitro and in vivo under hypoxic (1% O2) conditions. Functional assays were performed in HCC cells, HCC organoids, and nude mice to explore the tumor-promoting roles of circMAT2B in HCC. Biotin-coupled probe pull-down assays, biotin-coupled microRNA capture, luciferase reporter assays, fluorescence in situ hybridization, and RNA immunoprecipitation assays were performed to confirm the interaction among different RNAs. Mechanistically, we demonstrated that circMAT2B up-regulated expression levels of the microRNA (miR)-338-3p target gene PKM2, which encodes a key enzyme in the process of glycolysis, through “”sponging”” miR-338-3p; thus, glycolysis and HCC progression are promoted through this mechanism. Conclusion: CircMAT2B promoted HCC progression by enhanced glycolysis by activating the circMAT2B/miR-338-3p/PKM2 axis under hypoxia, which may provide a therapeutic target for HCC.

Hepatology (Hoboken, NJ, United States) published new progress about Cell invasion. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, SDS of cas: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

De Marco, Federica published the artcileInvolvement of SUT1 and SUT2 sugar transporters in the impairment of sugar transport and changes in phloem exudate contents in phytoplasma-infected plants, Formula: C4H6O5, the main research area is Candidatus SUT1 SUT2 phytoplasma infected plant; carbon allocation; defense; glycolate; glyoxylate; metabolome; peroxisome; phloem; photorespiration; phytoplasma; plant-pathogen interaction; source-sink relationships; sugar metabolism.

Phytoplasmas inhabit phloem sieve elements and cause abnormal growth and altered sugar partitioning. However, how they interact with phloem functions is not clearly known. The phloem responses were investigated in tomatoes infected by “”Candidatus Phytoplasma solani”” at the beginning of the symptomatic stage, the first symptoms appearing in the newly emerged leaf at the stem apex. Antisense lines impaired in the phloem sucrose transporters SUT1 and SUT2 were included. In symptomatic sink leaves, leaf curling was associated with higher starch accumulation and the expression of defense genes. The anal. of leaf midribs of symptomatic leaves indicated that transcript levels for genes acting in the glycolysis and peroxisome metabolism differed from these in noninfected plants. The phytoplasma also multiplied in the three lower source leaves, even if it was not associated with the symptoms. In these leaves, the rate of phloem sucrose exudation was lower for infected plants. Metabolite profiling of phloem sap-enriched exudates revealed that glycolate and aspartate levels were affected by the infection. Their levels were also affected in the noninfected SUT1- and SUT2-antisense lines. The findings suggest the role of sugar transporters in the responses to infection and describe the consequences of impaired sugar transport on the primary metabolism

International Journal of Molecular Sciences published new progress about Cell membrane. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yujing published the artcileDouble membrane gasholder for biogas storage: Odor pollution risk and permeation characteristics, Category: alcohols-buliding-blocks, the main research area is double membrane gasholder biogas odor pollution risk permeation.

Biogas is an important and sustainable biofuel. Encouraged by renewable energy policies, the biogas industry has developed rapidly worldwide. Double membrane gasholders are widely used as biogas storage facilities. This work aimed to reveal the odorant permeation characteristics of double membrane gasholders, evaluate the related odor pollution risk, and identify the priority odorants for permeation prevention. Gas samples below the inner membrane, between the inner and outer membranes, and in the ambient environment were collected and analyzed. Odor potential and contribution were evaluated using the odor activity value (OAV). The relationship between the samples was explored by the Pearson correlation anal. The permeation characteristics of the major odor contributors were analyzed by comparing odorant concentrations in samples from both sides of the membrane. Terpenes were found to be the dominant compounds (>75%) inside the double membrane gasholder. The total OAVs of the gas below the inner membrane, between the inner and outer membranes and in the ambient environment were 47,500, 484, and less than 100, resp. Terpenes and sulfur compounds were the dominant odor contributors (>95% in total) for the gas inside the double membrane gasholder. The composition of the gas between the membranes was significantly correlated to that of the gas below the inner membrane (r2 = 0.98, p ≤ 0.001), but had a poor correlation with that of the gas in the ambient environment (r2 < 0.01). Odorant permeation occurred through both the inner and outer membranes. Hydrogen sulfide and limonene were selected as the main indicators for determining the permeability of the double membrane gasholder. Suggestions were made for the permeability test methods and material selection for double membrane gasholders. Journal of Cleaner Production published new progress about Air pollution. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gibbs, Jonathan L. published the artcileDiesel exhaust particle exposure compromises alveolar macrophage mitochondrial bioenergetics, HPLC of Formula: 97-67-6, the main research area is diesel exhaust particle exposure alveolar macrophage mitochondrial bioenergetics; ceramides; diesel exhaust; inflammation; mitochondria.

Diesel exhaust particles (DEPs) are known pathogenic pollutants that constitute a significant quantity of air pollution. Given the ubiquitous presence of macrophages throughout the body, including the lungs, as well as their critical role in tissue and organismal metabolic function, we sought to determine the effect of DEP exposure on macrophage mitochondrial function. Following daily DEP exposure in mice, pulmonary macrophages were isolated for mitochondrial analyses, revealing reduced respiration rates and dramatically elevated H2O2 levels. Serum ceramides and inflammatory cytokines were increased. To determine the degree to which the changes in mitochondrial function in macrophages were not dependent on any cross-cell communication, primary pulmonary murine macrophages were used to replicate the DEP exposure in a cell culture model. We observed similar changes as seen in pulmonary macrophages, namely diminished mitochondrial respiration, but increased H2O2 production Interestingly, when treated with myriocin to inhibit ceramide biosynthesis, these DEP-induced mitochondrial changes were mitigated. Altogether, these data suggest that DEP exposure may compromise macrophage mitochondrial and whole-body function via pathol. alterations in macrophage ceramide metabolism

International Journal of Molecular Sciences published new progress about Air pollution. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, HPLC of Formula: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Kexian published the artcileGaseous pollutants from a small-scale aerobic biological treatment facility: odor and health risk assessment, HPLC of Formula: 584-02-1, the main research area is ammonia VOC occupational health hazard air pollution.

Biol. treatment technol. is good for the recovery of resources and energy from municipal solid waste (MSW) and cutting down biodegradable components in landfill waste. Recently, the aerobic biol. treatment of MSW has increased in rural areas of China. These facilities are usually open setup and close to nearby residents, and complaints tend to be received regarding odorous gases. A semi-in-vessel setup facility was built in recent years, and its impact on the environment and personnel is not clear. Ammonia was the predominant compound released from the windrow and its concentration was one order of magnitude higher than those of other compounds Terpenes and reduced sulfur compounds (RSCs) persisted throughout the entire active fermentation process, with only slight decreases. The biofilter pool had a greater odor impact on the surrounding neighborhood than the waste unloading and sorting operation. The concentrations of most compounds were reduced by the biofilter pool. Ten major substances that caused odors at the facility were analyzed, where most comprised RSCs. The odor impact of the facility was low, but it was associated with a carcinogenic risk to the operators, thereby indicating the need to improve personal protection. Large amounts of ammonia and volatile organic compounds were released from the composting units, but they had a low odor impact on the environment because of the semi-in-vessel setup. The odor impact of the facility was low but it was associated with a carcinogenic risk to the operators. This technol. can be popularized in rural areas.

Environmental Sciences Europe published new progress about Air pollution. 584-02-1 belongs to class alcohols-buliding-blocks, name is 3-Pentanol, and the molecular formula is C5H12O, HPLC of Formula: 584-02-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bi, Chenyang published the artcileDirect transfer of phthalate and alternative plasticizers from indoor source products to dust: Laboratory measurements and predictive modeling, Computed Properties of 111-87-5, the main research area is direct transfer phthalate alternative plasticizer indoor source product dust.

Phthalate and alternative plasticizers are semivolatile organic compounds (SVOCs) and among the most abundant indoor pollutants. Although ingestion of dust is one of the major exposure pathways to them, migration knowledge from source products to indoor dust is still limited. Systematic chamber measurements were conducted to investigate the direct transfer of these SVOCs between source products and dust in contact with the source. Substantial direct source-to-dust transfer of SVOCs was observed for all tests. The concentration of bis(2-ethylhexyl)phthalate in dust was 12 times higher than the pre-exptl. level after only two days of source-dust contact. A mechanistic model was developed to predict the direct transfer process, and a reasonable agreement between model predictions and measurements was achieved. The octanol/air partition coefficient (Koa) of SVOCs, the emission parameter of the source product (y0), and the characteristics of the dust layer (i.e., porosity and thickness) control the transfer, affecting the SVOC concentration in dust, the kinetics of direct transfer, or both. Dust mass loading has a significant influence on the transfer, while relative humidity only has a limited effect. The findings suggest that minimizing the use of SVOC-containing products and house vacuuming are effective intervention strategies to reduce young children’s exposure to SVOCs.

Environmental Science & Technology published new progress about Airborne dust. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Turan, Emre published the artcileBlack garlic as a substitute for fresh garlic to reduce off-flavor and enhance consumer acceptance and bioactive properties in cemen paste, Related Products of alcohols-buliding-blocks, the main research area is black garlic flavor bioactive property cemen paste.

The effects of black garlic aged at different periods as a substitute for fresh garlic (FG) on the overall quality of pastirma cemen paste were evaluated during 90 days of storage. The addition of black garlic increased the phenolic content and antioxidant activities of the cemen pastes, and decreased the firmness, stickiness, pH and color values compared to CON (Control). Total aerobic mesophilic bacteria counts of cemen pastes containing black garlic aged for ≥21 days were similar to those of CON, but the counts of yeast and molds of black garlic added-groups were higher than CON during storage. Incorporation of black garlic to cemen paste increased the content of volatile compounds such as esters and terpenes with fruity and sweet notes, while the concentration of sulfur compounds decreased. In this way, the off-flavor of cemen paste was eliminated and its sensory acceptability improved. Considering the overall data, the best results were obtained in the CP3 group produced with black garlic aged for 21 days. Consequently, black garlic can be used as a substitute for FG to improve the consumer acceptance and bioactive properties of cemen paste. Novelty impact statement : Some consumers avoid pastirma consumption because of the unpleasant off-flavor from cemen paste. Overcoming this problem is very important for both the producer and the consumer. The results of this study showed that black garlic improved the sensory acceptability and bioactive properties of cemen paste by eliminating the unpleasant smell of fresh garlic and increasing the antioxidant capacity. In conclusion, the use of cemen paste with black garlic in pastirma production has promising potential to enhance consumer acceptance and retard oxidative reactions.

Journal of Food Processing and Preservation published new progress about Allium nigrum. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ibraheem, Bashar published the artcileInfluence of high pressure compaction on solubility and intrinsic dissolution of ibuprofen binary mixtures employing standard excipients, Quality Control of 64519-82-0, the main research area is pressure compaction influence solubility intrinsic dissolution ibuprofen binary mixture; API, active pharmaceutical ingredient; ASD, amorphous solid dispersion; BCS, biopharmaceutics classification system; COM, co-milled; Crystal modification; Cs, aqueous solubility; DSC, differential scanning calorimetry; Drug/excipient interactions; Gr, granules; HCL, hydrochloric acid; HPC, hydroxypropylcellulose; HPC-SSL, super special-low viscosity hydroxypropylcellulose; High-pressure compaction; Hydrophilic excipients; IBU, ibuprofen; IDR, intrinsic dissolution rate; ISO, isomalt; Intrinsic dissolution; MANN, mannitol; MIX, mixtures; MUPS, multiple unit pellet system; PM, physical mixtures; SFE, surface free energy; SORB, sorbitol; ST, standard; Solubility enhancement; Tab, tablets; Tg, glass transition temperature; Tm, melting point; XRPD, X-ray powder diffraction.

Enabling formulations often depend on functional excipients. However, the question remains whether excipients regarded as standard establish similar interactions and subsequently improvement of solubility when employed at unusual manufacturing process conditions. In this study, compaction of API under high pressure in the presence of hydrophilic excipients is proposed as a technique to improve the solubility and/or dissolution rate with an acceptable preservation of the supersaturation state. Binary mixtures of ibuprofen (IBU) with hydroxypropyl cellulose, isomalt, mannitol and sorbitol were compacted applying high pressure (500 MPa) with and without a previous co-milling step. Intrinsic dissolution rate (IDR) was selected to characterize and evaluate dissolution performance. The IDR of neat IBU increased from 5 to 88 fold and the aqueous solubility in the range of 3 to 54%. Regarding the polyols isomalt showed the highest impact on solubility and dissolution, without changing the crystallinity of IBU independent of a co-milling step. Even higher impact was achieved in combination with HPC. However, only without a previous co-milling step, ibuprofen remained crystalline, while co-milling induced an amorphous IBU-content of 38%. Based on XRPD and DSC findings, higher IDR and solubility values correlated with crystal modifications as well as IBU/excipient interactions.

International Journal of Pharmaceutics: X published new progress about Amorphization. 64519-82-0 belongs to class alcohols-buliding-blocks, name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, and the molecular formula is C12H24O11, Quality Control of 64519-82-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts