Category: alcohols-buliding-blocks

Cui, Lei published the artcileData-driven prediction of the product formation in industrial 2-keto-L-gulonic acid fermentation, Related Products of alcohols-buliding-blocks, the publication is Computers & Chemical Engineering (2012), 386-391, database is CAplus.

Mixed culture fermentation of Bacillus megaterium and Gluconobacter oxydans is widely used to produce 2-keto-L-gulonic acid (2-KGA), a key precursor for L-ascorbic acid synthesis. For such mixed cultivation, kinetic modeling is difficult because the interactions between the two strains are not well known yet. In this paper, data-driven prediction of the product formation is presented for the purpose of better process monitoring. A rolling learning-prediction approach based on neural networks is practiced to predict 2-KGA formation. Techniques associated with the approach, such as the data pretreatment and the rolling learning-prediction mechanism, are given in more detail. The validation results by using the data from com. scale 2-KGA cultivation indicate that the prediction error is less than 5% in the later phase of fermentation and the reliable prediction time span is 8 h. The robustness of the prediction approach is further tested by adding extra noises to the process variables.

Computers & Chemical Engineering published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Ying published the artcileStructured modeling and validation for 2-KGA mixed cultivation, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Shanghai Jiaotong Daxue Xuebao (2012), 46(11), 1723-1728, database is CAplus.

The mechanism of interaction between Ketogulonicigenium vulgare and Bacillus megaterium was investigated for 2-keto-L-gulonic acid (2-KGA) mixed culture. Based on the metabolic pathway anal. in K. vulgare, a macrokinetic model was constructed, where, a first-order closed-loop regulator model was introduced to describe the induction of the enzyme pool responsible for the growth of K. vulgare at the beginning of the cultivation. The model describes the balance of intracellular substance and energy flow rates. The key reaction rates such as the specific substrate consumption rate, the specific growth rate, the specific acetyl-CoA formation rate as well as the specific oxygen uptake rate are obtained with this model. The specific substrate consumption rate and the specific growth rate are then coupled into a bioreactor model such that the relationship between substrate feeding rate and state variables is set up. The exptl. validation results were presented.

Shanghai Jiaotong Daxue Xuebao published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C65H82N2O18S2, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sun, Han published the artcileFluorinated Poly-oxalate Electrolytes Stabilizing both Anode and Cathode Interfaces for All-Solid-State Li/NMC811 Batteries, Application In Synthesis of 111-29-5, the publication is Angewandte Chemie, International Edition (2021), 60(33), 18335-18343, database is CAplus and MEDLINE.

The relatively narrow electrochem. steady window and low ionic conductivity are two critical challenges for Li⁺-conducting solid polymer electrolytes (SPE). Here, a family of poly-oxalate(POE) structures were prepared as SPE; among them, POEs composed from diols with an odd number of carbons show higher ionic conductivity than those composed from diols with an even number of carbons, and the POE composed from propanediol (C5-POE) has the highest Li⁺ conductivity The HOMO (HOMO) electrons of POE were found located on the terminal units. When using trifluoroacetate as the terminating unit (POE-F), not only does the HOMO become more neg., but also the HOMO electrons shift to the middle oxalate units, improving the antioxidative capability. Furthermore, the interfacial compatibility across the Li-metal/POE-F is also improved by the generation of a LiF-based solid-electrolyte-interlayer(SEI). With the trifluoroacetate-terminated C5-POE (C₅-POE-F) as the electrolyte and Li⁺-conducting binder in the cathode, the all-solid-state Li/LiNi_0.8Mn_0.1Co_0.1O₂(NMC811) cells showed significantly improved stability than the counterpart with poly-ether, providing a promising candidate for the forthcoming all-solid-state high-voltage Li-metal batteries.

Angewandte Chemie, International Edition published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C7H13NO2, Application In Synthesis of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yuan, Ke published the artcileTranscriptional response of Mycobacterium sp. strain A1-PYR to multiple polycyclic aromatic hydrocarbon contaminations, Related Products of alcohols-buliding-blocks, the publication is Environmental Pollution (Oxford, United Kingdom) (2018), 243(Part_B), 824-832, database is CAplus and MEDLINE.

Cometabolism mechanisms of organic pollutants in environmental microbes have not been fully understood. In this study, a global anal. of Mycobacterium sp. strain A1-PYR transcriptomes on different PAH substrates (single or binary of pyrene (PYR) and phenanthrene (PHE)) was conducted. Comparative results demonstrated that expression levels of 23 PAH degradation enzymes were significantly higher in the binary substrate than in the PYR-only one. These enzymes constituted an integrated enzymic system to actualize all transformation steps of PYR, and most of their encoded genes formed a novel gene cascade in the genome of strain A1-PYR. The roles of different genotypes of enzymes in PYR cometabolism were also discriminated even though all of their gene sequences were presented in the genome of this strain. NidAB and PdoA2B2 instead of NidA3B3 served the initial oxidization of PAHs, and PcaL replaced PcaCD to catalyze the formation of 3-oxoadipate. Novel genes associated with PYR cometabolism was also predicted by the relationships between their transcription profiles and PYR removal. The results showed that ABC-type transporters probably played important roles in the transport of PAHs and their metabolites through cell membrane, and [4Fe-4S] ferredoxin might be essential for dioxygenases (NidAB and PdoA2B2) to achieve oxidative activities. This study provided mol. insight in that microbial degrader subtly cometabolized recalcitrant PAHs with relatively more degradable ones.

Environmental Pollution (Oxford, United Kingdom) published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C14H14, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pilkington-Miksa, Michael A. published the artcileTargeting lipopolyplexes using bifunctional peptides incorporating hydrophobic spacer amino acids: Synthesis, transfection, and biophysical studies, Related Products of alcohols-buliding-blocks, the publication is Bioconjugate Chemistry (2007), 18(6), 1800-1810, database is CAplus and MEDLINE.

We have developed efficient synthetic routes to two hydrophobic amino acids, suitably protected for solid-phase peptide synthesis, and have successfully synthesized peptides containing these or other hydrophobic amino acids as spacers between a Lys₁₆ moiety and an integrin-targeting motif. These peptides have in turn been used to formulate a range of lipopolyplex vectors with Lipofectin and plasmid DNA. The transfection efficiencies of these vectors and their aggregation behavior in buffers and in serum have been studied. We have shown that vectors containing peptides incorporating long linkers that are entirely hydrophobic are less efficient transfection agents. However, linkers of equivalent length that are in part hydrophobic show improved transfection properties, which is probably due to the improved accessibility of the integrin-binding motif.

Bioconjugate Chemistry published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Gaoxiaozheng published the artcileConcise synthesis of xanthones by the tandem etherification-Acylation of diaryliodonium salts with salicylates, Computed Properties of 596-38-3, the publication is Chinese Chemical Letters (2018), 29(6), 985-988, database is CAplus.

An efficient synthetic method for multi-substituted xanthones, e.g., I was developed. The reaction of diaryliodonium salts (RC₆H₄)₂I⁺OTf^– (R = H, 3-Me, 4-F, etc.) and salicylates R¹C(O)₂CH₃ (R¹ = 4-Br-2-HOC₆H₃, 3-hydroxythiophen-2-yl, 3-hydroxynaphth-2-yl, etc.) was employed for the preparation of the xanthones. This method proceeded through an intermol. etherification-acylation to give target heterocycles in good yields (up to 91%). Multi-substituted xanthones I were gained by shifting the substituent of salicylates or diaryliodonium salts.

Chinese Chemical Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Computed Properties of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Lili published the artcileCopper-catalysed N-arylation of pyrrole with aryl iodides under ligand-free conditions, COA of Formula: C10H9NO, the publication is Journal of Chemical Research (2014), 38(3), 180-182, database is CAplus.

A simple, inexpensive and ligand-free copper-catalyzed N-arylation of nitrogen containing heterocycles such as pyrrole, imidazole, indole, and benzimidazole with aryl iodides has been developed, giving N-arylated products in moderate to excellent yields. The catalyst loading is relative low (5 mol%) and the catalyst system was stable in air.

Journal of Chemical Research published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, COA of Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pedrick, E. A. published the artcileReductive silylation of a uranyl dibenzoylmethanate complex: an example of controlled uranyl oxo ligand cleavage, Application of Triethylsilanol, the publication is Chemical Science (2014), 5(8), 3204-3213, database is CAplus.

Reaction of UO₂(dbm)₂(THF) (dbm = OC(Ph)CHC(Ph)O) with 1 equiv of R₃SiH (R = Ph, Et), in the presence of B(C₆F₅)₃, gave U(OB{C₆F₅}₃)(OSiR₃)(dbm)₂(THF) (R = Ph, 1; Et, 2), which were isolated as red-orange crystalline solids in good yields. The addition of 1 equiv of H(dbm) to 2 results in protonation of the -OSiEt₃ ligand and formation of U(OB{C₆F₅}₃)(dbm)₃ (4) in 33% yield, along with formation of HOSiEt₃. Furthermore, addition of HOSiEt₃ and 1 equiv of THF to 4, results in the formation 2, revealing that this process is reversible. The two-step conversion of UO₂(dbm)₂(THF) to 4 represents a rare example of controlled uranyl oxo ligand cleavage at ambient temperature and pressure. Comparison of diffraction and d. functional theory data for 4 suggests the inverse trans influence (ITI), with a very shallow potential energy well for distortion along the trans U-O bond.

Chemical Science published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Application of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Jie published the artcilePreparation of N-aryl-salicylamide derivatives as antitumor agents, HPLC of Formula: 328-90-5, the publication is Youji Huaxue (2013), 33(5), 1026-1034, database is CAplus.

According to the scaffold hopping, a series of N-aryl-salicylamide derivatives, which have fragments of tyrosine kinase inhibitors lapatinib and neratinib were designed and synthesized. Their structures were identified by IR, ¹H NMR, ¹³C NMR and MS techniques. The target compounds were tested for cytotoxic activity against four cancer cell lines, including A549, MCF-7, SGC-7901, Bel-7402, by Me thiazolyl tetrazolium (MTT) in vitro. All the compounds demonstrated certain antitumor abilities, and some of them were better than gefitinib.

Youji Huaxue published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C16H20N2, HPLC of Formula: 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Sheng published the artcileA high-throughput screening assay for identification of chemicals with liver tumor promoting potential using a transgenic zebrafish line, Name: 4,4′-Sulfonyldiphenol, the publication is Chemosphere (2022), 134169, database is CAplus and MEDLINE.

Traditional high-throughput methods for identification of chems. with liver tumor promotion potentials are based on established cancer cell lines, and rapid and cost-effective high-throughput screening assays in whole organisms are presently lacking. In this study, a transgenic zebrafish liver cancer model was employed to develop a method that could be used to identify chems. with liver tumor promotion effect quickly and accurately. The method consisted of three parts, including exposure preparation, exposure process and image acquisition. In brief, after chem. exposure for 7 days, 96-well plate exposure system for zebrafish larvae was assessed by microplate reader. Then, the liver cancer promoting potential chems. were evaluated by field area and field average intensity of fluorescence. The results were further validated by conducting histopathol. examination Our data demonstrated that the high-throughput screening assay developed in this study was reproducible and could be used to rapidly screen chems. with liver tumor promoting potentials by using tris-(2-chloropropyl)-phosphate (TDCIPP) as a pos. control. Furthermore, some other pos. chems. found in previous studies and environmental compounds were assessed using the established method. Results indicated that 86.7% of the pos. chems. and five environmental compounds out of seventeen compounds could enhance liver tumor progression.

Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts