Category: alcohols-buliding-blocks

Hayri-Senel, Tugba published the artcileThe use of poly(styrene-co-chloromethyl styrene) in the modification of triglyceride oils, HPLC of Formula: 96-20-8, the publication is Journal of Coatings Technology and Research, database is CAplus.

In this study, Poly(styrene-co-chloromethyl styrene) [Poly(St-co-CMS)] was prepared and used in the modification of triglyceride oils. The obtained modified triglyceride product was examined in view of oil-based binder. Nitroxide-mediated radical polymerization (NMRP) technique was applied for Poly(St-co-CMS) synthesis. Chloro groups on the Poly(St-co-CMS) backbone were reacted with 2-amino-1-butanol (2-AB) in order to obtain a polymer with hydroxyl ended side branches, [Poly(St-OH)], which were further combined with partial glycerides (PGs) through the reaction with toluene diisocyanate (TDI). The resulting product can also be considered as a polystyrene-modified urethane oil [Poly(St-OH)-SUO]. The structures of both intermediates, [Poly(St-co-CMS), Poly(St-OH)], and final products [Poly(St-OH)-SUO] were verified by using FTIR and ¹H-NMR analyses. Addnl., thermal properties of the samples were determined The film properties of Poly(St-OH)-SUO samples prepared with different polymer/oil ratios and classic urethane oil were examined Poly(St-OH)-SUO-40 sample exhibited the best film properties among the others. In the end, the obtained results showed that Poly(St-OH)-SUO-40 could be utilized as an oil-based binder.

Journal of Coatings Technology and Research published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, HPLC of Formula: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zong, Shuai published the artcilePolysaccharides from Lachnum sp. Inhibited colitis-associated colon tumorigenesis in mice by modulating fecal microbiota and metabolites, Synthetic Route of 621-37-4, the publication is International Immunopharmacology (2022), 108656, database is CAplus and MEDLINE.

It is still uncertain whether the consumption of Lachnum sp. polysaccharides (LEP) alleviates colorectal cancer (CRC) through the gut microbiota. In this study, our efforts are focused on the influence of LEP on CRC, intestinal barrier and inflammation, and fecal microbiota and the metabolites, in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CRC mice. Results showed that LEP inhibited CRC mouse colon shortening and weight loss, decreased tumor incidence, restored intestinal barrier integrity, and reduced excessive inflammation. LEP consumption significantly altered microbiota overall structure and community, with reduced pernicious bacteria (such as Parabacteroides, Escherichia_Shigella, Desulfovibrio and Helicobacter), and increased beneficial bacterium (such as Alistipes, Alloprevotella and Ruminiclostridium). Fecal-metabolome profile indicated that a total of 43 metabolites were clearly changed, with 10 down-regulated and 33 up-regulated metabolites. In addition, short-chain fatty acids (SCFAs), including acetic acid, propionic acid and n-butyric acid, were significantly increased after LEP administration. Moreover, a strong correlation between the fluctuant gut microbiota and metabolites was found. These findings provided not only deeper insights into the responsibility of LEP for CRC alleviation, and but also the potential of LEP as a promising candidate for CRC prevention and treatment.

International Immunopharmacology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C37H30ClIrOP2, Synthetic Route of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yu-Huang published the artcileReductive hydroxyalkylation/alkylation of amines with lactones/esters, COA of Formula: C8H19NO, the publication is Organic & Biomolecular Chemistry (2012), 10(32), 6504-6511, database is CAplus and MEDLINE.

We have developed a one-pot method for the direct intermol. reductive hydroxyalkylation or alkylation of amines using lactones or esters as the hydroxyalkylating/alkylating reagents. The method is based on the in situ amidation of lactones/esters with DIBAL-H-amine complex (for primary amines) or DIBAL-H-amine hydrochloride salt complex (for secondary amines), followed by reduction of the amides with an excess of DIBAL-H. Different from the reduction of Weinreb amides with DIBAL-H where aldehydes are formed, the reduction of the in situ formed Weinreb amides yielded amines. Moreover, this method is not limited to Weinreb amides, instead, it also works for other amides in general. A plausible mechanism is suggested to account for the outcome of the reactions.

Organic & Biomolecular Chemistry published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C6H5F4NO3S, COA of Formula: C8H19NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kuang, Yuting published the artcileInduction of Genes Implicated in Stress Response and Autophagy by a Novel Quinolin-8-yl-nicotinamide QN523 in Pancreatic Cancer, Computed Properties of 622-40-2, the publication is Journal of Medicinal Chemistry (2022), 65(8), 6133-6156, database is CAplus and MEDLINE.

Using a cytotoxicity-based phenotypic screen of a highly diverse library of 20,000 small-mol. compounds, we identified a quinolin-8-yl-nicotinamide, QN519, as a promising lead. QN519 represents a novel scaffold with drug-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. Subsequently, lead optimization campaign generated compounds with IC₅₀ values < 1μM. An optimized compound, QN523, shows significant in vivo efficacy in a pancreatic cancer xenograft model. QN523 treatment significantly increased the expression of HSPA5, DDIT3, TRIB3, and ATF3 genes, suggesting activation of the stress response pathway. We also observed a significant increase in the expression of WIPI1, HERPUD1, GABARAPL1, and MAP1LC3B, implicating autophagy as a major mechanism of action. Due to the lack of effective treatments for pancreatic cancer, discovery of novel agents such as the QN series of compounds with unique mechanism of action has the potential to fulfill a clear unmet medical need.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Computed Properties of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Yao published the artcileNonpeptidic quinazolinone derivatives as dual nucleotide-binding oligomerization domain-like receptor 1/2 antagonists for adjuvant cancer chemotherapy, Name: 3-Morpholinophenol, the publication is European Journal of Medicinal Chemistry (2020), 112723, database is CAplus and MEDLINE.

Nucleotide-binding oligomerization domain-containing protein 1 and 2 (NOD1/2) receptors are potential immune checkpoints. In this article, a quinazolinone derivative, I, as a NOD1/2 dual antagonist was identified that significantly sensitizes B16 tumor-bearing mice to paclitaxel treatment by inhibiting both nuclear factor κB (NF-κB) and mitogen-activated protein kinase inflammatory signaling that mediated by NOD1/2.

European Journal of Medicinal Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Name: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Kaifu published the artcileSynthesis of a Gold-Metal Oxide Core-Satellite Nanostructure for In Situ SERS Study of CuO-Catalyzed Photooxidation, Product Details of C9H22OSi, the publication is Angewandte Chemie, International Edition (2020), 59(41), 18003-18009, database is CAplus and MEDLINE.

This work reports on an assembling-calcining method for preparing gold-metal oxide core-satellite nanostructures, which enable surface-enhanced Raman spectroscopic detection of chem. reactions on metal oxide nanoparticles. By using the nanostructure, we study the photooxidation of Si-H catalyzed by CuO nanoparticles. As evidenced by the in situ spectroscopic results, oxygen vacancies of CuO are found to be very active sites for oxygen activation, and hydroxyl radicals (·OH) adsorbed at the catalytic sites are likely to be the reactive intermediates that trigger the conversion from silanes into the corresponding silanols. According to our finding, oxygen vacancy-rich CuO catalysts are confirmed to be of both high activity and selectivity in photooxidation of various silanes.

Angewandte Chemie, International Edition published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C21H24O8, Product Details of C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Kaifu published the artcileSynthesis of a Gold-Metal Oxide Core-Satellite Nanostructure for In Situ SERS Study of CuO-Catalyzed Photooxidation, Application of Triethylsilanol, the publication is Angewandte Chemie, International Edition (2020), 59(41), 18003-18009, database is CAplus and MEDLINE.

This work reports on an assembling-calcining method for preparing gold-metal oxide core-satellite nanostructures, which enable surface-enhanced Raman spectroscopic detection of chem. reactions on metal oxide nanoparticles. By using the nanostructure, we study the photooxidation of Si-H catalyzed by CuO nanoparticles. As evidenced by the in situ spectroscopic results, oxygen vacancies of CuO are found to be very active sites for oxygen activation, and hydroxyl radicals (·OH) adsorbed at the catalytic sites are likely to be the reactive intermediates that trigger the conversion from silanes into the corresponding silanols. According to our finding, oxygen vacancy-rich CuO catalysts are confirmed to be of both high activity and selectivity in photooxidation of various silanes.

Angewandte Chemie, International Edition published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is 0, Application of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Zhihao published the artcileSerum metabolomics reveals the effect of electroacupuncture on urinary leakage in women with stress urinary incontinence, Synthetic Route of 621-37-4, the publication is Journal of Pharmaceutical and Biomedical Analysis (2020), 113513, database is CAplus and MEDLINE.

Stress urinary incontinence (SUI), which is defined as an involuntary loss of urine upon phys. exertion coughing, sneezing or laughing, has a significant neg. impact on the quality of life of many women. Multi-center, large-scale and randomized clin. trials have illustrated that non-invasive electroacupuncture is an effective treatment for SUI, but its therapeutic mechanism in treating SUI remains unknown. Here, gas chromatog.-mass spectrometry based serum metabolomics was performed to reveal metabolic profiles and diagnostic biomarkers from recruitment of 25 patients and 25 healthy women before and after electroacupuncture. We identified 10 differentially abundant metabolites, including butantriol, 3,4-dihydroxybutanoic acid, succinic acid, 1-deoxypentitol, psicose, citric acid, 3-hydroxybutyric acid, hydracrylic acid, 3-hydroxyphenylacetic acid and D-mannitol, from patients between before and after electroacupuncture. The electroacupuncture therapy altered propanoate metabolism, butanoate metabolism and the tricarboxylic acid cycle. A panel of 8 biomarkers (butantriol, 3,4-dihydroxybutanoic acid, succinic acid, 1-deoxypentitol, psicose, citric acid, 3-hydroxybutyric acid and hydracrylic acid) was evaluated to determine the effect of electroacupuncture on SUI and differentiated well between before and after treatment. The area under the receiver operating characteristic curve was 0.962. The sensitivity, specificity and coincidence rate were 92%, 92% and 96%, resp., at a 95% confidence interval ranging from 0.9053 to 1. Furthermore, the levels of these diagnostic biomarkers were not significantly altered in healthy subjects after sham electroacupuncture. It was indicated that an 8-biomarker panel might be constructed for the therapeutic evaluation of electroacupuncture treatment for SUI.

Journal of Pharmaceutical and Biomedical Analysis published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C4H12ClNO, Synthetic Route of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Rui published the artcileBarbier-type anti-Diastereo- and Enantioselective Synthesis of β-Trimethylsilyl, Fluorinated Methyl, Phenylthio Homoallylic Alcohols, Recommanded Product: (E)-4,4,4-Trifluorobut-2-en-1-ol, the publication is Scientific Reports (2017), 7(1), 1-12, database is CAplus and MEDLINE.

Catalytic Asym. allylation of aldehydes with functionalized allylic reagents represents an important process in synthetic organic chem. because the resulting chiral homoallylic alcs. are valuable building blocks in diverse research fields. Despite the obvious advantages of allyl halides as allylation reagent under Barbier-type conditions, catalytic asym. version using functionalized allyl halides remains largely underdeveloped. Here, authors addressed this issue by employing a chromium-catalysis system. The use of readily available allyl bromides with γ substitutions including trimethylsilyl, fluorinated Me and phenylthio groups provided an efficient and convenient method to introduce those privileged functionalities into homoallylic alcs. Good yields, high anti-diastereo- and excellent enantioselectivities were achieved under mild reaction conditions.

Scientific Reports published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Recommanded Product: (E)-4,4,4-Trifluorobut-2-en-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Dengkang published the artcileModification mechanism of plantation wood via grafting epoxy monomers onto cell walls, Computed Properties of 645-56-7, the publication is Wood Science and Technology (2022), 56(3), 813-831, database is CAplus.

The range of application for fast-growing plantation wood is limited by its dimensional instability, susceptibility to biodegradation and low mech. strength. In this study, a novel method based on in situ reaction of a hydrophilic epoxy monomer (1,4-butanediol diglycidyl ether) in the wood cell walls was proposed to improve the performance of plantation wood. The effects of curing agent on the reaction mechanism and performance of treated wood were discussed in detail. The results demonstrated that after curing using Me hexahydro phthalic anhydride (MHHPA), an epoxy oligomer with a higher mol. weight and superior water resistance was formed inside the wood cell wall compared to curing with the 2-methylimidazole (2-MI). Moreover, the epoxy group was able to react with alc. and phenolic hydroxyl in wood through 2-MI catalysis resulting in a higher grafting ratio. After the modification reaction, notable improvements were observed in the dimensional stability (anti-swelling efficiency of more than 65%), fungal (Gloeophyllum trabeum) decay resistance (weight loss of < 6%) and compressive strength (increased by 17%) of the wood.

Wood Science and Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Computed Properties of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts