Category: alcohols-buliding-blocks

Yuan, Bo published the artcileDevelopment and validation of a micro-QuEChERS method with high-throughput enhanced matrix removal followed with UHPLC-QqQ-MS/MS for analysis of raspberry ketone-related phenolic compounds in adipose tissues, SDS of cas: 621-37-4, the publication is Talanta (2021), 122716, database is CAplus and MEDLINE.

Raspberry ketone (RK) is a major flavor compound in red raspberries, and it has been marketed as a popular weight-loss dietary supplement with high potential in accumulating in fatty tissues. However, challenges in extracting and characterizing RK and its associated phenolic compounds in fatty tissues persist due to the complex matrix effect. In this work, we reported a high-throughput sample preparation method for RK and 25 related phenolic compounds in white adipose tissues using an improved micro-scale QuEChERS (quick, efficient, cheap, easy, rugged and safe) approach with enhanced matrix removal (EMR)-lipid cleanup in 96-well plates, followed by UHPLC-QqQ-MS/MS anal. The absolute recovery was 73-105% at the extraction step, and achieved 71-96% at the EMR cleanup step. The EMR cleanup removed around 66% of total lipids in the acetonitrile extract as profiled by UHPLC-QTOF-MS/MS. The innovative introduction of a reversed-phase C18 sorbent into the extract significantly improved the analytes′ recovery during SpeedVac drying. The final accuracy achieved 80-120% for most analytes. Overall, this newly developed and validated method could serve as a powerful tool for analyzing RK and related phenolic compounds in fatty tissues.

Talanta published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C10H11N3O3S, SDS of cas: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hariri, Ali published the artcileMolecular imaging of oxidative stress using an LED-based photoacoustic imaging system, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Scientific Reports (2019), 9(1), 1-10, database is CAplus and MEDLINE.

LED-based photoacoustic imaging has practical value in that it is affordable and rugged; however, this technol. has largely been confined to anat. imaging with limited applications into functional or mol. imaging. Here, we report mol. imaging reactive oxygen and nitrogen species (RONS) with a near-IR (NIR) absorbing small mol. (CyBA) and LED-based photoacoustic imaging equipment. CyBA produces increasing photoacoustic signal in response to peroxynitrite (ONOO^–) and hydrogen peroxide (H₂O₂) with photoacoustic signal increases of 3.54 and 4.23-fold at 50μM of RONS at 700 nm, resp. CyBA is insensitive to OCl^–, NO, NO₂^–, NO₃^–, tBuOOH, O₂^–, C₄H₉O , HNO, and OH, but can detect ONOO^– in whole blood and plasma. CyBA was then used to detect endogenous RONS in macrophage RAW 246.7 cells as well as a rodent model; these results were confirmed with fluorescence microscopy. Importantly, CyB suffers photobleaching under a Nd:YAG laser but the signal decrease is <2% with the low-power LED-based photoacoustic system and the same radiant exposure time. To the best of our knowledge, this is the first report to describe mol. imaging with an LED-based photoacoustic scanner. This study not only reveals the sensitive photoacoustic detection of RONS but also highlights the utility of LED-based photoacoustic imaging.

Scientific Reports published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Yumei published the artcileAnti-inflammatory and anti-asthmatic effects of TMDCT decoction in eosinophilic asthma through Treg/ Th17 balance, HPLC of Formula: 621-37-4, the publication is Frontiers in Pharmacology (2022), 819728, database is CAplus and MEDLINE.

Tuo-Min-Ding-Chuan decoction (TMDCT) is a Traditional Chinese Medicine (TCM) formula consisting of twelve herbs that can relieve the symptoms and treat allergic asthma. Yet, the underlying mechanism of action is still unclear. In this study, we investigated the effect of TMDCT in regulating Treg/Th17 cells immune balance and explored potential metabolic and gut biomarkers associated with Treg and Th17 cells in eosinophilic asthma mice treated by TMDCT. We found that TMDCT increases Treg cells percentage and decreases Th17 cells percentage in the ovalbumin (OVA) -induced eosinophilic asthma mice model. Furthermore, Imidazoleacetic acid, DL-glutamine, L-pyroglutamic acid, 2-deoxy-D-glucose were preliminary identified as biomarkers in plasma metabolites treated by TMDCT, meanwhile genus Desulfovibrio, genus Butyricimonas and genus Prevotella 9 were preliminary identified as gut microbiota biomarkers after TMDCT treatment. These results provide an exptl. foundation for the treatment of allergic asthma with Chinese herbal compounds

Frontiers in Pharmacology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C37H30ClIrOP2, HPLC of Formula: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Truax, Valarie M. published the artcileDiscovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists, Synthetic Route of 6346-09-4, the publication is ACS Medicinal Chemistry Letters (2013), 4(11), 1025-1030, database is CAplus and MEDLINE.

A de novo hit-to-lead effort involving the redesign of benzimidazole-containing antagonists of the CXCR4 receptor resulted in the discovery of a novel series of 1,2,3,4-tetrahydroisoquinoline (TIQ) analogs. In general, this series of compounds show good potencies (3-650 nM) in assays involving CXCR4 function, including both inhibition of attachment of X4 HIV-1_IIIB virus in MAGI-CCR5/CXCR4 cells and inhibition of calcium release in Chem-1 cells. Series profiling permitted the identification of TIQ-(R)-stereoisomer I as a potent and selective CXCR4 antagonist lead candidate with a promising in vitro profile. The drug-like properties of I were determined in ADME in vitro studies, revealing low metabolic liability potential. Further in vivo evaluations included pharmacokinetic experiments in rats and mice, where I was shown to have oral bioavailability (F = 63%) and resulted in the mobilization of white blood cells (WBCs) in a dose-dependent manner.

ACS Medicinal Chemistry Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C7H6Cl2O, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Chunyang published the artcilePharmaceutical Cocrystals of Nicorandil with Enhanced Chemical Stability and Sustained Release, Synthetic Route of 86-48-6, the publication is Crystal Growth & Design (2020), 20(10), 6995-7005, database is CAplus.

Nicorandil (NCD) is a chem. unstable drug and sensitive to humidity, heat, and mech. stress in manufacturing processes. In this work, the cocrystals of NCD with organic acids were designed and synthesized to enhance the stability of NCD. Cocrystals of NCD with 1-hydroxy-2-naphthoic acid, salicylic acid, 3-hydroxybenzoic acid, and 2,5-dihydroxybenzoic acid were obtained. Hydrothermal stability study showed that cocrystals performed with remarkable stability advantages compared with pure NCD. On the basis of mechanism research, the stability improvements of NCD mols. can be attributed to the realignments of NCD mols. in cocrystals. After the formation of cocrystals, the novel packing styles of NCD break the self-catalyzed decomposition process in pure NCD structure. Moreover, intrinsic dissolution rate characterizations showed that the formation of cocrystals could also optimize the dissolution behavior of NCD to realize the objective of sustained release. The novel cocrystals stabilize nicorandil at mol. levels through lengthening the distances between N1 and C8 of adjacent mols.

Crystal Growth & Design published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Synthetic Route of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiong, Dazhen published the artcileTemperature-switchable deep eutectic solvents for selective separation of aromatic amino acids in water, SDS of cas: 645-56-7, the publication is Separation and Purification Technology (2021), 118479, database is CAplus.

Amino acids are vital compounds in animal and human nutrition. However, it is still a great challenge to develop a cost-effective process for selective separation of amino acids. In the present study, a class of deep eutectic solvents (DESs) with short-chain alkanolamines as hydrogen bond acceptors (HBAs) and phenolic compounds as hydrogen bond donors (HBDs) have been explored for selective separation of aromatic amino acids for the first time. It is found that these DESs exhibit upper critical solution temperature (UCST)-type phase behavior in water, and their phase transition temperature is related with the pK_a values of HBAs and HBDs as well as the hydrophobicity of HBDs. The UCST-type phase separation process is investigated by dynamic light scattering (DLS), FT-IR spectroscopy and temperature-variable ¹H NMR in details, and the stability of the DESs in water is also examined Interestingly, these UCST-type DESs/water systems are applicable to selective separation of aromatic amino acids. The separation factor between L-tryptophan and L-tyrosine as well as between L-tryptophan and L-phenylalanine can reach up to 476.1 and 87.9, resp., which is about 20 and 19 times that reported in ionic liquids-based extraction solvents.

Separation and Purification Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C10H18O4, SDS of cas: 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Shengnan published the artcileInvestigating the effect of three phenolic fractions on the volatility of floral, fruity, and aged aromas by HS-SPME-GC-MS and NMR in model wine, SDS of cas: 106-25-2, the publication is Food Chemistry: X (2022), 100281, database is CAplus and MEDLINE.

In this study, the volatility of three typical wine aromas in model wine was investigated by HS-SPME-GC-MS, NMR, and sensory evaluation as influenced by different concentrations and structural properties of phenolics. Results showed that three phenolic fractions (phenolic acids, monomeric/oligomeric and polymeric procyanidins) exhibited different matrix effects on floral, fruity, and aged aromas perception. Physico-chem. and sensory analyses together indicated that all fractions reduced the perceived intensity of fruity and aged aroma attributes, and displayed stronger retention effects on fruity aromas at higher mDP and concentrations Monomeric/oligomeric and polymeric procyanidins promoted highly hydrophobic floral aromas release, whereas inhibiting the volatility of low hydrophobic fruity aromas. NMR confirmed that the reduction in the volatility of rose oxide, Et butanoate and whiskey lactone was attributed to interactions with epicatechin. This study aims to provide new thoughts and theor. support for wine aroma regulation during winemaking by reconstructing the phenolic composition in wine.

Food Chemistry: X published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C8H14O2, SDS of cas: 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jian published the artcileStudy on synthesis of multivalent neoglycoproteins and their binding properties to hepatic stellate cells, Quality Control of 96345-79-8, the publication is Chinese Journal of Chemistry (2003), 21(7), 843-846, database is CAplus.

Neoglycoproteins of human serum albumin (HSA) were prepared by reaction of sugar-OC₆H₄N:C:S-p with HSA and the binding properties of the conjugates to hepatic stellate cells evaluated by confocal fluorescence microscopy. The bioactivity revealed that HSA modified with glucose showed high binding affinity.

Chinese Journal of Chemistry published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H31NO2, Quality Control of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xue, Tong published the artcileResearch on an abnormal reaction of N-methyl-di(2-hydroxyethyl)amine, Formula: C10H15NO, the publication is Huaxue Tongbao (2015), 78(12), 1162-1165, database is CAplus.

In organic synthesis, methanesulfonyl chloride was often used to react with alc. to turn hydroxyl into a more active leaving group-methanesulfonyl. However, we had found that, when N-methyl-di(2-hydroxyethyl)amine reacted with methanesulfonyl chloride, its hydroxyl groups were both substituted by chlorine atoms. A series of designed experiments indicated that the key reason of this phenomenon was the generation of three-membered ring azonia ion transition state. The formation of this transition state must meet three requirements: there must two carbon atoms between the nitrogen atom and hydroxyl group, nitrogen atom must have sufficient electron cloud d. and the steric hindrance around nitrogen atom cannot be too high.

Huaxue Tongbao published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H10O2, Formula: C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Kai published the artcileSynthesis of Diboronic Acid-Based Fluorescent Probes for the Sensitive Detection of Glucose in Aqueous Media and Biological Matrices, Quality Control of 673456-16-1, the publication is ACS Sensors (2021), 6(4), 1543-1551, database is CAplus and MEDLINE.

Reliable and accurate glucose detection in biol. samples is of great importance in clin. diagnosis and medical research. Chem. probes are advantageous in simple operation and flexible design, especially for the development of fluorescent probes. Anthracene-based diboronic acid (P-DBA) has shown potential in glucose probing because of its high sensitivity. However, poor solubility limits its applications in aqueous media. In this work, we systemically modify P-DBA by introducing fluoro (F-), chloro (Cl-), methoxyl (MeO-), or cyano (CN-) substituents. Among these probes, the cyano-substituted probe (CN-DBA) displays the highest glucose-binding constant (6489.5 M^-1, 33% MeOH). More importantly, it shows good water solubility in the aqueous solution (0.5% MeOH), with ultrasensitive recognition with glucose (LOD = 1.51 μM) and robust sensing from pH 6.0 to 9.0. Based on these features, the CN-DBA is finally applied to detect glucose in cell lysates and plasma, with satisfactory recovery and precision. These results demonstrate that CN-DBA could serve as an accurate, sensitive fluorescent probe for glucose assays in biol. samples.

ACS Sensors published new progress about 673456-16-1. 673456-16-1 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester,, name is 2-(2-(Bromomethyl)-4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C6H4ClNO2, Quality Control of 673456-16-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts