Category: alcohols-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 55977-10-1, 3-Bromo-7-hydroxy-4-methylchromen-2-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

General procedure: The appropriate 7-hydroxycoumarin 1a-g (2.0 mmol for 2a-gand 2i-r; 3.0 mmol for 1h) was suspended in anhydrous acetone(10 mL) before adding potassium carbonate (for 2a-g and 2i-r: 0.83 g, 6.0 mmol; for 1h: 1.2 g, 9.0 mmol), the suitable monohalide(for 1h: 2-[4-(bromomethyl)phenyl]ethanol, 3.0 mmol) or dihalide(for 2a-g and 2i-r: 6.0 mmol of alpha,alpha’-dibromo(chloro)-xylenes or trans-1,4-dibromo-2-butene; 10 mmol of 1,omega-dibromoalkanes) anda catalytic amount of KI in a Pyrex vessel charged with a magnetic stirring bar and aWeflon bar. The vessel was placed in a microwave apparatus and irradiated at 130 C for 30 min. After cooling to room temperature, the inorganic residue was filtered off after thorough washing with CH2Cl2. The solutionwas concentrated to dryness andthe resulting crude was purified as detailed below.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55977-10-1, 3-Bromo-7-hydroxy-4-methylchromen-2-one, and friends who are interested can also refer to it.

Reference:
Article; Rullo, Mariagrazia; Niso, Mauro; Pisani, Leonardo; Carrieri, Antonio; Colabufo, Nicola Antonio; Cellamare, Saverio; Altomare, Cosimo Damiano; European Journal of Medicinal Chemistry; vol. 161; (2019); p. 433 – 444;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 261763-21-7, (5-Chloro-2-(trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C8H6ClF3O, blongs to alcohols-buliding-blocks compound. COA of Formula: C8H6ClF3O

To a solution of(5-chloro-2- (trifluoromethyl)phenyl)methanol (400 mg, 1.90 mmol)and triethylamine (0.794 mL, 5.70mmol) in DCM (8 mL) was added methanesulfonyl chloride (0.148 mL, 1.90 mmol) at 0C. The reaction was stirred for 1 hour at 0 C, then quenched with water (10 mL) and extracted with DCM (10 mL x 3). The combined organic layers were washed with brine (saturated, 10 mL), dried over Mg504 and filtered. The filtrate was concentrated under reduced pressure to give the title compound, which was used in the next step without purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,261763-21-7, (5-Chloro-2-(trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; CHOBANIAN, Harry, R.; HE, Shuwen; HAO, Jinsong; PIO, Barbara; GUO, Yan; XIAO, Dong; (213 pag.)WO2018/118670; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 626-95-9, 1,4-Pentanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 626-95-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 626-95-9

General procedure: An aqueous solution containing 1,4-butanediol (0.5 mmol),cyclohexene (5 mmol, 0.506 mL, 10 equiv), KOH (25 mol%,0.007 g, 0.125 mmol), and 1 or 2 (10 mol%, 0.0506 g or 0.051 g,0.05 mmol) was heated to 100 C for 48 h in a sealed vessel. Oncompletion of the reaction, the products were extracted withDCM and injected into gas chromatography. gamma-Butyrolactonewith 73% and 84% yields was observed with the formation ofcyclohexane with 22% and 24% yields.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-95-9, 1,4-Pentanediol, and friends who are interested can also refer to it.

Reference:
Article; Bhatia, Anita; Kannan, Muthukumar; Muthaiah, Senthilkumar; Synlett; vol. 30; 6; (2019); p. 721 – 725;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C12H21NO4S, blongs to alcohols-buliding-blocks compound. Formula: C12H21NO4S

(R) -1,2-glyceryl distearate-glycerol-3-phosphatidic acid (0.2 g, 0.28 mmol)Was added to 60 mL of dry pyridine,It was heated at 50 0.5h,Then, choline p-toluenesulfonate (0.84 g, 3 mmol)And trichloroacetonitrile 5mL,The reaction was continued at 50 36h,Concentration under reduced pressure crude,Flash column chromatography (developing solvent CHCl3-CH3OH-H2O, 15: 5: 1) gave a white gel, 0.13 g, 59% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, and friends who are interested can also refer to it.

Reference:
Patent; Ji, Min; Cai, Jin; Gu, Ning; Li, Rui; (7 pag.)CN103408588; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 54410-90-1, 4-Pentylcyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C11H22O, blongs to alcohols-buliding-blocks compound. Computed Properties of C11H22O

Step 2:2L four bottles of the first step to add 200.8g (1179.0mmol, 1.0eq), 800.0 g of dichloroethane, 131.2 g (1279.0 mmol, 1.1 eq) of triethylamine, 14.4 g (117.8 mmol, 0.1 eq) of 4-dimethylaminopyridine,Into the ice machine cooling to -5 ~ 0 stand.A solution of 148.6 g (1297.0 mmol, 1.1 eq) of methanesulfonyl chloride and 200.8 g of dichloroethane was added dropwise over 1.5 h, and the dropping temperature was controlled at -5 to 5 C,Followed by 0 ~ 5 insulation stirring 1.0h.Add water 600g quenching reaction, then stop the cooling, the kettle temperature to room temperature, stirring 0.5h, standing for 0.5h, divided into an oil layer 1268.0g, the water back to the kettle by adding dichloroethane 200.0g secondary extraction, stirring 0.5 h, standing for 0.5h, separate the secondary reservoir 188.7g.Combined with a secondary oil layer, add water 400.0g washing, stirring 0.5h, standing for 0.5h, separated from the oil layer, desolvation, the use of ethanol to get 260.0g two-step product, the content of> 98%, yield 88% Cis – trans isomer ratio 56/44.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54410-90-1, 4-Pentylcyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; Dalian Jiu Xin Fine Chemical Co., Ltd.; Dai Yao; Liang Quande; Zhao Danyang; Liu Lingling; Wang Weixin; Wang Rongliang; (5 pag.)CN106916089; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 6214-45-5 ,Some common heterocyclic compound, 6214-45-5, molecular formula is C11H16O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In a 5 mL sealed tube, TBPB(30 mol%, 0.041 g), and TBHP (70 wt% in H2O, 1.0 mmol, 0.131 g) was added to a solution ofbenzyl alcohol 1a (0.4 mmol, 0.043 g) in chlorobenzene (1 mL). The resultant mixture washeated at 80 C for 2.5 h. After completion of the reaction as was indicated by TLC monitoring,the reaction mixture was cooled to ambient temperature and saturated NaHCO3 (2 mL) wasadded. The product was extracted with ethyl acetate (2 × 3 mL). The combined organic phasewas dried over Na2SO4. The solvent was removed under the reduced pressure. The residue waspurified by column chromatography using n-hexane-EtOAc (15:1) as eluent to afford pureproduct 2a as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6214-45-5, its application will become more common.

Reference:
Article; Adib, Mehdi; Pashazadeh, Rahim; Synlett; vol. 29; 1; (2018); p. 136 – 140;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 13588-28-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13588-28-8, name is 2-(2-Methoxypropoxy)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Jimroth type reflux condenser, Dean-Stark trap tube,In a 100 mL two-necked flask equipped with a nitrogen inlet tube,Dipropylene glycol monomethyl ether represented by the following formula (20) (with isomer) (7.41 g, 50 mmol), vinylacetic acid synthesized in Example 1 (formula (1-0),4.74 g, 55 mmol),p-Toluenesulfonic acid monohydrate (0.48 g, 2.5 mmol)And toluene (35 mL) was added.Immerse the two-necked flask in an oil bath,The temperature of the oil bath was raised to 130 C.While maintaining the same temperature, the mixture was stirred for 4 hours under a nitrogen stream to distill off the by-produced water.Cool the two-necked flask to room temperature (25 C),Wash twice with 5 wt% aqueous sodium bicarbonate (10 mL),Further, after washing twice with distilled water (10 mL), it was dried over magnesium sulfate. After removing the magnesium sulfate, the solution was concentrated under reduced pressure in the same manner as in Example 2. The obtained concentrated residue was purified by distillation under reduced pressure to isolate the compound (1-1b) (10.57 g, yield 98%)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13588-28-8, 2-(2-Methoxypropoxy)propan-1-ol.

Reference:
Patent; JNC Corporation; Masayuki, Sato; Urata, Yasuo; Yatsuda, Shinichi; Masuhara, Shigeo; Hashimoto, Kazuki; (20 pag.)JP5803424; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5617-32-3, name is 3,6,9,12,15,18-Hexaoxaicosane-1,20-diol, the common compound, a new synthetic route is introduced below. SDS of cas: 5617-32-3

General procedure: (Using the synthesis of macrocyclic sulfate 6a as an example). To a stirring solution of tetra(ethylene glycol) 5a (40.0 g, 205.95 mmol), triethylamine (100.73 g, 988.56 mmol), and DMAP (1.26 g, 10.30 mmol) in CH2Cl2 (3 L) at 0 °C was slowly added a solution of SOCl2 (50.30 g, 411.90 mmol, in 50 mL CH2Cl2). After the addition, the stirring mixture was warmed to 25 °C and monitored with TLC until the complete consumption of tetra(ethylene glycol). The reaction was quenched with 1.5 L water. The organic layer was collected, filtrated through a pad of silica gel, and concentrated under vacuum to provide the macrocyclic sulfite intermediate as brownish oil which was used directly in the next step. To the solution of macrocyclic sulfite in a mixture of CH2Cl2 (200 mL), CH3CN (200 mL), and water (300 mL) at 0 °C was added NaIO4 (52.86 g, 247.14 mmol) and RuCl3?3H2O (0.27 g, 1.03 mmol). The stirring mixture was gradually warmed to 25 °C and monitored with TLC. Upon complete consumption of the macrocyclic sulfite, the reaction mixture was filtered through a pad of Celite. Organic layer was collected, washed with brine, concentrated under vacuum, and recrystallized in methanol at -20 °C to afford the macrocyclic sulfate 6a as clear crystal (25.14 g, 47percent yield).

The synthetic route of 5617-32-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Deng, Tao; Mao, Xianglan; Xiao, Yan; Yang, Zhigang; Zheng, Xing; Jiang, Zhong-Xing; Bioorganic and Medicinal Chemistry Letters; vol. 29; 4; (2019); p. 581 – 584;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 15963-47-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15963-47-0, name is (3-Chlorocyclobutyl)methanol, molecular formula is C5H9ClO, molecular weight is 120.58, as common compound, the synthetic route is as follows.

(A) [[(3-Chlorocyclobutyl)methoxy]methyl]benzene A mixture of 3-chlorocyclobutanemethanol (17.3 g, 0.143 mole) and benzylbromide (26.96 g, 0.158 mole) in dry dimethylformamide (123 ml) was stirred at room temperature under an argon atmosphere and a 60% suspension of sodium hydride (6.31 g 0.158 g mole) was added. The reaction was stirred at ambient temperature for 22.5 hours. The reaction mixture was poured into 600 ml of water and the aqueous mixture extracted with ethyl acetate (4*500 ml). The ethyl acetate extracts were combined and dried over anhydrous sodium sulfate and the ethyl acetate evaporated in vacuo yielding the crude product as a yellow oil. The material was purified on a 2-liter Merck silica gel column eluding with 3 liters of hexane, followed by 5% ethyl acetate/hexane. The fractions containing the desired product were combined and the volatiles evaporated in vacuo yielding 28.6 g of the title compound as a pale yellow oil.

Statistics shows that 15963-47-0 is playing an increasingly important role. we look forward to future research findings about (3-Chlorocyclobutyl)methanol.

Reference:
Patent; E. R. Squibb & Sons, Inc.; US4918075; (1990); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 52221-92-8, 3-(2-Bromo-phenyl)-propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H11BrO, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H11BrO

EXAMPLES; EXAMPLE 1 : 3-(2-bromophenyl)propionaldehyde; Following the procedure described by Stambuli, JP. in J. Am. Chem. Soc. (2001 ), 123 (11 ), 2677-2678, for the reduction of 3-(4-bromophenyl)propionic acid, 3-(2-bromophenyl)propionic acid was reduced to 3-(2- bromophenyl)propan-1-ol using BH3 SMe2 in tetrahydrofurane. Then the alcohol was converted to the corresponding aldehyde following the procedure described by Cooke, MP. in J. Org. Chem. (1987), 52 (8), 1381 -1396.

The synthetic route of 52221-92-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FARMAPROJECTS, S. A.; WO2007/101841; (2007); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts