Category: alcohols-buliding-blocks

Related Products of 558-43-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 558-43-0, name is 2-Methylpropane-1,2-diol. This compound has unique chemical properties. The synthetic route is as follows.

Example 1 (not in Accordance with the Present Invention) Synthesis of the 2-hydroxy-2-methylpropyl Acrylate Precursor Under inert gas, triethylamine (66.8 g, 91.5 mL, 0.66 mol, 1.2 eq.) and 2-methylpropane-1,2-diol (49.6 g, 0.55 mol, 1 eq.) are initially charged in 300 mL of dichloromethane and cooled to 0 C. with an ice bath. A solution of 200 mL of dichloromethane and acryloyl chloride (49.8 g, 44.5 mL, 0.55 mol, 1 eq.) is added dropwise at room temperature via a dropping funnel in the course of an hour. A colorless precipitate was gradually formed in the course of the dropwise addition. The reaction solution was warmed to room temperature overnight and then the resultant precipitate was filtered off. The reaction solution was washed twice with 100 mL of water each time and dried over MgSO4. Then, the solvent was removed in a rotary evaporator and the crude product was distilled in vacuo. Boiling point 43-44 C./7.7-8.4 10-1 mbar. This gave 50.7 g (71%) of the pure product as a colorless clear liquid, storage at 7 C., stabilized with 4-methoxyphenol. 1H NMR (CDCl3): delta=1.21 (s, 6H, CH3), 2.30 (br s, 1H, OH), 3.99 (s, 2H, CH2), 5.81 (dd, 3JH,H=10.5 Hz, 1.5 Hz, 1H) 6.12 (dd, 3JH,H=10.5 Hz, 1.7 Hz, 1H), 6.39 ppm (dd, 3JH,H=1.5 Hz, 17 Hz, 1H). 13C NMR (CDCl3): delta=26.05 (2C, CH3), 69.72 (1C, COH), 72.01 (1C, CH2), 127.99 (1C, HC?CH2), 131.19 (1C, HC?CH2), 166.08 ppm (1C, ROC?O).

According to the analysis of related databases, 558-43-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wacker Chemie AG; FRITZ-LANGHALS, Elke; (7 pag.)US2018/201633; (2018); A1;,
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Adding a certain compound to certain chemical reactions, such as: 38584-37-1, 3-(Hydroxymethyl)adamantan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 3-(Hydroxymethyl)adamantan-1-ol, blongs to alcohols-buliding-blocks compound. Safety of 3-(Hydroxymethyl)adamantan-1-ol

(2) 1.0 Part of 1,1′-carbonyldiimidazol was added to a mixture of 1.9 parts of sodium difluorosulfoacetate (purity: 62.7%) and 9.5 parts of N,N-dimethylformamide, and the added mixture was stirred for 2 hours to obtain solution (referred to as solution A). 0.2 Part of sodium hydride was added to a mixture of 1.1 parts of 3-hydroxyadamantylmethanol and 5.5 parts of N,N-dimethylfomamide, and the added mixture was stirred for 2 hours to obtain solution (referred to as solution B). The solution A was added to the solution B, and the mixture was stirred for 15 hours to obtain sodium salt of 3-hydroxy-1-adamantylmethyl difluorosulfoacetate solution. The sodium salt of 3-hydroxy-1-adamantylmethyl difluorosulfoacetate solution was used for the next step without further separation or purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38584-37-1, 3-(Hydroxymethyl)adamantan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Sumitomo Chemical Company, Limited; US2006/194982; (2006); A1;,
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Adding a certain compound to certain chemical reactions, such as: 59012-91-8, 4-(Hydroxymethyl)phenyl pivalate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 59012-91-8, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

[01561] A suspension of 2-methyl-5-isobutyl-4-[2-(5-phosphono)furanyl]thiazole (1 mmole) in thionyl chloride (5 mL) was warmed at reflux for 4 h. The cooled reaction mixture was evaporated to dryness and the resulting yellow residue was dissolved in methylene chloride and treated with a solution of the corresponding benzyl alcohol (4 mmole) and pyridine (2.5 mmole) in methylene chloride. After stirring at 25 C. for 24 h the reaction mixture was subjected to extraction and chromatography to give the titled compounds.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,59012-91-8, its application will become more common.

Reference:
Patent; Metabasis Therapeutics, Inc.; US6756360; (2004); B1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1875-89-4, name is 2-(m-Tolyl)ethanol, the common compound, a new synthetic route is introduced below. name: 2-(m-Tolyl)ethanol

Part A. Preparation of 3-methylphenethyl bromide. To a solution of 3-methylphenethyl alcohol (5.0 g, 36.7 mmol) in methylene chloride at 0° C. was added triphenylphosphine (10.6 g, 40.4 mmol) and carbon tetrabromide (13.4 g, 40.4 mmol). The mixture was allowed to stir with warming to 25° C. for 16 h. The solvent was removed in vacuo and the residue was taken up in ether and filtered through a pad of silica gel. The solvent was removed in vacuo to afford 7.0 g (95percent) of the title bromide.

The synthetic route of 1875-89-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DuPont Pharmaceuticals Company; US6060462; (2000); A;,
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Synthetic Route of 92409-15-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 92409-15-9, name is 2-(2-Methoxyphenoxy)-1-(4-methoxyphenyl)propane-1,3-diol. This compound has unique chemical properties. The synthetic route is as follows.

1 part by weight of the compound2- (2-methoxyphenoxy) -1- (4-methoxyphenyl) -1-hydroxy-3-propanol and 1.8 parts by weightAl (NO3) 3 was added to 30 parts by weight of methanol,Set the microwave reactor power of 50W,Microwave frequency of 2450MHz, microwave-assisted heating at 80 for 40min.After completion of the reaction, the reaction was quenched with cold water immediately,The reaction solution was extracted with ethyl acetate,Take organic phase spin dry,Followed by further separation and purification by silica gel column chromatography,The mobile phase of ethyl acetate and n-hexane volume ratio of 1: 1, evaporated to dry the solvent that methylation products.

According to the analysis of related databases, 92409-15-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; South China University of Technology; Qiu, Xueqing; Ouyang, Xinping; Zhu, Guodian; Chen, Cheng; Jin, Dongxue; Zhao, Ying; (10 pag.)CN106117021; (2016); A;,
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Electric Literature of 205877-13-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.205877-13-0, name is (2-Amino-3-methoxyphenyl)methanol, molecular formula is C8H11NO2, molecular weight is 153.1784, as common compound, the synthetic route is as follows.

General procedure: To a solution of 1a (1.2 g, 7.61 mmol) in CH2Cl2 (20 mL) was added MnO2 (2.6 g, 30.1 mmol) and stirred at rt under an Ar atmosphere. After 23 h with stirring, the reaction mixture was filtrated and evaporated. The residue was crystallized from AcOEt to give 7a (1.0 g, 85%) as a yellow needle crystal.

The chemical industry reduces the impact on the environment during synthesis 205877-13-0, I believe this compound will play a more active role in future production and life.

Reference:
Article; Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5810 – 5831;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55977-10-1, name is 3-Bromo-7-hydroxy-4-methylchromen-2-one. A new synthetic method of this compound is introduced below., HPLC of Formula: C10H7BrO3

A mixture of 3-bromo-7-hydroxy-4-methyl-2H-chromen-2-one (1) (7.66 g, 30 mmol), 4-(2-morpholmoethylcarbamoyl)phenylboronic acid (2) (10.02 g, 36 mmol), Na3PO4 (17.21 g, 105 mmol) in a mixture of ethoxyethanol (0.140 g) and water (14 g) was purged with Argon for five minutes in a 250 mL pressure vessel. Ligand Sphos (738 mg, 1.8 mmol) and Pd(OAc)2(206 mg, 0.90 mmol) were added under an Argon atmosphere then the vessel was sealed and heated for 60 min in a 150 C. oil bath with strong stirring. This process was repeated once. Upon cooling, the reaction mixtures were filtered through a silica plug using CH2Cl2and MeOH wash. The unified solutions were evaporated to 100 mL slowly diluted with water (100 mL) and crystallized at 0 C. The product was filtered, washed with 50% MeOH (2×50 mL) and dried to afford 22.33 g (9.1%) of the title compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55977-10-1, 3-Bromo-7-hydroxy-4-methylchromen-2-one.

Reference:
Patent; MANNKIND CORPORATION; ZENG, QINGPING; TORO, ANDRAS; PATTERSON, JOHN BRUCE; WADE, WARREN STANFIELD; ZUBOVICS, ZOLTAN; YANG, YUN; WU, ZHIPENG; (403 pag.)JP2015/214548; (2015); A;,
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Adding a certain compound to certain chemical reactions, such as: 38584-37-1, 3-(Hydroxymethyl)adamantan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 3-(Hydroxymethyl)adamantan-1-ol, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 3-(Hydroxymethyl)adamantan-1-ol

(2) 5.0 Parts of the salt represented by the formula (g), 2.1 parts of (3-hydroxy-1-adamantyl)methanol, 50 parts of toluene and 0.3 part of concentrated sulfuric acid were mixed. The mixture obtained was heated and refluxed for 22 hours. The mixture was cooled, and then, concentrated. To the residue obtained, 90 parts of chloroform was added, and the solution obtained was repeated to wash with an ion-exchanged water until the aqueous layer obtained was neutralized. The organic layer obtained was concentrated and the residue obtained was mixed with 49 parts of ethyl acetate. The resultant mixture was stirred and filtrated to obtain the solid. The solid obtained was dried to obtain 5.4 parts of the salt represented by the above-mentioned formula (b). The 1H-NMR spectrum of the salt obtained was the same as that of the salt obtained in above-mentioned Salt Synthesis Example 1.

The synthetic route of 38584-37-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; US2008/86014; (2008); A1;,
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Electric Literature of 55357-38-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55357-38-5, name is 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, molecular formula is C12H21NO4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 1 A solution of 48.7 g of cholest-5-en-3beta-yl 2-hydroxyethylcarbonate and 10 ml of quinoline in 500 ml of methylene chloride is added dropwise at room temperature to a solution of 12.5 ml of phosphorus oxychloride. The solution is treated at room temperature while stirring with 60 ml of pyridine and 77 g of choline tosylate in 500 ml of methylene chloride, whereupon the reaction mixture is stirred at room temperature overnight. The mixture is treated with 125 ml of water and 34 g of sodium bicarbonate and then with 3000 ml of acetone. The precipitated product is filtered off under suction, dissolved in 1000 ml of chloroform-methanol 1:1 and stirred with 500 g of ion exchanger (Amberlite MB-3). The latter is filtered off under suction and the solution is evaporated. The resulting residue is recrystallized in a mixture of methylene chloride-methanol 1:1 and dioxan. There are obtained 39 g of O-[[2-[[(cholest-5-en-3beta-yloxy)carbonyl]oxy]ethoxy]hydroxyphosphinyl]choline hydroxide internal salt of melting point 224 C., MS: 640 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate.

Reference:
Patent; Hoffmann-La Roche Inc.; US5215972; (1993); A;,
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Electric Literature of 81156-68-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 81156-68-5, name is 2,4-Dichlorophenethyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

(ii) 3-[2-(2,4-Dichlorophenyl)-Ethoxy]-4-Ethoxy-Benzoic Acid Ethyl Ester 0.5 g (2.38 mmol) of 4-Ethoxy-3-hydroxy-benzoic acid ethyl ester was dissolved in 10 ml of anhydrous tetrahydrofuran. To this solution was added 0.5 g (2.62 mmol) of 2-(2,4-Dichlorophenyl)-ethanol, 2.38 g (equivalent to 7.13 mmol PPh3) of triphenylphosphine derivatized polystyrene and 1.24 g (7.13 mmol) of DEAD. The solution was shaken for 16 h at RT. The polymer was filtered off and washed with ethyl acetate. The solvent was removed under reduced pressure. The residue was taken-up in ethyl acetate and the solution was washed three times with water and twice with saturated aqueous sodium chloride. The organic phase was dried with magnesium sulphate, filtered and the solvent was removed under reduced pressure. The residue was chromatographed on silica gel eluding with ethyl acetate/n-heptane (1/4).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 81156-68-5, 2,4-Dichlorophenethyl alcohol.

Reference:
Patent; Nazare, Marc; Will, David William; Peyman, Anuschirwan; Matter, Hans; Zoller, Gerhard; Gerlach, Uwe; US2002/198195; (2002); A1;,
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