Category: 87905-98-4

Gao, Yongjun published the artcileEfficient Preparation of Glycoclusters from Silsesquioxanes, COA of Formula: C13H19NO3, the main research area is POSS polyhedral oligosilsesquioxane preparation photochem addition human glycoprotein receptor; human glycoprotein inhibition receptor glycocluster silsesquioxane preparation addition lectin; glycocluster silsesquioxane preparation lactoside mannoside photochem addition glycoside oligosaccharide.

A new type of glycocluster based on polyhedral oligo-silsesquioxanes (POSS) has been efficiently prepared from unprotected mannoside and lactoside employing a convergent approach of thiol-radical addition reaction. The versatility of this approach was demonstrated by functionalization of mannosides and lactosides of different-length spacers. Preliminary lectin binding study indicated that these novel glycoclusters showed strong inhibition of the binding of asialo-oligosaccharide mixture derived from human 1-acid glycoprotein by RCA120.

Organic Letters published new progress about Glycoproteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, COA of Formula: C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chang, Chun-Wei published the artcileAutomated Quantification of Hydroxyl Reactivities: Prediction of Glycosylation Reactions, Quality Control of 87905-98-4, the main research area is predictive stereoselective glycosylation automated quantification hydroxyl group reactivity; carbohydrates; diastereoselectivity; glycosylation; hydroxyl; predictive algorithms.

The stereoselectivity and yield in glycosylation reactions are paramount but unpredictable. We have developed a database of acceptor nucleophilic constants (Aka) to quantify the nucleophilicity of hydroxyl groups in glycosylation influenced by the steric, electronic and structural effects, providing a connection between experiments and computer algorithms. The subtle reactivity differences among the hydroxyl groups on various carbohydrate mols. can be defined by Aka, which is easily accessible by a simple and convenient automation system to assure high reproducibility and accuracy. A diverse range of glycosylation donors and acceptors with well-defined reactivity and promoters were organized and processed by the designed software program “”GlycoComputer”” for prediction of glycosylation reactions without involving sophisticated computational processing. The importance of Aka was further verified by random forest algorithm, and the applicability was tested by the synthesis of a Lewis A skeleton to show that the stereoselectivity and yield can be accurately estimated

Angewandte Chemie, International Edition published new progress about Algorithm. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Quality Control of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mazur, Marcelina published the artcile4′-Methoxyphenacyl-Assisted Synthesis of β-Kdo Glycosides, COA of Formula: C13H19NO3, the main research area is Kdo glycoside stereoselective synthesis anomeric methoxyphenacyl auxiliary group thioglycoside.

3-Deoxy-β-D-manno-oct-2-ulosonic acid (β-Kdo) glycosides are mainly found in capsular polysaccharides and extracellular exopolysaccharides from Gram-neg. bacteria. These compounds have profound biol. implications in immune response and act as virulence factors. We have developed a novel methodol. for the stereoselective synthesis of β-Kdo glycosides via the use of a 4′-methoxyphenacyl (Phen) auxiliary group at the C1 position of a peracetylated β-Kdo thioglycoside. Under the promotion of NIS/AgOTf in acetonitrile, a series of Kdo glycosides was synthesized in good yield and β-selectivity while minimizing the formation of undesirable glycals. Stereoselectivity of the glycosylation was shown to be modulated by various factors such as promotor, solvent, anomeric ratio of donor, nature of acceptor, and Phen substitution. Chemoselective cleavage of the Phen group was performed under the action of Zn/HOAc. DFT calculations together with exptl. results suggested that α-triflate and a six-membered α-spiroPhen are plausible intermediates of the reaction, accounting for the enhanced formation of β-Kdo glycosides. The developed methodol. could be applied to the synthesis of β-Kdo-containing glycans from pathogenic bacteria.

Journal of Organic Chemistry published new progress about Exopolysaccharides Role: NPO (Natural Product Occurrence), BIOL (Biological Study), OCCU (Occurrence) (extracellular). 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, COA of Formula: C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rouchaud, Anne published the artcileA new and efficient synthesis of derivatives of octahydro-4H-pyrrolo[1,2-c]pyrido[1′,2′-a]imidazole, Computed Properties of 87905-98-4, the main research area is octahydropyrrolopyridoimidazole preparation.

When di-Et malonate was added to a solution of Δ1-piperideine, generated in situ by oxidative desamination and decarboxylation of L-lysine by N-bromosuccinimide (NBS), formation of the unexpected tricyclic compound I was observed The structure of I was deduced from anal. of its spectroscopic data and was confirmed both by chem. degradation and by total synthesis. We proved that 3-bromo-1-piperideine was implicated in its formation. Moreover, based on this feature, a new and efficient synthesis of I was developed. The elaborated pathway was adapted to access derivatives related to I that differed in their C-4 substituent.

European Journal of Organic Chemistry published new progress about Michael reaction. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Computed Properties of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wendeln, Christian published the artcileCarbohydrate Microarrays by Microcontact Printing, Synthetic Route of 87905-98-4, the main research area is carbohydrate microarray microcontact printing.

This Article describes the preparation of carbohydrate microarrays by the immobilization of carbohydrates via microcontact printing (μCP) on glass and silicon substrates. To this end, diene-modified carbohydrates (galactose, glucose, mannose, lactose, and maltose) were printed on maleimide-terminated self-assembled monolayers (SAMs). A Diels-Alder reaction occurred exclusively in the contact area between stamp and substrate and resulted in a carbohydrate pattern on the substrate. It was found that cyclopentadiene-functionalized carbohydrates could be printed within minutes at room temperature, whereas furan-functionalized carbohydrates required long printing times and high temperatures By successive printing, microstructured arrays of up to three different carbohydrates could be produced. Immobilization and patterning of the carbohydrates on the surfaces was investigated with contact angle measurements, XPS, time-of-flight secondary ion mass spectrometry (TOF-SIMS), and fluorescence microscopy. Furthermore, the lectins Con A (ConA) and peanut agglutinin (PNA) bind to the microarrays, and the printed carbohydrates retain their characteristic selectivity toward these proteins.

Langmuir published new progress about Carbohydrates Role: ARG (Analytical Reagent Use), BUU (Biological Use, Unclassified), PEP (Physical, Engineering or Chemical Process), RCT (Reactant), SPN (Synthetic Preparation), TEM (Technical or Engineered Material Use), ANST (Analytical Study), USES (Uses), BIOL (Biological Study), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation) (diene-modified). 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Synthetic Route of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Connah, Liam published the artcileSynergy of Key Properties Promotes Dendrimer Conjugates as Prospective Ratiometric Bioresponsive Magnetic Resonance Imaging Probes, Formula: C13H19NO3, the main research area is polyamidoamine dendrimer MRI contrast agent calcium gadolinium.

Bioresponsive or smart contrast agents (SCAs) sensitive to Ca2+ are of extreme interest in the development of functional magnetic resonance imaging (MRI) techniques as they can aid in tracking neural activity in vivo. To this end, the design of macromol. systems based on nanoscaffolds such as dendrimers functionalized with multiple MRI contrast agents has been used to conveniently increase the local concentration of paramagnetic MR reporters and slow the diffusion time of the probe, which are favorable in vivo characteristics. Moreover, previous studies with Ca-sensitive dendrimeric MRI probes revealed favorable properties crucial in the development of a ratiometric T2/T1-imaging method that provided a higher contrast-to-noise ratio compared to conventional T1- or T2-weighted imaging protocols. We therefore developed a series of novel dendrimeric MRI probes (DCAs) with differing structural properties and charge distributions. We thoroughly studied their features such as the relaxometric behavior and size change and examined their electrostatic behaviors prior to and after the addition of Ca2+. The most active DCA displayed a common increase in r1 (3.11 to 5.72 mM-1 s-1) and a remarkable increase in r2 (7.44 to 34.57 mM-1 s-1), resulting in a r2/r1 ratio increase of the factor 2.52, which is greater than what was previously achieved. These changes in r1 and r2 were followed with a hydrodynamic diameter increase from 7.1 ± 1.2 to 8.5 ± 0.7 nm upon the addition of Ca2+, along with a decrease in the neg. surface charge of the nanoparticle. Overall, our findings indicate that highly responsive DCAs can be developed only through a combination of properties such as changes in hydration and size of the mol., which are a consequence of intramol. structural and electrostatic changes in the particle. In turn, they provide a model for future preparations of responsive DCAs that can be utilized for both T1-weighted and ratiometric T2/T1-weighted imaging to visualize essential biol. processes in a dynamic fashion.

Biomacromolecules published new progress about Hydration process. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Formula: C13H19NO3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nishi, Nobuya published the artcileSynthesis of a Pentasaccharide Repeating Unit of Lipopolysaccharide Derived from Virulent E. coli O1 and Identification of a Glycotope Candidate of Avian Pathogenic E. coli O1, Recommanded Product: Benzyl (5-hydroxypentyl)carbamate, the main research area is bovine serum albumin oligosaccharide aminoglycoside; stereoselective glycosylation lipopolysaccharide synthesis BSA oligosaccharide aminoglycoside transition state; BSA glycoconjugate pentasaccharide oligosaccharide antigen vaccine antibody; Avian Pathogenic Escherichia coli lipopolysaccharide pentasaccharide repeating unit; avian pathogenic Escherichia coli; boron-mediated aglycon delivery; glycoconjugate; glycotope; β-rhamnoside.

Avian pathogenic Escherichia coli (APEC) is a common bacterial pathogen infecting chickens, resulting in economic losses to the poultry industry worldwide. In particular, APEC O1, one of the most common serotypes of APEC, is considered problematic due to its zoonotic potential. Therefore, many attempts have been made to develop an effective vaccine against APEC O1. In fact, the lipopolysaccharide (LPS) O-antigen of APEC O1 has been shown to be a potent antigen for inducing specific protective immune responses. However, the detailed structure of the O-antigen of APEC O1 is not clear. The present study demonstrates the first synthesis of a pentasaccharide repeating unit of LPS derived from virulent E. coli O1 and its conjugate with BSA. ELISA tests using the semi-synthetic glycoconjugate and the APEC O1 immune chicken serum revealed that the pentasaccharide is a glycotope candidate of APEC O1, with great potential as an antigen for vaccine development.

Angewandte Chemie, International Edition published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Recommanded Product: Benzyl (5-hydroxypentyl)carbamate.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bunthitsakda, Warunda published the artcileControlled rapid synthesis and in vivo immunomodulatory effects of LM α(1,6)mannan with an amine linker, Category: alcohols-buliding-blocks, the main research area is lipomannan synthesis controlled polymerization glycan conjugate adjuvant vaccine; Adjuvant; Controlled polymerization; Glycan conjugation; Lipomannan glycan; Rapid synthesis.

The synthetic lipomannan (LM) α(1,6)mannans, already equipped with an amine linker on the reducing end, are rapidly synthesized in a size-, regio-, and stereocontrolled reaction. The size of the mannans is regulated through the concentration of the linker, applied during the controlled ring-opening polymerization reaction. The versatile amine linker enables a variety of glycan conjugations. The synthetic α(1,6)mannans exert adjuvant activities for a real vaccine antigen, tetanus toxoid (TT) in vitro, as demonstrated by the increased secretion of proinflammatory cytokines TNF-α and IL-6 from the treated macrophages. A conjugation of synthetic α(1,6)mannan with TT can also enhance immune response to TT in vivo after immunization as shown by an increase in TNF-α, IFN-γ, and IL-2 production in splenocytes.

Carbohydrate Polymers published new progress about Conjugation (bond). 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts