Category: 65-22-5

Pyridoxal: A New Alkylating Agent in Reactions with Phenols and Polyphenols was written by Kibardina, L. K.;Trifonov, A. V.;Burilov, A. R.;Gazizov, A. S.;Pudovik, M. A.. And the article was included in Russian Journal of General Chemistry in 2018.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

A possibility to use pyridoxal as an alkylating agent in the reactions of electrophilic mono-, di-, and trisubstitution in the aromatic core of various phenols and polyphenols was demonstrated for the first time. New types of hydroxyl-containing aromatic aldehydes containing vitamin B6 fragment were obtained, and the conditions for their synthesis were optimized. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Visible light induced hydrophosphinylation of unactivated alkenes catalyzed by salicylaldehyde was written by Yuan, Zeqin;Wang, Simin;Li, Miaomiao;Chen, Tian;Fan, Jiaye;Xiong, Fuying;Li, Qianggen;Hu, Ping;Wang, Bi-Qin;Cao, Peng;Li, Yang. And the article was included in Green Chemistry in 2021.Recommanded Product: 65-22-5 The following contents are mentioned in the article:

An air and water insensitive visible light induced hydrophosphinylation of unactivated alkenes is reported. A small amount of a simple and cheap compound, salicylaldehyde, is used as a photosensitizer. The reaction is carried out in a basic aqueous solution which enables the deprotonated salicylaldehyde to show visible light absorption. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Recommanded Product: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 65-22-5

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rhodamine B derivatives-modified upconversion nanoparticles as a fluorescent turn-off-on sensor for the highly sensitive detection of Cu²⁺ and pyrophosphate was written by Meng, Zhipeng;Wu, Suli;Zhong, Linghua;Zeng, Min;Sun, Xiaoqian;Li, Lu;Zhang, Shufen. And the article was included in RSC Advances in 2018.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

Rhodamine B derivatives (RBP)-modified UCNPs (UCNPs@mSiO₂-RBP) were developed as a fluorescent turn-off-on sensor based on FRET and IFE to detect Cu²⁺ and pyrophosphate (PPi) with a wide linear response range (0-10 μM for Cu²⁺ and 5-35 μM for PPi, much wider than that reported previously) and high sensibility (117 nM for Cu²⁺ and 70 nM for PPi). The MTT experiments and the bioimaging experiments show its promising prospect in tissue imaging. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

New 1-hetarylfuropyridines and chromenes based on pyridoxal and 4-hydroxycoumarin was written by Trifonov, Alexey V.;Kibardina, Lyudmila K.;Dobrynin, Alexey B.;Akhunov, Amirjon A. Ali;Pudovik, Mikhail A.;Burilov, Alexander R.. And the article was included in Mendeleev Communications in 2020.Electric Literature of C8H10ClNO3 The following contents are mentioned in the article:

Pyridoxal in the absence of a catalyst forms furo[3,4-c]pyridine species (ortho aldehyde and hydroxymethyl groups were involved) which is further transformed into C-C hybrid with 4-hydroxycoumarin. Different products of chromeno[3′,4′:5,6]pyrano[2,3-c]pyridine type were formed when pyridoxal hydrochloride or more sophisticated 2,4-dihydroxybenzaldehyde derivative were applied (herein, ortho aldehyde and hydroxy groups were involved into heterocyclization). This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Electric Literature of C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Electric Literature of C8H10ClNO3

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Alcohol – Wikipedia,
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High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles was written by Kritchenkov, Andreii S.;Kurasova, Margarita N.;Godzishevskaya, Anastasia A.;Mitrofanova, Elizaveta S.;Egorov, Anton R.;Yagafarov, Niyaz Z.;Ballesteros Meza, Moises J.;Tskhovrebov, Alexander G.;Artemjev, Alexey A.;Andrusenko, Elena V.;Khrustalev, Victor N.. And the article was included in Mendeleev Communications in 2021.Reference of 65-22-5 The following contents are mentioned in the article:

The pyridoxal derivatives of chitosan with various degrees of substitution (DS) were synthesized from low-, moderate- and high-mol.-weight chitosans by their reaction with pyridoxal followed by treatment with NaBH4. The derivative of moderate mol. weight and high DS demonstrated a maximum antibacterial activity against S. aureus and E. coli. The nanoparticles of this derivative obtained by ionic gelation are nontoxic, and they exhibit a high in vitro antibacterial effect, which slightly exceeds that of ampicillin and gentamicin. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Reference of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 65-22-5

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anticancer activity of novel 3-azaxanthenes was written by Kibardina, Lyudmila K.;Trifonov, Alexey V.;Dobrynin, Alexey B.;Pudovik, Michail A.;Burilov, Alexander R.;Voloshina, Alexandra D.;Strelnik, Anna G.;Gazizov, Almir S.. And the article was included in Mendeleev Communications in 2021.SDS of cas: 65-22-5 The following contents are mentioned in the article:

Novel 3-azaxanthenes have been synthesized via acid-catalyzed one-pot Friedel-Crafts reaction of pyridoxal/pyridoxal-5-phosphate with naphthols followed by dehydration of the intermediate bis(2-hydroxyaryl)-(pyridin-4-yl)methane derivatives The cytotoxicity of the obtained 3-azaxanthenes against M-HeLa and HuTu-80 tumor cell lines is comparable to that of tamoxifen, whereas the cytotoxicity against normal cell line is absent in the tested concentratons range, which makes this class of compounds interesting for further studies. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5SDS of cas: 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 65-22-5

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Alcohol – Wikipedia,
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Synthesis of pharmacophores containing a prolinate core using a multicomponent 1,3-dipolar cycloaddition of azomethine ylides was written by Selva, Elisabet;Castello, Luis M.;Mancebo-Aracil, Juan;Selva, Veronica;Najera, Carmen;Foubelo, Francisco;Sansano, Jose M.. And the article was included in Tetrahedron in 2017.Application of 65-22-5 The following contents are mentioned in the article:

Synthesis of pharmacophores containing a prolinate core, e.g. I, II, III and IV via silver acetate catalyzed multicomponent 1,3-dipolar cycloaddition reaction of heterocyclic aldehydes, amino esters and dipolarophiles was described. The preference of each tested amino esters toward different dipolarophiles was discussed. At the end, a selective reduction of an ester group allowed the preparation of dideoxiazanucleoside derivative V. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging was written by Yin, Cai-Xia;Qu, Li-Jun;Huo, Fang-Jun. And the article was included in Chinese Chemical Letters in 2014.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

A pyridoxal-based chemosensor (I) was synthesized by reacting hydrazine hydrate and pyridoxal hydrochloride in ethanol and characterized by NMR and ESI-MS. The optical properties of the compound were studied in a methanol: HEPES solution The compound displayed selectivity for Cu²⁺, as evidenced by a colorless to yellow color change, which was characterized using UV-visible spectroscopy. The fluorescence of the compound can be quenched only by Cu²⁺, accompanying by a color change from blue to colorless. Furthermore, it can be used in bioimaging. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reaction of Pyridoxal with Hydrophosphoryl Compounds was written by Kibardina, Lyudmila K.;Trifonov, Alexey V.;Dobrynin, Alexey B.;Pudovik, Michael A.;Burilov, Alexander R.;Sinyashin, Oleg G.. And the article was included in Heteroatom Chemistry in 2016.Related Products of 65-22-5 The following contents are mentioned in the article:

The products of carbonyl phosphonylation of pyridoxal with dialkylphosphinous acid, alkylphosphinic acid Et esters, and phosphorous acid dialkyl (or diphenyl) esters have been obtained for the first time. In some cases, the products of addition are hydrolytically unstable and stabilized by forming internal betaine structures. The reaction of pyridoxal with phosphorous acid in alc. solutions gives alkoxyfuropyridines possessing the iminium nitrogen atom. The structure and composition of the prepared compounds have been established by ³¹P and ¹H NMR spectroscopy, mass spectrometry (MALDI-TOF), and X-ray anal. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Related Products of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 65-22-5

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Transition metal complexes with thiosemicarbazide-based ligands. Part 60. Reactions of copper(II) bromide with pyridoxal S-methylisothiosemicarbazone (PLITSC). Crystal structure of [Cu(PLITSC-H)H₂O]Br·H₂O was written by Leovac, Vukadin M.;Vojinovic-Jesic, Ljiljana S.;Ivkovic, Sonja A.;Rodic, Marko V.;Jovanovic, Ljiljana S.;Hollo, Berta;Szecsenyi, Katalin Meszaros. And the article was included in Journal of the Serbian Chemical Society in 2014.COA of Formula: C8H10ClNO3 The following contents are mentioned in the article:

The synthesis and structural characterization of a square-planar copper(II) complex with pyridoxal S-methylisothiosemicarbazone (PLITSC) of the formula [Cu(PLITSC-H)H₂O]Br·H₂O (1) as the first Cu(II) complex with a monoanionic form of this ligand were described. Complex 1 together with two previously synthesized complexes [Cu(PLITSC)Br₂] (2) and [Cu(PLITSC)Br(MeOH)]Br (3) were characterized by elemental anal., IR and electronic spectroscopy and by the methods of thermal anal., conductometry and magnetic susceptibility. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5COA of Formula: C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts