Category: 647-42-7

Application of 647-42-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A succinic anhydride (9.7 g, 49 mmol), tetrahydrofuran (10 ml), and triethylamine (0.2 mL) were added to 2-(perfluorohexyl)ethanol (33.3 g, 46 mmol). A reaction was allowed for 60 min at an increased temperature of 100C while stirring the mixture. Water (100 mL) was added after cooling the mixture to 30C, and the precipitated crystals formed upon further cooling to 15C were filtered off to obtain carboxylic acid (5a; 39.7 g, 94%).

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FUJIFILM Corporation; MIZUMURA Masatoshi; KATOH Shunya; UEMURA Minoru; ISHIWATAYasuhiro; YOSHIKAWA Masaru; MATSUYAMA Hiroshi; EP2738155; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol

General procedure: A two-necked, 500-mL round bottom flask was equipped with a magnetic stirring bar and a three-way stopcock, of which one way was connected to an argon flow line and the other was connected to a vacuum line. The apparatus was flame-dried in vacuum, and allowed to cool to room temperature under an argon purge. To a solution of [IrCl(cod)]2 (1 mol%) in dry toluene triethylene glycol monomethyl ether, vinyl acetate (2.0 equiv), and Na2CO3 (0.60 equiv) were added and the mixture was stirred at 100 C for 3 h. After the reaction, the resulting salts were removed and washed with Et2O. The solvent was removed under reduced pressure. Purification of the residue by vacuum distillation (2 times distillation with CaH2) gave the product.

The synthetic route of 647-42-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Harada, Nari-Aki; Nishikata, Takashi; Nagashima, Hideo; Tetrahedron; vol. 68; 15; (2012); p. 3243 – 3252;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 647-42-7, Adding some certain compound to certain chemical reactions, such as: 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol,molecular formula is C8H5F13O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 647-42-7.

Ways carboxylic acid (3d) can be synthesized by a known method, using the above shown illustrated by a compound (3c) was synthesized. In addition, the use of thionyl chloride to the carboxylic acid (3d) to the acid chloride derivative, gallic acid and so hydrate obtained by reacting a carboxylic acid (3e). The use of thionyl chloride acid (. 3E) to the acid chloride derivative, in the presence of DIPEA diol (3d) obtained by reacting the compound (24).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Fuji Photo Film Co., Ltd.; Song, Shantashi; Jia, tengjunye; (56 pag.)CN104159996; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

647-42-7, Adding a certain compound to certain chemical reactions, such as: 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 647-42-7, blongs to alcohols-buliding-blocks compound.

General procedure: Dichloro-s-tetrazine (1 mmol) and fluorinated alcohol (1 mmol) were dissolved in anhydrous dichloromethane (10 mL). 2,4,6-collidine (1 mmol) was added dropwise at room temperature in the solution, and the mixture was stirred for 12 h under N2 atmosphere.The solvent was evaporated and the residue was passed through a column of silica (2/8 dichloromethane/petroleum ether v/v) to give compound 2 as a pink solid, with a ?yellow? fluorescence on TLC (using a standard laboratory UV lamp with a broad band centred at 365 nm).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,647-42-7, its application will become more common.

Reference:
Article; Ben Chaabane, Radhia; Guermazi, Refka; Clavier, Gilles; Audebert, Pierre; Hedhli, Ahmed; Dyes and Pigments; vol. 108; (2014); p. 64 – 69;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

647-42-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a stirred solution of the corresponding thiazoline 4a-c (2.0 mmol) in dry CH2Cl2 (8 mL) under N2 atmosphere at room temperature, were added subsequently the corresponding alcohol (2.0 mmol) EDCI (2.0 mmol) and catalytic amount of DMAP. After 16 h, the organic phase was transferred to an extraction funnel, washed with saturated NaHCO3 (2 ¡Á 10 mL), water (2 ¡Á 10 mL) and the organic layer was dried with Na2SO4. The solvent was evaporated and the remaining product was purified by chromatography (hexanes/AcOEt = 80:20).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Schneider, Juliana M. F. M.; Sales, Eric S.; Livotto, Paolo R.; Schneider, Paulo H.; Merlo, Aloir A.; Journal of the Brazilian Chemical Society; vol. 25; 8; (2014); p. 1493 – 1503;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

647-42-7, A common compound: 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol,molecular formula is C8H5F13O, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Into a 2 L four-necked flask equipped with a stirrer, a thermometer and a cooling tube,800 g (2.2 mol) of FA-6 (manufactured by Unimartech) and 175.78 g (4.4 mol) of granular NaOH (manufactured by Wako Pure Chemical Industries, Ltd.) were added. Under a nitrogen atmosphere, while stirring at 200 rpm with a Teflon (registered trademark) 12 cm crescent stirring blade, the temperature was heated to 60 C. in the flask.398.73 g (3.3 mol) of allyl bromide (manufactured by Wako Pure Chemical Industries, Ltd.) was added dropwise thereto over 2 hours. After completion of the dropwise addition, the mixture was stirred at 70 C. for 1 hour and at 80 C. for 1 hour.Thereafter, the temperature was raised to 130 C. to remove excess allyl bromide.After cooling to 60 C., 800 g of ion-exchanged water was added, stirred for 30 minutes, then allowed to stand to separate the layers.The upper aqueous layer was withdrawn, 800 g of ion-exchanged water was added, and the mixture was stirred again, allowed to stand still and the aqueous layer was removed. Dehydrated at 60 C./5 KPa and distilled at 100 C./2 KPa to obtain 774.9 g of C 6 F 13 –CH 2 CH 2 –O – CH 2 CHCH 2 (yield 88%) as a fraction.

With the rapid development of chemical substances, we look forward to future research findings about 647-42-7.

Reference:
Patent; KAO CORP; ??????; IIDA MASAYUKI; Iida Masayuki; SHINBO AYUMI; Susumu Kuni Ayumi; (15 pag.)JP2016/121094; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, molecular weight is 364.1, as common compound, the synthetic route is as follows.647-42-7

[0087] 2-(Perfluorohexyl)ethanol (18.2 g, 50 mmol) was added to toluene, and potassium hydroxide (3.5 g)/water (3.5 ml) was added to the mixture. Under ice-cooled condition, acrylic acid tert-butyl ester (10.3 ml, 70 mmol) and tetrabutylammonium bromide (1.61 g, 5 mmol) were added, and the mixture was stirred at room temperature for 3 hours. The reaction was quenched by addition of dilute hydrochloric acid. The mixture was separated in an ethyl acetate/water system, and the resulting liquid was concentrated with a rotary evaporator. After column purification, purified ester (7b; 19.0 g, yield 77%) was obtained.

Statistics shows that 647-42-7 is playing an increasingly important role. we look forward to future research findings about 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol.

Reference:
Patent; FUJIFILM Corporation; MIZUMURA Masatoshi; KATOH Shunya; UEMURA Minoru; ISHIWATAYasuhiro; YOSHIKAWA Masaru; MATSUYAMA Hiroshi; EP2738155; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

647-42-7 ,Some common heterocyclic compound, 647-42-7, molecular formula is C8H5F13O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A solution of TsCl (8.24212 mmol, 1 equiv) or MsCl (8.24 mmol, 1 equiv) in DCM (24 mL) was added dropwise to a stirred solution of fluorinated alcohol 1-5 (8.24 mmol, 1 equiv) and Et3N (1.78 mL, 1.55 equiv) at 0 C. After complete addition (10 min) the reaction mixture was allowed to reach rt and stirring was continued overnight. Then, the reaction mixture was washed with H2O (34 mL) and brine (34 mL). The organic layer was dried over Na2SO4 and concentrated to dryness under reduced pressure. The resulting crude product was crystallized from MeOH to afford 1a-5b.

According to the analysis of related databases, 647-42-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Tomaszewska, Joanna; Koroniak-Szejn, Katarzyna; Koroniak, Henryk; Arkivoc; vol. 2017; 2; (2016); p. 421 – 432;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol. A new synthetic method of this compound is introduced below., 647-42-7

The corresponding fluoroalcoholic substrate 1e (0.728 g, 2.0 mmol) was added to the reaction flask and anhydrous DMF (3 mL) was added.Additional DSC (0.613 g, 1.2 eq.) and pyridine (0.16 mL, 1.0 eq.).The mixture was heated at 40 C for 15 h.It was monitored by TLC until the alcohol was completely reacted. Cool the mixture to room temperature,Boc-t-Bu-lysine (0.604 g, 2.0 mmol) was added.Keep the temperature below 30 C.The reaction mixture was then stirred at room temperature overnight.It was monitored by TLC until the starting material was complete.Water (10 mL) and ethyl acetate (10 mL) were added to the mixture.The organic layer was separated and the aqueous layer was evaporated elutCombine the two organic layers, using 1 mol/L hydrochloric acid in sequence.Wash with water and saturated brine,It was dried over anhydrous magnesium sulfate. Concentrate the organic solution,Fluorine-containing amino acid derivative precursor obtained by flash column chromatography3e (0.598g, 1.86mmol),The yield is 93%.Purity is 99%,It is an oily substance.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Institute of Technology; Liu Meina; Zhu Yu; Wu Tong; Deng Wei; Xuan Maojie; Miao Dengyun; Liu Zhifeng; Shan Yu; (13 pag.)CN108997168; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 647-42-7, blongs to alcohols-buliding-blocks compound. 647-42-7

General procedure: A dry flask was charged with THF (9 mL), NaOH pellets (0.48 g, 12 mmol), and perfluorohexylethanol or perfluoroheptylmethanol (3 mmol). The flask was immersed in an ice-bath and the contents stirred for 10 min. Propargyl bromide (0.54 g, 4.5 mmol) was added dropwise and the reaction mixture stirred and gradually allowed to warm to r.t. over 24 h. The reaction mixture was poured into Et2O (20 mL) and water (50 mL), the layers separated and the aqueous layer extracted with more Et2O (3 ¡Á 20 mL). The combined organic extracts were washed with 10% HCl soln. followed by sat. aq. NaHCO3 and brine, and then dried over Na2SO4. Column chromatography (silica gel, Et2O/LP, 10:90) followed by Kulgelrohr distillation gave the desired products.

With the rapid development of chemical substances, we look forward to future research findings about 647-42-7.

Reference:
Article; Francis, Dominic V.; Miles, D. Howard; Mohammed, Adnan I.; Read, Roger W.; Wang, Xiaobei; Journal of Fluorine Chemistry; vol. 132; 11; (2011); p. 898 – 906;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts