Category: 6346-09-4

Williamson, Alice E. published the artcileRapid Generation of Complex Molecular Architectures by a Catalytic Enantioselective Dearomatization Strategy, Application In Synthesis of 6346-09-4, the publication is Synlett (2016), 27(1), 116-120, database is CAplus.

A catalytic enantioselective dearomatization strategy can be used to convert readily assembled phenols into complex polycyclic architectures. By combining oxidative dearomatization of phenols bearing a pendent nucleophile with enantioselective secondary amine catalysis, high enantiomeric excesses were obtained for the natural product-like products.

Synlett published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C17H14F3N3O2S, Application In Synthesis of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mushtaq, Sajid published the artcileEfficient and Site-Specific ¹²⁵I-Radioiodination of Bioactive Molecules Using Oxidative Condensation Reaction, Formula: C8H19NO2, the publication is ACS Omega (2018), 3(6), 6903-6911, database is CAplus and MEDLINE.

In this report, the novel and site-specific radioiodination of biomols. by using aryl diamine and alkyl aldehyde condensation reaction in the presence of a Cu²⁺ catalyst under ambient conditions was reported. ¹²⁵I-labeled alkyl aldehyde was synthesized using a tin precursor with a high radiochem. yield (72 ± 6%, n = 5) and radiochem. purity (>99%). The utility of the radioiodinated precursor was demonstrated through aryl diamine-installed c[RGDfK(C)] peptide and human serum albumin (HSA). Radioiodinated c[RGDfK(C)] peptide and HSA protein were synthesized with high radiochem. yields and purity. ¹²⁵I-HSA protein showed excellent in vivo stability and negligible thyroid uptake as compared with directly radioiodinated HSA by using the tyrosine group. Excellent reaction kinetics and the in vitro and in vivo stabilities of ¹²⁵I-labeled alkyl aldehyde have suggested the usefulness of the strategy for the radioiodination of bioactive mols.

ACS Omega published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smolobochkin, Andrey V. published the artcileSynthesis and evaluation of water-soluble 2-aryl-1-sulfonylpyrrolidine derivatives as bacterial biofilm formation inhibitors, SDS of cas: 6346-09-4, the publication is Chemistry & Biodiversity (2019), 16(1), n/a, database is CAplus and MEDLINE.

The approach to the novel 1-[(2-aminoethyl)sulfonyl]-2-arylpyrrolidines via unique intramol. cyclization/aza-Michael reactions of N-(4,4-diethoxybutyl)ethenesulfonamide have been developed, which benefits from high yields of target compounds, mild reaction conditions, usage of inexpensive and low-toxic reagents, and allows for wide variability in both amine and aryl moieties. Biotesting with whole-cell luminescent bacterial biosensors responding to DNA damage showed that all tested compounds are not genotoxic. Tested compounds differently affect the formation of biofilms by Vibrio aquamarinus DSM 26054. Some of the tested compounds were found to suppress the bacterial biofilms growth and thus are promising candidates for further studies.

Chemistry & Biodiversity published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C10H11NO4, SDS of cas: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Irie, Raku published the artcileStructure Revision of Protoaculeine B, a Post-translationally Modified N-Terminal Residue in the Peptide Toxin Aculeine B, Name: 4,4-Diethoxybutan-1-amine, the publication is Journal of Natural Products (2021), 84(4), 1203-1209, database is CAplus and MEDLINE.

The structure of protoaculeine B, the N-terminal residue of the marine peptide toxin aculeine B, is revised to the cis-1,3-disubstituted tetrahydro-β-carboline framework. We prepared two truncated model compounds that lack a long-chain polyamine using the one-step Pictet-Spengler reaction of tryptophan and compared their NMR, mass spectra, and chem. reactivity with those of the natural protoaculeine B. The synthetic models reproduced the profiles of the natural product well, which confirmed the appropriateness of the structure revision.

Journal of Natural Products published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Name: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Skorenski, Marcin published the artcilePhosphonate inhibitors of West Nile virus NS2B/NS3 protease, Application of 4,4-Diethoxybutan-1-amine, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2019), 34(1), 8-14, database is CAplus and MEDLINE.

West Nile virus (WNV) is a member of the flavivirus genus belonging to the Flaviviridae family. The viral serine protease NS2B/NS3 has been considered an attractive target for the development of anti-WNV agents. Although several NS2B/NS3 protease inhibitors have been described so far, most of them are reversible inhibitors. Herein, we present a series of α-aminoalkylphosphonate di-Ph esters and their peptidyl derivatives as potent inhibitors of the NS2B/NS3 protease. The most potent inhibitor identified was Cbz-Lys-Arg-(4-GuPhe)^P(OPh)₂ displaying K_i and k₂/K_i values of 0.4 μM and 28 265 M^-1s^-1, resp., with no significant inhibition of trypsin, cathepsin G, and HAT protease.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C15H14O3, Application of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sharma, Vishal R. published the artcileEfficient syntheses of macrocycles ranging from 22-28 atoms through spontaneous dimerization to yield bis-hydrazones, HPLC of Formula: 6346-09-4, the publication is RSC Advances (2020), 10(6), 3217-3220, database is CAplus and MEDLINE.

Acid treatment of a triazine displaying both a tethered acetal and BOC-protected hydrazine group leads to spontaneous condensation to yield macrocyclic dimers I (n = 1, 2; m = 1, 2, 3) in excellent yields and purity. By varying the length of the tether-the condensation product of an amino acid and amino acetal-rings comprising 22-28 atoms can be accessed. Glycine and β-alanine were used for the amino acid. The amino acetal comprised 2, 3 or 4 carbon atoms in the backbone. High-performance liquid chromatog. (HPLC) was employed to assess purity as well as to fingerprint the six homodimeric products. By combining the protected monomers and subjecting them to acid, mixtures of homodimers and heterodimers are obtained. When all six protected monomers are combined, at least 14 of the 21 theor. dimeric products are observed by HPLC. Single crystal X-ray diffraction and solution NMR studies reveal the diversity of shapes available to these mols.

RSC Advances published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C10H10O2, HPLC of Formula: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pohodylo, N. T. published the artcileSynthesis of 1-(1-aryl-1H-1,2,3-triazol-4-yl)-β-carboline derivatives, Application In Synthesis of 6346-09-4, the publication is Russian Journal of Organic Chemistry (2014), 50(2), 275-279, database is CAplus.

Reaction of 5-methyl-1-aryl-1H-1,2,3-triazole-4-carbonyl chlorides with tryptamines afforded 1-aryl-N-[2-(1H-indol-3-yl)ethyl]-5-methyl-1H-1,2,3-triazole-4-carboxamides. Subsequent Bischler-Napieralski cyclization by heating in toluene in the presence of POCl₃ and P₂O₅ gave 1-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-4,9-dihydro-3H-β-carbolines, which were transformed into β-carbolines and tetrahydro-β-carbolines.

Russian Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Application In Synthesis of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lesniak, Robert K. published the artcileHuman carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N^ε-trimethyllysine, Category: alcohols-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(2), 440-442, database is CAplus and MEDLINE.

N^ε-Trimethyllysine hydroxylase (TMLH) catalyzes the 1st step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism The stereochem. of the 3-hydroxy-N^ε-trimethyllysine product of TMLH has not been defined. Here, the authors report enzymic and asym. synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-N^ε-trimethyllysine.

Chemical Communications (Cambridge, United Kingdom) published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Basch, Corey H. published the artcileHarnessing Alkyl Amines as Electrophiles for Nickel-Catalyzed Cross Couplings via C-N Bond Activation, Product Details of C8H19NO2, the publication is Journal of the American Chemical Society (2017), 139(15), 5313-5316, database is CAplus and MEDLINE.

We developed a strategy to harness alkyl amines as alkylating agents via C-N bond activation. This Suzuki-Miyaura cross coupling of alkylpyridinium salts, readily formed from primary amines, is the first example of a metal-catalyzed cross coupling via C-N bond activation of an amine with an unactivated alkyl group. This reaction enjoys broad scope and functional group tolerance. Primary and secondary alkyl groups can be installed. Preliminary studies suggest a Ni^I/Ni^III catalytic cycle.

Journal of the American Chemical Society published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Product Details of C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ye, Juntao published the artcileDirect α-alkylation of primary aliphatic amines enabled by CO₂ and electrostatics, Recommanded Product: 4,4-Diethoxybutan-1-amine, the publication is Nature Chemistry (2018), 10(10), 1037-1041, database is CAplus and MEDLINE.

Primary aliphatic amines are important building blocks in organic synthesis due to the presence of a synthetically versatile NH₂ group. N-functionalization of primary amines is well established, but selective C-functionalization of unprotected primary amines remains challenging. Here, we report the use of CO₂ as an activator for the direct transformation of abundant primary aliphatic amines into valuable γ-lactams under photoredox and hydrogen atom transfer (HAT) catalysis. Exptl. and computational studies suggest that CO₂ not only inhibits undesired N-alkylation of primary amines, but also promotes selective intermol. HAT by an electrostatically accelerated interaction between the in situ-generated neg. charged carbamate and the pos. charged quinuclidinium radical. This electrostatic attraction overwhelms the inherent bond dissociation energies which suggest that HAT should occur unselectively. We anticipate that our findings will open up new avenues for amine functionalizations as well as selectivity control in HAT reactions.

Nature Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C15H24BNO3, Recommanded Product: 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts