Category: 627-27-0

Huang, Zhujun; Chen, Zhe; Jiang, Yuan; Li, Ning; Yang, Shicheng; Wang, Guowei; Pan, Xiangcheng published the artcile< Metal-Free Hydrosilylation Polymerization by Merging Photoredox and Hydrogen Atom Transfer Catalysis>, Category: alcohols-buliding-blocks, the main research area is metal hydrosilylation polymerization merging photoredox hydrogen atom transfer catalysis.

Organosilicon compounds and polymers have found wide applications as synthetic building blocks and functional materials. Hydrosilylation is a common strategy toward the synthesis of organosilicon compounds and polymers. Although transition-metal-catalyzed hydrosilylation has achieved great advances, the metal-free hydrosilylation polymerization of dienes and bis(silane)s, especially the one suitable for both electron-rich and electron-deficient dienes, is largely lacking. Herein, the authors report a visible-light-driven metal-free hydrosilylation polymerization of both electron-rich and electron-deficient dienes with bis(silane)s by using the organic photocatalyst and hydrogen atom transfer (HAT) catalyst. The authors achieved the well-controlled step-growth hydrosilylation polymerizations of the electron-rich diene and bis(silane) monomer due to the selective activation of Si-H bonds by the organic photocatalyst (4CzIPN) and the thiol polarity reversal reagent (HAT 1). For the electron-deficient dienes, hydrosilylation polymerization and self-polymerization occurred simultaneously in the presence of 4CzIPN and aceclidine (HAT 2), providing the opportunity to produce linear, hyperbranched, and network polymers by rationally tuning the concentration of electron-deficient dienes and the ratio of bis(silane)s and dienes to alter the proportion of the two polymerizations A wide scope of bis(silane)s and dienes furnished polycarbosilanes with high mol. weight, excellent thermal stability, and tunable architectures.

Journal of the American Chemical Society published new progress about Branched polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hirbawi, Nadia; Lin, Patricia C.; Jarvo, Elizabeth R. published the artcile< Halogenation Reactions of Alkyl Alcohols Employing Methyl Grignard Reagents>, Electric Literature of 627-27-0, the main research area is alkyl halide preparation; alc alkyl Grignard reagent halogenation.

Herein, an example of Grignard reagents acting as halide nucleophiles to form alkyl iodides RI [R = 1-(4-methoxyphenyl)-5-phenylpentan-3-yl, 4-phenylbutan-2-yl, 4-(2H-1,3-benzodioxol-5-yl)butan-2-yl, etc.] and alkyl bromides R1Br [R1 = 3-[4-(3-methoxyphenyl)phenyl]propyl, 2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl, 3-(4-bromophenyl)propyl, etc.] was reported. This work establishes that Grignard reagents can convert alkyl mesylates ROMs/R1OMs into alkyl halides RI/R1Br, as well as be employed in a one-pot halogenation reaction starting from alcs. ROH/R1OH, which proceed through mesylate intermediates. The halogenation reaction is confirmed to occur by an SN2 pathway with the inversion of configuration and is demonstrated to be efficient on a gram scale.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Hui; Gao, Kai; Ma, Haichen; Yip, Tsz Chun; Dai, Wei-Min published the artcile< Synthesis of the C19-C30 bis-THF fragment of iriomoteolide-13a via stepwise SN2 cyclization and intramolecular syn-oxypalladation>, Application In Synthesis of 627-27-0, the main research area is iriomoteolide fragment preparation; alkyne cyclization asym dihydroxylation.

The C19-C30 bis-THF fragment I [stereo = R or S] of the proposed structure of iriomoteolide-13a were synthesized. The ω-mesyloxy-substituted stereotetrad possessing three continuous hydroxy groups was generated by an anti-aldol reaction and asym. dihydroxylation was the key steps. Upon heating in pyridine, the stereotetrad underwent an SN2 cyclization to form the C19-C22 THF ring chemoselectively. The propargylic alc., after cleavage of the C28-OPMB ether, was reduced to the corresponding allylic alc. with spontaneous removal of the C23-OTBS protecting group. Finally, the ene triol was subjected to the Pd(II)-catalyzed intramol. syn-oxypalladation to give the C23-C26 THF ring. It was found that the C21-OH group, which might form a chelated Pd(II) complex along with the C23-OH group, was tolerated during the syn-oxypalladation process.

Organic Chemistry Frontiers published new progress about Cyclization, stereoselective. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application In Synthesis of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Jiajia; Zhang, Huihui; Wu, Xinxin; Zhu, Chen published the artcile< Intermolecular radical fluoroalkylative olefination of unactivated alkenes>, Electric Literature of 627-27-0, the main research area is vinyl preparation photochem regioselective chemoselective diastereoselective; alkene intermol radical fluoroalkylative olefination.

A novel, efficient radical-mediated intermol. fluoroalkylative olefination of inactivated alkenes RCH=CH2 [R = 2-hydroxypropan-2-yl, 1-(2-oxocyclohexyl)methyl, 3-(1-benzothiophen-2-yl)-3-oxopropyl, etc.] was disclosed. The transformation proceeded through a radical docking-migration cascade, in which a portfolio of strategically designed dual-function alkenylating reagents was harnessed to afford vinylated products RC(CH=CHR1)(C(Br)(F)(R2)) [R1 = Ph, 4-MePh, naphthalen-2-yl, etc.; R2 = CN, COOEt] with exclusive E-configuration. The reaction featured mild conditions, broad functional group compatibility, and unique chemo-, regio-, and stereoselectivities. The protocol has also provided a useful approach for late-stage olefination of complex natural products and drug derivatives containing alkenyl moieties.

CCS Chemistry published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dong, Wei; Fang, Zhuo-Yue; Cao, Tong-Yang; Cao, Jie-Hui; Zhao, Zi-Qiang; Zhang, Linlin; Li, Wei; Qi, Lin; Wang, Li-Jing published the artcile< Copper-Catalyzed Aminosulfonylation of O-Homoallyl Benzimidates with Sodium Sulfinates to Access Sulfonylated 1,3-Oxazines>, HPLC of Formula: 627-27-0, the main research area is sulfonyl oxazine preparation; homoallyl benzimidate sodium sulfinate aminosulfonylation copper catalyst.

A facile copper-catalyzed aminosulfonylation of O-homoallyl benzimidates with sodium sulfinates in the presence of tert-Bu peroxybenzoate (TBPB) and XPhos ligand has been developed. By using this protocol, a variety of potentially bioactive 1,3-oxazines were directly synthesized. This method has the merits of a cheap catalyst, easily available and stable sulfone reagents, and simple operation.

Organic Letters published new progress about Benzimidazoles Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Donthoju, Ashok; Munakala, Anandarao; Ellandula, Sushma; Chegondi, Rambabu published the artcile< Palladium(0)-Catalyzed Remote Decarboxylative Allylation and Base-Mediated 1,3-Migration>, Quality Control of 627-27-0, the main research area is tetrahydro benzofuranone preparation diastereoselective; allyl carbonate cyclohexadienone decarboxylative oxa Michael allylation migration palladium.

The palladium(0)-catalyzed decarboxylative oxa-Michael addition/remote α-allylation/1,3-migration of prochiral allyl carbonate-tethered cyclohexadienones I (R = Me, CD3, CH2CCH, etc.) is performed in good yields. This unconventional intramol. rearrangement is triggered by the base-mediated retro-Michael ring-opening reaction (β-elimination) and subsequent syn-selective oxa-Michael addition on the less substituted enone functionality. The generality of tandem decarboxylative allylation was examined with various substrates and in the gram-scale reaction.

Journal of Organic Chemistry published new progress about Allylation catalysts, stereoselective. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Ruzhang; Zhang, Yuanyuan; Xu, Jun published the artcile< Selective hydroboration of equilibrating allylic azides>, Electric Literature of 627-27-0, the main research area is azido boronic ester preparation pinacolborane oxidation; allylic azide hydroboration iridium catalyst.

The iridium(I)-catalyzed hydroboration of equilibrating allylic azides RCH:CHCH2N3 (R = pentyl, cyclohexylmethyl, 3-(pyrrol-1-yl)propyl, etc.) is reported to provide only the anti-Markovnikov products RCH(N3)CH2CH2OH of alk-1-ene isomers RCH(N3)CH:CH2 in good yields and with good functional group tolerance.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation) (azido-). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ehsan, Muhammad; Wang, Haoqing; Katsube, Satoshi; Munk, Chastine F.; Du, Yang; Youn, Taeyeol; Yoon, Soyoung; Byrne, Bernadette; Loland, Claus J.; Guan, Lan; Kobilka, Brian K.; Chae, Pil Seok published the artcile< Glyco-Steroidal Amphiphiles (GSAs) for Membrane Protein Structural Study>, SDS of cas: 627-27-0, the main research area is glycosteroidal amphiphile membrane protein structure; detergent design; detergent-detergent interactions; glyco-steroids; glycolipids; protein stabilization.

Integral membrane proteins pose considerable challenges to high resolution structural anal. Maintaining membrane proteins in their native state during protein isolation is essential for structural study of these bio-macromols. Detergents are the most commonly used amphiphilic compounds for stabilizing membrane proteins in solution outside a lipid bilayer. We previously introduced a glyco-diosgenin (GDN) detergent that was shown to be highly effective at stabilizing a wide range of membrane proteins. This steroidal detergent has addnl. gained attention due to its compatibility with membrane protein structure study via cryo-EM. However, synthetic inconvenience limits widespread use of GDN in membrane protein study. To improve its synthetic accessibility and to further enhance detergent efficacy for protein stabilization, we designed a new class of glyco-steroid-based detergents using three steroid units: cholestanol, cholesterol and diosgenin. These new detergents were efficiently prepared and showed marked efficacy for protein stabilization in evaluation with a few model membrane proteins including two G protein-coupled receptors. Some new agents were not only superior to a gold standard detergent, DDM (n-dodecyl-β-D-maltoside), but were also more effective than the original GDN at preserving protein integrity long term. These agents represent valuable alternatives to GDN, and are likely to facilitate structural determination of challenging membrane proteins.

ChemBioChem published new progress about Amphiphiles. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Linlin; Qi, Lin; Chen, Jia-Min; Dong, Wei; Fang, Zhuo-Yue; Cao, Tong-Yang; Li, Wei; Wang, Li-Jing published the artcile< Preparation of selenyl 1,3-oxazines via PhICl2/Cu2O-promoted aminoselenation of O-homoallyl benzimidates with diselenides>, Quality Control of 627-27-0, the main research area is aryl arylselanyl methyl dihydro oxazine preparation; homoallyl benzimidate diselenide aminoselenation catalyst dichloro phenyl iodane copper; oxide.

A practical electrophilic aminoselenation of O-homoallyl benzimidate with diselenides promoted by PhICl2/Cu2O had been developed. The easily available and stable diselenides were used as selenium sources. Various selenyl 1,3-oxazines I [Ar = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = H, Me; R2 = H, Ph; R3 = Me, n-Bu, Ph, etc.], which were important frameworks in medicinal and biol. chem., were easily obtained in moderate to good yields for the first time. Easy scaleup and scalability made this method attractive for the preparation of other valuable organoselenides.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Xing; Zheng, Leijie; Gong, Xiaolei; Chang, Honghong; Gao, Wenchao; Wei, Wenlong published the artcile< NBS/DBU-Promoted One-Pot Three-Component Cycloaddition of Malonic Acid Derivatives, Nitrosoarenes, and Alkenes: Synthesis of Isoxazolidines>, Synthetic Route of 627-27-0, the main research area is NBS DBU cycloaddition malonic acid nitrosoarene alkene isoxazolidine synthesis.

A general DBU-mediated one-pot three-component cycloaddition reaction of easily accessible malonic acid derivatives, nitrosoarenes, and alkenes has been successfully established with the aid of NBS to provide direct access to highly functionalized isoxazolidine derivatives with generally good to excellent yields, broad functional group tolerance, and excellent regio- and diastereo-selectivities under mild conditions. The mechanism study shows that the NBS-mediated formation of bromomalonic acid derivatives from malonic acid derivatives and DBU-promoted synthesis of nitrone intermediates via the reaction of bromomalonic acid derivatives with nitrosoarenes are key steps.

Journal of Organic Chemistry published new progress about [3+2] Cycloaddition reaction (of nitrone intermediate with olefin, regio- and stereoselective). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts