Category: 627-27-0

Dong, Wei; Fang, Zhuo-Yue; Cao, Tong-Yang; Cao, Jie-Hui; Zhao, Zi-Qiang; Zhang, Linlin; Li, Wei; Qi, Lin; Wang, Li-Jing published the artcile< Copper-Catalyzed Aminosulfonylation of O-Homoallyl Benzimidates with Sodium Sulfinates to Access Sulfonylated 1,3-Oxazines>, HPLC of Formula: 627-27-0, the main research area is sulfonyl oxazine preparation; homoallyl benzimidate sodium sulfinate aminosulfonylation copper catalyst.

A facile copper-catalyzed aminosulfonylation of O-homoallyl benzimidates with sodium sulfinates in the presence of tert-Bu peroxybenzoate (TBPB) and XPhos ligand has been developed. By using this protocol, a variety of potentially bioactive 1,3-oxazines were directly synthesized. This method has the merits of a cheap catalyst, easily available and stable sulfone reagents, and simple operation.

Organic Letters published new progress about Benzimidazoles Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Donthoju, Ashok; Munakala, Anandarao; Ellandula, Sushma; Chegondi, Rambabu published the artcile< Palladium(0)-Catalyzed Remote Decarboxylative Allylation and Base-Mediated 1,3-Migration>, Quality Control of 627-27-0, the main research area is tetrahydro benzofuranone preparation diastereoselective; allyl carbonate cyclohexadienone decarboxylative oxa Michael allylation migration palladium.

The palladium(0)-catalyzed decarboxylative oxa-Michael addition/remote α-allylation/1,3-migration of prochiral allyl carbonate-tethered cyclohexadienones I (R = Me, CD3, CH2CCH, etc.) is performed in good yields. This unconventional intramol. rearrangement is triggered by the base-mediated retro-Michael ring-opening reaction (β-elimination) and subsequent syn-selective oxa-Michael addition on the less substituted enone functionality. The generality of tandem decarboxylative allylation was examined with various substrates and in the gram-scale reaction.

Journal of Organic Chemistry published new progress about Allylation catalysts, stereoselective. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Ruzhang; Zhang, Yuanyuan; Xu, Jun published the artcile< Selective hydroboration of equilibrating allylic azides>, Electric Literature of 627-27-0, the main research area is azido boronic ester preparation pinacolborane oxidation; allylic azide hydroboration iridium catalyst.

The iridium(I)-catalyzed hydroboration of equilibrating allylic azides RCH:CHCH2N3 (R = pentyl, cyclohexylmethyl, 3-(pyrrol-1-yl)propyl, etc.) is reported to provide only the anti-Markovnikov products RCH(N3)CH2CH2OH of alk-1-ene isomers RCH(N3)CH:CH2 in good yields and with good functional group tolerance.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation) (azido-). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ehsan, Muhammad; Wang, Haoqing; Katsube, Satoshi; Munk, Chastine F.; Du, Yang; Youn, Taeyeol; Yoon, Soyoung; Byrne, Bernadette; Loland, Claus J.; Guan, Lan; Kobilka, Brian K.; Chae, Pil Seok published the artcile< Glyco-Steroidal Amphiphiles (GSAs) for Membrane Protein Structural Study>, SDS of cas: 627-27-0, the main research area is glycosteroidal amphiphile membrane protein structure; detergent design; detergent-detergent interactions; glyco-steroids; glycolipids; protein stabilization.

Integral membrane proteins pose considerable challenges to high resolution structural anal. Maintaining membrane proteins in their native state during protein isolation is essential for structural study of these bio-macromols. Detergents are the most commonly used amphiphilic compounds for stabilizing membrane proteins in solution outside a lipid bilayer. We previously introduced a glyco-diosgenin (GDN) detergent that was shown to be highly effective at stabilizing a wide range of membrane proteins. This steroidal detergent has addnl. gained attention due to its compatibility with membrane protein structure study via cryo-EM. However, synthetic inconvenience limits widespread use of GDN in membrane protein study. To improve its synthetic accessibility and to further enhance detergent efficacy for protein stabilization, we designed a new class of glyco-steroid-based detergents using three steroid units: cholestanol, cholesterol and diosgenin. These new detergents were efficiently prepared and showed marked efficacy for protein stabilization in evaluation with a few model membrane proteins including two G protein-coupled receptors. Some new agents were not only superior to a gold standard detergent, DDM (n-dodecyl-β-D-maltoside), but were also more effective than the original GDN at preserving protein integrity long term. These agents represent valuable alternatives to GDN, and are likely to facilitate structural determination of challenging membrane proteins.

ChemBioChem published new progress about Amphiphiles. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Linlin; Qi, Lin; Chen, Jia-Min; Dong, Wei; Fang, Zhuo-Yue; Cao, Tong-Yang; Li, Wei; Wang, Li-Jing published the artcile< Preparation of selenyl 1,3-oxazines via PhICl2/Cu2O-promoted aminoselenation of O-homoallyl benzimidates with diselenides>, Quality Control of 627-27-0, the main research area is aryl arylselanyl methyl dihydro oxazine preparation; homoallyl benzimidate diselenide aminoselenation catalyst dichloro phenyl iodane copper; oxide.

A practical electrophilic aminoselenation of O-homoallyl benzimidate with diselenides promoted by PhICl2/Cu2O had been developed. The easily available and stable diselenides were used as selenium sources. Various selenyl 1,3-oxazines I [Ar = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = H, Me; R2 = H, Ph; R3 = Me, n-Bu, Ph, etc.], which were important frameworks in medicinal and biol. chem., were easily obtained in moderate to good yields for the first time. Easy scaleup and scalability made this method attractive for the preparation of other valuable organoselenides.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Xing; Zheng, Leijie; Gong, Xiaolei; Chang, Honghong; Gao, Wenchao; Wei, Wenlong published the artcile< NBS/DBU-Promoted One-Pot Three-Component Cycloaddition of Malonic Acid Derivatives, Nitrosoarenes, and Alkenes: Synthesis of Isoxazolidines>, Synthetic Route of 627-27-0, the main research area is NBS DBU cycloaddition malonic acid nitrosoarene alkene isoxazolidine synthesis.

A general DBU-mediated one-pot three-component cycloaddition reaction of easily accessible malonic acid derivatives, nitrosoarenes, and alkenes has been successfully established with the aid of NBS to provide direct access to highly functionalized isoxazolidine derivatives with generally good to excellent yields, broad functional group tolerance, and excellent regio- and diastereo-selectivities under mild conditions. The mechanism study shows that the NBS-mediated formation of bromomalonic acid derivatives from malonic acid derivatives and DBU-promoted synthesis of nitrone intermediates via the reaction of bromomalonic acid derivatives with nitrosoarenes are key steps.

Journal of Organic Chemistry published new progress about [3+2] Cycloaddition reaction (of nitrone intermediate with olefin, regio- and stereoselective). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Chao; Song, Liangliang; Peshkov, Vsevolod A.; Van der Eycken, Erik V. published the artcile< Transition metal-free selective C-S bond cleavage of Ugi-adducts for rapid preparation of peptidomimetics>, SDS of cas: 627-27-0, the main research area is peptidomimetic aminal synthesis natural product; Ugi adduct Mannich reaction copper catalyst reaction bond cleavage; Mannich reaction mechanism deprotonation.

A transition metal-free C-S bond cleavage and subsequent Mannich reaction of Ugi-adducts with alcs. as well as thiols is developed. Diverse novel peptidomimetics containing N,O- or N,S-aminals are synthesized in a rapid, highly efficient and step-economical fashion. This method features exclusive selectivity, broad substrate scope, excellent yield and functional group tolerance, and was applied on substrates derived from the pharmaceuticals febuxostat, probenecid and memantine.

Green Chemistry published new progress about Aminals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kleban, Ihor; Krokhmaliuk, Yevhen; Reut, Sofiia; Shuvakin, Serhii; Pendyukh, Vyacheslav V.; Khyzhan, Oleksandr I.; Yarmoliuk, Dmytro S.; Tymtsunik, Andriy V.; Rassukana, Yuliya V.; Grygorenko, Oleksandr O. published the artcile< Multigram Synthesis of Heterabicyclo[n.1.0]alkan-1-yl Trifluoroborates>, Application of C4H8O, the main research area is enyne hetero preparation hydroboration; bromoallyl derivative preparation lithiation borylation; heterabicycloalkanyl trifluoroborate preparation.

An approach to the synthesis of oxa- and azabicyclo[n.1.0]alkan-1-yl trifluoroborates on a multigram scale was developed. Two synthetic strategies were evaluated: the 1st based on the lithiation-borylation of the corresponding 2-bromoallyl derivatives, and the other relying on regioselective hydroboration of the appropriate hetera-substituted enynes. The 2nd method appeared to be more efficient in terms of scalability and substrate scope. Further steps included ring closing-metathesis, mild Pd-catalyzed cyclopropanation with diazomethane, and reaction with KHF2 and furnished the title compounds in up to 50 g scale in a single run (10-41% overall yield, 4-5 steps).

European Journal of Organic Chemistry published new progress about Alkenynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lenormand, Anthony; Reyes Mendez, Lucia; Coulomb, Julien published the artcile< Relay-Heck Cross-Coupling Between Alkenyl Halides and Unsaturated Alcohols in the Synthesis of Open-Chain Analogues of Musk Odorant Vulcanolide>, HPLC of Formula: 627-27-0, the main research area is alkenyl halide alkenol palladium catalyst Heck cross coupling; carbonyl compound preparation; Heck reactions; alkenyl halides; palladium; relay; unsaturated alcohols.

Unactivated alkenyl iodides and bromides underwent an unprecedented palladium-catalyzed relay-Heck cross-coupling with a whole range of alkenols of different chain lengths linking the alkene and the alc., affording unsaturated aldehydes and ketones in moderate to good yields. In contrast, alkenyl triflates were not suitable partners for this reaction. This method allowed the preparation of open-chain analogs of the musk odorant Vulcanolide, several of which retained key olfactory properties of the parent mol.

Chemistry – A European Journal published new progress about Alkenyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chmiel, Alyah F.; Williams, Oliver P.; Chernowsky, Colleen P.; Yeung, Charles S.; Wickens, Zachary K. published the artcile< Non-innocent Radical Ion Intermediates in Photoredox Catalysis: Parallel Reduction Modes Enable Coupling of Diverse Aryl Chlorides>, Synthetic Route of 627-27-0, the main research area is radical ion intermediates photoredox Catalysis parallel reduction mode.

We describe a photocatalytic system that elicits potent photoreductant activity from conventional photocatalysts by leveraging radical anion intermediates generated in situ. The combination of an isophthalonitrile photocatalyst and sodium formate promotes diverse aryl radical coupling reactions from abundant but difficult to reduce aryl chloride substrates. Mechanistic studies reveal two parallel pathways for substrate reduction both enabled by a key terminal reductant byproduct, carbon dioxide radical anion.

Journal of the American Chemical Society published new progress about Borylation (photochem.). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts