Category: 627-27-0

Fischer, Oliver; Heinrich, Markus R. published the artcile< 2-Fluoro-5-nitrophenyldiazonium: A Novel Sanger-Type Reagent for the Versatile Functionalization of Alcohols>, Category: alcohols-buliding-blocks, the main research area is aryl alkoxy nitrobenzenediazonium tetrafluoroborate preparation; alc fluoro nitrophenyldiazonium tetrafluoroborate nucleophilic aromatic substitution; C−C bond formation; C−H activation; Sanger reagent; diazonium; nucleophilic aromatic substitution.

As a novel Sanger-type reagent, 2-fluoro-5-nitrophenyldiazonium tetrafluoroborate enabled the versatile functionalization of primary aliphatic alcs. e.g., β-citronellol and secondary aliphatic alcs. e.g., trans-1,2-cyclohexandiol. Based on a mild nucleophilic aromatic substitution of the fluorine atom under unprecedented, base-free conditions, the diazonium unit on the aromatic core of the resulting aryl-alkyl ether e.g., I could be employed for such diverse transformations as radical C-H activation and cyclization, as well as palladium catalyzed cross-coupling reactions.

Chemistry – A European Journal published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Willems, Suzanne; Toupalas, Georgios; Reisenbauer, Julia C.; Morandi, Bill published the artcile< A site-selective and stereospecific cascade Suzuki-Miyaura annulation of alkyl 1,2-bisboronic esters and 2,2'-dihalo 1,1'-biaryls>, Computed Properties of 627-27-0, the main research area is dihydrophenanthrene preparation regioselective; bisboronic ester biaryl Suzuki Miyaura annulation cascade palladium catalyst.

A cascade Suzuki-Miyaura cross-coupling gave rise to 9,10-dihydrophenanthrenes I [R1 = n-Pr, n-hexyl, (CH2)2Ph, etc.; R2 = H, 3-Me, 2-F, etc.; R3 = H, 6-Me, 7-F, etc.] was developed. Using biaryls with unsym. substitution-pattern full site-selectivity was observed Furthermore, this cross-coupling of an alkyl 1,2-bisboronic pinacol ester proceeded through the challenging coupling of a secondary boronate with complete stereoretention.

Chemical Communications (Cambridge, United Kingdom) published new progress about Biaryls Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Computed Properties of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yao, Zhengdong; Feng, Huangdi; Xi, Hui; Xi, Chuanjun; Liu, Weiping published the artcile< CF3SO3H-enabled cascade ring-opening/dearomatization of indole derivatives to polycyclic heterocycles>, Category: alcohols-buliding-blocks, the main research area is fused polycyclic indoline amine preparation; indole trifluoromethanesulfonic acid cascade ring opening dearomatization.

A novel dearomatization process to produce fused polycyclic indolines via a CF3SO3H-mediated cascade ring-opening of a β-lactam and hydroaminative cyclization is demonstrated. It provides a new strategy for the synthesis of important polycyclic indoline-2-amine derivatives in moderate to excellent yields, as well as with good functional group tolerance. Moreover, transformation of the product was performed to deliver the corresponding acid, alc. and amide smoothly.

Organic & Biomolecular Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cai, Dong; Li, Jinbin; Ma, Zhuang; Gan, Zhanhui; Shao, Yu; Xing, Qian; Tan, Rui; Dong, Xue-Hui published the artcile< Effect of Molecular Architecture and Symmetry on Self-Assembly: A Quantitative Revisit Using Discrete ABA Triblock Copolymers>, Quality Control of 627-27-0, the main research area is architecture symmetry assembly discrete diblock triblock copolymer.

The inherent statistical heterogeneities associated with chain length, composition, and architecture of synthetic block copolymers compromise the quant. interpretation of their self-assembly process. This study scrutinizes the contribution of mol. architecture on phase behaviors using discrete ABA triblock copolymers with precise chem. structure and uniform chain length. A group of discrete triblock copolymers with varying composition and symmetry were modularly synthesized through a combination of iterative growth methods and efficient coupling reactions. The sym. ABA triblock copolymers self-assemble into long-range ordered structures with expanded domain spacings and enhanced phase stability, compared with the diblock counterparts snipped at the middle point. By tuning the relative chain length of two end blocks, the mol. asymmetry reduces the packing frustration, and thus increases the order-to-disorder transition temperature and enlarges the domain sizes. This study would serve as a quant. model system to correlate the exptl. observations with the theor. assessments and to provide quant. understandings for the relationship between mol. architecture and self-assembly.

ACS Macro Letters published new progress about Catalysts, Karstedt’s. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ren, Xiaoxiao; Gao, Xing; Min, Qiao-Qiao; Zhang, Shu; Zhang, Xingang published the artcile< (Fluoro)alkylation of alkenes promoted by photolysis of alkylzirconocenes>, Electric Literature of 627-27-0, the main research area is difluoroalkyl compound preparation; alkene alkylzirconocene preparation photochem fluoroalkylation.

An unprecedented example of alkylzirconocenes Cp2ZrCl(CH2)2R (R = Bn, dimethyl(phenyl)silyl, trimethylsilyl, etc.) promoted difluoroalkylation of alkyl- and silyl-alkenes RCH=CH2 with a variety of unactivated difluoroalkyl iodides and bromides R1C(F2)X (R1 = [(ethanesulfonyl)oxy]methyl, (morpholin-4-yl)carbonyl, 3-[(4-chlorophenyl)carbonyloxy]propyl, etc.; X = I, Br) under the irradiation of visible light without a catalyst. The resulting difluoroalkylated compounds RC(F2)R1 can serve as versatile synthons in organic synthesis. The reaction can also be applied to activated difluoroalkyl, trifluoromethyl, perfluoroalkyl, monofluoroalkyl, and nonfluorinated alkyl halides, providing a general method to controllably access fluorinated compounds Preliminary mechanistic studies reveal that a single electron transfer (SET) pathway induced by a Zr(III) species is involved in the reaction, in which the Zr(III) species is generated by the photolysis of alkylzirconocene with blue light.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thiyagarajan, Subramanian; Sankar, Raman Vijaya; Anjalikrishna, Puthannur K.; Suresh, Cherumuttathu H.; Gunanathan, Chidambaram published the artcile< Catalytic Formal Conjugate Addition: Direct Synthesis of δ-Hydroxynitriles from Nitriles and Allylic Alcohols>, Quality Control of 627-27-0, the main research area is delta hydroxynitrile preparation green chem; nitrile allylic alc selective formal conjugate addition ruthenium catalyst.

Alcs. and nitrile functionalities have widespread applications in biochem. and chem. synthesis. Catalytic transformations involving C-C bond formation relying on unsaturated coupling partners create important pathways for processes in synthetic, material, and medicinal chem. The discovery of a simple and selective coupling of nitriles with allylic alcs. catalyzed by a ruthenium pincer complex is described, which tolerates reactive functional groups such as carbamate, sulfonate, olefin, cyano, and trifluoromethyl-substituted benzyl nitriles. Homo allylic alcs. also provided 1,4-addition products following the isomerization of double bonds. Mechanistic studies supported that the allylic alcs. initially undergo selective oxidation by the catalyst to α,β-unsaturated carbonyl compounds followed by 1,4-conjugate addition of benzyl nitriles catalyzed by a base and subsequent catalytic reduction of carbonyl functionality, leading to the formation of δ-hydroxynitrile products. The catalytic cycle of this tandem process is established by d. functional theory studies. Remarkably, anipamil drug is successfully synthesized using this catalytic protocol. The utility of the δ-hydroxynitrile products in the synthesis of biol. active mols. and their further functionalization are also demonstrated.

ACS Catalysis published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Zhongcheng; Bisoyi, Hari Krishna; Huang, Yinliang; Wang, Meng; Yang, Hong; Li, Quan published the artcile< Thermo- and Mechanochromic Camouflage and Self-Healing in Biomimetic Soft Actuators Based on Liquid Crystal Elastomers>, Recommanded Product: But-3-en-1-ol, the main research area is thermo mechanochromic camouflage selfhealing biomimetic actuator liquid crystal elastomer; Biomimetic actuator; Camouflage; Chromophore; Liquid crystal elastomer; Self-healing.

In nature, many mysterious creatures capable of deformation camouflage, color camouflage, and self-healing have inspired scientists to develop various biomimetic soft robots. However, the systematic integration of all the above functionalities into a single soft actuator system still remains a challenge. Here we chem. introduce a multi-stimuli-responsive tetraarylsuccinonitrile (TASN) chromophore into a liquid crystal elastomer (LCE) network through a facile thiol-ene photoaddn. method. The obtained TASN-LCE soft actuators not only exhibit reversible shape-morphing and reversible color-changing behavior in response to heat and mech. compression, but also show excellent self-healing, reprogramming and recycling characteristics. We hope that such a TASN-LCE actuator system endowed with dynamic distortion, thermo- and mechano-chromic camouflage, and self-healing functionalities would pave the way for further development of multifunctional biomimetic soft robotic devices.

Angewandte Chemie, International Edition published new progress about Actuators (photoresponsive). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cox, Lydia; Zhu, Yuxiang; Smith, Philip J.; Christensen, Kirsten E.; Sidera Portela, Mireia; Donohoe, Timothy J. published the artcile< Alcohols as Alkylating Agents in the Cation-Induced Formation of Nitrogen Heterocycles>, Synthetic Route of 627-27-0, the main research area is pyrrolidine substituted piperidine diastereoselective regioselective preparation; homoallylic amine alc endo trig cyclization titanium isopropoxide catalyst; Azacycles; Carboamination; Carbocations; Hexafluoroisopropanol; Lewis Acid Catalysis.

A Ti(Oi-Pr)4 promoted 5- or 6-endo-trig cyclization to make nitrogen heterocycles was presented. The utilization of HFIP as a key solvent enabled stereoselective preparation of di- tri-substituted pyrrolidines, e.g. I and piperidines, e.g. II while forming a new C-C bond at same time. The process was triggered by a cationic intermediate generated from an allylic or benzylic alc. and led to simultaneous generation of both a C-C and a C-N bond in a single step. Notably, either 2,3-trans- or 2,3-cis-substituted heterocycles could be obtained by using a nucleophilic amine bearing different substituents. Lastly, stereoselective synthesis of enantiopure products was achieved by using readily available enantiopure acyclic starting materials.

Angewandte Chemie, International Edition published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thiyagarajan, Subramanian; Sankar, Raman Vijaya; Anjalikrishna, Puthannur K.; Suresh, Cherumuttathu H.; Gunanathan, Chidambaram published the artcile< Catalytic Formal Conjugate Addition: Direct Synthesis of δ-Hydroxynitriles from Nitriles and Allylic Alcohols>, Quality Control of 627-27-0, the main research area is delta hydroxynitrile preparation green chem; nitrile allylic alc selective formal conjugate addition ruthenium catalyst.

Alcs. and nitrile functionalities have widespread applications in biochem. and chem. synthesis. Catalytic transformations involving C-C bond formation relying on unsaturated coupling partners create important pathways for processes in synthetic, material, and medicinal chem. The discovery of a simple and selective coupling of nitriles with allylic alcs. catalyzed by a ruthenium pincer complex is described, which tolerates reactive functional groups such as carbamate, sulfonate, olefin, cyano, and trifluoromethyl-substituted benzyl nitriles. Homo allylic alcs. also provided 1,4-addition products following the isomerization of double bonds. Mechanistic studies supported that the allylic alcs. initially undergo selective oxidation by the catalyst to α,β-unsaturated carbonyl compounds followed by 1,4-conjugate addition of benzyl nitriles catalyzed by a base and subsequent catalytic reduction of carbonyl functionality, leading to the formation of δ-hydroxynitrile products. The catalytic cycle of this tandem process is established by d. functional theory studies. Remarkably, anipamil drug is successfully synthesized using this catalytic protocol. The utility of the δ-hydroxynitrile products in the synthesis of biol. active mols. and their further functionalization are also demonstrated.

ACS Catalysis published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Zhongcheng; Bisoyi, Hari Krishna; Huang, Yinliang; Wang, Meng; Yang, Hong; Li, Quan published the artcile< Thermo- and Mechanochromic Camouflage and Self-Healing in Biomimetic Soft Actuators Based on Liquid Crystal Elastomers>, Recommanded Product: But-3-en-1-ol, the main research area is thermo mechanochromic camouflage selfhealing biomimetic actuator liquid crystal elastomer; Biomimetic actuator; Camouflage; Chromophore; Liquid crystal elastomer; Self-healing.

In nature, many mysterious creatures capable of deformation camouflage, color camouflage, and self-healing have inspired scientists to develop various biomimetic soft robots. However, the systematic integration of all the above functionalities into a single soft actuator system still remains a challenge. Here we chem. introduce a multi-stimuli-responsive tetraarylsuccinonitrile (TASN) chromophore into a liquid crystal elastomer (LCE) network through a facile thiol-ene photoaddn. method. The obtained TASN-LCE soft actuators not only exhibit reversible shape-morphing and reversible color-changing behavior in response to heat and mech. compression, but also show excellent self-healing, reprogramming and recycling characteristics. We hope that such a TASN-LCE actuator system endowed with dynamic distortion, thermo- and mechano-chromic camouflage, and self-healing functionalities would pave the way for further development of multifunctional biomimetic soft robotic devices.

Angewandte Chemie, International Edition published new progress about Actuators (photoresponsive). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts