Category: 627-27-0

Bowser, Brandon H.; Wang, Shu; Kouznetsova, Tatiana B.; Beech, Haley K.; Olsen, Bradley D.; Rubinstein, Michael; Craig, Stephen L. published the artcile< Single-Event Spectroscopy and Unravelling Kinetics of Covalent Domains Based on Cyclobutane Mechanophores>, COA of Formula: C4H8O, the main research area is spectroscopy unravelling kinetics covalent cyclobutane mechanophore.

Mechanochem. reactions that lead to an increase in polymer contour length have the potential to serve as covalent synthetic mimics of the mech. unfolding of noncovalent “”stored length”” domains in structural proteins. Here we report the force-dependent kinetics of stored length release in a family of covalent domain polymers based on cis-1,2-substituted cyclobutane mechanophores. The stored length is determined by the size (n) of a fused ring in an [n.2.0] bicyclic architecture, and it can be made sufficiently large (>3 nm per event) that individual unravelling events are resolved in both constant-velocity and constant-force single-mol. force spectroscopy (SMFS) experiments Replacing a methylene in the pulling attachment with a Ph group drops the force necessary to achieve rate constants of 1 s-1 from ca. 1970 pN (dialkyl handles) to 630 pN (diaryl handles), and the substituent effect is attributed to a combination of electronic stabilization and mech. leverage effects. In contrast, the kinetics are negligibly perturbed by changes in the amount of stored length. The independent control of unravelling force and extension holds promise as a probe of mol. behavior in polymer networks and for optimizing the behaviors of materials made from covalent domain polymers.

Journal of the American Chemical Society published new progress about Conformers. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Zi-Qi; Cao, Yilin; Kang, Taeho; Engle, Keary M. published the artcile< Electrophilic Sulfur Reagent Design Enables Directed syn-Carbosulfenylation of Unactivated Alkenes>, Electric Literature of 627-27-0, the main research area is alkene boronic ester sulfur reagent nickel catalyst regioselective carbosulfenylation; thioalkane preparation.

A multi-component approach to structurally complex organosulfur products was described via the nickel-catalyzed 1,2-carbosulfenylation of unactivated alkenes with organoboron nucleophiles and tailored organosulfur electrophiles. The key to the development of this transformation was the identification of a modular N-alkyl-N-(arylsulfenyl)arenesulfonamide family of sulfur electrophiles. Tuning the electronic and steric properties of the leaving group in these reagents controls pathway selectivity, favoring three-component coupling and suppressing side reactions, as examined via computational studies. The unique syn-stereoselectivity differed from traditional electrophilic sulfenyl transfer processes involving a thiiranium ion intermediate and arose from the directed arylnickel(I) migratory insertion mechanism, as elucidated through reaction kinetics and control experiments Reactivity and regioselectivity are facilitated by a collection of monodentate, weakly coordinating native directing groups, including sulfonamides, alcs., amines, amides, and azaheterocycles.

Journal of the American Chemical Society published new progress about Boronic acids, esters Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Meng; Chu, Da; Liu, Li; Huang, Shuai; Chen, Xu-Man; Liu, Zhi-Yang; Yang, Hong published the artcile< Intelligent Surfaces Thermally Switchable between the Highly Rough and Entirely Smooth States>, Category: alcohols-buliding-blocks, the main research area is intelligent surface liquid crystal elastomer switchable topol structure.

Reversible switching from a highly rough surface to another entirely smooth surface under external stimuli is crucial for intelligent materials applied in the fields of anti-fogging, self-cleaning, oil-water separation and biotechnol. In this work, a thermal-responsive liquid crystal elastomer (LCE) surface covered with oriented micropillars is prepared via a facile two-step crosslinking method coupled with an extrusion molding program. The reversible change of topol. structures of the LCE surface along with temperature is investigated by metallog. microscope, at. force microscopy and optical contact angle measuring system. At room temperature, the LCE sample is filled with plenty of micropillars with an average length of 8.76 Μm, resulting in a super-hydrophobic surface with a water contact angle (WCA) of 135°. When the temperature is increased to above the clearing point, all the micropillars disappear, the LCE surface becomes entirely flat and presents a hydrophilic state with a WCA of 64°. The roughness-related wetting property of this microstructured LCE surface possesses good recyclability in several heating/cooling cycles. This work realizes a truly reversible transformation from a highly rough surface to an entirely smooth surface, and might promote the potential applications of this dynamic-responsive LCE surface in smart sensors and biomimetic control devices.

Chinese Journal of Polymer Science published new progress about Antifogging agents. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fathalinejad, Samin; Taarning, Esben; Christensen, Peter; Christensen, Jan H. published the artcile< Chemical composition analysis of carbohydrate fragmentation products>, Recommanded Product: But-3-en-1-ol, the main research area is carbohydrate fragmentation product chem composition analysis.

Fragmentation of simple sugars, using fluidized thermal bed cracking, results in a mixture that contains a variety of polar oxygenated compounds, some yet unknown to the industries. This lack of understanding of the product composition, hinders the downstream processes in conversion of sugars to useful chems. The aim of this study was fourfold: to develop a GC-MS identification workflow for carbohydrate fragmentation compounds, to build a library of compounds detected by five GC-MS methods including liquid injection, liquid-liquid extraction, static headspace, solid-phase microextraction and derivatization, to investigate and compare the compound coverage of the five methods, and finally investigate possible reaction pathways for some of the analytes in the mixture The anal. was done on a mixture of seven representative sugar fragmentation samples. The identification workflow was based on mass spectral match factors (>80%), retention indexes and anal. standards A total of 389 compounds were detected, out of which, 46 compounds were fully identified (through confirmatory anal. of anal. standards), 87 were tentatively identified (spectral match factors above 80%), 71 were un-identified with spectral match factors of below 80% and 185 were discarded (contaminants in blanks, etc.). The production pathway for some of the identified compounds in the sugar conversion mixtures were also discussed. In conclusion, solid-phase microextraction detected the highest number of analytes (93), mostly volatile organic compounds and the derivatization GC-MS technique detected the lowest number of analytes (19) but was the only method to detect the largest mols. (C6-C12) in size. This library of CF products can be used as a suspect-screening database for other biomass fragmentation mixtures

Journal of Analytical and Applied Pyrolysis published new progress about Biomass refining. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Yang; Bao, Jiamin; Zhang, Yu; Peng, Xue; Yu, Weijie; Wang, Tao; Yang, Dengtao; Liu, Qun; Zhang, Qian; Fu, Junkai published the artcile< Three-component aminofluorination of alkenes with electronically rich amino sources>, Category: alcohols-buliding-blocks, the main research area is alkene bromo dialkyl amine silver fluoride regioselective aminofluorination; fluoro alkyl amine preparation.

The first intermol. three-component aminofluorination of alkenes with electronically rich amino sources was developed via an umpolung strategy. In this reaction, electrophilic N-bromodialkylamines were employed as amine electrophiles, whereas multifunctional AgF served as both a nucleophilic fluoride source and a reductive catalyst, for the first time, to initiate a single-electron transfer with N-bromodialkylamines. The addition of hexafluoroisopropanol as a cosolvent was crucial to promote protonated alkylaminyl radical formation and maintain the nucleophilicity of fluoride ion. This protocol exhibited excellent functional-group tolerance toward various aryl and unactivated alkenes, furnishing the corresponding β-fluoroamines with high regioselectivity. Mechanistic investigation revealed an aziridinium intermediate via a radical pathway. The synthetic utility of this transformation was demonstrated by the aminofluorination of several bioactive mols., including an efficient route to a Rizatriptan analog. This finding holds promise for new discoveries in medicinal chem. and the amination reactions.

Chem published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yong; Xing, Shuya; Zhang, Jing; Liu, Wen; Xu, Yuenian; Zhang, Yan; Yang, Kefang; Yang, Lei; Jiang, Kezhi; Shao, Xinxin published the artcile< Construction of diverse C-S/C-Se bonds via nickel catalyzed reductive coupling employing thiosulfonates and a selenosulfonate under mild conditions>, Safety of But-3-en-1-ol, the main research area is organic iodide thiosulfonate nickel catalyst chemoselective reductive coupling; thioether preparation; selenosulfonate organic iodide nickel catalyst chemoselective reductive coupling; selenoether preparation.

A nickel-catalyzed reductive cross coupling between organic iodides and thiosulfonates and a selenosulfonate under mild conditions was disclosed. This practical method provides a facile access to a series of unsym. thioethers with low catalyst loading, good functional group tolerance, and excellent chemo-selectivity. Notably, the synthetic applications of the approach feature scaling-up of reactions, late-stage modification of pharmaceuticals, and preparation of various useful targeted compounds, including sulfoximine, bipyridine, and vortioxetine. Primary mechanistic studies showed that a radical pathway was involved. Moreover, diverse C-S/C-Se bond formations were achieved under mild reaction conditions.

Organic Chemistry Frontiers published new progress about Chemoselectivity. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Potrzasaj, Aleksandra; Ociepa, Michal; Chaladaj, Wojciech; Gryko, Dorota published the artcile< Bioinspired Co-Catalysis Enables Generation of Nucleophilic Radicals from Oxetanes>, Computed Properties of 627-27-0, the main research area is oxetane radical ring opening regioselective cobalt catalyst.

Oxetanes are valuable building blocks due to their well-explored propensity to underwent ring-opening reactions with nucleophiles. However, their application as precursors of radical species is still elusive. Herein, authors present a bioinspired cobalt catalysis-based strategy to access unprecedented modes of radical reactivity via oxetane ring opening. This powerful approach give access to nucleophilic radicals that engage in reactions with SOMOphiles and low-valent transition metals. Importantly, the regioselectivity of these processes complements known methodologies.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Computed Properties of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Qiang; Yu, Wan-Lei; Luo, Yong-Chun; Hu, Xiu-Qin; Xu, Peng-Fei published the artcile< A Photosensitizer-Free Radical Cascade for Synthesizing CF3-Containing Polycyclic Quinazolinones with Visible Light>, Product Details of C4H8O, the main research area is trifluoroethyl pyrroloquinazolinone preparation; alkenyl cyanobenzamide trifluoroacetic anhydride tandem photocyclization; trifluoromethyl spiro cycloalkane pyrroloquinazolinone preparation; cycloalkenyl cyanobenzamide trifluoroacetic anhydride tandem photocyclization.

An efficient photoinduced radical tandem trifluoromethylation/cyclization reaction of N-cyanamide alkenes for the synthesis of functionalized quinazolinones was reported. Importantly, the reaction was carried out under mild conditions without any addnl. photosensitizer, metal or extra additives. A series of trifluoromethyl quinazolinones were prepared efficiently with good yields and excellent functional group tolerance. Preliminary mechanism experiments were conducted to indicate that the transformation proceeded via a possible mechanism involving photoexcited EDA complex and chain propagation.

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Product Details of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Qi; Zhou, Xiaoxuan; Zhang, Si; Pan, Ling; Liu, Qun; Li, Yifei published the artcile< Visible-Light-Induced Sulfur-Alkenylation of Alkenes>, Application In Synthesis of 627-27-0, the main research area is dialkyl butenedithiol preparation diastereoselective regioselective; alkene ketene dithioacetal sulfur alkenylation trimethylphenylacridinium perchlorate photoredox catalyst.

A visible-light-induced intermol. sulfur-alkenylation of alkenes RCH=CR1R2 (R = H, Me, ethyl; R1 = H, Me, ethyl; R2 = Et, Ph, 2-naphthyl, acetyloxy, etc.; R1R2 = -(CH2)4-, -(CH2)5-; RR2 = -(CH2)3-, -(CH2)4-, -(CH2)2CH=CH-, etc.), 6,6-dimethyl-2-methylene-bicyclo[3.1.1]heptane including both activated and unactivated alkenes, mols. even induced by sunlight under ambient conditions is described. This sulfur-alkenylation reaction proceed in a highly regio- and stereospecific manner involving the visible-light-induced conversion of a ketene dithioacetal to the thiavinyl 1,3-dipole intermediate, followed by a formal [3+2] cycloaddition and C-S bond cleavage. Furthermore, it is also an efficient approach for the late-stage functionalization of natural products and complex mols., even being induced by sunlight under ambient conditions.

Organic Letters published new progress about [3+2] Cycloaddition reaction catalysts (stereo-, regioselective). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application In Synthesis of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Qi-Ping; Jia, Jia; Li, Wei-Piao; Wang, An-Jun; Zhao, Liang published the artcile< Atom transfer radical additions (ATRAs) promoted by catalytic amounts of amines: the effective iododifluoroalkylation of alkenes/alkynes>, Safety of But-3-en-1-ol, the main research area is alkene alkyne iodination difluoroalkylation regioselective dimethylpiperazine catalyst.

Recently, fluoroalkylation reactions initiated via noncovalent interaction (halogen bond or EDA complexes) have become an attractive method to access fluoro-containing compounds, and most of those reactions were promoted by visible light and stoichiometric electron-donor compounds Here, a novel atom transfer radical addition (ATRA) reaction promoted by catalytic amount of 1,4-dimethylpiperazine on heating has been developed. This protocol enables a simple and practical alternative for the effective iododifluoroalkylation of alkenes or alkynes, which features synthetic simplicity, wide substrate scope and feasibility of product transformations.

Synthetic Communications published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts