Category: 621-37-4

On November 30, 2021, Ding, Xiaowei; Liu, Kaihui; Yan, Qingyun; Liu, Xingyu; Chen, Ni; Wang, Guoliang; He, Shuai published an article.HPLC of Formula: 621-37-4 The title of the article was Sugar and organic acid availability modulate soil diazotroph community assembly and species co-occurrence patterns on the Tibetan Plateau. And the article contained the following:

Metabolites can mediate species interactions and the assembly of microbial communities. However, how these chems. relate to the assembly processes and co-occurrence patterns of diazotrophic assemblages in root-associated soils remains largely unknown. Here, we examined the diversity and assembly of diazotrophic communities and further deciphered their links with metabolites on Tibetan Plateau. We found that the distribution of sugars and organic acids in the root-associated soils was significantly correlated with the richness of diazotrophs. The presence of these two soil metabolites explains the variability in diazotrophic community compositions The differential concentrations of these metabolites were significantly linked with the distinctive abundances of diazotrophic taxa in same land types dominated by different plants or dissimilar soils by same plants. The assembly of diazotrophic communities is subject to deterministic ecol. processes, which are widely modulated by the variety and amount of sugars and organic acids. Organic acids, for instance, 3-(4-hydroxyphenyl)propionic acid and citric acid, were effective predictors of the characteristics of diazotrophic assemblages across desert habitats. Diazotrophic co-occurrence networks tended to be more complex and connected within different land types covered by the same plant species. The concentrations of multiple sugars and organic acids were coupled significantly with the distribution of keystone species, such as Azotobacter, Azospirillum, Bradyrhizobium, and Mesorhizobium, in the co-occurrence network. These findings provide new insights into the assembly mechanisms of root-associated diazotrophic communities across the desert ecosystems of the Tibetan Plateau. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to sugar organic acid availability soil metabolite diazotroph community plateau, co-occurrence network, community assembly, diazotrophic diversity, sugars and organic acids, Plant Biochemistry: Metabolism and other aspects.HPLC of Formula: 621-37-4

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On December 1, 2021, da Silva, Dariane Trivisiol; Smaniotto, Franciele Aline; Costa, Isabella Ferreira; Baranzelli, Julia; Muller, Aline; Somacal, Sabrina; Monteiro, Camila Sant’Anna; Vizzotto, Marcia; Rodrigues, Eliseu; Barcia, Milene Teixeira; Emanuelli, Tatiana published an article.Formula: C8H8O3 The title of the article was Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract. And the article contained the following:

This study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS anal. of blood and cecal feces. Non-compartmental pharmacokinetic anal. revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochems., choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3

The Article related to blueberry phenolic compound bioavailability natural deep eutectic solvent, absorption, anthocyanins, green solvent, intestinal stability, metabolites, pharmacokinetic, Food and Feed Chemistry: Analysis and other aspects.Formula: C8H8O3

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On July 31, 2021, Magdaleno-Tapia, Cristina; Quifer-Rada, Paola; Rodriguez-Rodriguez, Elena; Estevez-Santiago, Rocio; Waterhouse, Andrew L.; Lamuela-Reventos, Rosa M.; Olmedilla-Alonso, Begona; Perez-Jimenez, Jara published an article.Safety of 3-Hydroxyphenylacetic acid The title of the article was Evaluation of the potential of total proanthocyanidin content in feces as an intake biomarker. And the article contained the following:

Due to the health benefits associated with proanthocyanidins (PAs), it is useful to identify dietary PA biomarkers that can be determined by simple methods. Since increased levels of circulating PA metabolites are associated with increased fecal PA content, this study explores the spectrophotometric measurement of fecal PA content and its use as a biomarker of PA intake. To this end, fecal PA content was measured using an adaptation of Porters spectrophotometric method in samples from a preclin. study and an observational study. In the former, excretion of 250-400 mg PA polymer equivalent/100 g feces was observed during supplementation and the day after, together with a significant association (p < 0.05) between PA intake and the excretion of both intact PAs and some PA metabolites, i.e., (+)-catechin, (-)-epicatechin and syringic acid. No relationship between intake and excretion was found in the observational study, either for the entire group (mean excretion of 240 ± 226 mg PA polymer equivalent/100 g feces) or after stratification into tertiles of consumption. In conclusion, the spectrophotometric determination of total PA content in feces proved to be a valid compliance marker in a preclin. study, but it was not associated with PA intake in free-living subjects. The potential of total PA excretion in observational studies, determined in fecal samples collected the day before dietary recall or in several fecal samples from the same subject, remains to be elucidated, as does a complete validation of the method proposed here. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Safety of 3-Hydroxyphenylacetic acid

The Article related to proanthocyanidin content feces intake biomarker, metabolism, observational study, polyphenols, preclinical study, Food and Feed Chemistry: Analysis and other aspects.Safety of 3-Hydroxyphenylacetic acid

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On March 31, 2021, Hao, Yuxin; Yang, Jing; Cui, Jingyan; Fan, Yanling; Li, Nana; Wang, Chunyu; Liu, Yongping; Dong, Yuemeng published an article.Synthetic Route of 621-37-4 The title of the article was Stability and mechanism of phenolic compounds from raspberry extract under in vitro gastrointestinal digestion. And the article contained the following:

Raspberry extract (RE) is a raspberry product with high anthocyanins and low sugar. In the present study, to evaluate the metabolic behavior of phenolic compounds of RE under in vitro digestion (gastric (GF), gastric to intestinal (G-IF), and colonic fermentation (CF)), the changes of 30 phenolic compounds were investigated by High Performance Liquid Chromatog.-Mass Spectrometry. The results showed that phenolic compounds were relatively stable in GF, but rapidly decreased in G-IF and CF. Five anthocyanins accounted for 61.1% of total polyphenol contents (TPCs). Among them, anthocyanins bound to glucose or with two hydroxyl groups on B-ring were metabolized more quickly. The catabolic activity of the human microbiota resulted in the production of a series of low mol. weight phenolics, such as hydroxybenzoic acids. Ellagic acid, accounting for 17.7% of TPCs, was rapidly metabolized to urolithin B and urolithin C in CF. Moreover, urolithin C showed the highest antioxidant activity in all ellagic acid metabolites by DPPH assay. Consequently, the metabolic behavior of phenolic compounds was mainly influenced by pH and intestinal microbiota, which provided the basis for further in vivo and in vitro study and efficient utilization of the extract The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Synthetic Route of 621-37-4

The Article related to stability mechanism raspberry extract phenolic compound gastrointestinal digestion, Food and Feed Chemistry: Analysis and other aspects.Synthetic Route of 621-37-4

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On July 12, 2022, Zaitsu, Kei; Asano, Tomomi; Kawakami, Daisuke; Chang, Jiarui; Hisatsune, Kazuaki; Taniguchi, Masaru; Iguchi, Akira published an article.Safety of 3-Hydroxyphenylacetic acid The title of the article was Metabolomics and Data-Driven Bioinformatics Revealed Key Maternal Metabolites Related to Fetal Lethality via Di(2-ethylhexyl)phthalate Exposure in Pregnant Mice. And the article contained the following:

We performed serum metabolome anal. of di(2-ethylhexyl)phthalate (DEHP)-exposed and control pregnant mice. Pregnant mice (n = 5) were fed a DEHP-containing diet (0.1% or 0.2% DEHP) or a normal diet (control) from gestational days 0-18. After maternal exposure to 0.2% DEHP there were no surviving fetuses, indicating its strong fetal lethality. There were no significant differences in the numbers of fetuses and placentas between the 0.1% DEHP and control groups, although fetal viability differed significantly between them, suggesting that maternal exposure to 0.1% DEHP could inhibit fetal growth. Metabolomics successfully detected 169 metabolites in serum. Principal component anal. (PCA) demonstrated that the three groups were clearly separated on PCA score plots. The biol. interpretation of PC1 was fetal lethality, whereas PC2 meant metabolic alteration of pregnant mice via DEHP exposure without fetal lethality. In particular, the first component was significantly correlated with fetal viability, demonstrating that maternal metabolome changes via DEHP exposure were strongly related to fetal lethality. Levels of some amino acids were significantly increased in the DEHP-exposed groups, whereas those of some fatty acids, nicotinic acid, and 1,5-anhydroglucitol were significantly decreased in the DEHP groups. DEHP-induced increases in glycine levels could cause fetal neurol. disorders, and decreases in nicotinic acid could inhibit fetal growth. In addition, a machine-learning Random forest could determine 16 potential biomarkers of DEHP exposure, and data-driven network anal. revealed that nicotinic acid was the most influential hub metabolite in the metabolic network. These findings will be useful for understanding the effects of DEHP on the maternal metabolome in pregnancy and their relationship to fetal lethality. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Safety of 3-Hydroxyphenylacetic acid

The Article related to metabolome fetus pregnancy serum metabolite dehp, Placeholder for records without volume info and other aspects.Safety of 3-Hydroxyphenylacetic acid

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On December 31, 2022, Valdes, Alberto; Moreno, Lorena Ortega; Rello, Silvia Rojo; Orduna, Antonio; Bernardo, David; Cifuentes, Alejandro published an article.Category: alcohols-buliding-blocks The title of the article was Metabolomics study of COVID-19 patients in four different clinical stages. And the article contained the following:

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the coronavirus strain causing the respiratory pandemic COVID-19 (coronavirus disease 2019). To understand the pathobiol. of SARS-CoV-2 in humans it is necessary to unravel the metabolic changes that are produced in the individuals once the infection has taken place. The goal of this work is to provide new information about the altered biomol. profile and with that the altered biol. pathways of patients in different clin. situations due to SARS-CoV-2 infection. This is done via metabolomics using HPLC-QTOF-MS anal. of plasma samples at COVID-diagnose from a total of 145 adult patients, divided into different clin. stages based on their subsequent clin. outcome (25 neg. controls (non-COVID); 28 pos. patients with asymptomatic disease not requiring hospitalization; 27 pos. patients with mild disease defined by a total time in hospital lower than 10 days; 36 pos. patients with severe disease defined by a total time in hospital over 20 days and/or admission at the ICU; and 29 pos. patients with fatal outcome or deceased). Moreover, follow up samples between 2 and 3 mo after hospital discharge were also obtained from the hospitalized patients with mild prognosis. The final goal of this work is to provide biomarkers that can help to better understand how the COVID-19 illness evolves and to predict how a patient could progress based on the metabolites profile of plasma obtained at an early stage of the infection. In the present work, several metabolites were found as potential biomarkers to distinguish between the end-stage and the early-stage (or non-COVID) disease groups. These metabolites are mainly involved in the metabolism of carnitines, ketone bodies, fatty acids, lysophosphatidylcholines/phosphatidylcholines, tryptophan, bile acids and purines, but also omeprazole. In addition, the levels of several of these metabolites decreased to “normal” values at hospital discharge, suggesting some of them as early prognosis biomarkers in COVID-19 at diagnose. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks

The Article related to human covid metabolomics clin stage, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

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Bajkacz, Sylwia; Ligor, Magdalena; Baranowska, Irena; Buszewski, Boguslaw published an article in 2021, the title of the article was Separation and Determination of Chemopreventive Phytochemicals of Flavonoids from Brassicaceae Plants.Category: alcohols-buliding-blocks And the article contains the following content:

The main aim of this study was to develop a method for the isolation and determination of polyphenols-in particular, flavonoids present in various morphol. parts of plants belonging to the cabbage family (Brassicaceae). Therefore, a procedure consisting of maceration, acid hydrolysis and measurement of the total antioxidant capacity of plant extracts (using DPPH assay) was conducted. Qual. anal. was performed employing thin-layer chromatog. (TLC), which was presented to be a suitable methodol. for the separation and determination of chemopreventive phytochems. from plants belonging to the cabbage family. The study involved the anal. of 25 vegetal samples, including radish, broccoli, Brussels sprouts, kale, canola, kohlrabi, cabbage, Chinese cabbage, red cabbage, pak choi and cauliflower. In addition, selected flavonoids content in free form and bonded to glycosides was determined by using an RP-UHPLC-ESI-MS/MS method. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks

The Article related to flavonoid brassicaceae plant chemopreventive phytochem determination, cabbage family, flavonoids, glycosides, phenolic acids, Pharmaceuticals: Pharmacognostic Products and other aspects.Category: alcohols-buliding-blocks

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On December 31, 2020, Kozlowicz, Katarzyna; Rozylo, Renata; Gladyszewska, Bozena; Matwijczuk, Arkadiusz; Gladyszewski, Grzegorz; Chocyk, Dariusz; Samborska, Katarzyna; Piekut, Jolanta; Smolewska, Marzena published an article.Product Details of 621-37-4 The title of the article was Identification of sugars and phenolic compounds in honey powders with the use of GC-MS, FTIR spectroscopy, and X-ray diffraction. And the article contained the following:

This work aimed at the chem. and structural characterization of powders obtained from chestnut flower honey (HFCh) and honey with Inca berry (HBlu). Honey powders were obtained by spray drying technique at low temperature (80/50 °C) with dehumidified air. Maltodextrin (DE 15) was used as a covering agent. The isolation and evaluation of phenolic compounds and sugars were done by gas chromatog.-mass spectrometry anal. SEM, Fourier-transform IR (FTIR) spectroscopy, and X-ray diffraction were performed to determine the morphol. of the studied honey powders. The obtained results showed that the content of simple sugars amounted to 72.4 and 90.2 g x 100 g-1 in HFCh and HBlu, resp. Glucose was found to be the dominant sugar with a concentration of 41.3 and 51.6 g x 100 g-1 in HFCh and HBlu, resp. 3-Phenyllactic acid and ferulic acid were most frequently found in HFCh powder, whereas m-coumaric acid, benzoic acid, and cinnamic acid were the most common in HBlu powder. The largest changes in the FTIR spectra occurred in the following range of wavenumbers: 3335, 1640, and below 930 cm-1. The X-ray diffraction profiles revealed wide peaks, suggesting that both honey powders are amorphous and are characterized by a short-range order only. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Product Details of 621-37-4

The Article related to honey powder sugar phenolic compound gcms ftir xray diffraction, Placeholder for records without volume info and other aspects.Product Details of 621-37-4

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On December 31, 2021, Malheiros, Jessica Moraes; Correia, Banny Silva Barbosa; Ceribeli, Caroline; Cardoso, Daniel Rodrigues; Colnago, Luiz Alberto; Junior, Stanislau Bogusz; Reecy, James Mark; Mourao, Gerson Barreto; Coutinho, Luiz Lehmann; Palhares, Julio Cesar Pascale; Berndt, Alexandre; de Almeida Regitano, Luciana Correia published an article.Safety of 3-Hydroxyphenylacetic acid The title of the article was Comparative untargeted metabolome analysis of ruminal fluid and feces of Nelore steers (Bos indicus). And the article contained the following:

We conducted a study to identify the fecal metabolite profile and its proximity to the ruminal metabolism of Nelore steers based on an untargeted metabolomic approach. Twenty-six Nelore were feedlot with same diet during 105 d. Feces and rumen fluid were collected before and at slaughter, resp. The metabolomics anal. indicated 49 common polar metabolites in the rumen and feces. Acetate, propionate, and butyrate were the most abundant polar metabolites in both bio-samples. The rumen presented significantly higher concentrations of the polar compounds when compared to feces (P < 0.05); even though, fecal metabolites presented an accentuated representability of the ruminal fluid metabolites. All fatty acids present in the ruminal fluid were also observed in the feces, except for C20:2n6 and C20:4n6. The identified metabolites offer information on the main metabolic pathways (higher impact factor and P < 0.05), as synthesis and degradation of ketone bodies; the alanine, aspartate and glutamate metabolisms, the glycine, serine; and threonine metabolism and the pyruvate metabolism The findings reported herein on the close relationship between the ruminal fluid and feces metabolic profiles may offer new metabolic information, in addition to facilitating the sampling for metabolism investigation in animal production and health routines. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Safety of 3-Hydroxyphenylacetic acid

The Article related to bso metabolome analysis nmr spectroscopy ruminal fluid feces, Placeholder for records without volume info and other aspects.Safety of 3-Hydroxyphenylacetic acid

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Fraga, Layanne Nascimento; Coutinho, Camille Perella; Rozenbaum, Adriana Campos; Tobaruela, Eric de Castro; Lajolo, Franco Maria; Hassimotto, Neuza Mariko Aymoto published an article in 2021, the title of the article was Blood pressure and body fat % reduction is mainly related to flavanone phase II conjugates and minor extension by phenolic acid after long-term intake of orange juice.HPLC of Formula: 621-37-4 And the article contains the following content:

Hesperidin and narirutin are the major flavanones present in orange juice, and they are associated with a reduction in risk of cardiometabolic disease. However, there is heterogeneity in their biol. responses, which is partly due to the large interindividual variation in these flavonoids bioavailability. We investigated the relation between interindividual variability in the excretion of phase II conjugates and gut-derived phenolic acids, and cardiometabolic biomarkers response. Seventy-four subjects, both men and women, were included in a single-arm study. Over the 60 days, volunteers consumed 500 mL of orange juice daily. All measurements and blood collections were performed before and after the intervention period. Moreover, 24 h urine collection was performed after first consumption. Individuals were stratified according to the excretion of phase II conjugates and, for the first time, according to phenolic acids in high, medium, and low excretors. Furthermore, for the first time, the ratio between phenolic acids and flavanones-phase II conjugates has shown groups with different metabolization patterns. Groups with a low or intermediate ratio, corresponding to a higher amount of phase II conjugates excreted, showed a significant reduction in body fat % and blood pressure. This finding suggests that these improvements could be associated in a major way to flavanones-phase II conjugates, as well as to phenolic acids and stratification of volunteers according to metabolite excretions could be a good strategy to better understand the effects of orange juice on metabolism and health. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to orange juice blood pressure flavanone phase ii phenolic acid, Placeholder for records without volume info and other aspects.HPLC of Formula: 621-37-4

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