Category: 621-37-4

Vaillant, Fabrice; Corrales-Agudelo, Vanesa; Moreno-Castellanos, Natalia; Angel-Martin, Alberto; Henao-Rojas, Juan Camilo; Munoz-Durango, Katalina; Poucheret, Patrick published an article in 2021, the title of the article was Plasma Metabolome Profiling by High-Performance Chemical Isotope-Labelling LC-MS after Acute and Medium-Term Intervention with Golden Berry Fruit (Physalis peruviana L.), Confirming Its Impact on Insulin-Associated Signaling Pathways.Electric Literature of 621-37-4 And the article contains the following content:

Golden berry (Physalis peruviana L.) is an exotic fruit exported from Colombia to different countries around the world. A review of the literature tends to demonstrate a hypoglycemic effect with an improvement in insulin sensitivity after oral ingestion of fruit extracts in animal models. However, little is known about their potential effects in humans, and very little is known about the mechanisms involved. This study aimed at identifying discriminant metabolites after acute and chronic intake of golden berry. An untargeted metabolomics strategy using high-performance chem. isotope-labeling LC-MS was applied. The blood samples of eighteen healthy adults were analyzed at baseline, at 6 h after the intake of 250 g of golden berry (acute intervention), and after 19 days of daily consumption of 150 g (medium-term intervention). Forty-nine and 36 discriminant metabolites were identified with high confidence, resp., after the acute and medium-term interventions. Taking into account up- and downregulated metabolites, three biol. networks mainly involving insulin, epidermal growth factor receptor (EGFR), and the phosphatidylinositol 3-kinase pathway (PI3K/Akt/mTOR) were identified. The biol. intracellular networks identified are highly interconnected with the insulin signalling pathway, showing that berry intake may be associated with insulin signalling, which could reduce some risk factors related to metabolic syndrome. Primary registry of WHO. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Electric Literature of 621-37-4

The Article related to diet supplement physalis plasma metabolome insulin egfr putrescine vitamina, physalis peruviana, insulin, metabolomic, nutritional intervention, Animal Nutrition: Other and other aspects.Electric Literature of 621-37-4

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On December 31, 2021, Barfoot, Katie Louise; Istas, Geoffrey; Feliciano, Rodrigo Pedro; Lamport, Daniel Joseph; Riddell, Patricia; Rodriguez-Mateos, Ana; Williams, Claire Michelle published an article.Related Products of 621-37-4 The title of the article was Effects of daily consumption of wild blueberry on cognition and urinary metabolites in school-aged children: a pilot study. And the article contained the following:

Acute intervention with wild blueberry (WBB) has previously revealed pos. cognitive and mood effects in typically developing children; however, it is unclear whether effects persist after daily supplementation. In addition, no data have been published exploring the metabolite profiles of children following berry consumption, to our knowledge. A study of this kind could provide insight into a mechanism of action for the cognitive and mood improvements observed previously in children. The aim of this pilot study was to assess cognitive performance and urinary metabolite concentrations in healthy 7-10-yr-old children across a 4 wk daily WBB drink intervention. This pilot study examined the effects of daily WBB consumption for 4 wk (766 mg total polyphenols; 253 mg anthocyanins; equivalent to 240 g fresh blueberries per day) on cognition and mood in 15 healthy 7-10-yr-old children. Polyphenol metabolites were measured in 24 h urine before and after the 4 wk intervention. Chronic WBB-related benefits were seen on cognitively demanding trials on the modified attention network task, a task measuring executive functioning. Specifically, the WBB group maintained significantly higher accuracy on incongruent trials (96%; SE 0.03) compared with placebo participants (85%; SE 0.03; p = 0.038) after the 4 wk intervention, suggesting WBB was of most benefit on the more difficult aspects of the task. No significant WBB-related effects were observed on the auditory verbal learning task or the childs version of the pos. and neg. affect schedule. Urinary metabolite analyses indicated significant increases in different metabolites in WBB and placebo groups after 4 wk consumption. The research demonstrates 24 h WBB bioavailability in a child cohort for the first time with increases in urinary hippuric acid excretion during 2 wk daily WBB consumption. This study highlights the importance of conducting a larger study in children investigating the mechanism of action behind cognitive effects using bioavailability data. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4

The Article related to blueberry cognition metabolites urine anthocyanins, blueberries, children, cognition, executive function, flavonoids, metabolite, Animal Nutrition: Other and other aspects.Related Products of 621-37-4

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On September 30, 2022, Mori, Nagisa; Murphy, Neil; Sawada, Norie; Achaintre, David; Yamaji, Taiki; Scalbert, Augustin; Iwasaki, Motoki; Inoue, Manami; Gunter, Marc J.; Tsugane, Shoichiro published an article.Category: alcohols-buliding-blocks The title of the article was Prediagnostic plasma polyphenol concentrations and colon cancer risk: The JPHC nested case-control study. And the article contained the following:

Epidemiol. studies that assessed the associations between dietary polyphenol intakes and colon cancer risk have reported largely null results, possibly due to measurement error associated with dietary assessment. We adopted an objective approach by measuring prediagnostic plasma concentrations of 35 polyphenols and assessing associations with colon cancer risk.We conducted a nested-case control study within the Japan Public Health Center-based prospective study (JPHC Study) utilizing plasma samples collected at the time of a five-year follow-up survey between 1995 and 1999. We identified colon cancer cases who developed cancer during the follow-up from the time of blood collection. Controls were matched by age, sex, area code, population size of the area, season of blood collection, year of blood collection, and duration of fasting time before the blood collection. Prediagnostic concentrations of 35 polyphenols from 375 incident colon cancer cases (followed until 2012) and 710 matched controls were measured by tandem mass spectrometry coupled with ultra-high-pressure liquid chromatog. We used multivariable conditional logistic regression models adjusted for established colon cancer risk factors to estimate odds ratios (ORs) and 95% confidence intervals (CIs).In sexes combined log2-transformed multivariable models, circulating levels of 3,4-dihydroxyphenylpropionic acid (P = 0.02), ferulic acid (P = 0.02), and caffeic acid (P = 0.03) were inversely, and 3-hydroxybenzoic acid (P = 0.03) was pos., associated with colon cancer risk. For men only, circulating levels of 3,4-dihydroxyphenylpropionic acid was inversely, and 3,5-dihydroxyphenylpropionic acid, gallic acid, (+)-epigallocatechin, 3-hydroxybenzoic acid, and epicatechin were pos., associated with colon cancer risk. In women, plasma caffeic acid and ferulic acid concentration were inversely associated with colon cancer risk. However, all these associations were nonsignificant after adjustment for multiple comparisons. The remaining polyphenols were not associated with colon cancer risk. Coffee-derived 3,4-dihydroxyphenylpropionic acid, ferulic acid, and caffeic acid concentrations were inversely associated with colon cancer risk although the association were nonsignificant after adjustment for multiple comparisons. These results support a possible role of coffee polyphenols in preventing colorectal cancer. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks

The Article related to colon cancer risk prediagnosis blood plasma polyphenol japan, colon cancer, japanese, phytochemicals, plasma, polyphenols, Animal Nutrition: Other and other aspects.Category: alcohols-buliding-blocks

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On May 31, 2021, Vlckova, Hana Kocova; Catapano, Maria Carmen; Mitasik, Lucia; Kotland, Ondrej; Nejmanova, Iveta; Pourova, Jana; Mladenka, Premysl; Novakova, Lucie published an article.HPLC of Formula: 621-37-4 The title of the article was Featuring ultimate sensitivity of high-resolution LC-MS analysis of phenolics in rat plasma. And the article contained the following:

Sensitive anal. of very low-mol. weight metabolites using liquid chromatog. with quadrupole-time-of-flight mass spectrometry is challenging due to the high losses of ions in a time-of-flight analyzer. Improvement in sensitivity for these analytes via the optimization of advanced parameters, including quadrupole profile, ion guide parameters, and duty cycle, has been achieved. The optimization of the method was carried out using a large spectrum of structurally different compounds including (iso)flavonoids and their known metabolites. These compounds can be categorized into two major groups, i.e., compounds with (iso)flavonoid core and low-mol. weight phenolics. The optimization of the duty cycle enabled up to a 15-fold increase in analyte responses while the contribution of tuning ion optics and quadrupole profile was negligible. The limits of quantifications of our new method were assessed using both standard solutions and rat plasma. They were decreased at least 10 times for several low-mol. weight phenolics enabling measurement of their concentrations in a range of 1-50 ng/mL in rat plasma after protein precipitation Concurrently, the limits of quantifications for compounds with (iso)flavonoid core did not increase distinctly allowing their detection in a range of 0.5-10 ng/mL. The new method was used for the targeting of phenolics in biol. samples from pharmacokinetics experiments The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to plasma isoflavonoid phenolics lc ms pharmacokinetics, high-resolution mass spectrometry, low-molecular weight analytes, metabolites, phenolics, quadrupole-time-of-flight, Pharmacology: Methods and other aspects.HPLC of Formula: 621-37-4

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Ono, Kenjiro; Tsuji, Mayumi; Yamasaki, Tritia R.; Pasinetti, Giulio M. published an article in 2020, the title of the article was Anti-aggregation effects of phenolic compounds on 伪-synuclein.SDS of cas: 621-37-4 And the article contains the following content:

A review. The aggregation and deposition of 伪-synuclein (伪S) are major pathol. features of Parkinson’s disease, dementia with Lewy bodies, and other 伪-synucleinopathies. The propagation of 伪S pathol. in the brain plays a key role in the onset and progression of clin. phenotypes. Thus, there is increasing interest in developing strategies that attenuate 伪S aggregation and propagation. Based on cumulative evidence that 伪S oligomers are neurotoxic and critical species in the pathogenesis of 伪-synucleinopathies, we and other groups reported that phenolic compounds inhibit 伪S aggregation including oligomerization, thereby ameliorating 伪S oligomer-induced cellular and synaptic toxicities. Heterogeneity in gut microbiota may influence the efficacy of dietary polyphenol metabolism Our recent studies on the brain-penetrating polyphenolic acids 3-hydroxybenzoic acid (3-HBA), 3,4-dihydroxybenzoic acid (3,4-diHBA), and 3-hydroxyphenylacetic acid (3-HPPA), which are derived from gut microbiota-based metabolism of dietary polyphenols, demonstrated an in vitro ability to inhibit 伪S oligomerization and mediate aggregated 伪S-induced neurotoxicity. Addnl., 3-HPPA, 3,4-diHBA, 3-HBA, and 4-hydroxybenzoic acid significantly attenuated intracellular 伪S seeding aggregation in a cell-based system. This review focuses on recent research developments regarding neuroprotective properties, especially anti-伪S aggregation effects, of phenolic compounds and their metabolites by the gut microbiome, including our findings in the pathogenesis of 伪-synucleinopathies. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to review phenolics anti aggregation alpha synuclein neurotoxicity, parkinson鈥檚 disease, gut microbiome, phenolic compounds, 伪-synuclein, Toxicology: Reviews and other aspects.SDS of cas: 621-37-4

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