Category: 621-37-4

On June 30, 2020, Honorato de Castro, Ana Cristina; Alves, Livia Maria; Siquieroli, Ana Carolina Silva; Madurro, Joao Marcos; Brito-Madurro, Ana Graci published an article.Formula: C8H8O3 The title of the article was Label-free electrochemical immunosensor for detection of oncomarker CA125 in serum. And the article contained the following:

This paper reports the construction of a new electrochem. immunosensor for detection of oncomarker CA125 for diagnosis and monitoring of ovarian cancer. The platform was developed using screen-printed carbon electrodes modified with poly(3-hydroxyphenylacetic acid) and anti-CA125 as probe for evaluate the biomol. interactions (anti-CA125:CA125) onto the solid surface. Current response of the system has a linear relationship of anti-CA125 concentration in the range of 5 to 80 U mL-1 with a limit of detection of 1.45 U mL-1, discriminating between neg. and pos. serum. The immunosensor was successfully applied to determination of CA-125 in real biol. samples using differential pulse voltammetry (DPV), surface plasmon resonance (SPR) and at. force microscopy (AFM). The results showed the developed immunosensor is versatile, easily integrated to the point of care applications, being an interesting platform to ovarian cancer diagnose in complex samples. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3

The Article related to ovarian cancer serum oncomarker electrochem immunosensor, Biochemical Methods: Cytochemical and Histochemical and other aspects.Formula: C8H8O3

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Alcohols – Chemistry LibreTexts

On October 31, 2020, Muhialdin, Belal J.; Kadum, Hana; Fathallah, Salahaldin; Meor Hussin, Anis Shobirin published an article.Formula: C8H8O3 The title of the article was Metabolomics profiling and antibacterial activity of fermented ginger paste extends the shelf life of chicken meat. And the article contained the following:

Fermented ginger paste is a traditional condiment in South East Asia used to marinate meat to extend the shelf life and improve the taste. The present study aimed to determine the metabolomics profile of fermented ginger and the effects on the shelf life of chicken meat. Sterilized chicken meat slices were marinated using the fermented and fresh ginger paste and incubated at 8°C to determine the effects on the microbial growth. The bioactive metabolites were identified using 1H NMR based anal. The results demonstrated that fermentation significantly (p<0.05) increased the antibacterial activity of the ginger paste against Salmonella enterica serotype Typhimurium (97%), Listeria monocytogenes (97%) and Staphylococcus aureus (100%), with the microbial load significantly (p < 0.05) reducing to 4.0 and 4.5 Log10 CFU g-1 in the chicken meat slices marinated in fermented ginger. Fermented ginger paste significantly reduced the pH value, moisture content and water activity of chicken meat slices after the incubation for 2 days at 8°C. A total of 25 metabolites were identified in the fermented ginger paste. These results revealed the potential application of fermented ginger paste to enhance the safety of chicken meat via reducing the microbial load. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3

The Article related to chicken meat ginger paste metabolomics antibacterial activity, Food and Feed Chemistry: Meat, Eggs, Fish, and Seafood and other aspects.Formula: C8H8O3

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Alcohol – Wikipedia,
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On August 5, 2021, Li, Na; Mao, Weimin; Gao, Yun; Wang, Ding; Song, Zhengbo; Chen, Zhongjian published an article.Application In Synthesis of 3-Hydroxyphenylacetic acid The title of the article was Liquid chromatography-mass spectrometry based metabolic characterization of pleural effusion in patients with acquired EGFR-TKI resistance. And the article contained the following:

Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) acquired resistance remains a major barrier in the clin. treatment of lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations. Despite extensive efforts, mechanism of acquired resistance has not yet been elucidated clearly. The subject of this study was to characterize the metabolic signatures relevant to acquired EGFR-TKI resistance in pleural effusion (PE), and identify potential biomarkers in PE of patients with acquired EGFR-TKI resistance. PE from EGFR-TKI untreated group (n = 30) and EGFR-TKI resistant group (n = 18) was analyzed using liquid chromatog.-mass spectrometry (LC-MS) based metabolomic. Multivariate statistical anal. revealed distinctive diff ;erences between the groups. A total of 34 significantly differential metabolites in PE were identified, among which, the acquired EGFR-TKI resistant group had higher levels of L-lysine, taurine, ornithine and citrulline, and lower levels of L-tryptophan, kynurenine, L-phenylalanine, L-leucine, N-formyl-L-methionine, 3-hydroxyphenylacetic acid and N-acetyl-D-phenylalanine in PE than that of the EGFR-TKI untreated group. These metabolites are mainly involved in six amino acid metabolic pathways. In addition, 3-hydroxyphenylacetic acid and N-acetyl-D-phenylalanine showed the highest AUC values of 0.934 and 0.929 in receiver operating characteristic anal. Through LC-MS metabolomics, our study identified potential biomarkers in PE, differentiating EGFR-TKI resistant patients from untreated patients, as well as the mechanisms underlying acquired EGFR-TKI resistance; thus, providing novel insights into acquired EGFR-TKI resistance. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application In Synthesis of 3-Hydroxyphenylacetic acid

The Article related to egfr tki resistance liquid chromatog mass spectrometry pleural effusion, biomarker, egfr-tki, lung cancer, metabolomics, pleural effusion, resistance, Mammalian Pathological Biochemistry: Respiratory Diseases and other aspects.Application In Synthesis of 3-Hydroxyphenylacetic acid

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Taladrid, Diego; de Celis, Miguel; Belda, Ignacio; Bartolome, Begona; Moreno-Arribas, M. Victoria published an article in 2022, the title of the article was Hypertension- and glycaemia-lowering effects of a grape-pomace-derived seasoning in high-cardiovascular risk and healthy subjects. Interplay with the gut microbiome.Computed Properties of 621-37-4 And the article contains the following content:

Grape pomace (GP) is a winery byproduct rich in polyphenols and dietary fiber. Some recent results suggest that GP-derived extracts could be promising additives in food, specially recommended for low-salt diets. The hypothesis tested in this paper is that the regular consumption of GP-derived seasonings could help in the control of hypertension and glycemia. A randomized intervention study (6 wk) was performed in high-risk cardiovascular subjects (n = 17) and in healthy subjects (n = 12) that were randomly allocated into intervention (2 g day-1 of GP seasoning) or control (no seasoning consumed) groups. Blood samples, faeces, urine and blood pressure (BP) were taken at the baseline and at the end of the intervention. Faecal samples were analyzed for microbiota composition (16S rRNA gene sequencing) and microbial-derived metabolites (short chain fatty acids and phenolic metabolites). Among the clin. parameters studied, BP and fasting blood glucose significantly decreased (p < 0.05) after the seasoning intervention, but not for the control group. Notably, application of a novel approach based on ASV (Amplicon Sequence Variant) co-occurrence networks allowed us to identify some bacterial communities whose relative abundances were related with metadata. Our primary findings suggest that GP-seasoning may help in the modulation of cardiometabolic risk factors, mainly in the early stages. Furthermore, it evidences modulation of gut microbiota and functional bacterial communities by grape pomace, which might mediate the cardiometabolic effects of this byproduct. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Computed Properties of 621-37-4

The Article related to grape pomace cardiovascular risk hypertension glycemia gut microbiome human, Food and Feed Chemistry: Dairy Products (Including Butter) and other aspects.Computed Properties of 621-37-4

Referemce:
Alcohol – Wikipedia,
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On December 31, 2021, Yamauchi, Takafumi; Ochi, Daisuke; Matsukawa, Naomi; Saigusa, Daisuke; Ishikuro, Mami; Obara, Taku; Tsunemoto, Yoshiki; Kumatani, Satsuki; Yamashita, Riu; Tanabe, Osamu; Minegishi, Naoko; Koshiba, Seizo; Metoki, Hirohito; Kuriyama, Shinichi; Yaegashi, Nobuo; Yamamoto, Masayuki; Nagasaki, Masao; Hiyama, Satoshi; Sugawara, Junichi published an article.Safety of 3-Hydroxyphenylacetic acid The title of the article was Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis. And the article contained the following:

The elucidation of dynamic metabolomic changes during gestation is particularly important for the development of methods to evaluate pregnancy status or achieve earlier detection of pregnancy-related complications. Some studies have constructed models to evaluate pregnancy status and predict gestational age using omics data from blood biospecimens; however, less invasive methods are desired. Here we propose a model to predict gestational age, using urinary metabolite information. In our prospective cohort study, we collected 2741 urine samples from 187 healthy pregnant women, 23 patients with hypertensive disorders of pregnancy, and 14 patients with spontaneous preterm birth. Using gas chromatog.-tandem mass spectrometry, we identified 184 urinary metabolites that showed dynamic systematic changes in healthy pregnant women according to gestational age. A model to predict gestational age during normal pregnancy progression was constructed; the correlation coefficient between actual and predicted weeks of gestation was 0.86. The predicted gestational ages of cases with hypertensive disorders of pregnancy exhibited significant progression, compared with actual gestational ages. This is the first study to predict gestational age in normal and complicated pregnancies by using urinary metabolite information. Minimally invasive urinary metabolomics might facilitate changes in the prediction of gestational age in various clin. settings. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Safety of 3-Hydroxyphenylacetic acid

The Article related to pregnancy gestational age urinary metabolomic analysis machine learning approach, Biochemical Methods: Other (Not Covered At Other Subsections) and other aspects.Safety of 3-Hydroxyphenylacetic acid

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Alcohol – Wikipedia,
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On December 31, 2021, He, Zhen; Wu, Jinjie; Gong, Junli; Ke, Jia; Ding, Tao; Zhao, Wenjing; Cheng, Wai Ming; Luo, Zhanhao; He, Qilang; Zeng, Wanyi; Yu, Jing; Jiao, Na; Liu, Yanmin; Zheng, Bin; Dai, Lei; Zhi, Min; Wu, Xiaojian; Jobin, Christian; Lan, Ping published an article.HPLC of Formula: 621-37-4 The title of the article was Microbiota in mesenteric adipose tissue from Crohns disease promote colitis in mice. And the article contained the following:

Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat is a pathol. characteristic of Crohns disease (CD). The reserve of creeping fat in surgery is associated with poor prognosis of CD patients, but the mechanism remains unknown. Mesenteric microbiome, metabolome, and host transcriptome were characterized using a cohort of 48 patients with CD and 16 non-CD controls. Multidimensional data including 16S rRNA gene sequencing (16S rRNA), host RNA sequencing, and metabolome were integrated to reveal network interaction. Mesenteric resident bacteria were isolated from mAT and functionally investigated both in the dextran sulfate sodium (DSS) model and in the Il10 gene-deficient (Il10-/-) mouse colitis model to validate their pro-inflammatory roles. Mesenteric microbiota contributed to aberrant metabolites production and transcripts in mATs from patients with CD. The presence of mAT resident microbiota was associated with the development of CD. Achromobacter pulmonis (A. pulmonis) isolated from CD mAT could translocate to mAT and exacerbate both DSS-induced and Il10 gene-deficient (Il10-/-) spontaneous colitis in mice. The levels of A. pulmonis in both mAT and mucous layer from CD patients were higher compared to those from the non-CD group. This study suggests that the mesenteric microbiota from patients with CD sculpt a detrimental microenvironment and promote intestinal inflammation. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to microbiota mesenteric adipose tissue crohns disease promote colitis mice, bacterial translocation, crohn’s disease, mesenteric adipose tissue, microbiota, Mammalian Pathological Biochemistry: Digestive Tract Diseases and other aspects.HPLC of Formula: 621-37-4

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Alcohol – Wikipedia,
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On November 30, 2022, Sun, Xiaowei; Dey, Priyankar; Bruno, Richard S.; Zhu, Jiangjiang published an article.Product Details of 621-37-4 The title of the article was EGCG and catechin relative to green tea extract differentially modulate the gut microbial metabolome and liver metabolome to prevent obesity in mice fed a high-fat diet. And the article contained the following:

Green tea extract (GTE) alleviates obesity, in part, by modulating gut microbial composition and metabolism However, direct evidence regarding the catechin-specific bioactivities that are responsible for these benefits remain unclear. The present study therefore investigated dietary supplementation of GTE, epigallocatechin gallate (EGCG), or (+)-catechin (CAT) in male C57BL6/J mice that were fed a high-fat (HF) diet to establish the independent contributions of EGCG and CAT relative to GTE to restore microbial and host metabolism We hypothesized that EGCG would regulate the gut microbial metabolome and host liver metabolome more similar to GTE than CAT to explain their previously observed differential effects on cardiometabolic health. To test this, we assessed metabolic and phenolic shifts in liver and fecal samples during dietary HF-induced obesity. Ten fecal metabolites and ten liver metabolites (VIP > 2) primarily contributed to the differences in the metabolome among different interventions. In fecal samples, nine metabolic pathways (e.g., tricarboxcylic acid cycle and tyrosine metabolism) were differentially altered between the GTE and CAT interventions, whereas three pathways differed between GTE and EGCG interventions, suggesting differential benefits of GTE and its distinctive bioactive components on gut microbial metabolism Likewise, hepatic glycolysis / gluconeogenesis metabolic pathways were significantly altered between GTE and EGCG interventions, while only hepatic tyrosine metabolism was altered between CAT and GTE interventions. Thus, our findings support that purified catechins relative to GTE uniquely contribute to regulating host and microbial metabolic pathways such as central energy metabolism to protect against metabolic dysfunction leading to obesity. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Product Details of 621-37-4

The Article related to epigallocatechin gallate catechin green tea extract liver microbial metabolome, cat, egcg, gte intervention, metabolic regulation, metabolomics, obesity, Animal Nutrition: Nonnutrient Growth and Metabolic Stimulants and other aspects.Product Details of 621-37-4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 1, 2021, Yuan, Bo; Zhao, Danyue; Lyu, Weiting; Yin, Zhiya; Kshatriya, Dushyant; Simon, James E.; Bello, Nicholas T.; Wu, Qingli published an article.COA of Formula: C8H8O3 The title of the article was Development and validation of a micro-QuEChERS method with high-throughput enhanced matrix removal followed with UHPLC-QqQ-MS/MS for analysis of raspberry ketone-related phenolic compounds in adipose tissues. And the article contained the following:

Raspberry ketone (RK) is a major flavor compound in red raspberries, and it has been marketed as a popular weight-loss dietary supplement with high potential in accumulating in fatty tissues. However, challenges in extracting and characterizing RK and its associated phenolic compounds in fatty tissues persist due to the complex matrix effect. In this work, we reported a high-throughput sample preparation method for RK and 25 related phenolic compounds in white adipose tissues using an improved micro-scale QuEChERS (quick, efficient, cheap, easy, rugged and safe) approach with enhanced matrix removal (EMR)-lipid cleanup in 96-well plates, followed by UHPLC-QqQ-MS/MS anal. The absolute recovery was 73-105% at the extraction step, and achieved 71-96% at the EMR cleanup step. The EMR cleanup removed around 66% of total lipids in the acetonitrile extract as profiled by UHPLC-QTOF-MS/MS. The innovative introduction of a reversed-phase C18 sorbent into the extract significantly improved the analytes’ recovery during SpeedVac drying. The final accuracy achieved 80-120% for most analytes. Overall, this newly developed and validated method could serve as a powerful tool for analyzing RK and related phenolic compounds in fatty tissues. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).COA of Formula: C8H8O3

The Article related to rubus adipose tissue ketone quechers uhplc qqq ms, bioavailability, fatty tissue, lipid removal, raspberry ketone, solid phase extraction, uhplc-qqq-ms/ms, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.COA of Formula: C8H8O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 1, 2020, Wang, Yanling; Berhow, Mark A.; Black, Molly; Jeffery, Elizabeth H. published an article.Application of 621-37-4 The title of the article was A comparison of the absorption and metabolism of the major quercetin in brassica, quercetin-3-O-sophoroside, to that of quercetin aglycone, in rats. And the article contained the following:

Although flavonoid sophorosides are common glycosides in brassica vegetables, red raspberries and other food plants, there is a lack of studies of absorption and metabolism of any sophoroside. The aim of this study was to characterize the absorption, phase II metabolism and microbial catabolism of quercetin-3-O-sophoroside, compared to that of quercetin aglycon. Quercetin-3-O-sophoroside was purified from Apocynum venetum and characterized by MS2, 1H and 13C NMR. Using an in situ rat gut model, we found intact, methylated, sulfated and both methylated and sulfated quercetin sophoroside in the plasma following jejunal introduction of the sophoroside; we found derivatives of benzoic acid, phenylacetic acid, and Ph propionic acid in the cecal contents following cecal introduction. This novel finding, that quercetin sophoroside was absorbed intact, without deglycosylation, points to a possible role for the terminal sugar and/or the type of linkage among glycosidic moieties in the mechanism of absorption of flavonoid glycosides. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application of 621-37-4

The Article related to quercetin sophoroside aglycon absorption metabolism intestine, flavonol absorption, metabolism, microbial catabolism, quercetin sophoroside, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Application of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 1, 2022, Pitcher, Noel P.; Harjani, Jitendra R.; Zhao, Yichao; Jin, Jianwen; Knight, Daniel R.; Li, Lucy; Putsathit, Papanin; Riley, Thomas V.; Carter, Glen P.; Baell, Jonathan B. published an article.Related Products of 621-37-4 The title of the article was Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract. And the article contained the following:

Colonization of the gastrointestinal (GI) tract with pathogenic bacteria is an important risk factor for the development of certain potentially severe and life-threatening healthcare-associated infections, yet efforts to develop effective decolonization agents have been largely unsuccessful thus far. Herein, we report modification of the 1,2,4-oxadiazole class of antimicrobial compounds with poorly permeable functional groups in order to target bacterial pathogens within the GI tract. We have identified that the quaternary ammonium functionality of analog 26a (I) results in complete impermeability in Caco-2 cell monolayers while retaining activity against GI pathogens Clostridioides difficile and multidrug-resistant (MDR) Enterococcus faecium. Low compound recovery levels after oral administration in rats were observed, which suggests that the analogs may be susceptible to degradation or metabolism within the gut, highlighting a key area for optimization in future efforts. This study demonstrates that modified analogs of the 1,2,4-oxadiazole class may be potential leads for further development of colon-targeted antimicrobial agents. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4

The Article related to gastrointestinal tract antimicrobial quaternary ammonium clostridioides mdr enterococcus oxadiazole, Pharmacology: Effects Of Gastrointestinal and Respiratory Drugs and other aspects.Related Products of 621-37-4

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