Category: 621-37-4

On March 31, 2022, Pozo-Martinez, Josue; Salgado, Francisco; Liempi, Ana; Kemmerling, Ulrike; Mera-Adasme, Raul; Olea-Azar, Claudio; Moncada-Basualto, Mauricio; Borges, Fernanda; Uriarte, Eugenio; Matos, Maria Joao published an article.SDS of cas: 621-37-4 The title of the article was Synthesis and study of the trypanocidal activity of catechol-containing 3-arylcoumarins, inclusion in β-cyclodextrin complexes and combination with benznidazole. And the article contained the following:

American trypanosomiasis or Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and is considered a neglected disease, being an important problem for public health. Benznidazole (BZN) is the drug used to treat the disease. However, it has limited efficacy and adverse side effects. Therefore, the development of new therapeutic alternatives is necessary. In this work, the trypanocidal activity and cytotoxicity of a series of catechol-containing 3-arylcoumarins, their combination with BZN, and the inclusion in β-cyclodextrins (β-CDs), were evaluated. The results obtained showed that the entire series has moderate trypanocidal activity on the trypomastigote form of the parasite, being the 3-(4′-bromophenyl)-6,7-dihydroxycoumarin (8) the most active compound (IC50 = 34 μM) and the most cytotoxic in Vero cells (IC50 = 162 μM) as well. By forming the inclusion complex 8-β-CDs, the trypanocidal activity and cytotoxicity decreased. In addition, the formation of inclusion complexes increased the solubility The possible mechanism of action of 8 was evaluated and proved to be through the generation of oxidative stress. The combination with BZN presented a synergistic effect on the trypanocidal activity, reducing the necessary dose of BZN. The presence of a catechol in the studied scaffold seems to modulate the trypanocidal activity, and the combination of drugs proved to be a promising alternative strategy for treating the disease. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to benznidazole trypanocidal activity catechol arylcoumarin beta cyclodextrin complex, Placeholder for records without volume info and other aspects.SDS of cas: 621-37-4

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Mohamedshah, Zulfiqar; Hayes, Micaela; Chadwick-Corbin, Sydney; Neilson, Andrew P.; Ferruzzi, Mario G. published an article in 2022, the title of the article was Bioaccessibility, gut microbial metabolism and intestinal transport of phenolics from 100% Concord grape juice and whole grapes are similar in a simulated digestion and fecal fermentation model.Recommanded Product: 3-Hydroxyphenylacetic acid And the article contains the following content:

Phenolic rich 100% grape juice has been associated with many health benefits, but its place in dietary guidance is controversial relative to whole fruit. Direct comparisons of phenolic profiles and bioavailability between these food forms are needed. Phenolic bioaccessibility and metabolism from Concord (CG) and Niagara (NG) grapes and corresponding 100% juices were investigated using an in vitro digestion coupled with anaerobic gut fermentation model. Intestinal transport of resulting bioaccessible phenolics and microbial metabolites was estimated using a Caco-2 cell model. Total bioaccessible phenolics from both upper and lower digestion were similar (P > 0.05) between NG (400.9 ± 26.3 μmol per 100 g) and NGJ (349.5 ± 8.3 μmol per 100 g) and significantly different (P < 0.05) between CG (417.2 ± 24.4 μmol per 100 g) and CGJ (294.3 ± 45.4 μmol per 100 g) total cellular transport of phenolics was similar (P > 0.05) between whole grapes (89.4 ± 5.3 μmol per 100 g for CG, and 71.8 ± 2.4 μmol per 100 g for NG) and 100% juices (88.0 ± 5.6 μmol per 100 g for CGJ, and 85.3 ± 9.4 μmol per 100 g for NGJ). Differences were observed between the location of phenolic metabolism, bioaccessibility and subsequent cellular transport of individual phenolics between grapes and juice matrixes. Specifically, greater amounts of phenolics were transported from grape juices than whole grapes from the upper tract. However, cumulative bioaccessibility and transport from upper and lower GI digestion/fermentation together indicates that the absorbable phenolics from 100% grape juice is similar to that of whole grapes, suggesting that phenolic-mediated health benefits from consumption of whole fruit and juice may be similar. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Recommanded Product: 3-Hydroxyphenylacetic acid

The Article related to grape juice phenolics digestion fecal fermentation bioaccessibility gut microbiota, Placeholder for records without volume info and other aspects.Recommanded Product: 3-Hydroxyphenylacetic acid

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On February 25, 2021, Li, Zhuo; Wang, Bing; Cui, Guo-Yi; Zhang, Bing-Bing; Wang, Ya-Fei; Yang, Lin; Ma, Hai-Xia; Jiao, Lin-Yu; Pang, Ling-Yan; Ma, Xiao-Xun published an article.Formula: C8H8O3 The title of the article was Construction of novel trimeric π-interaction subphthalocyanine-sensitized titanium dioxide for highly efficient photocatalytic degradation of organic pollutants. And the article contained the following:

In this study, highly active TiO2 sensitized by a novel axial substituted subphthalocyanine H12SubPcB-OPHCH2COOH (SubPc-3) was successfully prepared via a solvothermal method. Based on the crystallog. strategy, a new packing motif of SubPc-3 consisting of ligand-convex concave-concave head-head π-interaction was discovered for the first time, which affected its catalytic performance significantly. Furthermore, the DFT and TD-DFT methods were used to study the electronic feature and excited-state properties in SubPc-3 utilizing an optimized structure. By examining the degradation of methyl orange (MO) and bromophenol blue (BB) under visible light, the photocatalytic activities of the nanocomposites were investigated. The photocatalytic degradation rate of MO and BB degradation with TiO2/SubPc-3 are 97.8% and 99.5%, which are approx. 5.26 and 1.41 times compared to pure TiO2, resp. Besides, the reusability studies indicated that the photocatalytic activity of TiO2/SubPc-3 (25:1) could be maintained above 90.1% after five circulating photo-degradation This work revealed the correlation between π-interaction of sensitizer and photocatalytic performance, as well as further confirmed the great potential of TiO2/SubPc-3 photocatalytic materials in environmental remediation. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3

The Article related to trimeric interaction subphthalocyanine sensitized titanium dioxide photocatalyst, Placeholder for records without volume info and other aspects.Formula: C8H8O3

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Beale, David J.; Shah, Rohan; Karpe, Avinash V.; Hillyer, Katie E.; McAuley, Alexander J.; Au, Gough G.; Marsh, Glenn A.; Vasan, Seshadri S. published an article in 2021, the title of the article was Metabolic profiling from an asymptomatic ferret model of SARS-CoV-2 infection.HPLC of Formula: 621-37-4 And the article contains the following content:

Coronavirus disease (COVID-19) is a contagious respiratory disease that is causing significant global morbidity and mortality. Understanding the impact of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection on the host metabolism is still in its infancy but of great importance. Herein, we investigated the metabolic response during viral shedding and post-shedding in an asymptomatic SARS-CoV-2 ferret model (n = 6) challenged with two SARS-CoV-2 isolates. Virol. and metabolic analyses were performed on (minimally invasive) collected oral swabs, rectal swabs, and nasal washes. Fragments of SARS-CoV-2 RNA were only found in the nasal wash samples in four of the six ferrets, and in the samples collected 3 to 9 days post-infection (referred to as viral shedding). Central carbon metabolism metabolites were analyzed during viral shedding and post-shedding periods using a dynamic Multiple Reaction Monitoring (dMRM) database and method. Subsequent untargeted metabolomics and lipidomics of the same samples were performed using a Liquid Chromatog. Quadrupole Time-of-Flight Mass Spectrometry (LC-QToF-MS) methodol., building upon the identified differentiated central carbon metabolism metabolites. Multivariate anal. of the acquired data identified 29 significant metabolites and three lipids that were subjected to pathway enrichment and impact anal. The presence of viral shedding coincided with the challenge dose administered and significant changes in the citric acid cycle, purine metabolism, and pentose phosphate pathways, amongst others, in the host nasal wash samples. An elevated immune response in the host was also observed between the two isolates studied. These results support other metabolomic-based findings in clin. observational studies and indicate the utility of metabolomics applied to ferrets for further COVID-19 research that advances early diagnosis of asymptomatic and mild clin. COVID-19 infections, in addition to assessing the effectiveness of new or repurposed drug therapies. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to covid 19 asymptomatic metabolomics viral shedding, covid-19, sars-cov-2, animal model, ferret, lipidomics, metabolomics, systems biology, Placeholder for records without volume info and other aspects.HPLC of Formula: 621-37-4

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On March 15, 2022, Iio, Keita; Saitoh, Tsuyoshi; Ohshita, Ryuichiro; Hino, Tsubasa; Amezawa, Mao; Takayama, Yoshiaki; Nagumo, Yasuyuki; Yamamoto, Naoshi; Kutsumura, Noriki; Irukayama-Tomobe, Yoko; Ishikawa, Yukiko; Tanimura, Ryuji; Yanagisawa, Masashi; Nagase, Hiroshi published an article.Application In Synthesis of 3-Hydroxyphenylacetic acid The title of the article was Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring. And the article contained the following:

A novel series of 1-amino-tetralin derivatives were designed and synthesized based on the putative binding mode of the naphthalene-type orexin receptor agonist 5 and their agonist activities against orexin receptors were evaluated. The introduction of N-methyl-(3-methoxyphenyl)acetamide unit onto the 1-amino-tetralin skeleton remarkably enhanced the potency of the agonist. The asym. synthesis of 6 revealed that (-)-6 having a (S)-1-amino-tetralin skeleton showed a OX2R selective agonist activity (EC50 = 2.69 nM for OX2R, OX1R/OX2R = 461) yet its enantiomer (R)-(+)-6 showed a potent OX1/2R dual agonist activity (EC50 = 13.5 nM for OX1R, 0.579 nM for OX2R, OX1R/OX2R = 23.3). These results suggested that upward orientation of the amide side chain against the tetralin scaffold (S-configuration) would be selective for OX2R activation, and the downward orientation (R-configuration) would be significant for dual agonist activity. To our best knowledge, there have been no reports thus far that the stereochem. of one carbon center on the agonist structure regulates the orexin receptor selectivity. Our results would provide important information for the development of OX1R selective agonists. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application In Synthesis of 3-Hydroxyphenylacetic acid

The Article related to orexin 2 receptor agonists chirality structure activity, agonist, diarylsulfonamide, ox1r, ox2r, orexin, orexin receptor, tetraline, Placeholder for records without volume info and other aspects.Application In Synthesis of 3-Hydroxyphenylacetic acid

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On January 1, 2022, Hillyer, Katie E.; Raes, Eric; Karsh, Kristen; Holmes, Bronwyn; Bissett, Andrew; Beale, David J. published an article.Quality Control of 3-Hydroxyphenylacetic acid The title of the article was Metabolomics as a tool for in situ study of chronic metal exposure in estuarine invertebrates. And the article contained the following:

Estuaries are subject to intense human use globally, with impacts from multiple stressors, such as metal contaminants. A key challenge is extending beyond traditional monitoring approaches to understand effects to biota and system function. To explore the metabolic effects of complex metal contaminants to sediment dwelling (benthic) fauna, we apply a multiple-lines-of-evidence approach, coupling environmental monitoring, benthic sampling, total metals anal. and targeted metabolomics. We characterize metabolic signatures of metal exposure in three benthic invertebrate taxa, which differed in distribution across sites and severity of metal exposure: sipunculid (very high), amphipod (high), maldanid polychaete (moderate). We observed sediment and tissue metal loads far exceeding sediment guidelines where toxicity-related adverse effects may be expected, for metals including, As, Cd, Pb, Zn and Hg. Change in site- and taxa-specific metabolite profiles was highly correlated with natural environmental drivers (sediment total organic carbon and water temperature). At the most metal influenced sites, metabolite variation was also correlated with sediment metal loads. Using supervised multivariate regression, taxa-specific metabolic signatures of increased exposure and possibility of toxic effects were characterised against multiple reference sites. Metabolic signatures varied according to each taxon and degree of metal exposure, but primarily indicated altered cysteine and methionine metabolism, metal-binding and elimination (lysosomal) activity, coupled to change in complex biosynthesis pathways, responses to oxidative stress, and cellular damage. This novel multiple-lines-of-evidence approach combining metabolomics with traditional environmental monitoring, enabled detection and characterization of chronic metal exposure effects in situ in multiple invertebrate taxa. With capacity for application to rapid and effective monitoring of non-model species in complex environments, these approaches are critical for improved assessment and management of systems that are increasingly subject to anthropogenic drivers of change. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Quality Control of 3-Hydroxyphenylacetic acid

The Article related to metal contaminant metabolomics estuarine invertebrate, bioavailability, bioindicator, contaminant, metabolomics, toxicity, zinc, Placeholder for records without volume info and other aspects.Quality Control of 3-Hydroxyphenylacetic acid

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On January 31, 2022, Jaskiw, George E.; Xu, Dongyan; Obrenovich, Mark E.; Donskey, Curtis J. published an article.Synthetic Route of 621-37-4 The title of the article was Small phenolic and indolic gut-dependent molecules in the primate central nervous system: levels vs. bioactivity. And the article contained the following:

Rapidly growing body of data documents associations between disease of the brain and small mols. generated by gut-microbiota (GMB). While such metabolites can affect brain function through a variety of mechanisms, the most direct action would be on the central nervous system (CNS) itself. Identify indolic and phenolic GMB-dependent small mols. that reach bioactive concentrations in primate CNS. We conducted a PubMed search for metabolomic studies of the primate CNS [brain tissue or cerebrospinal fluid (CSF)] and then selected for phenolic or indolic metabolites that (i) had been quantified, (ii) were GMB-dependent. For each chem. we then conducted a search for studies of bioactivity conducted in vitro in human cells of any kind or in CNS cells from the mouse or rat. 36 metabolites of interests were identified in primate CNS through targeted metabolomics. Quantification was available for 31/36 and in vitro bioactivity for 23/36. The reported CNS range for 8 metabolites 2-(3-hydroxyphenyl)acetic acid, 2-(4-hydroxyphenyl)acetic acid, 3-(3-hydroxyphenyl)propanoic acid, (E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid [caffeic acid], 3-hydroxybenzoic acid, 4-hydroxybenzoic acid, 2-acetamido-3-(1H-indol-3-yl)propanoic acid [N-acetyltryptophan], 1H-indol-3-yl hydrogen sulfate [indoxyl-3-sulfate] overlapped with a bioactive concentration However, the number and quality of relevant studies of CNS neurochem. as well as of bioactivity were highly limited. Structural isomers, multiple metabolites and potential confounders were inadequately considered. The potential direct bioactivity of GMB-derived indolic and phenolic mols. on primate CNS remains largely unknown. The field requires addnl. strategies to identify and prioritize screening of the most promising small mols. that enter the CNS. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Synthetic Route of 621-37-4

The Article related to phenol indole central nervous system, bioactivity, brain, cerebrospinal fluid, gut microbiota, indolic, neuroactivity, phenolic, Placeholder for records without volume info and other aspects.Synthetic Route of 621-37-4

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On May 31, 2021, van den Berg, Fons F.; van Dalen, Demi; Hyoju, Sanjiv K.; van Santvoort, Hjalmar C.; Besselink, Marc G.; Wiersinga, Willem Joost; Zaborina, Olga; Boermeester, Marja A.; Alverdy, John published an article.Category: alcohols-buliding-blocks The title of the article was Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate. And the article contained the following:

The gut microbiota are the main source of infections in necrotising pancreatitis. We investigated the effect of disruption of the intestinal microbiota by a Western-type diet on mortality and bacterial dissemination in necrotising pancreatitis and its reversal by butyrate supplementation. C57BL/6 mice were fed either standard chow or a Western-type diet for 4 wk and were then subjected to taurocholate-induced necrotising pancreatitis. Blood and pancreas were collected for bacteriol. and immune anal. The cecum microbiota composition of mice was analyzed using 16S rRNA gene amplicon sequencing and cecal content metabolites were analyzed by targeted (ie, butyrate) and untargeted metabolomics. Prevention of necrotising pancreatitis in this model was compared between faecal microbiota transplantation (FMT) from healthy mice, antibiotic decontamination against Gram-neg. bacteria and oral or systemic butyrate administration. Addnl., the faecal microbiota of patients with pancreatitis and healthy subjects were analyzed. Mortality, systemic inflammation and bacterial dissemination were increased in mice fed Western diet and their gut microbiota were characterised by a loss of diversity, a bloom of Escherichia coli and an altered metabolic profile with butyrate depletion. While antibiotic decontamination decreased mortality, Gram-pos. dissemination was increased. Both oral and systemic butyrate supplementation decreased mortality, bacterial dissemination, and reversed the microbiota alterations. Paradoxically, mortality and bacterial dissemination were increased with FMT administration. Finally, patients with acute pancreatitis demonstrated an increase in Proteobacteria and a decrease of butyrate producers compared with healthy subjects. Butyrate depletion and its repletion appear to play a central role in disease progression towards necrotising pancreatitis. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks

The Article related to necrotising pancreatitis mortality microbiota butyrate, acute pancreatitis, antibiotics, bacterial infection, butyrate, diet, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

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On August 1, 2022, Macia, Alba; Romero, Maria-Paz; Yuste, Silvia; Ludwig, Iziar; Pedret, Anna; Valls, Rosa Maria; Salamanca, Patricia; Sola, Rosa; Jose Motilva, Maria; Rubio, Laura published an article.HPLC of Formula: 621-37-4 The title of the article was Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study. And the article contained the following:

The present study aimed to evaluate the metabolism and bioavailability of anthocyanins (ACN) and other phenolics from red-fleshed apple (RFA) and to define the intake biomarkers compared to common white-fleshed apple (WFA). Acute and sustained (6-wk) interventions were combined in a randomized, controlled and parallel study with 121 hypercholesterolemic subjects. Another arm consuming ACN-rich infusion from aronia fruit (ARO) provided matched content and profile of ACN. Plasma, urine and faeces samples were analyzed using UPLC-MS/MS. Results showed higher bioavailability of ACN after ARO compared to RFA, showing a clear apple matrix effect. The dihydrochalcone phloretin-2′-O-glucuronide was the most discriminant intake biomarker of both apples. The urinary peonidin-3-O-galactoside was a good biomarker after both ARO and RFA intakes, whereas peonidin-O-arabinoside was reported to be specific from ARO. The elucidation of the phenolic metabolism and the selection of intake biomarkers is a promising approach to relate phenolic compounds and human health. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to malus phenol metabolic fingerprint biomarker, anthocyanins, intake biomarkers, metabolism, red-fleshed apple, uplc-ms/ms, Placeholder for records without volume info and other aspects.HPLC of Formula: 621-37-4

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Pourafshar, Shirin; Nicchitta, Mira; Tyson, Crystal C.; Svetkey, Laura P.; Corcoran, David L.; Bain, James R.; Muehlbauer, Michael J.; Ilkayeva, Olga; O’Connell, Thomas M.; Lin, Pao-Hwa; Scialla, Julia J. published an article in 2021, the title of the article was Urine and plasma metabolome of healthy adults consuming the DASH (dietary approaches to stop hypertension) diet: a randomized pilot feeding study.Reference of 3-Hydroxyphenylacetic acid And the article contains the following content:

We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc anal. of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 wk of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatog./mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Reference of 3-Hydroxyphenylacetic acid

The Article related to feeding urine phenolic acid plasma metabolome hypertension, dash, blood pressure, metabolomics, nutrition, polyphenols, Placeholder for records without volume info and other aspects.Reference of 3-Hydroxyphenylacetic acid

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