Category: 621-37-4

Pereira-Caro, Gema; Gaillet, Sylvie; Ordonez, Jose Luis; Mena, Pedro; Bresciani, Letizia; Bindon, Keren A.; Del Rio, Daniele; Rouanet, Jean-Max; Moreno-Rojas, Jose Manuel; Crozier, Alan published an article in 2020, the title of the article was Bioavailability of red wine and grape seed proanthocyanidins in rats.Application of 621-37-4 And the article contains the following content:

This study explored plasma levels and urinary and fecal excretion of metabolites and microbial-derived catabolites over a 24 h period following the ingestion of red wine (RWP) or grape seed (GSP) proanthocyanidin-rich extracts by rats. In total, 35 structurally-related (epi)catechin metabolites (SREMs) and 5-carbon side chain ring fission metabolites (5C-RFMs) (phenyl-γ-valerolactones and phenylvaleric acids), and 50 phenolic acid and aromatic catabolites were detected after intakes of both extracts The consumption of the RWP extract, but not the GSP extract, led to the appearance of a ∼200 nmol L-1 peak plasma concentration of SREMs formed from flavan-3-ol monomers. In contrast, ingestion of the GSPs, but not the RWPs, resulted in a substantial increase in microbiota-derived 5-carbon side chain ring fission metabolites (5C-RFMs) in plasma. 5C-RFMs, along with low mol. weight phenolic catabolites were detected in urine after ingestion of both extracts The GSP and RWP extracts had resp. mean degrees of polymerization 5.9 and 6.5 subunits, and the RWP extract had an upper polymer size of 21 subunits compared to 44 subunits for the GSP extract The differences in plasma metabolite profiles might, therefore, be a consequence of this polydispersity impacting on the microbiota-mediated rates of cleavage of the proanthocyanidin subunits and their subsequent metabolism and absorption. Urinary excretion of phenolic catabolites indicated that 11% of RWPs and 7% for GSPs were subjected to microbial degradation In all probability these figures, rather than representing the percentage of proanthocyanidins that are completely degraded, indicate partial cleavage of monomer subunits producing a much higher percentage of shortened proanthocyanidin chains. Obtaining more detailed information on the in vivo fate of proanthocyanidins is challenging because of the difficulties in analyzing unabsorbed parent proanthocyanidins and their partially degraded flavan-3-ol subunit chains in feces. Further progress awaits the development of improved purification and anal. techniques for proanthocyanidins and their use in feeding studies, and in vitro fecal and bacterial incubations, with radio and/or stable isotope-labeled substrates. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application of 621-37-4

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On June 15, 2022, Armbruster, Michael R.; Grady, Scott F.; Arnatt, Christopher K.; Edwards, James L. published an article.Quality Control of 3-Hydroxyphenylacetic acid The title of the article was Isobaric 4-Plex Tagging for Absolute Quantitation of Biological Acids in Diabetic Urine Using Capillary LC-MS/MS. And the article contained the following:

Isobaric labeling in mass spectrometry enables multiplexed absolute quantitation and high throughput, while minimizing full scan spectral complexity. Here, we use 4-plex isobaric labeling with a fixed pos. charge tag to improve quantitation and throughput for polar carboxylic acid metabolites. The isobaric tag uses an isotope-encoded neutral loss to create mass-dependent reporters spaced 2 Da apart and was validated for both single- and double-tagged analytes. Tags were synthesized inhouse using deuterated formaldehyde and Me iodide in a total of four steps, producing cost-effective multiplexing. No chromatog. deuterium shifts were observed for single- or double-tagged analytes, producing consistent reporter ratios across each peak. Perfluoropentanoic acid was added to the sample to drastically increase retention of double-tagged analytes on a C18 column. Excess tag was scavenged and extracted using hexadecyl chloroformate after reaction completion. This allowed for removal of excess tag that typically causes ion suppression and column overloading. A total of 54 organic acids were investigated, producing an average linearity of 0.993, retention time relative standard deviation (RSD) of 0.58%, and intensity RSD of 12.1%. This method was used for absolute quantitation of acid metabolites comparing control and type 1 diabetic urine. Absolute quantitation of organic acids was achieved by using one isobaric lane for standards, thereby allowing for anal. of six urine samples in two injections. Quantified acids showed good agreement with previous work, and six significant changes were found. Overall, this method demonstrated 4-plex absolute quantitation of acids in a complex biol. sample. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Quality Control of 3-Hydroxyphenylacetic acid

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On October 31, 2021, Yang, Jing; Hao, Yuxin; Li, Nana; Wang, Chunyu; Liu, Yongping published an article.Application In Synthesis of 3-Hydroxyphenylacetic acid The title of the article was Metabolic and microbial modulation of phenolic compounds from raspberry leaf extract under in vitro digestion and fermentation. And the article contained the following:

Raspberry leaves, byproducts in raspberry production, are also a rich source of bioactive phytochems. In this study, the changes of phenolic compounds in raspberries leaf extract (RLE) under in vitro digestion and colonic fermentation were further studied by HPLC-MS anal. and 16S rRNA. The results showed that the phenolic compounds in RLE were relatively stable during in vitro gastric digestion; however, in the subsequent intestinal digestion and colonic fermentation, their content decreased sharply. A large amount of hydroxyphenylpropionic acid, hydroxyphenylacetic acid and urolithins were produced under the action of gut microbiota. Moreover, compared with corresponding control, RLE significantly reduced the ratio of Firmicutes/Bacteroidetes in all volunteers, increased the relative abundances of some beneficial bacteria, Enterococcus, Prevotella, and decreased the relative abundances of potential pathogens, Clostridium and Faecalibacterium. These findings suggest that RLE during in vitro digestion and fermentation has pos. effects on gut microbiota and potential value of maintaining intestinal health. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application In Synthesis of 3-Hydroxyphenylacetic acid

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Mohammadifarani, Ahmad; Mousavi, Hosna Sadat Zamani; Hosseini, Amin; Aliabadi, Alireza published an article in 2020, the title of the article was Synthesis and cytotoxicity evaluation of N-(5-mercapto-4H-1,2,4-triazol3-yl)-2-phenylacetamide derivatives as apoptosis inducers with potential anticancer effects.Related Products of 621-37-4 And the article contains the following content:

Discovery of new anticancer drugs is one of the urgent issues in the medicinal chem. researches. Incidence of severe side effects and acquired resistance to the current medications are the logical reasons for the development of novel antineoplastic agents. Herein, a new series of 4H-1,2,4-triazole derivatives was synthesized and subsequently their cytotoxicity was assessed using dimethylthiazol diphenyltetrazolium bromide assay. Furthermore, activity of caspase 3, mitochondrial membrane potential (MMP), and generation of reactive oxygen species (ROS) were investigated. All synthesized derivatives (3a-3o) were tested against Hela (cervical cancer), A549 (lung carcinoma), and U87 (glioblastoma), and the obtained data were compared with doxorubicin. Among the chlorinated derivatives, compound 3c with para positioning of the chlorine on the Ph residue possessed higher cytotoxicity (IC50 = s3.2 ± 0.6 μM) than compounds 3a and 3b, which positioned chlorine at ortho and meta position, resp. Chlorine as electron-withdrawing moiety caused enhancement in cytotoxicity. Fortunately, most of the tested compounds showed remarkable cytotoxic activity toward applied cells, especially Hela. Activation of caspase 3, MMP reduction, and ROS generation were also observed for the studied compounds The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4

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On March 31, 2022, Luo, Ming; Li, Aixin; Wang, Feiqi; Jiang, Junfeng; Wang, Zhengbiao; You, Jiangfeng published an article.COA of Formula: C8H8O3 The title of the article was Integrative analysis of multiple metabolomes and transcriptome revealed color expression mechanism in red skin root syndrome of Panax ginseng. And the article contained the following:

Red skin root syndrome causes reduction of both production and quality of Panax ginseng (ginseng). However, its development process and key metabolites are still unknown. Multiple metabolomes including non-targeted metabolome, and anthocyanins-targeted and carotenoids-targeted metabolomes were performed on field grown red skin and healthy ginseng. The detected metabolites were analyzed in combination with previous transcriptome results. The total metabolite profiles revealed that primary metabolites especially citrate was decreased, but secondary metabolites mainly involved in phenylpropanoid pathway were increased in red skin ginseng compared to those in healthy ginseng. Targeted metabolome found that each gram of fresh red skin ginseng sample contained 8 μg β-carotene, 0.56 μg α-carotene, 0.017 μg rutin, 0.248 μg chalcone, and some anthocyanins including 0.023 μg cyanidin and 0.037 μg quercetin 3-O-glucoside, albeit in low concentrations but higher than those in healthy ginseng. Furthermore, integrative metabolome and transcriptome anal. revealed that changes of metabolites related to anthocyanins synthesis were correlated with the related gene expression patterns. Addnl., jasmonate (JA) and its precursor 12-oxophytodienoic acid increased their concentrations dramatically in red skin ginseng, suggesting the possible role of JA or JA signaling pathway in regulating red skin syndrome. Consistently, the expressions of 17 MYB transcription factors were differentially regulated in red skin ginseng. JA related cis-elements are widely distributed at their promoters. Taken together, our study revealed reduction of primary metabolism but increase of secondary metabolism in red skin ginseng. MYB transcription factors of JA signal pathway were supposed to mediate accumulation of anthocyanins and carotenoids that contributed to the development of red skin ginseng. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).COA of Formula: C8H8O3

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Seguido, Miguel Angel; Tarradas, Rosa Maria; Gonzalez-Ramila, Susana; Garcia-Cordero, Joaquin; Sarria, Beatriz; Bravo-Clemente, Laura; Mateos, Raquel published an article in 2022, the title of the article was Influence of 8-week daily consumption of a new product combining green coffee hydroxycinnamates and beta-glucans on polyphenol bioavailability in subjects with overweight and obesity.Recommanded Product: 621-37-4 And the article contains the following content:

Nutraceuticals based on plant extracts rich in polyphenols, as well as dietary fibers, are new means to fight overweight/obesity and associated diseases. However, to understand the potential effects of polyphenols on health it is critical to study their bioavailability and metabolic fate. Consumption of a green coffee phenolic extract (GCPE) in combination with oat beta-glucan (BG) could affect the pharmacokinetic profile of the main polyphenols present in coffee (hydroxycinnamates). Moreover, the regular intake of the combination could also induce changes. Nine overweight men and women consumed a novel nutraceutical product containing 300 mg of green coffee hydroxycinnamic acids and 2.5 g of BG twice a day for 8 wk. A pharmacokinetic study was carried out in blood and urine samples taken before (baseline) and at week 8 after the nutraceutical intervention, collecting samples at different times in a 0-24 h interval. Faecal samples were also obtained at 0 and 24 h after the intake of the nutraceutical at baseline and week 8. Phenolic metabolites were analyzed by LC-MS-QToF. Results showed that polyphenols were differentially absorbed and extensively metabolized throughout the gastrointestinal tract. An apparent reduction in the excretion of small intestinal metabolites was accompanied by a tendency to increase colonic metabolites after sustained intake (p = 0.052). In conclusion, continued consumption of the GCPE/BG nutraceutical appears to enhance the absorption of hydroxycinnamates by increasing the colonic bioavailability of their derived metabolites compared to baseline, although the regular intake of the nutraceutical did not modify the metabolite profile in any of the biol. samples. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Recommanded Product: 621-37-4

The Article related to human green coffee hydroxycinnamate betaglucan polyphenol bioavailability overweight obesity, Placeholder for records without volume info and other aspects.Recommanded Product: 621-37-4

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On March 31, 2022, Pozo-Martinez, Josue; Salgado, Francisco; Liempi, Ana; Kemmerling, Ulrike; Mera-Adasme, Raul; Olea-Azar, Claudio; Moncada-Basualto, Mauricio; Borges, Fernanda; Uriarte, Eugenio; Matos, Maria Joao published an article.SDS of cas: 621-37-4 The title of the article was Synthesis and study of the trypanocidal activity of catechol-containing 3-arylcoumarins, inclusion in β-cyclodextrin complexes and combination with benznidazole. And the article contained the following:

American trypanosomiasis or Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and is considered a neglected disease, being an important problem for public health. Benznidazole (BZN) is the drug used to treat the disease. However, it has limited efficacy and adverse side effects. Therefore, the development of new therapeutic alternatives is necessary. In this work, the trypanocidal activity and cytotoxicity of a series of catechol-containing 3-arylcoumarins, their combination with BZN, and the inclusion in β-cyclodextrins (β-CDs), were evaluated. The results obtained showed that the entire series has moderate trypanocidal activity on the trypomastigote form of the parasite, being the 3-(4′-bromophenyl)-6,7-dihydroxycoumarin (8) the most active compound (IC50 = 34 μM) and the most cytotoxic in Vero cells (IC50 = 162 μM) as well. By forming the inclusion complex 8-β-CDs, the trypanocidal activity and cytotoxicity decreased. In addition, the formation of inclusion complexes increased the solubility The possible mechanism of action of 8 was evaluated and proved to be through the generation of oxidative stress. The combination with BZN presented a synergistic effect on the trypanocidal activity, reducing the necessary dose of BZN. The presence of a catechol in the studied scaffold seems to modulate the trypanocidal activity, and the combination of drugs proved to be a promising alternative strategy for treating the disease. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

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Mohamedshah, Zulfiqar; Hayes, Micaela; Chadwick-Corbin, Sydney; Neilson, Andrew P.; Ferruzzi, Mario G. published an article in 2022, the title of the article was Bioaccessibility, gut microbial metabolism and intestinal transport of phenolics from 100% Concord grape juice and whole grapes are similar in a simulated digestion and fecal fermentation model.Recommanded Product: 3-Hydroxyphenylacetic acid And the article contains the following content:

Phenolic rich 100% grape juice has been associated with many health benefits, but its place in dietary guidance is controversial relative to whole fruit. Direct comparisons of phenolic profiles and bioavailability between these food forms are needed. Phenolic bioaccessibility and metabolism from Concord (CG) and Niagara (NG) grapes and corresponding 100% juices were investigated using an in vitro digestion coupled with anaerobic gut fermentation model. Intestinal transport of resulting bioaccessible phenolics and microbial metabolites was estimated using a Caco-2 cell model. Total bioaccessible phenolics from both upper and lower digestion were similar (P > 0.05) between NG (400.9 ± 26.3 μmol per 100 g) and NGJ (349.5 ± 8.3 μmol per 100 g) and significantly different (P < 0.05) between CG (417.2 ± 24.4 μmol per 100 g) and CGJ (294.3 ± 45.4 μmol per 100 g) total cellular transport of phenolics was similar (P > 0.05) between whole grapes (89.4 ± 5.3 μmol per 100 g for CG, and 71.8 ± 2.4 μmol per 100 g for NG) and 100% juices (88.0 ± 5.6 μmol per 100 g for CGJ, and 85.3 ± 9.4 μmol per 100 g for NGJ). Differences were observed between the location of phenolic metabolism, bioaccessibility and subsequent cellular transport of individual phenolics between grapes and juice matrixes. Specifically, greater amounts of phenolics were transported from grape juices than whole grapes from the upper tract. However, cumulative bioaccessibility and transport from upper and lower GI digestion/fermentation together indicates that the absorbable phenolics from 100% grape juice is similar to that of whole grapes, suggesting that phenolic-mediated health benefits from consumption of whole fruit and juice may be similar. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Recommanded Product: 3-Hydroxyphenylacetic acid

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On February 25, 2021, Li, Zhuo; Wang, Bing; Cui, Guo-Yi; Zhang, Bing-Bing; Wang, Ya-Fei; Yang, Lin; Ma, Hai-Xia; Jiao, Lin-Yu; Pang, Ling-Yan; Ma, Xiao-Xun published an article.Formula: C8H8O3 The title of the article was Construction of novel trimeric π-interaction subphthalocyanine-sensitized titanium dioxide for highly efficient photocatalytic degradation of organic pollutants. And the article contained the following:

In this study, highly active TiO2 sensitized by a novel axial substituted subphthalocyanine H12SubPcB-OPHCH2COOH (SubPc-3) was successfully prepared via a solvothermal method. Based on the crystallog. strategy, a new packing motif of SubPc-3 consisting of ligand-convex concave-concave head-head π-interaction was discovered for the first time, which affected its catalytic performance significantly. Furthermore, the DFT and TD-DFT methods were used to study the electronic feature and excited-state properties in SubPc-3 utilizing an optimized structure. By examining the degradation of methyl orange (MO) and bromophenol blue (BB) under visible light, the photocatalytic activities of the nanocomposites were investigated. The photocatalytic degradation rate of MO and BB degradation with TiO2/SubPc-3 are 97.8% and 99.5%, which are approx. 5.26 and 1.41 times compared to pure TiO2, resp. Besides, the reusability studies indicated that the photocatalytic activity of TiO2/SubPc-3 (25:1) could be maintained above 90.1% after five circulating photo-degradation This work revealed the correlation between π-interaction of sensitizer and photocatalytic performance, as well as further confirmed the great potential of TiO2/SubPc-3 photocatalytic materials in environmental remediation. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3

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Seguido, Miguel Angel; Tarradas, Rosa Maria; Gonzalez-Ramila, Susana; Garcia-Cordero, Joaquin; Sarria, Beatriz; Bravo-Clemente, Laura; Mateos, Raquel published an article in 2022, the title of the article was Influence of 8-week daily consumption of a new product combining green coffee hydroxycinnamates and beta-glucans on polyphenol bioavailability in subjects with overweight and obesity.Recommanded Product: 621-37-4 And the article contains the following content:

Nutraceuticals based on plant extracts rich in polyphenols, as well as dietary fibers, are new means to fight overweight/obesity and associated diseases. However, to understand the potential effects of polyphenols on health it is critical to study their bioavailability and metabolic fate. Consumption of a green coffee phenolic extract (GCPE) in combination with oat beta-glucan (BG) could affect the pharmacokinetic profile of the main polyphenols present in coffee (hydroxycinnamates). Moreover, the regular intake of the combination could also induce changes. Nine overweight men and women consumed a novel nutraceutical product containing 300 mg of green coffee hydroxycinnamic acids and 2.5 g of BG twice a day for 8 wk. A pharmacokinetic study was carried out in blood and urine samples taken before (baseline) and at week 8 after the nutraceutical intervention, collecting samples at different times in a 0-24 h interval. Faecal samples were also obtained at 0 and 24 h after the intake of the nutraceutical at baseline and week 8. Phenolic metabolites were analyzed by LC-MS-QToF. Results showed that polyphenols were differentially absorbed and extensively metabolized throughout the gastrointestinal tract. An apparent reduction in the excretion of small intestinal metabolites was accompanied by a tendency to increase colonic metabolites after sustained intake (p = 0.052). In conclusion, continued consumption of the GCPE/BG nutraceutical appears to enhance the absorption of hydroxycinnamates by increasing the colonic bioavailability of their derived metabolites compared to baseline, although the regular intake of the nutraceutical did not modify the metabolite profile in any of the biol. samples. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Recommanded Product: 621-37-4

The Article related to human green coffee hydroxycinnamate betaglucan polyphenol bioavailability overweight obesity, Placeholder for records without volume info and other aspects.Recommanded Product: 621-37-4

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